Amoxiclav ndi wothandizirana ndi antibacterial. Amagwiritsidwa ntchito kwambiri pochiza matenda osiyanasiyana, kuphatikizapo mitundu yosakhazikika. Gwiritsani ntchito mankhwalawa mosamala, poganizira zomwe wodwalayo ali ndi mwayi wokhudzana ndi mankhwala ena.
Dzinalo Losayenerana
INN Amoxiclav - Amoxicillin ndi enzyme inhibitor.
ATX
Code ya ATX ya mankhwalawa ndi J01CR02.
Amoxiclav ndi wothandizirana ndi antibacterial.
Kupanga
Mankhwalawa amapangidwa m'njira zingapo. Pali mapiritsi okhala ndi enteric ophatikizidwa mu filimu yovindikira ya hypromellose, mtundu wa piritsi yotsitsimutsanso ndi mitundu iwiri ya ufa woyimitsidwa pakamwa ndi mayankho a jekeseni. Zomwe zimagwiritsidwa ntchito pazochitika zonse ndi mchere wa potaziyamu wa clavulanic acid ndi mankhwala oletsa antioxidin omwe ali ndi mchere wa sodium (wa mankhwala a jakisoni) kapena mawonekedwe a trihydrate (pazinthu zamkamwa zamitundu mitundu).
Mapiritsi, zomwe sodium clavulanate ndi 125 mg, ndipo amoxicillin imatha kukhala 250, 500 kapena 875 mg. Mu mawonekedwe a kuyimitsidwa, mawonekedwe oyambira akhoza kuyimiridwa ndi chiwerengero chotsatira cha maantibayotiki ndi ma inhibitor (mu 5 ml ya kuyimitsidwa koyimitsidwa): 125 mg ndi 31.25 mg, 250 mg ndi 62,5 mg, 400 mg ndi 57 mg, motsatana. Othandizira:
- citric acid;
- benzoate ndi sodium citrate;
- chingamu;
- colloidal mawonekedwe a silicon dioxide;
- sodium saccharase;
- carmellose;
- mannitol;
- kulawa.
Amoxiclav kit imaphatikizapo malangizo ndi mlingo womaliza pipette / supuni yoyezera.
Thupi limayikidwa m'mabotolo agalasi a 140, 100, 70, 50 35, 25, 17,5 kapena 8.75 ml. Phukusi lakunja lopangidwa ndi makatoni. Bokosi limaphatikizapo malangizo ndi supuni ya payipi yomaliza / supuni yoyezera.
Kukonzekera kwa ufa kwa jakisoni kumakhala ndi mankhwala omwe amagwira - amoxicillin 500 kapena 1000 mg ndi clavulanic acid 100 kapena 200 mg. Ufa uwu umayikidwa m'mabotolo agalasi, omwe amawonetsedwa muzidutswa 5. m'matumba a makatoni.
Zotsatira za pharmacological
Amoxiclav ndi kuphatikiza kwa magawo awiri omwe amagwira ntchito - amoxicillin wokhala ndi sodium clavulanate. Yoyamba mwa izi ndi penicillin wopanga, yemwe ali m'gulu la mankhwala oletsa beta-lactam. Imatha kuletsa ma enzyme omwe amaphatikizidwa ndi kapangidwe ka peptidoglycan ka cell khoma la mabakiteriya. Chifukwa cha izi, maselo amadziwononga okha ndipo tizilombo toyambitsa matenda timafa.
Koma magawo azomwe amachita amoxicillin ndi ochepa chifukwa chakuti tizilombo tating'onoting'ono taphunzira kupanga ases-lactamases - mapuloteni enzyme omwe amaletsa maantiotic.
Amoxiclav imatha kuwononga ma gram opanda pake komanso gram-virus.
Apa clavulanic acid imathandiza. Ilibe kutulutsa katundu wa antimicrobial, koma imatha kulepheretsa zochitika za β-lactamases. Zotsatira zake, kukana kwa penicillin kwa tizilombo toyambitsa matenda kumachepa ndipo mawonekedwe a antiotic zochita akufalikira. Pamaso pa clavulanate, imatha kuwononga ma gramu ambiri osayenderana ndi gramu-gramu, monga:
- staphilo, strepto ndi gonococci;
- enterobacteria;
- clostridia;
- Helicobacter;
- Preotellas;
- m'mimba ndi hemophilic bacillus;
- nsomba;
- Shigella
- Proteus
- chlamydia
- leptospira;
- causative wothandizila anthrax, pertussis, cholera, syphilis.
Pharmacokinetics
Pambuyo pakukonzekera pakamwa, mankhwalawa amalowerera mu madzi a m'magazi. Mlingo wake bioavailability ukufika 70%. Zida zake zogawika zimagawidwa pamisempha ndi mafayilo amadzimadzi, zimadutsa mkaka wa m'mawere ndi magazi omwe amatuluka m'magazi, koma chotchinga cha magazi pakalibe kuteteza kwawoko sichingawavute.
Mankhwala Amoxiclav pambuyo m`kamwa makonzedwe mofulumira kulowa plasma.
Ambiri mwa maantibayotiki amasefa ndi impso ndikuwachotsa mkodzo momwe adalili kale. Metabolite yake yogwira imasiya thupi chimodzimodzi. Pafupifupi theka la kuchuluka kwa asidi wa clavulanic amachotsedwa ndi kusefera kwamafuta m'njira yosasinthika. Zotsalazo zimapukusidwa ndikuchotsedwa ndi mkodzo, ndowe ndi mpweya wotha ntchito.
Hafu ya moyo wa zigawo za Amoxiclav pafupifupi 1-1,5 maola. Kuchepa kwambiri kwaimpso, kutalika kwa mankhwalawa kumachulukitsa kangapo.
Zisonyezero zogwiritsira ntchito Amoxiclav ufa
Mankhwala amathandizidwa kulimbana ndi matenda omwe tizilombo toyambitsa matenda timakhudzidwa ndi zochita zake. Zowonetsa:
- tracheitis, pachimake bronchitis, kuphatikizapo zovuta ndi superinfection, kuyambiranso matenda a chifuwa, chibayo, kusangalala;
- sinusitis, sinusitis, mastoiditis;
- atitis media, yokhazikika pakatikati;
- matenda a pharyngeal;
- kutupa kwamitsempha;
- prostatitis
- osteomyelitis, periodontitis;
- kutukusira kwa ziwalo zapakhazi;
- matenda a khungu wosanjikiza ndi zimakhala zofewa, kuphatikiza mano, kulumwa, matenda a postoperative;
- cholecystitis, angiocholitis.
Mankhwala a jakisoni a Amoxiclav amasonyezedwa matenda am'matumbo ndi matenda opatsirana pogonana.
Contraindication
Mankhwala sangathe kumwedwa pamaso pa hypersensitivity kuti agwirizane ndi chilichonse cha zigawo zake. Zotsutsa zina zazikulu zimaphatikizapo:
- beta-lactam antiotic tsankho (mbiri);
- kukanika kwa chiwindi, kuphatikizapo cholestatic jaundice, komwe kumachitika chifukwa chotenga amoxicillin kapena β-lactamase inhibitor (mbiri);
- monocytic tonillitis;
- lymphocytic leukemia.
Kusamalidwa makamaka kuyenera kuchitika kwa odwala omwe akudwala matenda opatsirana a pseudomembranous colitis, okhala ndi zotupa zam'mimba, aimpso kwambiri, komanso azimayi omwe ali ndi pakati.
Amoxiclav sangathe kumwedwa ndi chiwindi ntchito.
Momwe mungatenge Amoxiclav ufa
Amoxiclav ufa adayikidwa ndi adotolo, amathandizanso kupanga dosing ndikuwona nthawi ya chithandizo. Ndikulimbikitsidwa kwambiri kuti musamadzipewe mankhwala omwe mumalandira. Mlingo wa tsiku ndi tsiku umatsimikizika ndikuvuta kwa matendawa. Mlingo wa ana, kuphatikiza wakhanda, zimadalira thupi la mwana. Muyenera kumwa mankhwalawa pafupipafupi kuti muzikhala ndi nthawi yoyenera.
Momwe zimaswana
Kuyimitsidwa kwamlomo kumakonzedwa ndikuwonjezera madzi owiritsa ku ufa. Wobayira jakisoni amatha kuchepetsedwa ndi kuphatikiza kawiri, mchere, njira ya Ringer kapena osakaniza a Hartman.
Asanadye kapena pambuyo chakudya
Pofuna kuteteza m'mimba pazotsatira zoyipa za Amoxiclav, tikulimbikitsidwa kumwa mankhwalawa kumayambiriro kwa chakudyacho kapena musanayambe.
Amoxiclav akulimbikitsidwa kumayambiriro kwa chakudya.
Kumwa mankhwala a shuga
Njira yayitali ya chithandizo imafunikanso.
Zotsatira zoyipa za Amoxiclav ufa
Mankhwalawa amaloledwa ndi odwala. Zotsatira zosafunika ndizochepa.
Matumbo
Kutsegula m'mimba nthawi zambiri kumachitika, osachepera - nseru, kupatuka kwam'mimba, kupweteka kwam'mimba, gastritis, colitis, dysbiosis, kuyesa kwa dzino, stomatitis, chiwindi ntchito, chiwindi. Hepatic pathologies imatha kukhala yovuta ndi chithandizo cha nthawi yayitali ndi mankhwala kapena poika mankhwala omwe angakhale ndi hepatotoxic.
Hematopoietic ziwalo
Mwina kusintha kwa kuchuluka kwa magazi ndi kuphwanya kwa coagulability.
Pakati mantha dongosolo
Mutu, chizungulire, zizindikiro zotsimikiza zimachitika. Kuthokoza ndikotheka. Milandu ya matenda a aseptic meningitis akuti.
Mutu ukhoza kukhala zotsatira zoyipa za Amoxiclav ufa.
Kuchokera kwamikodzo
Tubulointerstitial nephritis imayamba. Mafuta amkati kapena makristoni amchere nthawi zina amapezeka mkodzo.
Kuchokera pamtima
Thrombophlebitis pamalo opangira jekeseni ndizotheka.
Matupi omaliza
Momwe thupi lawo siligwirizana lingawonekere ndi kuyabwa, kuzimiririka, kutsekeka, komanso kupezeka kwa exudate, kutupa, anaphylaxis, vasculitis, ndi zizindikiro za serum syndrome. Ncrolysis yotheka ya epidermal wosanjikiza.
Malangizo apadera
Pa mankhwala opha maantibayotiki, ndikofunikira kuwunika momwe mawonekedwe a impso, chiwindi ndi ziwalo za hematopoietic. Pamaso pa anuria ndi mavuto ena a impso, mlingo wa mankhwalawa uyenera kusintha. Jekeseni wamitsempha ndizoletsedwa.
Kugwiritsa ntchito mankhwalawa kungayambitse kukula kwa microflora yosagwirizana ndi zochita zake, zomwe zimapangidwa ndi kuwonjezeranso matenda ena, kuphatikizapo matenda oyamba ndi fungus.
Popereka mankhwala akuluakulu a Amoxiclav, ndikofunikira kutsatira njira yoyenera yomwera kuti muchepetse crystalluria.
Mgwirizano wamankhwala amoxiclav amaletsedwa.
Mankhwalawa angakhudze zotsatira za mayeso a chiwindi ntchito ndi mayeso a Coombs.
Pambuyo pakutha kwa zizindikiro zazikulu, chithandizo chikuyenera kupitilizidwa kwa masiku ena awiri.
Momwe mungaperekere ana
Fomu lokonda kukamwa ndi kuyimitsidwa. Kuyambira wazaka 12, Mlingo wachikulire umayikidwa.
Pa mimba ndi mkaka wa m`mawere
Palibe deta yoyesera yokwanira pa mankhwalawa omwe amachitika pathupi. Panthawi yobereka mwana ndi kuyamwitsa, ndikofunika kuti azimayi asiye kumwa mankhwala.
Bongo
Ngati mulingo wapitirira, chithandizo chamankhwala chimafunikira. Kusamba kumachitika pasanathe maola 4 kuchokera pakamwa. Magawo onse omwe amagwira mankhwalawa amachotsedwa bwino ndi hemodialysis. Peritoneal dialysis siyabwino kwenikweni.
Pankhani ya bongo, onse omwe amagwira ntchito a Amoxiclav amachotsedwa bwino ndi hemodialysis.
Kuchita ndi mankhwala ena
Mankhwalawa sayenera kuphatikizidwa ndi zinthu monga:
- anticoagulants;
- Allopurinol;
- Disulfiram;
- Rifampicin;
- mankhwala othandizira;
- mafuta emulsions;
- sulfonamides;
- bacteriostatic mankhwala;
- kulera kwamlomo, etc.
Analogi
Mapiritsi amofanana:
- Panklav;
- Flemoklav;
- Augmentin.
Gwiritsani ntchito ufa wopangira jakisoni:
- Amoxivan;
- Amovicomb;
- Verklav;
- Clamosar;
- Fibell;
- Novaklav;
- Foraclav.
Kupita kwina mankhwala
Palibe mankhwala ogulitsa.
Kodi ndingagule popanda kulandira mankhwala?
Yoperekedwa ndi mankhwala.
Mtengo
Mtengo wa ufa wopanga madzi oyimitsidwa umachokera ku ma ruble 110. kwa 125 mg, mankhwala a jakisoni - kuchokera 464 ma ruble.
Zosungidwa zamankhwala
Mankhwalawa amasungidwa kutentha mpaka + 25 ° C.
Tsiku lotha ntchito
Moyo wa alumali wa kuyimitsidwa okonzeka wafika pa sabata 1, ufa wambiri ndi zaka 2.
Wopanga
Mankhwalawa amapangidwa ndi kampani yopanga mankhwala ku Austria Sandoz International Gmbh.
Amoxiclav amasungidwa kutentha mpaka + 25 ° C.
Ndemanga za odwala ndi madokotala
Korvatov V. L., dokotala wa matenda opatsirana, Tyumen
Amoxiclav ndi mankhwala amphamvu koma otetezeka a antibacterial. Chachikulu ndichakuti musinthe mlingo wake ndipo musayiwale za kufunika koteteza matumbo anu.
Arina, wazaka 26, Izhevsk
Amoksiklav adatenga mwana wake wamwamuna ndi matenda oopsa a bronchitis. Ndikufuna kuwona kukoma kosangalatsa, kukhathamiritsa komanso kulekerera bwino kwa mankhwalawa. Pambuyo masiku 5, palibe matenda.
