Nateglinide ndi mankhwala opangidwa ndi katundu wa hypoglycemic, kugwiritsa ntchito komwe kumakupatsani mwayi wowongolera glycemia m'magazi omwe ali ndi matenda a shuga a mtundu wa 2.
Nateglinide ndimtundu wa amino acid wokhala ndi katundu wa hypoglycemic.
Kugwiritsa ntchito mankhwalawa kumakupatsani mwayi wolamulira glycemia m'thupi la wodwala yemwe ali ndi matenda ashuga.
Kuwongolera kuchuluka kwa shuga mthupi la wodwalayo kumachitika chifukwa cha kukondweretsedwa kwa kuphatikizika kwa insulin yam'madzi m'maselo a beta a kapamba ndimankhwala.
Mankhwalawa ndi ufa woyera womwe umasungunuka mosavuta mu methyl ndi ethyl mowa ndi chloroform. Imasungunukanso mu ether, ndizovuta kupasuka mu acetonitrile ndi octanol. Mankhwala ndi osapindulira m'madzi. Kulemera kwa ma cell ndi 317.45.
Pharmacodynamics wa mankhwala
Mankhwala ndi othandizira pakamwa hypoglycemic, mankhwalawa amachokera ku phenylalanine.
Munthawi ya mankhwala ndi mankhwala, mankhwala ali ndi kusiyana kwakukulu kuchokera ku mankhwala ena a hypoglycemic.
Kugwiritsa ntchito mankhwalawa kumakuthandizani kuti mubwezeretsenso njira yoyambira yotulutsira insulin, yomwe imachepetsa kufalikira kwa glucose m'magazi am'magazi komanso kuchuluka kwa hemoglobin HbA1c.
Njira ya katulutsidwe koyambirira ka insulin monga yankho la kuchuluka kwa shuga m'magazi ndi njira yofunika kwambiri yokhazikitsira index ya glycemic, yomwe imatsimikizira magwiridwe antchito amthupi.
Pankhani ya chitukuko cha mitundu iwiri ya matenda a shuga a insulin osadalira inshuwaransi, kapangidwe ka insulin kamene kamasokonezeka. Kuphatikiza apo, gawo loyambirira la kaphatikizidwe limatha kutha kwathunthu. Nateglinide, yomwe imatengedwa musanadye chakudya, imakhala mwanjira yoti thupi libwezeretse gawo ili la kuphatikiza kwa mahomoni.
Limagwirira a ntchito ya mankhwala ndiwofulumira komanso kusintha kosangalatsa kwa yogwira mankhwala pa ATP-amadalira potaziyamu potaziyamu zomwe zimapanga ma cell a beta a pancreatic minofu. Nateglinide imayambitsa kaphatikizidwe ka insulin m'mphindi 15 zoyambirira mukatha kudya. Kuchita izi kwa mankhwalawa kumathandizira kuti muchepetse kupendekera kosinthasintha kwa shuga m'magazi am'magazi.
Maola otsatirawo, chizindikiro cha insulini chimayambiranso kukhala chachilendo, chomwe chimapewa kuchitika kwa hyperinsulinemia, komwe kumayambitsa kukula kwa hypoglycemia.
Zizindikiro ndi contraindication ntchito, bongo
Nateglenide imagwiritsidwa ntchito ngati wodwala ali ndi mtundu wachiwiri wa insulin wodalira matenda osagwirizana ndi inshuwaransi chifukwa chosintha zabwino mukamagwiritsa ntchito mankhwala othandizira pakudya komanso machitidwe olimbitsa thupi.
Mankhwalawa angagwiritsidwe ntchito onse awiri pa monotherapy komanso ngati gawo la mankhwala ochizira matenda a shuga a mtundu II.
Nthawi zambiri, mankhwalawa amagwiritsidwa ntchito limodzi ndi Metformin.
Mukamagwiritsa ntchito mankhwalawa, pali zotsutsana zingapo zomwe zimagwiritsidwa ntchito. Zomwe zili pakati pa contraindication ogwiritsa ntchito Nateglinide ndi awa:
- kukhalapo kwa wodwala wodwala matenda a shuga 1;
- kukhalapo kwa wodwala matenda a shuga mellitus zizindikiro za chitukuko cha matenda ashuga ketoacidosis;
- kudziwika kwa zovuta ntchito chiwindi;
- nthawi ya bere ndi nthawi yoyamwitsa;
- zaka za ana odwala wodwala matenda ashuga;
- kukhalapo kwa kuchuluka kwa chidwi ndi zigawo zomwe zimaphatikizidwa ndi mankhwala.
Kutengera kapangidwe kazomwe mankhwala amapangira thupi, zitha kuganiziridwa kuti chotsatira chachikulu cha kuphwanya kwa mankhwala othandizira pochizira matenda a shuga ndikukhazikika kwa hypoglycemia wodwala, komwe kumatha kuwonekera pang'onopang'ono kusiyanasiyana kutengera kukula kwa mankhwala osokoneza bongo panthawi yamankhwala.
Kusankhidwa kwa njira yochizira matenda osokoneza bongo kumadalira kuchuluka kwa mawonekedwe.
Pomwe mukukhalabe wodwalayo ndikusazindikira mawonekedwe a mitsempha, ndikofunikira kuti mutenge glucose kapena shuga mkati ndikusintha kudya.
Ndi kukula kwambiri mawonekedwe a hypoglycemic boma, momwe muli chitukuko cha chikomokere, tikulimbikitsidwa kuchita intravenous shuga njira.
Njira ya hemodialysis ndi njira yabwino, popeza Nateglitin ali ndi miyeso yambiri yomanga mapuloteni a plasma.
Malangizo ogwiritsira ntchito mankhwalawa
Kumwa mankhwala osokoneza bongo kuli mkati.
Pankhani ya monotherapy, muyeso wa 120-180 mg katatu patsiku ndi mankhwala.
Ngati Nateglinide imagwiritsidwa ntchito ngati imodzi mwazinthu zovuta kwambiri zochizira, mulingo woyenera panthawi ya mankhwalawa umachokera pa 60 mpaka 120 mg katatu patsiku.
Pogwiritsa ntchito mankhwalawa, wodwalayo amatha kukulitsa zovuta zina mthupi.
Zotsatira zoyipa mukamamwa mankhwalawa zimawonetsedwa poyenda zotsatirazi ndi ziwalo za thupi la wodwala:
- Kuphwanya kwamanjenje ndi ziwalo zamagetsi.
- Zosokoneza pakugwira ntchito kwa kupuma.
- Kulephera m'matumbo am'mimba.
- Matenda a metabolism.
Kuphatikiza apo, mavuto amabwera omwe amakhudza zomwe zimachitika mthupi.
Ngati pali zovuta m'mitsempha, wodwalayo amakhala ndi chizungulire.
Zovuta mu kupuma zimawonekera mwa kuwonekera kwa kupuma kwa wodwala, kukula kwa zizindikiro za bronchitis, ndi mawonekedwe a chifuwa.
Pakachitika zovuta zomwe zimakhudza kugwira ntchito kwa m'mimba, wodwalayo amawoneka ngati akutsegula m'mimba komanso akumva mseru.
Zotsatira zoyipa za kusokonezeka kwa kagayidwe kachakudya ndi kakulidwe ka matenda a hypoglycemic m'thupi la wodwalayo, komanso m'mavuto akulu kwambiri a glycemic coma.
Kukula kwa chikhalidwe cha hypoglycemic pogwiritsa ntchito Nateglinide pa mankhwala ndizosowa kwambiri.
Khansa ya m'mimba ndi kutsegula m'mimba monga zotsatira zoyipa za mankhwalawa zimawonekeranso kawirikawiri, nthawi zambiri zotsatirazi zimadza mwa munthu pogwiritsa ntchito zovuta za mtundu 2 za shuga ngati Metformin ndi imodzi mwazachipatala.
Nthawi zina mukatenga Netelinid wodwala yemwe ali ndi matenda osokoneza bongo, monga mbali yotsatira, mawonekedwe a kupweteka kwa msana amadziwika.
Kuphatikiza apo, mikhalidwe yonga chimfine imatha kukula m'thupi la wodwalayo.
Mndandanda wa mankhwalawa, kusunga ndi mtengo wa mankhwalawo
Mankhwalawa amayenera kusungidwa m'malo amdima. Kutentha kosungiramo mankhwalawa kuyenera kukhala kosiyanasiyana mpaka 15 mpaka 30 digiri Celsius.
Alumali moyo wa mankhwala ndi zaka ziwiri. Ikatha nthawi yosungirako, mankhwalawo amaletsedwa kugwiritsa ntchito mankhwalawa. Katundu womalizira ayenera kubwezerezedwanso.
Malo osungira mankhwalawa sayenera kupezeka kwa ana.
Mpaka pano, makampani opanga zamankhwala amatulutsa mitundu yambiri ya mankhwala omwe ali ndi vuto lofanana ndi thupi la odwala omwe ali ndi matenda a shuga a mtundu wa 2.
Mankhwala omwe ali ndi vuto lofanana ndi awa:
- Guarem;
- Amaryl;
- Victoza;
- Kuphatikizana;
- Galvus Met;
- Metformin Teva;
- Langerine;
- Siofor850 ndi ena.
Odwala ambiri omwe agwiritsa ntchito Natelitid munthawi yamankhwala amasiya ndemanga zabwino za mankhwalawa.
Kukhalapo kwa malingaliro oyipa okhudzana ndi mankhwalawa nthawi zambiri kumayenderana ndi vuto la Mlingo.
Mankhwalawa atha kugulidwa ku malo ogulitsa mankhwala mwachinsinsi
Mtengo wa mankhwala ku Russian Federation zimatengera dera lomwe mankhwalawo amagulitsidwa.
Mtengo wa mankhwala ku Russian Federation, kutengera dera, ukhoza kuchoka pa 6300 mpaka 10500 rubles pa phukusi lililonse.
Ndi mankhwala ati omwe angagwiritsidwe ntchito pochiza matenda a shuga angakuwuzeni kanema munkhaniyi.
