Glucovans adapangira odwala matenda ashuga. Nthawi zambiri amagwiritsidwa ntchito posagwiritsa ntchito njira zina zamankhwala, zakudya ndi masewera olimbitsa thupi.
Dzinalo Losayenerana
Metformin + Glibenclamide.
ATX
A10BD02.
Glucovans ndi mankhwala a odwala matenda ashuga.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwala amapezeka piritsi.
Zinthu zofunikira:
- 500 mg metformin hydrochloride;
- glibenclamide mu voliyumu ya 2.5-5 mg, kutengera mtundu wa kumasulidwa.
Zowonjezera:
- magnesium wakuba;
- povidone;
- croscarmellose sodium;
- MCC;
- povidone K-30;
- madzi oyeretsedwa;
- oxide wakuda wachitsulo;
- macrogol;
- oxide wachikasu;
- Opadry 31F22700 kapena Opadry PY-L-24808.
Glucovans wa mankhwalawa akupezeka mu mawonekedwe a mapiritsi, pomwe zosakaniza zazikuluzikulu ndi metformin hydrochloride ndi glibenclamide.
Zotsatira za pharmacological
Mankhwalawa ndi kuphatikiza kwa mitundu iwiri ya mankhwala a hypoglycemic. Metformin hydrochloride ndi biguanide. Thupi limathandiza kuchepetsa kuchuluka kwa shuga wa m'magazi. Sichiyambitsa kupanga insulini motero siyambitsa mkwiyo wa hypoglycemia. Metformin nthawi yomweyo imakhala ndi njira zitatu za pharmacotherapeutic zochita:
- amachepetsa kapangidwe ka shuga wa hepatic poletsa glycogenolysis ndi gluconeogeneis;
- imawonjezera kukhudzika kwa ma receptor angapo ku chinthu cha insulin, kugwiritsa ntchito / kumwa kwa glucose ndi maselo amisempha;
- amalepheretsa mayamwidwe a shuga kuchokera m'mimba.
Glibenclamide ndi imodzi mwazomwe zimachokera ku sulfonylurea.
Magulu a glucose amachepetsa chifukwa cha kuchuluka kwa insulin yopangidwa ndi maselo a beta omwe amapezeka pancreas.
Zinthu zomwe zikufunsidwazo zimakhala ndi njira zosiyanasiyana zochitira zinthu, koma zimathandizana mogwirizana ndi zochitika za hypoglycemic ndikuwongolera magwiridwe antchito a hormone.
Pharmacokinetics
Pakaperekedwa pakamwa, glibenclamide imatenga 95% kuchokera m'matumbo. Kuchuluka kwazinthu zambiri m'madzi am'madzi zimawonedwa pambuyo maola 4-4,5. Imagawanika kwathunthu m'chiwindi. Hafu ya moyo ndi maola 4-12.
Ndi pakamwa makonzedwe a mankhwala a Glucovans, mphamvu yake yogwira - glipenclamide - imatengedwa 95% kuchokera m'matumbo ndipo imawonongeka m'chiwindi.
Metformin imatengedwa kuchokera m'mimba. Mulingo wake wokwera kwambiri mu seramu umapezeka mkati mwa maola 2-2,5.
Pafupifupi 30% ya chinthucho imatulutsidwa ndi matumbo mwanjira yosasintha. Otopa kwambiri, Hafu ya moyo ndi pafupifupi maola 7. Odwala omwe ali ndi vuto la impso, nthawi imeneyi imawonjezeka mpaka maola 9-12.
Zizindikiro zogwiritsidwa ntchito
Type 2 shuga mwa akulu:
- Popeza kulibe mphamvu zoyenera kuchokera pakulimbitsa thupi, mankhwala othandizira pakudya ndi monotherapy;
- odwala odwala glycemia olamulidwa ndi okhazikika.
Matenda a shuga a Mtundu Wachiwiri ndiye chizindikiro chachikulu chotengera Glucovans, kuphatikiza kwa odwala omwe ali ndi glycemia yokhazikika.
Contraindication
Mankhwala sangathe kugwiritsidwa ntchito pazotsatira zotsatirazi:
- mimba ndi kuyamwitsa;
- tsankho;
- matenda a shuga a ketoacidosis;
- porphyria;
- mitundu pachimake matenda a mtima;
- kulephera kwa chiwindi;
- kulephera kwa aimpso ndi CC mpaka 60 ml / min;
- matenda ashuga / mtima;
- kuphatikiza ndi miconazole;
- mtundu woperewera wauchidakwa ndi kuledzera komwe kumayambitsidwa ndi zakumwa zoledzeretsa;
- lactic acidosis;
- mtundu 1 matenda a shuga;
- kuchitapo kanthu kwa opaleshoni (yotakata);
- matenda aakulu / pachimake omwe amatsatana ndi minofu hypoxia (kuphatikizapo kupuma / kulephera kwa mtima).
Ndi chisamaliro
Sikoyenera kugwiritsa ntchito mankhwalawa kwa anthu okalamba omwe akuchita ntchito yolimbitsa thupi. Izi zimaphatikizidwa ndi chiopsezo cha lactic acidosis mwa anthu am'gululi.
Mankhwalawa ali ndi lactose, motero amalembedwa mosamala kwa anthu omwe ali ndi mitundu yachilengedwe ya majini omwe amaphatikizidwa ndi GGM syndrome, kusowa kwa lactase, kapena hypersensitivity kwa galactose.
Kuphatikiza apo, mankhwalawa amalembedwa mosamala kuti adrenal insufficiency, matenda a febrile ndi matenda a chithokomiro.
Momwe mungatenge Glucovans
Mlingo watsimikiza ndi dokotala aliyense payekha. Pafupifupi koyambirira - piritsi 1 limodzi patsiku. Kuchuluka kwa mankhwalawa kungathe kuwonjezeka ndi 0,5 g ya metformin ndi 5 mg ya glibenclamide patsiku lililonse masabata angapo mpaka kuchuluka kwa shuga m'magazi kumakhazikika.
Mlingo wapamwamba ndi mapiritsi 6 a mankhwala a mapiritsi a 2,5 + 500 mg kapena 4 (5 + 500 mg).
Mankhwala ayenera kumwedwa pakudya. Nthawi yomweyo, chakudya chizikhala ndi chakudya chamagulu ambiri momwe mungathere.
Kumwa mankhwala a shuga
Anthu odwala matenda ashuga omwe amagwiritsa ntchito mankhwalawa akuyenera kuwonetsetsa kuti shuga ya magazi ndi kusintha kwa insulin.
Zotsatira zoyipa za Glucovans
Matumbo
Kuwonongeka kwa chakudya, kusasangalala ndi m'mimba, kusanza / nseru. Chizindikiro ichi chimawonedwa kwambiri kumayambiriro kwa mankhwala ndipo chimachoka mkati mwa masiku 3-4.
Hematopoietic ziwalo
Nthawi zina, thromocytopenia, leukopenia, pancytopenia, mars aplasia, hemolytic mawonekedwe a magazi. Izi zoyipa zimatha pambuyo posiya kugwiritsa ntchito mankhwalawa.
Pakati mantha dongosolo
Kuchokera kumbali yamkati yamanjenje, chizungulire pang'ono, kukhumudwa, kupweteka mutu komanso kulawa kwazitsulo pamlomo wamkamwa kumatha kuonedwa.
Pa mbali ya ziwalo zamasomphenya
M'masiku oyamba kumwa mankhwalawa, kuwonongeka kwa maso kumachitika chifukwa cha kuchepa kwa kuchuluka kwa shuga m'magazi.
Kuchokera kumbali ya kagayidwe
Zotsatira zoyipa kwambiri ndizo hypoglycemia. Pozindikira matenda am'madzi a mtundu wa megaloblastic, kuopsa kwa etiology yofananira kuyenera kukumbukiridwa.
Zotsatira zoyipa kwambiri zakumwa Glucovans ndi hypoglycemia.
Matupi omaliza
Nthawi zina, anaphylaxis. Payekha tsankho zimachitika sulfonamide zotumphukira kuonedwa.
Zokhudza mphamvu pakuwongolera njira
Wodwala ayenera kudziwitsidwa za kukhala ndi vuto la hypoglycemia komanso kuti poyendetsa, kugwiritsa ntchito njira zovuta komanso ngati pakufunika chidwi chambiri, ayenera kusamala.
Malangizo apadera
Gwiritsani ntchito mu ukalamba
Kwa anthu omwe ali mgululi, mankhwalawa amalamula kutengera ndi impso.
Kuchuluka koyamba sikuyenera kupitirira piritsi limodzi la 2,5 + 500 mg. Pankhaniyi, wodwalayo ayenera kuperekedwa powunika impso.
Kulembera a Glucovans kwa ana
Osavomerezeka kuti agwiritsidwe ntchito kwa odwala azaka zochepa.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Mankhwalawa ndi osayenera kugwiritsa ntchito pakhungu. Mukakonzekera kutenga pakati, mankhwalawa ayenera kuthetsedwa ndipo chithandizo cha insulin chimayamba.
Mukakonzekera kukhala ndi pakati, mankhwala a Glukvans ayenera kuthetsedwa.
The ntchito aimpso kuwonongeka
Osavomerezeka kuti agwiritsidwe ntchito kwa anthu omwe ali ndi vuto lolephera.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Kwa anthu omwe ali ndi vuto la chiwindi, mankhwalawa amaperekedwa mosamala kwambiri.
Glucovans bongo
Mukamamwa mankhwala okwanira, hypoglycemia imatha kuchitika. Kutalika kwa nthawi yayitali kumatha kuyambitsa lactic acidosis, kupuma kosafunikira ndi mawonekedwe ena olakwika.
Zizindikiro zolimbitsa thupi / zofatsa za hypoglycemia pomwe mukukhazikika wodwala zimatha kuwongoleredwa ndi shuga. Zikatero, wodwalayo amafunikira kusintha kosiyanasiyana.
Kuwoneka kwa zovuta zazikulu za hypoglycemic mu odwala matenda ashuga kumaphatikizapo kupereka chithandizo chamankhwala mwachangu.
Panthawi yamavuto osaneneka a mankhwala osokoneza bongo a Glucovans, chithandizo chamankhwala chofunikira ndichofunikira.
Mankhwalawa samachotsedwa pakachitika dialysis.
Kuchita ndi mankhwala ena
Kuphatikiza kophatikizidwa
Mukaphatikiza mankhwalawa pamafunso ndi miconazole, pamakhala chiwopsezo cha hypoglycemia, chomwe chitha kupangitsa kuti muwoneke.
Njira zokhala ndi ayodini ziyenera kuperekedwa kwa maola 48 musanamwe mankhwalawa, mosasamala chakudya.
Osavomerezeka kuphatikiza
Phenylbutazone imawonjezera hypoglycemic zotsatira za sulfonylurea. Ndikofunika kupatsa chidwi ndi mankhwala ena odana ndi kutupa omwe alibe mphamvu kwambiri.
Kuphatikiza kwa glibenclamide, mowa ndi bosentan kumawonjezera mwayi wa hepatotoxic. Ndikofunika kuti musagwiritse ntchito zinthu izi.
Kuphatikiza komwe kumafunikira kusamala
Mlingo waukulu wa chlorpromazine ndi danazol umachulukitsa glycemia, ndikuchepetsa kupanga kwa insulin. Mukaphatikiza mankhwalawa ndi mapiritsi omwe akufunsidwa, wodwalayo ayenera kuchenjezedwa za kufunika koyendetsa kuchuluka kwa shuga m'magazi.
Tetracosactide ndi glucocorticosteroids amakulitsa kuchuluka kwa plasma kwa glucose ndipo kungayambitse ketosis. Ndi kuphatikiza uku, wodwala amayenera kuwongolera kuchuluka kwa shuga m'magazi. Ma diuretics ndi zotumphukira za coumarin zimatha kukhala ndi zotsatira zofananazi.
Ndi kuphatikiza kwa mankhwala Glucovans omwe ali ndi glucocorticosteroids, wodwalayo ayenera kuwunika kuchuluka kwa glucose m'magazi.
Kugwiritsidwa ntchito mosiyanasiyana kwa mankhwalawa ndi fluconazole ndi ACE zoletsa kumawonjezera theka la moyo wa glibenclamide ndi chiwopsezo cha zizindikiro za hypoglycemic.
Kuyenderana ndi mowa
Munthawi yogwiritsira ntchito mankhwalawa, kugwiritsa ntchito mankhwala okhala ndi ethanol ndi mowa kuyenera kupewedwa.
Analogi
- Glybophor;
- Glibomet;
- Duotrol;
- Douglimax;
- Amaryl;
- Dibizide M;
- Avandamet;
- Vokanamet.
Kupita kwina mankhwala
Kodi ndingagule popanda kulandira mankhwala?
Sungalandiridwe popanda mankhwala a dokotala.
Zochuluka motani
Mtengo muma pharmacies aku Russia ukuyambira pa 270 rubles. pa paketi iliyonse ya mapiritsi 30 a 2.5 + 500 mg.
Amaril ndi amodzi mwa fanizo la mankhwala a Glucovans.
Zosungidwa zamankhwala
Malangizowo akuti ndikofunikira kusunga mankhwalawo pansi pa kutentha + mkati mwa 15 ° ... 26 ° C. Pewani ziweto ndi ana.
Tsiku lotha ntchito
Mpaka zaka zitatu.
Wopanga
Kampani yaku Norway-France Merck Sante.
Ndemanga za Glucovans
Madokotala
Alevtina Stepanova (wochiritsa), wazaka 43, St. Petersburg
Mankhwala otetezeka komanso othandiza. Iyi ndi njira yabwino ngati monotherapy ndi mankhwala ena, zolimbitsa thupi ndi zakudya sizipereka kufunika.
Valery Torov (wochiritsa), wazaka 35, Ufa
Zotsatira zoyipa mukamamwa mankhwalawa nthawi zambiri zimawonedwa, koma zimakhala ndi kanthawi kochepa ndipo zimadzithandizira pazokha masiku oyambira atangoyamba kumene chithandizo. Ndimakonda mtengo wogwira komanso wotsika mtengo pamankhwala.
Mankhwala a Glucovans amaperekedwa kokha mwa mankhwala, mankhwalawa amayenera kusungidwa pa kutentha kwa + 15 ° C mpaka + 26 ° C.
Odwala
Lyudmila Korovina, wazaka 44, Vologda
Ndinayamba kumwa piritsi limodzi la mankhwala m'mawa uliwonse. Kuzungulira kwa shuga mu seramu kumachepera 12 mpaka 8. Zizindikiro posakhalitsa zimakhazikika. Izi zisanachitike, palibe mankhwala azitsamba kapena mankhwala omwe anathandizira. Ndinadabwa kuti ngakhale kachilomboka kakang'ono ngati kameneka “kamagwira ntchito” ndipo kamapereka mphamvu zabwino. Tsopano ndikufuna kulandiranso njira zamatenda, kenako thanzi langa lidzakhala longa unyamata wanga.
Valentina Sverdlova, wazaka 39, Moscow
Amuna anga ankakonda kugwiritsa ntchito Bagomet, komabe, anasowa ku malo ogulitsa mankhwala m'dera lathu, ndipo kunalibenso nthawi kapena kulimbikira kuti mupite ku likulu madzulo pambuyo pantchito. Mkhalidwe wa mnzakeyo udayamba kuwonongeka. Shuga anali lokwera nthawi zonse, zikondamoyo zinayamba kugwira ntchito, ngakhale milomo yake imakhala yabuluu. Dokotala adalangiza kugwiritsa ntchito mankhwalawa. M'masiku angapo oyambirira, mkazi kapena mwamuna anali wongomva pang'ono, koma posakhalitsa chisangalalocho chinazimiririka, ndipo shugayo adatsikira ku 8.
