Mafuta amtunduwu amakhala ndi maselo oteteza thupi omwe angayambitse kukula kwa zotupa, matenda a shuga ndi matenda ena. Koma muziyamba kuchita zinthu zofunika kwambiri
Gulu loyipa
Monga mukudziwa, matenda a shuga a 2 nthawi zambiri amakhala ndi onenepa kwambiri. Nayi mtundu wamabwalo oyipa. Chifukwa chakuti minofu imaleka kuyankha mwachizolowezi ku insulin ndikumata shuga, kagayidweko kamatayika, kamene kamakhala ndi ma kilogalamu owonjezera.
Mwa anthu onenepa kwambiri, maselo amafuta amawonongeka nthawi zonse, ndipo amasinthidwa ndi ena atsopano, ochulukirapo. Zotsatira zake, DNA yaulere yama cell akufa imawoneka m'magazi ndipo shuga imakwera. Kuchokera m'magazi, DNA yaulere imalowa m'maselo a chitetezo, macrophages oyendayenda mu minofu ya adipose. Asayansi ochokera ku yunivesite ya Tokushima ndi University of Tokyo apeza kuti poyankha chitetezo cha mthupi, chotupa chimayamba.
Nkhani zoipa
Ofufuza ochokera ku Yunivesite ya California, San Diego apeza kuti zotchulidwa zakale za macrophages zotchulidwa - ma microscopic vesicles omwe amathandizira kusinthanitsa chidziwitso pakati pa maselo. Exosomes muli microRNA - mamolekyulu oyendetsera omwe amakhudza kaphatikizidwe kazinthu kena. Kutengera ndi omwe microRNA idzavomerezedwe mu "uthenga" ndi foni yomwe mukufuna, njira zowongolera zimasinthira malinga ndi zomwe zalandira. Zotuluka zina - zotupa - zimakhudza kagayidwe kachakudya kotero kuti ma cell amakhala insulin.
Panthawi yoyesererayi, zotupa zakunyentchera zimayikidwa mu nyama zathanzi, ndipo chidwi chake cha minofu ya insulin chinadodometsedwa. Mosiyana ndi izi, "wathanzi" limaperekedwa kwa nyama zodwala zomwe zimabwezeretsa insulin.
Lawi
Ngati kuli kotheka kudziwa kuti ndi ma microRNA ati ochokera ku exosomes omwe amayambitsa matenda ashuga, madokotala amalandira "mipherezo" yopangira mankhwala atsopano. Malinga ndi kuyesa kwa magazi, momwe kumakhala kosavuta kudzipatula miRNA, ndizotheka kufotokoza momveka bwino mwayi wokhala ndi matenda ashuga mwa wodwala wina, komanso kusankha mankhwala omwe angamuthandize. Kusanthula koteroko kungathenso kusintha mtundu wopweteka womwe umagwiritsidwa ntchito pofufuza momwe minofu iliri.
Asayansi akukhulupirira kuti kuwonjezeranso kuphunzira ma miRNA sikungathandize popewa matenda ashuga, komanso ku mavuto ena a kunenepa kwambiri.
