Vipidia ndi mankhwala omwe amapangidwira kuti athandize odwala matenda ashuga a mtundu wosadalira insulini.
Mankhwalawa amagwiritsidwa ntchito pokhazikitsa monotherapy, komanso panjira yovuta ya matenda ngati mankhwala.
Alogliptin ndi mtundu watsopano wa mankhwala ogwiritsidwa ntchito pochiza matenda ashuga, omwe samadalira insulin. Mankhwala amtunduwu ali m'gulu la mankhwala otchedwa incretinomimetics.
Gululi limaphatikizapo ma glucagon-ndi glucose-omwe amadalira insulinotropic polypeptides. Mankhwalawa amayankha kukhudzana kwa anthu polimbikitsa kuphatikizira kwa insulin.
Gululi muli magulu amitundu iwiri ya apretin mimetics:
- Mankhwala okhala ndi chochita chofanana ndi zochita za ma impretins. Mankhwala amenewa amaphatikiza liraglutide, exenatide ndi lixisenatide.
- Mankhwala omwe amatha kutalikitsa zochita za insretin zomwe zimapangidwa mthupi. Kukula kwa incretin kanthu kumachitika chifukwa chakuchepa kwa kupanga kwapadera kwa puloteni, dipeptidyl peptidase-4, yomwe imachita chiwonongeko cha ma insretin. Zinthu zoterezi zimaphatikizapo sitagliptin, vildagliptin, saxagliptin, linagliptin ndi alogliptin.
Alogliptin ali ndi mphamvu yosankha zoletsa pakapangidwe kabwino ka enzyme dipeptidyl peptidase-4. Kusankha kwoletsa kutulutsa mphamvu pa enzyme DPP-4 mu alogliptin ndikwapamwamba kwambiri poyerekeza ndi zomwe zimachitika mu ma enzymes okhudzana.
Vipidia ikhoza kusungidwa kwa zaka zitatu. Pambuyo pa nthawi imeneyi, kugwiritsa ntchito mankhwala koletsedwa. Malo osungiramo mankhwalawa amayenera kutetezedwa kuti asayang'anitsidwe ndi dzuwa. Ndipo kutentha m'malo osungirako sikuyenera kupitirira 25 digiri.
Zizindikiro ndi contraindication kuti mugwiritse ntchito
Vipidia ndi mankhwala amkamwa a hypoglycemic. Chida ichi chikugwiritsidwa ntchito pochiza matenda a shuga a mtundu wachiwiri. Mankhwalawa a shuga amathandizira kusintha kwa glycemia m'magazi a munthu wodwala. Mankhwala amagwiritsidwa ntchito ngati kugwiritsidwa ntchito kwa mankhwala othandizira pakudya komanso kuchita masewera olimbitsa thupi mopatsa thupi sikufuna.
Mankhwala angagwiritsidwe ntchito ngati chinthu chokhacho pa monotherapy. Kuphatikiza apo, Vipidia ikhoza kugwiritsidwa ntchito limodzi ndi mankhwala ena a hypoglycemic pochiza matenda a shuga 2 mwa njira yovuta yothandizira.
Mankhwala angagwiritsidwe ntchito pochiza matenda a shuga limodzi ndi insulin.
Monga mankhwala aliwonse, Vipidia imakhala ndi zotsutsana zingapo zomwe zimachepetsa kugwiritsa ntchito mankhwalawa. Mfundo zazikuluzikulu ndi izi:
- kukhalapo kwa mtundu wachiwiri wa shuga wodwala, hypersensitivity kuti alogliptin ndi gawo lothandizira la mankhwalawa;
- wodwala amadwala matenda a shuga;
- chizindikiritso cha ketoacidosis opezeka m'thupi la wodwalayo motsutsana ndi matenda a shuga;
- chizindikiritso choopsa cha mtima;
- zovuta mu chiwindi, zomwe zimayendera limodzi ndi kupezeka kwa magwiridwe antchito;
- chitukuko cha matenda a impso, omwe limodzi ndi kukhalapo kwa magwiridwe antchito;
- nthawi yobereka mwana;
- nthawi yotsekera;
- wodwala zaka mpaka 18.
Chenjezo liyenera kuchitika pamene wodwalayo ali ndi kapamba komanso kuchepa kwa chiwopsezo chaimpso ndi kwa chiwindi.
Kuphatikiza apo, muyenera kusamala mukamagwiritsa ntchito mankhwalawa monga gawo limodzi pakachira matenda a shuga a mtundu II.
Malangizo ogwiritsira ntchito mankhwalawa
Mankhwala amatengedwa pakamwa. Nthawi zambiri, mankhwala achire omwe amalimbikitsidwa kuti agwiritse ntchito ndi 25 mg.
Mlingo wovomerezeka wa kugwiritsa ntchito mankhwalawa umaperekedwa ndi dokotala woganizira zotsatira zomwe zimapezeka poyeza thupi la wodwalayo ndi machitidwe ake.
Mankhwalawa amatengedwa kamodzi patsiku, mankhwalawa amatengedwa mosasamala ndondomeko yakudya. Kumwa mankhwalawo limodzi ndi kumwa madzi ambiri.
Kugwiritsa ntchito mankhwala ndikotheka munthawi zotsatirazi:
- Ngati mankhwala a monotherapy a mtundu 2 matenda a shuga.
- Pakukhazikitsa zovuta mankhwala a matenda, monga gawo la mankhwala. Mogwirizana ndi vipidia, metformin, sulfonylurea zotumphukira kapena insulin akhoza kumwedwa.
Pankhani ya Vipidia osakanikirana ndi Metformin, kusintha kwa mankhwalawa sikufunika. Kusintha kwa Mlingo kumafunika mukamagwiritsa ntchito mankhwala molumikizana ndi mankhwala omwe amachokera ku sulfonylurea kapena insulin.
Mlingo umasinthidwa kuti muchepetse kuyambika kwa hypoglycemic state mwa wodwala yemwe ali ndi matenda osokoneza bongo.
Chenjezo liyenera kulimbikitsidwa mukamagwiritsa ntchito Vipidia pophatikiza ndi Metformin Teva ndi thiazolidinedione pochiza matenda ashuga.
Zizindikiro zoyambirira za hypoglycemia zitawoneka, mulingo wa Metformin ndi thiazolidinedione uyenera kuchepetsedwa.
Mukamamwa Vipidia, zotsatirazi zimakhala zotsatirazi:
- Kuchokera kwamanjenje, kumachitika kwa mutu pafupipafupi;
- Kuchokera m'mimba, mawonekedwe a kupweteka pamimba, ndikuponya zomwe zili m'mimba m'mimba, kukulira kwa zizindikiro za kapamba;
- kuchokera ku hepatobiliary system, kumachitika zosokoneza mu ntchito ya chiwindi ndikotheka;
- thupi lawo siligwirizana angayambe mu mawonekedwe a kuyabwa, totupa, edincke;
- kutupa kwa mphuno ndi pharynx n`zotheka;
Kuphatikiza apo, chitetezo chamthupi chimatha kuyambitsa zovuta, zowonetsedwa ngati anaphylaxis.
Mtengo wa Vipidia ndi fanizo zake
Kugwiritsa ntchito mapiritsi a Vipidia a matenda ashuga nthawi zambiri kumakhala koyenera.
Ngati tiweruza mankhwalawa ndi ndemanga zomwe anthu omwe amagwiritsa ntchito Vipidia amasiya, tingathe kunena kuti mankhwalawa ndi mankhwala othandiza kwambiri omwe amatha kuwongolera bwino matenda a glycemia m'thupi la munthu yemwe akudwala matenda a shuga a mtundu wachiwiri.
Mankhwala chopangira chogwira, chomwe ndi alogliptin mpaka pano, kuwonjezera pa Vipidia sichinalembedwe.
Mankhwala opangidwa, omwe amagwira ntchito omwe amaphatikizidwa ndi gulu la incretinomimetics.
Mankhwala omwe ali ngati chiwongola dzanja cha Vipidia ndi awa:
- Januvia ndi mankhwala a hypoglycemic opangidwa pamaziko a sitagliptin. Kutulutsidwa kwa mankhwalawa kuli ngati mapiritsi omwe ali ndi 25, 50 ndi 100 mg yogwira ntchito. Zizindikiro zogwiritsira ntchito Januvia ndizofanana ndi zomwe Vipidia ali nazo. Mankhwalawa amatha kugwiritsidwa ntchito ndi monotherapy kapena ndi zovuta mankhwala.
- Yanumet ndi kukonzekera kovuta, komwe kumakhala ndi sitagliptin ndi metformin ngati zigawo zogwira ntchito. Mlingo wa gawo loyambirira ndi 50 mg, ndipo metformin mu kapangidwe kamankhwala imatha kupezeka mosiyanasiyana. Mankhwalawa amapezeka m'mitundu itatu - 50, 850 ndi 1000 mg.
- Galvus ngati gawo logwira lomwe lili ndi vildagliptin, yomwe ndi analogue ya alogliptin. Mlingo wa zomwe zimagwiritsidwa ntchito pokonzekera ndi 50 mg. Mlingo wa metformin wopangidwa ndi mankhwalawa ndi 500, 850, ndi 1000 mg.
- Onglisa mu kapangidwe kake ngati yogwira popanga pali saxagliptin. Pulogalamuyi ikukhudzana ndi zinthu zomwe zimalepheretsa enzyme kutsitsa incretin. Mankhwala amapezeka mu mlingo wa 2,5 ndi 5 mg.
- Combogliz Prolong ndi kuphatikiza kwa saxagliptin ndi metformin. Mankhwalawa amapezeka piritsi. Kutulutsidwa kwa magawo omwe amagwira ntchito kumachitika mu mawonekedwe osachedwa.
- Trazhenta ndi mankhwala a hypoglycemic opangidwa pamaziko a linagliptin. Kuphatikizika kwa mankhwalawa kumakhala ndi 5 mg yogwira ntchito.
Mtengo wa mankhwala umatengera dera lomwe mankhwalawo amagulitsidwa ku Russia. Mtengo wapakati wa mankhwalawa ndi ma ruble 843.
Ndi zithandizo zina ziti zomwe zingagwiritsidwe ntchito pochiza matenda osokoneza bongo zomwe zafotokozedwa muvidiyoyi.
