Rosulip tikulimbikitsidwa kuti muchepetse cholesterol. Amagwiritsidwa ntchito pa matenda a shuga mellitus, atherosclerosis, matenda oopsa komanso matenda ena a mtima. Chopanga chachikulu ndi zochita zake ndi rosuvastatin.
Rosuvastatin ndi mankhwala osokoneza bongo a statin. Gawolo limathandizira kuyamwa kwa lipoprotein ndi triglycerides mu chiwindi cha wodwalayo. Mankhwalawa sadziwika ndi kuchitapo kanthu mwachangu. The achire zotsatira zimadziwika sabata pambuyo ntchito.
Pakatha mwezi umodzi chithandizo, zotsatira zotchulidwa zimadziwika. Ndili ndi malingaliro awa kuti atha kusankha kupitiliza chithandizo chamankhwala kapena kupereka analogue ya mankhwala ngati zotsatira zake sizikwanira kwa wodwala.
Mankhwala amapezeka piritsi, mitundu yosiyanasiyana. Ganizirani zamankhwala omwe mankhwalawa amakhala nawo akakhala kuti akuyenera kugwiritsidwa ntchito, komanso ngati mankhwala omwewa amasankhidwa?
Kutulutsa Fomu ndi Zizindikiro Zogwiritsira Ntchito
Rosulip imapezeka piritsi. Piritsi lililonse limakhala lophimba. Mapiritsiwo ndi ozungulira kapena ozungulira, mtundu ndi woyera kapena pastel, mbali ina pali zolemba ndi zilembo "E", mbali inayo pali manambala omwe akuwonetsa kipimo. Mwachitsanzo, nambala 591 imatanthawuza kuti kuchuluka kwake ndi ma milligram asanu, ndipo chiwerengero cha 592 ndi chofanana ndi 10 mg pazomwe zimagwira.
Pamankhwala mutha kugula Rosulip 10 mg ndi 5 mg, 20 ndi 40 mg. Dokotala amakupangira mankhwala a odwala matenda ashuga, simungathe kumwa nokha. Kuphatikiza pa gawo lokangalika, zida zothandizira zimaphatikizidwa. Makamaka, povidone, lactose monohydrate, magnesium stearate, crospovidone ndi zinthu zina.
Mankhwala osokoneza maziko a ntchito ali ndi lipid-yotsitsa, ndi gulu la mankhwala a statins.
Zisonyezero zogwiritsira ntchito mankhwalawa:
- Chithandizo cha chachikulu mawonekedwe a 2a hypercholesterolemia. Mtundu wa 2b umagwiritsidwa ntchito ngati cholumikizira zakudya.
- Kuphatikiza pa chakudya chopatsa thanzi komanso njira zina zamankhwala zomwe zimathandizira kuchepetsa kuchuluka kwa mafuta mthupi ndi mtundu wa homozygous hypercholesterolemia.
- Kuchuluka kwa triglycerides m'magazi a wodwala (mapiritsi amaphatikizidwa ndi zakudya).
- Kuphatikiza chakudya chopatsa thanzi komanso chosasamalitsa chothandiza kuchepetsa kuchepa kwa cholesterol mwa anthu odwala matenda ashuga omwe ali ndi mbiri ya pang'onopang'ono.
Chida chimagwiritsidwa ntchito ngati chisonyezo cha zovuta zochokera mumtima ndi m'mitsempha yamagazi. Amachepetsa chiopsezo cha matenda a mtima, hemorrhagic stroke. Ndikulimbikitsidwa kwa kusintha kwa moyo wa asymptomatic, koma ndi chiopsezo chokhala ndi matenda amtima.
Amawerengera pamaso pa zinthu zoyipa monga matenda oopsa, kuchepa kwa mafuta ambiri; Ngati mbiri ya banja idakhalapo ndi matenda a m'matumbo oyamba.
Anthu odwala matenda ashuga amalangizidwa kuti atenge zomwe zili mu LDL zatha magawo atatu.
Ngati mbiri yodwala matenda a mtima yapezeka, ndiye kuti mankhwalawo amayankhidwa ndi mtima, osagwirizana ndi cholesterol.
Pharmacological kanthu ndi pharmacokinetics
Rosuvastatin monga gawo logwira ntchito limawoneka ngati wopikisana pa mpikisano wa HMG-CoA reductase enzyme, womwe umathandizira kusintha zinthu zina kukhala mevalonate, cholesterol precursor wodziwika bwino.
Chifukwa cha kuchuluka kwa cholesterol yotsika kwambiri mu hepatocytes mothandizidwa ndi chinthu chogwira, njira ya mayamwidwe ndi catabolism ya cholesterol yoyipa imakulitsidwa. Njira zopanga ma lipoprotein mu chiwindi zimaphatikizidwanso.
Kutalika kwa mankhwalawa chifukwa cha mankhwalawa kumakuthandizani kuti muchepetse LDL pang'onopang'ono koma mosalekeza, yomwe imachepetsa kwambiri zovuta m'mtima ndi m'mitsempha yamagazi.
Mankhwala ndi mankhwala ali motere:
- Zomwe zimakhala ndi cholesterol yayitali kwambiri m'thupi la odwala matenda ashuga zimachuluka;
- Kuchuluka kwa LDL ndi cholesterol yathunthu, triglycerides yafupika;
- Mlingo wa apolipoprotein A-I ukuwonjezeka;
- Mlingo wa apolipoprotein B. umachepa.
Chipangizocho chili ndi katundu wophatikizidwa, kotero kusintha koyambirira kumawululidwa pakatha sabata. Kuchuluka kwazomwe kumagwira ntchito m'magazi a anthu kumatha kuchitika pambuyo pa masabata 3-4 ogwiritsa ntchito - pakadali pano, mankhwalawa amapereka zotsatira za 90% zomwe zingatheke.
Zokwanira pazinthu zotsutsana ndi maziko azogwiritsidwa ntchito mwadongosolo zimapezeka maola asanu mutatha kugwiritsa ntchito. The bioavailability ya mankhwalawa ndi 20%; imawonjezeka molingana ndi mlingo womwe waperekedwa.
Rosuvastatin, wotengeka ndi chiwindi, amalumikizana ndi cholesterol, chifukwa chomwe cholesterol yotsika pang'ono imawotchedwa. Pafupifupi 90% ya chinthu chogwira ntchito m'thupi la munthu chimamangiriza mapuloteni.
Pafupifupi 90% ya Mlingo wovomerezeka umatulutsidwa mwachilengedwe ndi ndowe, pafupifupi 5% imachoka m'thupi mu impso.
Hafu ya moyo wa mankhwalawa ndi maola 18 - 19 (sizitengera mlingo womwe watengedwa).
Malangizo ogwiritsira ntchito mankhwalawa
Momwe mungatenge Rosulip 10MG muuzeni dokotala. Muyenera kugula mankhwala ku pharmacy; mankhwala a dokotala amafunikira. Mtengo umasiyanasiyana wopanga. Chithandizo chotsika mtengo kwambiri chachipatala chimadya ma ruble 690, mankhwala okwera mtengo achilendo ochokera ku ruble 850.
Mapiritsi a zincuvastatin nthaka ayenera kumwedwa. Kuonetsetsa kufunika kwa achire, zimamezedwa zonse, zosambitsidwa ndi madzi okwanira. Ndizosatheka kupera mu ufa, kutafuna, kuphwanya, ndi zina, chifukwa izi zimaphwanya umphumphu wa enteric ating kuyanika, motero, malo ankhanza am'mimba "amapha" chinthu chomwe chimagwira.
Palibe ubale pakati pa chakudya ndi mankhwala. Mapiritsi amatha kumwa ndi chakudya, musanadye chakudya cham'mimba, kapena chakudya. Malangizo ogwiritsira ntchito akuwonetsa kuti mankhwalawa amayenera kuphatikizidwa ndi zakudya zomwe zimakhazikitsidwa ndi zakudya zomwe zimakhala zotsika mafuta m'thupi.
Rosulip adapangidwira odwala matenda ashuga pamene kuwunika kwa cholesterol kwawonetsa zotsatira zopitilira 3 mmol pa lita. Mukamasankha, gawo la wodwala yemwe ali ndi matenda ashuga liyenera kukumbukiridwa.
Malangizo azikhalidwe:
- Njira yochizira imayamba ndi kuchuluka kwa 5-10 mg. Ngati cholesterol ikadalipo pambuyo pa milungu 4, ndiye kuti kuchuluka kwa mankhwalawa, Rosulip 20 mg ikhoza kutumikiridwa.
- Pambuyo pa chithandizo cha milungu 4, odwala omwe ali ndi vuto la hypercholesterolemia omwe ali pachiwopsezo cha matenda a mtima ndi mtima amapatsidwa 40 mg tsiku lililonse.
- Akuluakulu odwala matenda ashuga amadalira 5 mg wa mankhwala patsiku. Pambuyo pake, mlingo samakulira chifukwa cha zoletsa zaka.
- Ngati wodwalayo wasokoneza ntchito yaimpso yolimbitsa thupi (mtundu wa creatinine mpaka 60 ml), mbiri yakudziwikiratu kwa myopathy komanso kwa odwala amtundu waku Asia, mlingo woyambira ndi 5 mg; 20-40 mg sasankhidwa konse.
Pomwe chithandizo cha Rosulip cha matenda a shuga sichinathandize kuchepetsa LDL ndi triglycerides, mankhwala ena amaphatikizidwa mu regimen ya chithandizo - nicotinic acid, ndalama kuchokera ku gulu la fibrate.
Kuwonjezeka kwa mlingo wa Rosulip pambuyo pa milungu 4 ya mankhwala kumachitika pokhapokha kuwunikira zizindikiro za mafuta kagayidwe.
Contraindication ndi zoyipa
Nthawi zambiri, simungagwiritse ntchito mankhwalawa kuti muchepetse cholesterol, chifukwa imakhala ndi zotsutsana ndi zamankhwala. Cholozera china chimaperekedwa ngati wodwala wakhazikitsa kapena kukayikira Hypersensitivity pazomwe zimagwira kapena zinthu zina za mankhwala.
Iwo ali osavomerezeka kuti agwiritse ntchito maziko a gawo la chiwindi, omwe amaphatikizidwa ndi kuwonjezereka kwa ntchito ya ma seramu transaminases; kwambiri zinchito kuwonongeka kwa impso (creatinine chilolezo zosakwana 30 ml pa unit nthawi).
Osamalembera ana ochepera zaka 18 omwe akudwala matenda ashuga. Ndizosatheka ndi myopathy komanso chizolowezi cha myotoxic zovuta, glucose-galactose malabsorption, kuchepa kwa lactase.
Gawani mosamala pazithunzi zotsatirazi:
- The chiwopsezo cha myopathy, mkhutu aimpso ntchito;
- Matenda a chiwindi;
- Sepsis;
- Matenda oopsa
- Hypothyroidism
Ndikulimbikitsidwa mosamala kwa odwala omwe ali ndi mbiri yodalira mowa. Kuchiza kumabweretsa zotsatira zoyipa. Zojambulidwa zambiri, zoyipa za mawonekedwe opepuka komanso kudutsa msanga zimadziwika.
Kugwiritsa ntchito mankhwala a Rosulip kungayambitse:
- Angioneurotic edema (kawirikawiri).
- Mutu, chizungulire (nthawi zambiri), kuchepa kwa chidwi, mavuto a kukumbukira (kawirikawiri).
- Kusokoneza kwam'mimba, kuphwanya m'mimba / kudzimbidwa, nseru, kupweteka kwa epigastric dera (nthawi zambiri). Kuchulukitsidwa kwa chiwindi michere, kukula kwa kapamba kapamba (kawirikawiri). Jaundice wowopsa, hepatitis (osowa kwambiri).
- Mu odwala matenda ashuga, monga mbali, kuyabwa kwa khungu kumawonedwa, urticaria, totupa zingapo zimawonekera pakhungu.
- Myalgia (nthawi zambiri).
- Chifuwa chosabereka, kupuma movutikira, kupuma movutikira (kawirikawiri).
Mankhwalawa, odwala matenda ashuga ayenera kuyang'anitsitsa shuga wawo wamagazi, chifukwa nthawi zina Rosulip amakhumudwitsa kusinthasintha kwa glycemia.
Analogs ndi ndemanga
Ndemanga pa mankhwala ndizochepa. Anthu odwala matenda ashuga omwe amamwa mankhwalawa amawona kuti amagwira ntchito limodzi ndi zakudya. Kugwiritsa ntchito kosavuta kumayimiranso, popeza ndizokwanira kumwa kamodzi patsiku, mosasamala za chakudya.
Analogue ya kapangidwe ka mankhwala Rosulip - Rosart. Kuphatikizikako kuli ndi chinthu chimodzi chomwe chikugwira. Mlingo wa kutulutsidwa - mapiritsi mu muyeso wa 5-10- 20 mg. Ndi gawo la gulu la ma statins, limagwiritsidwa ntchito pochiza mafuta ambiri a cholesterol komanso matenda a pathological omwe amayenderana ndi kuwonjezeka kwa magazi LDL. Iwo tikulimbikitsidwa monga prophylaxis matenda a mtima dongosolo.
Rosart imayamba kutengedwa ndi 5 mg. Ngati ndi kotheka, mlingo umakulitsidwa mpaka mamiligalamu 10, nthawi ya maphunziro imatsimikiziridwa payekhapayekha - kutengera mulingo wa LDL m'magazi a odwala. Anthu odwala matenda ashuga amayikidwa mosamala.
Contraindication kuti agwiritse ntchito:
- Nthawi yobereka mwana;
- Gawo la kukhathamira kwa ma cell a chiwindi;
- Hypersensitivity;
- Kulera;
- Ana a zaka mpaka 18;
- Matenda aimpso.
Rosucard amathandizira kutsitsa lipid. Zotsatira za mankhwalawa zimachitika chifukwa cha kuchuluka kwa mankhwala omwe ali pakamwa. Mosiyana ndi Rosulip, ili ndi zotsutsana zochepa. Izi zimaphatikizapo kutenga pakati, kuyamwa, myopathy, matenda a impso / chiwindi, kusalolera kwa organic. Osati kupatsidwa kwa azimayi amisinkhu yobala mosayang'ana kumbuyo kwa kulera. Mankhwalawa amalembera mosamala zakumwa zoledzeretsa, zakumwa zoledzeretsa komanso kuphatikiza ndi ma fiber.
Mutha kuwonjezera mndandanda wazofanana ndi mankhwala - Klivas, Rosuvastatin Sandoz, Akorta, Atomax, Simvastol ndi mankhwala ena. Ndi kukula kwa zoyipa zimachitika, dokotala amasankha cholowa m'malo, mlingo umatsimikiziridwa molingana ndi gawo loyambirira la cholesterol, simungathe kudzilimbitsa. The achire zotsatira amapezeka pokhapokha limodzi ndi chakudya.
Zambiri zokhudzana ndi ma statins zimaperekedwa kanema munkhaniyi.
