Clindamycin ndi chinthu chogwiritsidwa ntchito chomwe ndi gawo lamankhwala ena kuchokera pagulu la mankhwala opanga ma semios a mfululizo wa linkosamine. Mankhwala okhala ndi dzina lomwelo amapezeka m'njira zosiyanasiyana. Nthawi zambiri amatchedwa molakwika kuti gel, clindamycin pomwe amagwira ntchito ngati chinthu.
Musanagwiritse ntchito mankhwala omwe ali ndi gawo la clindamycin, kufunsa kwa dokotala komanso kudziwa mwatsatanetsatane malangizo omwe angagwiritse ntchito ndikofunikira.
Mitundu yomwe ilipo ndi kapangidwe kake
Clindamycin ikupezeka mu mitundu ili:
- Vaginal kirimu: amaperekedwa kuzipatala zamankhwala mu chubu ndi olemba. Kuphatikizikako ndikuphatikiza zomwe zidanenedwa kale mu mawonekedwe a phosphate ndi ochulukitsa: mafuta a castor, glycol, sodium benzoate, polyethylene oxide-1500, emulsifier No. 1. Mafutawa amakhala ndi fungo linalake ndipo amakhala ndi mtundu woyera kapena wonyezimira.
- Makapisozi a Gelatin: Anagulitsa 16 ma PC. mu paketi ndikukhala ndi pepala lofiirira wokhala ndi chivindikiro chofiirira. Kuphatikizidwa kwa mankhwalawa kumaphatikizapo hydrochloride ya yogwira mankhwala ndi zina zowonjezera: magnesium stearate, lactose monohydrate, talc, chimanga wowuma.
- Ma ampoules agalasi okhala ndi yankho lomveka bwino kapena lachikasu la jakisoni (i / m ndi i / v): amawaika m'mapulasitiki ndikuwakhoma mumapaketi (ma PC 10). The zikuchokera mankhwala muli yogwira ntchito.
- Ma suppositories a Vaginal: amapezeka m'matumba am'manja (makandulo atatu), omwe amaikidwa pabokosi. Mankhwalawa ali ndi mawonekedwe a cylindrical komanso oyera kapena oyera ndi mtundu wachikasu.
Gel yokhala ndi clindamycin ya mankhwala imakhala ndi mayina osiyanasiyana ndipo imaperekedwa ku mabungwe azachipatala omwe amapezeka ndi 15 kapena 30 g. Pazowonjezereka zomwe zimafunsidwa kuti zigwiritsidwe ntchito panja zimafikira 1%.
Ndi miyala iti yomwe imaphatikizapo
Clindamycin ndi gawo limodzi mwa ma gels otsatirawa:
- Adapalene;
- Dalacin;
- Copper Wedge;
- Clincitop;
- Clindoxyl;
- Kuchulukitsa kwa Clindacite B;
- Clindacin;
- Clindacin T;
- Klindovit;
- Klenzit-S.
Clindamycin ndi gawo la gel kapena Dalacin.
Zotsatira za pharmacological
Ikadziwika ndi thupi, clindamycin imagwira ngati bacteriostatic. Gawo limalepheretsa kuphatikiza mapuloteni ndipo limayenderana ndi tizilombo tating'onoting'ono tomwe timayambitsa matenda: anaerobic ndi microaerophilic gram-cocci (Clostridium tetani, Mycoplasma spp.), Staphylococcus, bacilli ndi mitundu yambiri ya Clostridium perfringens.
Malinga ndi chiwonetsero cha antimicrobial, thunthu limafanana ndi lincomycin, koma nthawi zina limakhala lothandiza kwambiri (nthawi 2-10).
Pharmacokinetics
Kuyamwa kwa chophatikizacho kumatchulidwa m'nthawi yochepa, pambuyo pake clindamycin amalowa m'matupi ndi timadzi tamthupi.
Kutalika kokwanira kwa chigawo chimodzi m'magazi ndikugwiritsa ntchito pakamwa kumawonedwa mkati mwa ola limodzi, ndi jekeseni wamitsempha - pambuyo pa ola limodzi mwa munthu wamkulu komanso pambuyo pa maola atatu ali mwana.
Gelali imagwiritsidwa ntchito kunja, choncho ikalowa mkamwa kapena m'maso, kusamba mokwanira ndi madzi ambiri ndikofunikira.
Pankhani ya kulowetsedwa kwa mtsempha, ndende yapamwamba imadziwika kumapeto kwa kulowetsedwa. Thupi limachedwetsedwa m'madzi am'magazi kwa maola 8-12, ndi theka la moyo wa 2-2,5 maola. Zigawo za mankhwalawa zimaphatikizidwa m'chiwindi, ndipo pakatha masiku 4 zimatulutsidwa m'matumbo ndi impso.
Gelali imagwiritsidwa ntchito kunja, choncho ikalowa mkamwa kapena m'maso, kusamba mokwanira ndi madzi ambiri ndikofunikira.
Momwe mungagwiritsire ntchito mankhwala a Chitosan Tiens?
Kodi zovuta za mtundu woyamba wa shuga ndi ziti?
Kodi madontho a Ciprolet amagwiritsidwa ntchito bwanji - werengani zambiri za izi m'nkhaniyi.
Zisonyezero zogwiritsa ntchito clindamycin
Mankhwala okhala ndi zomwe amafunsidwazi adafotokozeredwa motere:
- matenda a ziwalo za ENT - otitis media, pharyngitis, tonsillitis;
- kuwonongeka kwa mafupa ndi mafupa - osteomyelitis, nyamakazi;
- matenda kupuma dongosolo - kutukusira kwa mapangidwe a pleural, purulent-yowononga njira yaying'ono m'mapapu, bronchitis, chibayo;
- mabala a purulent ndi matenda a minofu yofewa ndi epidermis - ziphuphu zakumaso, kutupa pachimake kwa cell, furunculosis, zotupa za purring zam'manja ndi / kapena mapazi, erysipelas;
- kuwonongeka kwam'mimba ziwalo - peritonitis, abscesses;
- Matenda a gynecological - colpitis, salpingitis, chlamydia, adnexitis, endometritis, neoplasms yoyipa.
Contraindication
Contraindication yogwiritsira ntchito mankhwala a bacteriostatic ndi monga:
- kusalolera kwa chimodzi kapena zingapo;
- chiwindi kapena impso;
- mphumu ya bronchial;
- zilonda zam'mimba;
- matenda a autoimmune okhudza ma neuromuscular synapses;
- zaka mpaka mwezi umodzi;
- ukalamba;
- mimba ndi mkaka wa m`mawere (kupatula kugwiritsa ntchito kunja).
Momwe mungagwiritsire ntchito clindamycin
Gel yokhala ndi chophatikizira cha dzina lomweli imagwiritsidwa ntchito pofowoka pa malo aziphuphu ndi ziphuphu, mutatha kuyeretsa khungu.
Mlingo wa makapisozi kwa akulu ndi ana azaka zopitilira 15 umalamulidwa ndi katswiri wazachipatala. Chithandizo cholimbikitsidwa: 1 pc. 4 pa tsiku kapena awiri mapiritsi atatu waukulu (pamaso pa matenda oopsa).
V / m ndi / koyambirira:
- achikulire: 300 mg 2 kawiri pa tsiku kapena 1.2-2.7 g patsiku (kutengera momwe wodwalayo alili);
- ana opitirira zaka 3: 15-25 mg (kapena 25-40 mg) pa kilogalamu. Mlingo wathunthu umagwiritsidwa ntchito mu Mlingo wa 3-4.
Intravaginal makonzedwe a suppositories ayenera kupangidwa 1 nthawi patsiku asanagone.
Ndi matenda ashuga
Maantibayotiki a matenda a shuga amapatsidwa mankhwala atamuwonetsa. Mlingo umatengera wodwalayo komanso momwe thupi lake limakhalira.
Zotsatira zoyipa za clindamycin
Sichikuphatikizidwa pokhapokha thupi limakumana ndi mavuto osiyanasiyana.
Kuchokera minofu ndi mafupa
Maonekedwe a ululu wammbuyo mwadongosolo.
Kupweteka kumbuyo kungachitike chifukwa chomwa mankhwalawo.
Matumbo
Kuchokera m'mimba yogaya odwala ena, zotsatirazi zoyipa zimadziwika:
- kusanza ndi kusanza
- kutsegula m'mimba komanso kusasangalala kwam'mimba;
- mitengo;
- kukomera kwazitsulo (pambuyo pa iv pakupereka mlingo waukulu wa mankhwala);
- kutupa kwa mucous nembanemba wa esophagus (pamene ntchito makapisozi);
- hyperbilirubinemia;
- kuchuluka kwa chiwindi michere ndi bilirubin m'madzi a m'magazi;
- zosokoneza pakugwira ntchito kwa chiwindi ndi jaundice (kawirikawiri).
Kuchokera kugaya chakudya, odwala ena amakhala ndi mseru komanso kusanza.
Hematopoietic ziwalo
Nthawi zina, kuchepa kwa manambala a leukocytes, ma neutrophilic granulocytes ndi mapulateleti m'magazi.
Kuchokera pamtima
Ndi kukonzekera kwamphamvu kwa mankhwalawa, kuthamanga kwa magazi kumatha kuchepa, kufooka komanso chizungulire.
Matupi omaliza
Zoyipa zomwe zingachitike ndi izi:
- urticaria;
- anaphylactic mantha;
- malungo
- Edema ya Quincke;
- kutupa kwa khungu ndi mucous nembanemba (mwaokha);
- erythema multiforme;
- anaphylactic mantha (kawirikawiri).
Momwe zimachitika kuti thupi lanu lizigwirizana ndi monga urticaria.
Mukamagwiritsa ntchito gelisi, kulumikizana ndi dermatitis komanso zotsatira zoyipa zimayamba. Pankhani ya intravaginal makonzedwe, zotsutsana kuchokera ku ziwalo zam'maganizo zimapezeka: chizungulire, vertigo.
Zokhudza mphamvu pakuwongolera njira
Ndi chiwonetsero chokhazikika cha zotsatira zoyipa mu mawonekedwe a kusanza, thupi lanu siligwirizana, chizungulire kapena kuchepa kwa magazi, tikulimbikitsidwa kusiya kusiya kuyendetsa galimoto mukamalandira chithandizo.
Malangizo apadera
Gelalo yokhala ndi chophatikizira sichikulimbikitsidwa kuti izigwiritsidwa ntchito pakhungu pambuyo pofufuta, chifukwa izi zimadzetsa mkwiyo waukulu pakhungu.
Odwala omwe ali ndi matenda am'mimba thirakiti ayenera kusamala akamagwiritsa ntchito makapisozi. Pankhani ya matenda otsekula m'mimba kapena zizindikiro za colitis panthawi ya mankhwala, muyenera kufunsa dokotala.
Odwala omwe ali ndi matenda am'mimba thirakiti ayenera kusamala akamagwiritsa ntchito makapisozi.
Mukalamba
Musamale ngati mwakusonyezani.
Kwa ana
Clindamycin mu mawonekedwe a yankho akuwonetsedwa zochizira ana kuyambira zaka 3, mu mawonekedwe a makapisozi - kuyambira zaka 8.
Pa mimba ndi mkaka wa m`mawere
Kugwiritsa ntchito clindamycin pa nthawi ya bere (mimba yoyambirira) ndi kuyamwitsa sikulimbikitsidwa.
Gel yothetsa ziphuphu iyenera kugwiritsidwa ntchito mosamala.
Bongo
Ngati mukugwiritsa ntchito kwambiri mankhwala othandizira, zotsatira zake zingakhale zabwino, chifukwa amathandizira omwe amathandizira kuti adziwe mankhwala.
Kuchita ndi mankhwala ena
Thupi limalimbikitsa mphamvu yamankhwala omwe amagwiritsidwa ntchito kuti apumule minofu ya mafupa. Synergism imawonedwa pakutenga mankhwala othandizira ndi metronidazole, ceftazidime ndi ciprofloxacin.
Synergism imawonedwa mukutenga mankhwala othandizira ndi metronidazole.
Kugwiritsa ntchito limodzi ndi opioidic kungayambitse kupuma kwa ntchito, komanso ndi sympathomimetics, macrolides ndi chloramphenicol, ku mpikisano womwe.
Chosakaniza chophatikizacho chimachepetsa mphamvu ya aminoglycosides.
Kuyenderana ndi mowa
Kuphatikiza kwa maantibayotiki ndi mowa ndikosavomerezeka.
Analogi
Mu matenda a gynecology, ma fementi ena a ukazi amatha kuperekedwa m'malo mwa clindamycin. Zina mwa izo ndi:
- Dalacin;
- Clindatop;
- Ma Clines;
- Klindovit;
- Clindacin.
Mu matenda a gynecology, clindovit akhoza kuikidwa m'malo mwa clindamycin.
Otsatirawa amadziwika kuti makapisozi ofanana ndi magwiridwe antchito:
- Klimitsin;
- Dalacin C;
- Klindafer;
- Pulksipron;
- Clindagexal.
Mankhwala ofanana ndi jakisoni ndi monga:
- Dalacin C. Phosphate;
- Zerkalin;
- Klimitsin.
Mankhwala ofanana ndi jakisoni amaphatikizapo Zerkalin.
Wothandiza kwambiri ndi genomy ndi Linkomycin.
Kupita kwina mankhwala
Kukonzekera komwe kumakhala ndi chophatikizika chamafunso ndi mankhwala.
Kodi ndingagule popanda kulandira mankhwala?
Pali milandu yogulitsa mankhwala popanda mankhwala a dokotala. Komabe, kudzipereka nokha kumatha kubweretsa zotsatirapo zoyipa.
Mtengo
Mtengo wa gel, womwe umaphatikizapo gawo lomwe limagwira, umasiyanasiyana kuchoka ku 300 mpaka 800 rubles. kutengera wopanga ndi malo ogulitsa.
Mtengo wa mankhwalawa m'mapiritsi umachokera ku ma ruble 135, mu mawonekedwe a mafuta amkati - kuchokera ku ma ruble 350, ma ampoules omwe ali ndi yankho la jakisoni - kuchokera ku ma ruble 170, mwanjira yama suppositories - kuchokera ku ma ruble 500.
Zosungidwa zamankhwala
Mankhwala amayenera kusungidwa ndi achinyamata. Kutentha kotsimikizika kwa mpweya ndi + 15 ... + 25 ° C.
Tsiku lotha ntchito
Mafuta ndi jakisoni wamkati angagwiritsidwe ntchito mkati mwa zaka ziwiri kuyambira tsiku lomwe wopanga amapanga. Makapisozi, zowonjezera ndi gel osakaniza ndi yogwira mankhwala - zaka zitatu.
Wopanga
Hemofarm (Serbia) ndi VERTEX (Russia).
Ndemanga za madotolo ndi odwala
Valery, wazaka 42, urologist, Moscow
Ndimapereka mankhwala ochizira bakiteriya vaginitis mwa akazi ndi anaerobic balanitis mwa amuna. Mankhwalawa ndi othandizira erythrasma.
Marina, wazaka 38, Ryazan
Anatenga clindamycin kuti ateteze kutupa pakumwa mano. Zotsatira zake ndi zabwino. Palibe mavuto omwe adawonedwa. Chojambula chokha cha gel osakaniza ndi mtengo wake wokwera.
