Pochita zamtima, mankhwala omwe amachepetsa cholesterol ya amkati adayamba kutchuka. Ziwerengero zotere zimayenderana ndi kuchuluka kwa mtima kwamatenda am'mimba omwe amayamba chifukwa cha kusakhazikika kwa lipid. Malinga ndi mapuloteni apadziko lonse lapansi, mankhwala a group la statin ndi gawo loyamba la mankhwala omwe wodwala amapeza.
Madokotala nthawi zambiri amakhala ndi chisankho - Simvastatin kapena Atorvastatin?
Kusankha pakati pa mankhwalawa kumapangidwa ndi adokotala odwala okha, poganizira mawonekedwe onse a wodwalayo.
Ngakhale kutchuka kopanda pake komwe kumakupangitsani kukhalapo kwa zovuta zambiri, ma statin ndi mankhwala othandiza kwambiri kuti athetse kufa kuchokera ku zochita za atherosselotic.
Zisonyezo za ma statins
Statin ali m'gulu la mankhwala ochepetsa lipid.
Chizindikiro chachikulu pakupangidwako ndikukonzanso kwa metabolidi ya lipid.
Mankhwala oyamba amakupatsani mwayi kusintha kagayidwe kake ka mafuta ndikuchotsa zisonyezo zonse za kuwonongeka kwa mtima wamatenda.
Muzochita zamankhwala, kugwiritsa ntchito ma statins ndikulimbikitsidwa:
- zovuta mankhwala osakanikirana ndi kudya dosed zolimbitsa thupi odwala omwe ali ndi milingo yayitali ya atherogenic lipids m'magazi;
- kuwonjezera milingo ya antiatherogenic lipoproteins;
- ntchito odwala omwe amafotokoza za madandaulo a mtima, koma ali pachiwopsezo (mbiri yakale yolowa, kusuta, matenda oopsa, matenda ashuga);
- mankhwalawa matenda a mtima, omwe amawonetsedwa ndi angina pectoris;
- kupewa mavuto obwera ndi mtima;
- Chithandizo cha matenda obadwa nawo omwe amachitika ndi matenda a dyslipidemic.
- mankhwalawa kagayidwe kachakudya matenda.
Momwe mungagwiritsire ntchito mankhwalawa ndi lipid metabolism.
Kusankha komwe kumayenerera Atorvastatin kapena Simvastatin, omwe ali m'gulu lomwelo la zinthu, kutengera zinthu zambiri. Mwachitsanzo, statin yoyamba ikhoza kukhala yothandiza kwambiri kupewa, yachiwiri ndi kulandira chithandizo.
Komanso, kusankha kumadalira kupezeka kwa ma contraindication komanso zoletsa kugwiritsa ntchito.
Kumalangiza mankhwala enaake, kukhala osaphunzira muzochitika zamankhwala, ndi cholakwika chosasamala. Kukhazikitsidwa kumafunika kuzindikira kwathunthu kwa odwala.
Makhalidwe ambiri a statins
Malinga ndi gulu lapadziko lonse lapansi, ma statin amagawidwa kukhala mankhwala osakanikirana oyambitsidwa ndipo, pambuyo pake, opangidwa. 4 mibadwo 4 ya mankhwala imasiyananso.
Simvastatin ndi mbadwo wopanga wam'badwo woyamba. Atorvastatin - njira zopangira m'badwo wachinayi. M'badwo wachinayi wa ma statins amadziwika ndi kukwera kwambiri komanso mawonekedwe ochepa azotsatira.
Hypolipidemic Therapy imapangitsa kuchepetsa kuchuluka kwa atherogenic lipids ndi gawo limodzi mwa magawo atatu.
Molumikizana ndi kudya moyenera komanso kuchita masewera olimbitsa thupi, mankhwalawa amatha kupangitsa matenda a lipid kutulutsa.
Odwala ambiri akudzifunsa kuti pali kusiyana kotani pakati pa mankhwalawa Simvastatin ndi Rosuvastatin wodziwika bwino (dzina lamalonda - Crestor). Mpaka pano, akatswiri amakonda mankhwala a Rosuvastatin. Chotsirizachi ndi mankhwala amakono azachipatala. Mukamasankha simvastatin kapena rosuvastatin yomwe ili bwinoko, makonda ayenera kupatsidwa rosuvastatin. Kapangidwe ka kachitidwe kake ndiko kuphatikiza mwachangu kwa mamolekyulu omwe amapanga ma hepatocytes, momwe amathandizira pamlingo wa cholesterol yophatikizika. Zotsatira zake, kuchuluka kwa cholesterol ya amkati kumachepa ndipo magulu opanga ma atherosrance amawonongeka.
Ndikofunikira kumvetsetsa kuti ndizoletsedwa kugwiritsa ntchito ma statins popanda mankhwala a dokotala. Kuletsa kokhwima kotereku kumagwirizanitsidwa ndi zosiyana siyana komanso zoletsa.
Oposa theka la odwala omwe amamwa ma statins adasiya ndemanga zosagwirizana ndi mankhwalawa. Komabe, zoyipa zambiri sizizindikiro kuti pakubwera mankhwala.
Mwambiri, ma statins amatha kuloledwa bwino ndipo amakhala ndi phindu pa metabolidi ya lipid.
Malangizo ogwiritsira ntchito simvastatin
Mankhwala ndi oimira ena opanga a m'badwo woyamba wa ma statins. Kudya kwake pafupipafupi kumathandizira kuchepetsa kuchepa kwa cholesterol ya atherogenic komanso kupewa kupewa kwa matenda ambiri a mtima.
Tsoka ilo, mphamvu ya Simvastatin poyerekeza ndi mibadwo ina ndiyotsika. Komabe, pofatsa pang'ono zamtundu wa atherosulinosis komanso kuphatikiza zakudya ndi kupsinjika, mankhwalawa ali ndi mphamvu yokwanira yothandizira wodwalayo.
Malinga ndi malangizo olembetsa, malonda amapangidwira kuti azigwiritsa ntchito mkati. Mankhwalawa amapezeka piritsi.
Ndikofunika kumwa kamodzi pa mankhwalawa usiku, popanda kuphwanya umphumphu wa chipolopolo.
Mlingo wa tsiku ndi tsiku umatsimikiziridwa nthawi imodzi. Musanayambe mankhwala ndi simvastatin, tikulimbikitsidwa kuti tikwaniritse kukonzanso kwa metabolidi ya lipid pogwiritsa ntchito masewera olimbitsa thupi komanso kudya mokwanira. Mankhwala atha kutumikiridwa pokhapokha ngati pali zovuta zakudya ndi kupsinjika.
Kutalika kwa maphunziridwe ndi kuchuluka kwa simvastatin kumatsimikiziridwa ndi dokotala wodwala, kutengera kuyambira kwa cholesterol ndi mawonekedwe a thupi.
Mlingo wa tsiku ndi tsiku wa mankhwalawa umasiyana ndi 5 mpaka 80 milligrams.
Mlingo sayenera kusinthidwa pasanadutse mwezi umodzi chiyambireni chithandizo.
Sizoletsedwa popanda kusintha komanso kuwonjezera mankhwala.
Kukhazikitsidwa koyenera kwa mankhwalawa kumathandizira kuyambika kwa kuchiritsa kumapeto kwa mwezi woyamba wa mankhwala.
Pakatha mwezi ndi theka, mulingo wa cholesterol ya atherogenic imasinthidwa.
Ma Statin alibe zotsala. Mankhwala amagwira ntchito pokhapokha ngati akukonzekera.
Ngati simutsatira moyo wathanzi atasiya kumwa mankhwalawo, patapita nthawi, kuyambika kwa cholesterol amkaka kumatha kuwonjezekanso.
Malangizo ogwiritsira ntchito atorvastatin
Mankhwalawa atha kukhala ndi kutanthauzira komanso kuthamanga. Iyenera kulembedwa kuti ikhale ndi cholesterol yayikulu, matenda a mtima, matenda oopsa a shuga komanso kupewa masoka achilengedwe.
Atorvastatin adalandira ndemanga yayikulu kwambiri kuchokera kwa akatswiri azachipatala zokhudzana ndi kugwirira ntchito kwake kwakukulu.
Atorvastatin ndi mankhwala opangira pakamwa. Momwemonso momwe zimakhalira ndi Simvastatin, Atorvastatin iyenera kukhazikitsidwa pokhapokha kulephera kwathunthu kwa mankhwala osagwiritsa ntchito mankhwala.
Mlingo wa tsiku ndi tsiku amasankhidwa poganizira kuopsa kwa matendawa komanso mikhalidwe ya wodwalayo.
Mlingo woyambirira wa mankhwalawa ndi 10 mg. Malangizo amachitika pakatha mwezi umodzi kuyambira chiyambi cha chithandizo.
Kumwa mankhwalawa pafupipafupi kumapereka kuchepa kwa kuchuluka kwa atherogenic lipids oposa theka.
Mbali ya mankhwalawa imakhudza modekha ma nephrons. Pankhaniyi, amavomerezeka kuti agwiritsidwe ntchito ndi odwala omwe akudwala aimpso. Mlingo wapamwamba wa mankhwalawa ndi 80 mg. Atorvastatin akuwonetsedwa kwa ana muyezo wosaposa 20 mg.
Asanatenge, ndikofunikira kuwunika ma enzymes a chiwindi.
Ndikofunika panthawi ya chithandizo ndikuwunikanso ntchito ya chiwindi.
Zotsatira zoyipa ndi zotsutsana kwa ma statins
Chomwe chimagwiritsidwa ntchito pa Atorvastatin ndi Simvastatin ndikuwunika kosalekeza kwamankhwala ndi machitidwe ofunikira. Mankhwala osokoneza bongo amathandizira kwambiri metabolism yamafuta. Paziphatikazi amaphatikizidwa kuti azisunga thupi.
Statins yatchulapo zochitika zamankhwala, chifukwa chake, kugwiritsa ntchito kwawo kumakhala kochepa muzochitika zina zakuthupi komanso za m'mikhalidwe.
Otsatirawa ndi contraindication kugwiritsa ntchito ma statins:
- Mbiri ya hypersensitivity pamankhwala osankhidwa.
- Lactose tsankho. Zomwe zimapangidwira zokonzekera zimakhala ndi lactose.
- Mitundu yosiyanasiyana ya myopathy.
- Matenda a chiwindi mu mawonekedwe.
- Ana a zaka mpaka 10.
- Mowa
- Matenda opatsirana owopsa.
- Chiwopsezo chachikulu cha kulephera kwa impso.
- Chithandizo cha ma immunosuppressants.
- Kukonzekera opaleshoni yayikulu.
- Sizoletsedwa kuyendetsa magalimoto ndi magawo omwe amafunikira kwambiri komanso kuyang'aniridwa pamene mukutenga ma statins.
- Mimba Mankhwala ali wamphamvu teratogenic kwenikweni. Mu mgwirizano uwu, ndizoletsedwa kugwiritsidwa ntchito mwa amayi apakati.
- Kuchepetsa.
Mukatenga ma statin opangidwa ndi theka, ndikofunikira kusiya zipatso za zipatso, chifukwa akaphatikizidwa, chiopsezo cha zotsatirapo zake chimakulanso.
Zotsatira zoyipa zimakonda kupezeka chifukwa cha Mlingo wosankhidwa bwino. Komabe, nthawi zina, zotsatira zoyipa sizikugwirizana ndi kuchuluka kwa mankhwalawa.
Zotsatira zotsatirazi ndizofanana ndi ma statins:
- mutu, mpaka kukulitsa ululu wammbuyo ndi migraine;
- matumbo dongosolo;
- zosokoneza za kugona ndi magawo;
- kufooka, kutopa;
- kukanika kwa chiwindi;
- chifuwa
- Matenda a CNS.
Chochulukitsa kwambiri komanso chotsimikizika cha mankhwala a statin ndikupanga rhabdomyolysis. Vutoli limachitika chifukwa cha kuwopsa kwa mankhwalawa paminyewa ya minofu.
Rhabdomyolysis ndiowopsa kwambiri komwe kumayambitsa kuwonongeka kwa ma rebu tubules komanso kukulitsa kulephera kwa impso.
Kusankhidwa kwa mankhwala
Kudziwa mphamvu ya mankhwala ndikotheka pokhapokha mutagwiritsa ntchito wodwala wina. Poyerekeza ndi mankhwala, Atorvastatin ndi chida chamakono kwambiri komanso champhamvu, ngati titenga mankhwala opanga ochepa poyerekeza. Kusiyana kwakukulu kumakhala mu mawonekedwe a kaphatikizidwe ndi mankhwala a pharmacodynamics a mankhwala.
Kugwiritsidwa ntchito kwa atorvastatin kumaphatikizira kudzikundikira kwa poizoni wa metabolic - sterol, yomwe imayambitsa zotsatira zoyipa pamapangidwe amisempha. Kulandila Simvastatin kumagwirizananso ndi zotsatira za myotoxic, koma pang'ono.
Kusanthula kofananako kwa mankhwala kumawonetsa kuti atorvastatin imathandizira kuti cholesterol ikhale yofulumira. Ichi ndiye kusiyana kwakukulu pakati pa zida ziwiri.
Malinga ndi kafukufukuyu, kuphatikiza mankhwala othandizira ndi phyto kumathandiza. Kuphatikiza uku kumakhala ndi mwayi wopanga, komanso kumachepetsa mavuto azachuma. Sitinganene kuti mankhwala azitsamba, mwachitsanzo, Ateroklefit kapena Ravisol, ndi othandiza kwambiri kuposa mankhwala apamwamba a Atorvastatin, koma kuti ndibwino kuwatenga limodzi.
Malinga ndi ziwerengero, kugwiritsa ntchito Atorvastatin ndi koyenera kwa mitundu yapamwamba ya matendawa, pomwe Simvastatin imalimbikitsa kuti ikhale ndi prophylaxis. Muyenera kugula mankhwala osokoneza mankhwalawa kapena muma pharmacistine. Mtengo ku Russia ndi CIS zimatengera wopanga.
Ubwino wogwiritsa ntchito ma statins akufotokozedwa mu kanema munkhaniyi.
