Liptonorm (liptonorm) - mankhwala ochokera ku gulu la ma statins, amagwiritsidwa ntchito kutsitsa cholesterol yamagazi. Zinthu zomwe zimagwiritsidwa ntchito ndi mankhwala zimalepheretsa kupanga isoprenoids, zimathandizira kukulitsa kwamitsempha yamagazi.
Mankhwala otsika triglycerides, otsika kachulukidwe kolesterol, kumawonjezera zomwe zili ndi kachulukidwe kachulukidwe kake ngati zinthu, polypoprotein A. Nthawi zambiri, wodwala matenda ashuga azitha kuwona zotsatira za mankhwalawa patatha masiku 14 chiyambireni chithandizo, masabata anayi akuyenera kudutsa pazotheka kwambiri.
Mankhwalawa sachiwopsezedwa kwambiri ndi matumbo, amatulutsidwa m'thupi limodzi ndi ndulu. Hafu ya moyo ndi maola 14. Chifukwa cha kukhalapo kwa metabolites yogwira, mphamvu ya inhibitory imatha maola 20 mpaka 30. Pa hemodialysis, mankhwalawa samachotsedwa, osakwana 2% ya mlingo wovomerezeka amapezeka mu mkodzo.
Zisonyezero zogwiritsidwa ntchito zimaphatikizidwa hyperlipidemia, hypercholesterolemia, heterozygous ndi homozygous achibale hypercholesterolemia.
Mtengo wa mankhwala Liptonorm m'masitolo ndi ma ruble 190, mutha kugula popanda kuuzidwa ndi dokotala.
Malangizo ogwiritsira ntchito mankhwalawa
Musanapereke mankhwala, tikulimbikitsidwa kusinthana ndi zakudya zoyenera zomwe zimapatsa cholesterol yotsika m'magazi. Zakudya zimamatira nthawi yonse ya chithandizo.
Maupangiri othandizira amalimbikitsa kumwa piritsi limodzi la mankhwalawa patsiku, nthawi yakudya siziwathandiza, koma mankhwalawa amayenera kumwa nthawi yomweyo. Mlingo woyambirira wa munthu wodwala matenda ashuga ndi 10 mg ya chinthucho, mtsogolomo kuchuluka kwa mankhwalawa kumasankhidwa payekhapayekha.
Mlingo wa mankhwalawa umatengera kuchuluka kwa cholesterol yotsika, kuopsa kwa njira ya pathological, kugwiritsa ntchito bwino kwa mankhwala ambiri. Kusintha kwa dose kumapangidwa masabata osachepera anayi.
Mankhwala okwanira 80 mg amatha kumwa patsiku.
Zotsatira zoyipa
Liptonorm imatha kupangitsa kuti pakhale mavuto. Kuchokera kumbali ya chapakati mantha dongosolo, chizungulire, kusowa tulo, kugona, malaise, mutu, zotumphukira neuropathy zimawonedwa. Nthawi zambiri pamakhala kuchepa kwa chikumbumtima, mayiko ovutitsa, amnesia, ziwalo zam'maso, ataxia, hyperkinesis, kuvutikanso mtima. Pa chithandizo, zolakwika zimatha kuvutitsa wodwala.
Kumbali yamalingaliro am'maganizo, kupotoza kukoma kapena kuwonongeka, kusokonezeka kwa malo okhala, kununkhira, tinnitus, kukha magazi m'maso, ugonthi, kuuma kwa conjunctiva, glaucoma ndikotheka.
Kuchokera kumbali ya mtima wamtima, wodwalayo amatha kusokonezeka ndi kupweteka pachifuwa, migraines, kuchuluka kwa kuthamanga kwa magazi, kusintha kwa mtima, komanso kugunda kwamtima mofulumira. Angina pectoris, postural hypotension, vasodilation samachotsedwa.
Kuchokera kupuma dongosolo mbali zimachitika ndi:
- rhinitis;
- bronchitis;
- nosebleeds;
- chibayo
- dyspnea.
Pa gawo la chakudya cham'mimba, pakamwa pouma, cheilitis, kupweteka pamimba, zotupa za mucous membranes, belching, nseru, kutsekula m'mimba, kapena kutsekula m'mimba ndizotheka. Wodwalayo amatha kuyamba magazi otupa, hepatitis, hepatic colic, duodenal ulcer, esophagitis.
Thupi la minofu ndi mafupa amathandizira chithandizo cha bursitis, nyamakazi, myositis, myalgia, minofu hypertonicity, arthralgia kapena mgwirizano wophatikizika.
Kuchokera ku genitourinary system, zimachitika zoyipa zimapezeka:
- zotumphukira kufalikira;
- kulimbikitsa kukodza;
- kutulutsa magazi mu maliseche;
- dysuria;
- utachepa libido;
- kusabala.
Zotsatira zoyipa ndizotsatira zamitundu mitundu: kukhetsa thukuta kwambiri, seborrhea, petechiae, kusowa kwa tsitsi, chikanga. Thupi lawo siligwirizana amakhazikikanso: kukhudzana dermatitis, zotupa pakhungu, kutupa kwa nkhope, poizoni necrolysis, urticaria.
Malinga ndi ndemanga, zotsatira zoyipa sizimakhalapo, nthawi zambiri zimapitilira kuchuluka kwa mankhwalawa.
Contraindication
Pali zotsutsana mwamtheradi komanso zoyenera mogwirizana ndi mankhwalawa. Gulu loyamba lidaphatikizira chiwindi cha matenda osiyanasiyana a chiwindi, kulephera kwa chiwindi, matenda a chiwindi, kuphatikizapo matenda a hepatitis, mowa.
Izi zimaphatikizanso kuchuluka kwa zochitika za hepatic transaminase, zaka zodwala mpaka zaka 18, pakati, komanso nthawi yoyamwitsa. Dokotala amaletsa kugwiritsa ntchito mankhwalawa pamaso pa hypersensitivity pamagawo a mankhwala.
Contraindication achibale anali mbiri ya matenda a chiwindi, ochepa hypotension, uchidakwa, metabolic ndi endocrine mavuto, kwambiri pachimake matenda, sepsis.
Gululi linaphatikizaponso kukhudzidwa kosalamulirika, kuvulala, uchidakwa, kusungunuka kwa electrolyte, njira zina zaposachedwa zopangira opaleshoni.
Mankhwala osokoneza bongo komanso malangizo apadera
Ngati mulingo wovomerezeka udapitilira, kukula kwa zizindikiro, zomwe zimaphatikizidwa mndandanda wazovuta zamthupi, ndizotheka. Komabe, maphunziro awo amadziwika. Palibe mankhwala enieni a Liptonorm;
Wodwalayo amalimbikitsidwa kuti azigwira ntchito yofunikira ya ziwalo zamkati popewa kuyamwa kwina kwa zinthu zomwe zimagwiritsidwa ntchito ndi mankhwala. Hemodialysis sikubweretsa tanthauzo lalikulu.
Kwa nthawi yamankhwala, kuyang'anira mosamala mayeso a ma laboratori ndi matenda othandizira ndikofunikira. Ngati masinthidwe ofunika a pathological apezeka, kuchepa kwa kuchuluka kwa mankhwalawo kumasonyezedwa.
Musanayambe chithandizo ndikatha 6, 12 milungu, ndikofunikira kuwunika ntchito ya chiwindi. Kenako mayesowo amachitika miyezi isanu ndi umodzi iliyonse. Ndi kuwonjezeka kwa hepatic transaminase ntchito, wodwalayo ayenera kuyang'aniridwa ndi dokotala mpaka mkhalidwe utasintha.
Kutenga mankhwalawa kumayendera limodzi ndi kuthekera kotukuka kwa myopathy, motero, odwala amatha kuonjezera zizindikiro:
- kufooka kwa minofu ndi ulesi;
- kuchuluka kwakukulu kwa creatine phosphokinase;
- kuphwanya wamba.
Ngati zizindikiro zomwe zalembedwa, kutentha thupi, kupweteka kwa minofu kumayamba, muyenera kufunsa dokotala. Amasiya mankhwalawo kapena amamulembera fanizo.
Ngati kuli koyenera kuchitira chithandizo pamodzi ndi nikotini komanso zotumphukira za asidi, ma immunosuppressants, othandizira antifungal, ndikofunikira kuti muyambe kufufuza za zotsatira zomwe zikuyembekezeka komanso kuchuluka kwake. M'miyezi yoyambirira ya chithandizo, ndikofunikira kuyang'anitsitsa momwe wodwalayo alili.
Pali milandu yodziwika ya zotsatira zoyipa za mankhwalawa kuthamanga kwa psychomotor reaction, kuthekera kwambiri. Amayi a msinkhu wobereka amalimbikitsidwa kugwiritsa ntchito njira zodalirika zakulera. Ngati mimba yakonzekera, mankhwalawo amathetsedwa mwezi umodzi pasadakhale.
Mankhwala a Liptonorm saloledwa kugwiritsidwa ntchito panthawi yomwe muli ndi pakati komanso poyamwitsa. Mankhwalawa amaletsedwa kwa ana, achinyamata osakwana zaka 18.
Ndi kuphwanya chiwindi, matenda a ziwalo m'mbiri ya mapiritsi amatsutsana. Tikuyankhula za gawo la matenda a chiwindi, matenda oopsa a hepatitis, biliary pancreatitis, kuwonjezereka kwa ntchito ya hepatic transaminases ya etiology yosadziwika, matenda a chiwindi, ndi kulephera kwa chiwindi.
Koma odwala matenda ashuga okalamba, kusintha kwa mankhwalawa sikofunikira kwa iwo.
Kuyanjana kwa mankhwala osokoneza bongo
Kugwiritsa ntchito limodzi kwa ma antacid nthawi yomweyo ndi 35% kumachepetsa kuchuluka kwa zinthu zomwe zimachitika mu Liptonorm m'magazi, koma zotsatira za kuchuluka kwa cholesterol sizisintha. Mlingo wa tsiku ndi tsiku wa mankhwalawa ndi 20% umachulukitsa kuchuluka kwa mapiritsi ogwiritsira ntchito pakamwa, omwe ali ndi digoxin, ethinyl estradiol, norethindrone.
Kugwiritsira ntchito mankhwalawa limodzi ndi Warfarin patsiku loyamba kumachepetsa nthawi ya prothrombin, chizindikirochi chidzabwereranso pakapita pafupifupi milungu iwiri. Odwala omwe amalandira kuphatikiza uku, ndikofunikira kuwongolera nthawi ya prothrombin nthawi zambiri.
Pogwiritsa ntchito munthawi yomweyo mapuloteni ena a proteinase, kuwonjezereka kwa ntchito kwa Liptonorm m'madzi a m'magazi kumaonekera. Akaphatikizidwa ndi mankhwala a antifungal, index ya atorvastatin m'magazi imachuluka, mwayi wokhala ndi myopathy umakulanso. Tikulankhula za mankhwala ozikidwa pa erythromycin, fibrate, immunosuppressants, nicotinamide, clarithromycin, cyclosporine.
Kuchiza ndi Colestipol kumathandizira kupeza mphamvu yomwe imaposa ija ya mankhwalawa mosiyana. Madzi a mphesa amatha kuwonjezera kuchuluka kwa zinthu zomwe zimagwiritsidwa ntchito, chifukwa chake ndikofunikira kusiya zakumwa panthawi ya chithandizo.
Mitu ya mankhwalawa
Ngati Liptonorm sioyenera pazifukwa zilizonse, dokotala amamufotokozera. Otchuka kwambiri aiwo adakhala: Aterocardium, Lipona, Torvakard, Atorvastatin, Anvistat, Atomaks, Liprimar.
Mtengo wa mankhwalawa umatengera wopanga, chifukwa mapiritsi a Liptonorm mtengo ndiwotsika mtengo.
Zambiri zokhudzana ndi ma statins zimaperekedwa kanema munkhaniyi.
