Trypsin ndi puloteni ya puloteni yotchedwa proteinolytic (enzyme) yomwe imasungidwa ndi gawo la pancreas. Poyamba, wotsogolera wake wosagwirizana, trypsinogen, amapangidwa.
Imalowa mu duodenum 12, ndipo imayambitsa ntchito chifukwa cha enzyme ina pa iyo - enterokinase.
Kapangidwe ka mankhwala a trypsin amadziwika kuti ndi mapuloteni. Pochita, zimapezeka kuchokera ku ng'ombe.
Ntchito yofunika kwambiri ya trypsin ndi proteinolysis, i.e. kugawanitsa kwa mapuloteni ndi ma polypeptides m'magawo ang'onoang'ono - amino acid. Ndizothandiza kwambiri.
Mwanjira ina, trypsin imaphwanya mapuloteni. Ma enymes ena a pancreatic amadziwikanso - lipase, yomwe imakhudzidwa ndi chimbudzi cha mafuta, ndi alpha-amylase, yomwe imaphwanya chakudya. Amylase sikuti ndi encyme ya pancreatic yokha, imapangidwanso m'matumbo a salivary, koma ochepa.
Trypsin, amylase ndi lipase ndi zinthu zofunika kwambiri m'mimba. Pakakhala osachepera amodzi a iwo, chimbudzi cha chakudya chimachepa kwambiri.
Kuphatikiza pa kutenga nawo gawo pakudya chimbudzi, trypsin enzyme imathandiza kwambiri pochiza matenda osiyanasiyana:
- amathandizira kuchepetsa kutupa mthupi;
- imathandizira kuchiritsa kwa kupsa, mabala akulu;
- amatha kugawanitsa minofu yakufa kuti zopangidwa ndi necrosis zisalowe m'magazi ndikuyambitsa kuledzera;
- amapanga makutu owonda, makutu amatulutsa madzi ambiri;
- imathandizira liquefaction yamagazi magazi;
- amathandizira pochiza matenda omwe ali ndi kutupa kwa fibrinous;
- Amachotsa kuchotsedwa kwa masamba a purulent;
- amachitira zilonda zamkati zamkati;
Pokhala kuti ndiopanda ntchito, pompopompo ndiotetezeka kwathunthu.
Popeza trypsin ili ndi katundu wotero wochiritsa, imagwiritsidwa ntchito popanga mankhwala.
Monga mankhwala ena aliwonse omwe amagwiritsidwa ntchito ndi mankhwala
Pogwiritsa ntchito mankhwala omwe amaphatikiza trypsin, malangizo a dokotala ndi malangizo ogwiritsira ntchito mankhwalawa amayenera kuonedwa mosamala.
Gulu la Trypsin:
- Amorphous - itha kugwiritsidwa ntchito kokha (pokhapokha pakhungu).
- Crystalline - imabwera mumtundu wa ufa-wachikaso wachikasu, pakalibe fungo labwino. Amagwiritsidwa ntchito mopangika komanso chifukwa cha makonzedwe amkati.
Trypsin imapezeka pansi pa mayina osiyanasiyana: "Pax-trypsin", "Terridekaza", "Ribonuclease", "Asperase", "Lizoamidase", "Dalcex", "Profezim", "Irukson". Zokonzekera zonse ziyenera kusungidwa pamalo owuma, amdima pamtunda wosaposa madigiri khumi.
Zizindikiro zogwiritsidwa ntchito ndi:
- matenda a m'mapapo ndi ma airways (bronchitis, chibayo, exudative pleurisy);
- matenda a bronchiectatic (kupezeka kwa zowonjezera pachimake mu bronchi);
- kachilombo koyaka ndi zilonda zam'mimba zotulutsira;
- aakulu kutupa pakati khutu (otitis media);
- purulent kutupa kwa frontal ndi maxillary sinuses;
- kufooka kwa mafupa (osteomyelitis);
- matenda a periodontal;
- kufalikira kwa ngalande yopanda pake;
- kutupa kwa Iris;
- zironda;
- mavuto pambuyo opaleshoni ya maso.
Zoyipa zotsutsana ndi trypsin ndi:
- Thupi lawo siligwirizana ndi trypsin.
- Kuchulukitsa kwa mapapu, kapena emphysema.
- Kuperewera kwa mtima.
- Kusintha kwa Dystrophic ndi kutupa mu chiwindi.
- Chifuwa chachikulu
- Matenda a impso.
- Pancreatitis ndi yogwira.
- Kuphwanya munjira yazakudya ndi zoyipa.
- Njira zotupa mu impso (yade).
- Hemorrhagic diathesis.
Kodi zotsatila zake zingakhale ndi chiyani mutatha kugwiritsa ntchito trypsin?
- chifuwa
- kukoka kwamtima;
- redness ndi kupweteka pambuyo mu mnofu jekeseni;
- Hyperthermia.
Kuphatikiza apo, kupsya mtima kumatha kuwonekera m'mawu a wodwala.
Mukamagwiritsa ntchito pochiza mabala owuma kapena mabala omwe ali ndi minofu yakufa, ma trypsin oikidwa mankhwalawa amagwiritsidwa ntchito.
Kuti muchite izi, muyenera kusungunula 50 mg ya kukonzekera kwa enzyme mu 50 mg ya saline yamoyo (sodium chloride, kapena 0,9% saline).
Nthawi zambiri gwiritsani ntchito kupukuta kwapadera kwamitundu itatu.
Mukatha kugwiritsa ntchito compress, imakhazikika ndi bandeji ndikusiya maola makumi awiri ndi anayi.
Intramuscular management 5 mg ya trypsin imasungunuka mu 1-2 ml ya saline, lidocaine kapena novocaine. Akuluakulu, jakisoni amapangidwa kawiri pa tsiku, kwa ana - kamodzi.
Ntchito zamkati. Pambuyo pa kukhazikitsidwa kwa mankhwalawa, simungakhale mumalo omwewo kwa nthawi yayitali, chifukwa izi zimapangitsa kuti zikhale zovuta kufotokozera chinsinsi. Nthawi zambiri, patatha masiku awiri, chinsinsi ichi chimatuluka kudzera mu ngalande.
Kugwiritsa ntchito pakhungu. Kuyeserera kwa Trypsin kumachitika pogwiritsa ntchito inhaler kapena bronchoscope. Pambuyo pa maphunzirowa, ndibwino kutsuka mphuno yanu kapena pakamwa panu ndi madzi ofunda (kutengera momwe machitidwewo adachitikira).
Mwanjira yamaso akutsikira. Afunika kuti azikhodomoka maola 6 kapena atatu aliwonse kwa masiku atatu.
Zomwe mungagwiritse ntchito trypsin:
- Trypsin amaletsedwa kugwiritsa ntchito mabala otulutsa magazi.
- Sangagwiritsidwe ntchito pochiza khansa, makamaka zilonda zam'mimba.
- Osati kutumikiridwa kudzera m'mitseko.
- Pochitira ana aang'ono, njira inayake imakonzedwa.
- Amayi oyembekezera kapena oyembekezera amayenera kumwa mankhwalawa pokhapokha ngati chiwopsezo cha imfayo kapena imfa ya fetal ndiyofunika kwambiri.
Pharmacokinetics, i.e. kufalitsa mankhwala m'thupi sikunaphunzirepo. Zimadziwika kuti galu amalowa m'thupi, trypsin imamangiriza kwa alpha-macroglobulins ndi alpha-1-antitrypsin (inhibitor yake).
Pakadali pano, pali ndemanga zabwino zambiri zokhudzana ndi mankhwala okhala ndi trypsin. Makamaka osiyanasiyana ake ntchito mu ophthalmology. Ndi iyo, kutaya magazi, ma adhesions, kutupa ndi ma dystrophic machitidwe a Iris amathandizidwa, chifukwa ma pathologies omwe amapezeka pakalibe chithandizo chokwanira angayambitse khungu losasintha. Kuphatikiza pa mankhwalawa kukonzekera kwa enzyme ndimankhwala ochepetsa nkhawa, maantibayotiki, mahomoni, mankhwala a glaucoma ndi othandiza kwambiri, omwe amachititsa kuti minofu ipangidwe.
Trypsin anathandizira kuchepetsa njira ya matenda ophatikizika, monga nyamakazi, polyarthritis, arthrosis, ndi matenda amitsempha. Amathandizanso kupweteka, kupondereza kutupa, kubwezeretsa kusuntha kwathunthu.
Ndi kuvulala kwambiri, kudula kwakuya, kuwotcha, enzyme imalola, osachepera, kuchepetsa thanzi la wozunzidwayo, ndikuthandizira kuchira.
Mtengo wamba wa kukonzekera kwa trypsin ku Russia umachokera ku ruble 500.
Mwazi, trypsin yotchedwa "immunoreactive" imatsimikizika pamodzi ndi chinthu chomwe chimalepheretsa ntchito yake - alpha-1-antitrypsin. Mlingo wa trypsin ndi 1-4 μmol / ml.min. Kukula kwake kumawonedwa pakuwonekera kwa kutupa kwa kapamba, mapangidwe a uncological mmenemo, ndi cystic fibrosis, kulephera kwa impso, komanso kumatha kuyenda ndi matenda a virus. Kuchepa kwa kuchuluka kwa enzyme kumatha kuwonetsa mtundu wa 1 shuga mellitus, kapena matenda omwe ali pamwambapa, koma mwa mawonekedwe osakhazikika komanso pambuyo pake.
Kuphatikiza pa kuyezetsa magazi, odwala nthawi zambiri amapatsidwa pulogalamu. Phunziroli lisanachitike, maantibayotiki atatu samalimbikitsidwa masiku atatu. Mukamveketsa trypsin mu ndowe sizingaonekere. Izi nthawi zambiri zimayimira njira ya cystic fibrous mu kapamba. Kutsika kowopsa kumawonedwa ndi cystic fibrosis, koma izi sizitanthauza kuti matendawa atsimikiziridwa, ndipo kafukufuku owonjezera amafunikira kuti afotokozere. Pakadali pano, akukhulupirira kuti kutsimikiza kwa ntchito ya trypsin mu ndowe sizikuwonetsa chilichonse.
Zambiri mwachidule za trypsin ndi ma enzyme ena zimaperekedwa mu kanema munkhaniyi.
