Metformin Sandoz ndi amodzi mwa mankhwala odziwika omwe amagwiritsidwa ntchito onse amtundu wa shuga I kuphatikiza jakisoni wa insulin komanso matenda a mtundu II, pamene maphunziro olimbitsa thupi komanso kudya moyenera sizipereka kuchuluka kwa shuga.
Chifukwa cha zomwe zimagwira, kutsika kwa kuchuluka kwa shuga mu seramu yamagazi kumachitika, ndipo kufunikira kwa glucose kumachepetsedwa.
Monga mukudziwa, mankhwala aliwonse ali ndi zotsutsana zingapo, zoyipa ndi zina za mankhwala. Chifukwa chake, ndikofunikira kudziwa zambiri momwe zingathekere za mankhwalawa. Momwe mungagwiritsire ntchito mankhwalawa?
Zambiri pazamankhwala a hypoglycemic
Wothandizidwa ndi hypoglycemic ali ndi mankhwala othandizira, metformin hydrochloride, omwe ndiye woimira kalasi yayikulu. Kutengera mtundu wa Mlingo, mapiritsi amapangidwa omwe amaphatikiza 500 kapena 850 mg ya mankhwala othandizira. Kuphatikizika kwa zamankhwala zam'mimba zimagwirizanitsidwa ndi mphamvu yolepheretsa kupanga kwa glucose kuchokera ku mankhwala osagwiritsa ntchito chakudya (gluconeogeneis).
Kuphatikiza pa metformin hydrochloride, piritsi limodzi la mankhwalawa limakhala ndi wowuma sodium, magnesium stearate, silicon dioxide, colloidal anhydrous, Copolyvidone Va64 ndi cellcosestalline ya microcrystalline.
Mankhwalawa samatulutsanso kupangika kwa timadzi timene timachepetsa shuga, chifukwa chake anthu athanzi omwe amamwa mankhwalawa samadziona ngati ali ndi hypoglycemia. Pakati pazabwino za mankhwalawa, ndikofunikira kufotokoza izi:
- Kuponderezedwa kwa gluconeogeneis.
- Kuchuluka kwa chiwopsezo cha maselo olimbana ndi insulin.
- Kukopa kwa glucose komwe kumachitika ndi myocyte.
- Kuchepetsa thupi, makamaka mwa anthu onenepa.
- Tsitsimutsani shuga ndi zofunika zonse mukatha kudya.
- Zabwino pa lipid metabolism (kuchepa kwa cholesterol, triglycerides ndi LDL).
- Kuchepetsa njala.
- Kulimbikitsa anaerobic glycolysis.
- Kuchedwa kuyamwa kwa matumbo m'matumbo.
Wothandizira antidiabetic amatengedwa mkati, kuphatikiza kwakukulu kumawonedwa pambuyo maola 2,5. Kuperewera kwa chigawo chachikulu kumachitika m'mimba.
Metformin hydrochloride imachotsedwera mawonekedwe osasintha ndi mkodzo.
Malangizo ogwiritsira ntchito mapiritsi
Monga tanena kale koyambirira, mankhwalawa amatha kugwiritsidwa ntchito ngati odwala matenda a shuga a insulin komanso osadalira insulin. Ndi dokotala yekhayo amene angatchule mlingo woyenera wa mankhwalawa, potengera kuchuluka kwa shuga ndi zina zokhudzana ndi wodwalayo.
Pogula mankhwala, wodwalayo sayenera kutsatira malingaliro a dokotala, komanso adziwitse yekha ndi ma phukusi. Ngati mafunso abuka, ayenera kufunsidwa ndi akatswiri azachipatala.
Kumayambiriro kwa mankhwalawa, mlingo wotsika tsiku lililonse umasankhidwa - 500 kapena 1000 mg yokha. Pakatha milungu iwiri, adokotala amatha kuwonjezera kuchuluka kwa mankhwalawo, poganizira shuga zomwe zili m'magazi. Mankhwala oyamba ndi mankhwalawa akhoza kutsagana ndi kuphwanya kwam'mimba. Zizindikiro zosasangalatsa zoterezi zimafotokozedwa ndikusintha kwa thupi kuzinthu zomwe zimagwira ndipo patatha masiku 10-14 zimadutsa zokha. Kuti mukhale ndi shuga wabwinobwino, muyenera kudya 1,500-2,000 mg patsiku. Mlingo waukulu kwambiri ndi 3000 mg. Kuti muchepetse zotsatira zoyipa za mankhwalawa m'matumbo oyamba, muyenera kugawa mankhwalawa kangapo.
Kuphatikiza Metformin Sandoz ndi insulin, kuchepetsedwa kothandizadi kwa ndende ya shuga kungatheke. Mankhwalawa amatengedwa kawiri kapena katatu patsiku, 500 mg aliyense. Ponena za kuchuluka kwa insulin, zimatengera kuchuluka kwa shuga m'magazi.
Anthu odwala matenda ashuga okalamba omwe amagwiritsa ntchito Metformin Sandoz amafunikira chisamaliro chapadera. Dokotala ndi amene amawerengera kuchuluka kwa mankhwalawa, chifukwa cha impso.
Pogula mankhwala, munthu sayenera kuyiwala za kuyang'ana tsiku lotha ntchito, lomwe nthawi zambiri limakhala zaka 5.
Mankhwalawa amasungidwa m'malo owuma pamtunda wosaposa 25 digiri Celsius.
Contraindication ndi zoyipa zimachitika
Mankhwala osavomerezeka kwa odwala okalamba (opitilira zaka 60), omwe kugwira ntchito kwawo kumalumikizidwa ndi kuchita masewera olimbitsa thupi.
Kumwa mankhwala okhala ndi katundu wambiri kumawonjezera mwayi wokhala ndi lactic acid chikomokere.
Malangizo ogwiritsira ntchito amaphatikiza matenda ndi zina zomwe munthu wothandizila wodwala sangathe kugwiritsa ntchito.
Mwa zina zazikulu zotsutsana ndi izi:
- matenda ashuga, wodwala ndi matenda ashuga ketoacidosis;
- impso mkhutu ntchito, momwe creatinine chilolezo (kuthamanga magazi kudzera impso) zosakwana 60 ml pa mphindi;
- kukulitsa kwa pathologies a pachimake komwe kungayambitse vuto la impso. Amatha kukhala madzi am'mimba, malungo, hypoxia, matenda osiyanasiyana;
- opaleshoni yaposachedwa komanso kuvulala koopsa;
- kukula kwa hyperlactatacidemia, makamaka mu anamnesis;
- matenda owopsa kapena osachiritsika omwe amawonjezera mwayi wamatenda a hypoxia, kuphatikizapo kulowerera m'mitsempha, kupuma komanso kulephera kwa mtima;
- uchidakwa wosalekeza, chakumwa choledzeretsa chachikulu;
- kuphwanya chiwindi;
- kugwiritsa ntchito mankhwala okhala ndi ayodini m'masiku awiri isanachitike komanso pambuyo pa ma radioisotope ndi mayeso a radiology;
- Hypocaloric zakudya, momwe osaposa 1000 kcal patsiku;
- mimba ndi kuyamwitsa.
Chifukwa chokhala ndi bongo mopitirira muyeso kapena osagwirizana ndi malingaliro onse a dokotala, zotsatira zosafunikira kuchokera ku mankhwalawa zimatha kuchitika. Izi zikuphatikiza:
- Kusokonezeka kwa chakudya cham'mimba - kulawa kwazitsulo mkamwa, kusanza, kusanza, kuchepa kapena kusowa chilimbikitso, kupweteka m'mimba, kupangika kwa mapangidwe a gasi, kutsekula m'mimba. Zizindikirozi zimachitika chifukwa choti thupi limazolowera mankhwala.
- Matenda a hepatitis - hepatitis ndi chiwindi kukanika.
- Matenda a metabolic - kuchepa kwa vitamini B12 ndi lactic acid chikomokere.
- Kuphwanya hematopoietic dongosolo - megaloblastic anemia.
- Momwe khungu limakhudzira ndikumayamwa, erythema, zotupa ndi urticaria.
Choyipa choopsa kwambiri ndi lactic coma (lactic acidosis). Ndi chitukuko chake, wodwalayo amakhala ndi vuto la m'mimba, kupweteka m'matumbo ndi m'mimba, kuwonjezeka kwa kutentha kwa thupi, chizungulire, chisokonezo, kupumira mwachangu komanso kukula kwa chikomokere. Pankhaniyi, wodwala ayenera kuchipatala nthawi yomweyo.
Nthawi zambiri, dokotala amachita hemodialysis - njira yothandiza kwambiri yothetsera lactate ndi metformin.
Metformin Sandoz: Zochita Zamankhwala
Tiyenera kukumbukira kuti mankhwalawa amatha kuwonjezera kapena kuchepetsa Hypoglycemic zotsatira za mankhwalawa. Zina mwazomwe zimayambitsa lactic acid chikomokere.
Pankhani imeneyi, katswiri wothandizirayo ayenera kudziwa matenda onse omwe wodwalayo akumakumana nawo kuti apewe mavuto. Wodwalayo, sayenera kuletsa dokotala zina zamankhwala kupatula shuga.
Chifukwa chake, m'munsimu muli mayina a mankhwala omwe amachepetsa mphamvu ya mankhwalawa, potero kumakulitsa kuchuluka kwa glycemia mwa odwala:
- Danazole;
- Chlorpromazine;
- antipsychotic;
- glucagon;
- mahomoni a chithokomiro;
- thiazide okodzetsa;
- nicotinic acid zotumphukira;
- sympathomimetics;
- othandizira a estrogen-progestogen;
- beta-2-adrenergic zolandilira;
- glucocorticosteroids am'deralo komanso mwatsatanetsatane kanthu.
Pali mitundu ingapo ya mankhwala omwe, m'malo mwake, imathandizira Hypoglycemic zotsatira za wothandizila wodwala. Izi zikuphatikiza:
- Acarbose.
- Kutenga nthawi yayitali komanso kuchita insulin pang'ono.
- Beta-2 adrenergic olimbana nawo.
- Mao ndi ACE zoletsa.
- Zochokera ku sulfonylureas.
- Salicylates.
- Zothandiza pofikira.
- NSAIDs.
- Cyclophosphamide, komanso zotumphukira zake.
- Oxytetracycline.
Imawonjezera mwayi wa lactic acidosis kumwa mankhwala ndi mowa komanso mankhwala okhala ndi ethanol, okhala ndi ayodini omwe amaphatikizana ndi cimetidine ndi diuretics.
Mtengo wa mankhwalawa, ndemanga ndi fanizo
Mankhwalawa atha kugulidwa ku mankhwala aliwonse omwe mumalandira ndi dokotala. Kuti musunge ndalama, mankhwalawo amalamulidwa patsamba logula lazogulitsa.
Pafupifupi, mtengo wa mankhwalawo umasiyanasiyana kuchokera ku ruble 230 mpaka 800, kutengera mtundu wa kumasulidwa. Chifukwa chake, othandizira odwala matenda ashuga amapezeka m'magulu onse a anthu, omwe, ndi mwayi wawo.
Pa intaneti mutha kupeza ndemanga zambiri zabwino kuchokera kwa odwala omwe amamwa mankhwalawa. Imatsika bwino ndipo imakhazikika m'magulu a shuga. Zimathandizanso kutaya mapaundi owonjezera pama diabetes a onenepa. Wothandizirana ndi hypoglycemic monga mapiritsi ndiosavuta kutenga. Kuphatikiza apo, sikuti zimayambitsa zovuta (kuwonjezera pakusokoneza pamimba).
Komabe, pali malingaliro oyipa okhudza mankhwalawa. Amalumikizidwa ndi vuto logaya chakudya lomwe limapezeka munthawi yophatikiza thupi kuti lizigwira ntchito. Mwa odwala ena, zizindikiro zotere zimatchulidwa kuposa ena, motero amayenera kuyika mankhwala ena othandizawa ndi mankhwala ena.
Madokotala salimbikitsa kuti munthu azimwa mankhwala athanzi kuti muchepetse thupi. Amaletsedwanso kotheratu kugwiritsa ntchito zakumwa zoledzeretsa pamankhwala.
Nthawi zina madokotala amayenera kusintha njira yochiritsira odwala. Izi zitha kukhala chifukwa chosintha mosiyanasiyana. Kusintha mankhwala osagwirizana kungachitike ndi zinthu zomwe zili ndi ntchito yomweyo kapena zofananira.
Metformin hydrochloride ndi gawo lodziwika padziko lonse lapansi, chifukwa chake imagwiritsidwa ntchito popanga mankhwala ambiri a hypoglycemic. Ndizosadabwitsa kuti Metformin Sandoz ali ndi mitundu yambiri ya mitundu, yomwe pali:
- Gliformin (ma ruble 112).
- Metformin-Teva (ma ruble 136);
- Glucophage (ma ruble 223).
- Metformin Richter (ma ruble 183);
- Metfogamma 850 (134 ma ruble), Metfogamm 1000 (168 ma ruble).
- Metformin Zentiva (134 ma ruble).
- Siofor (ma ruble 245).
- Metformin Canon (ma ruble 172).
- Formetin (ma ruble 100).
Monga mukuwonera, Metformin Sandoz ndi mankhwala othandizadi omwe amachotsa matenda a hyperglycemia ndi matenda a shuga mwa odwala akuluakulu. Pogwiritsa ntchito bwino chida ichi, mutha kukhala ndi glycemia wabwinobwino kwa nthawi yayitali.
Akatswiri adzakuwuzani za zomwe Metformin amachita pazomwe zimayambitsa matenda ashuga zomwe zili mu vidiyoyi.
