Mankhwala ndi gulu la mankhwala a hypoglycemic. Amatengedwa pakamwa. Ntchito yayikulu ndikuwunikira njira za insulin. Komabe, izi sizitanthauza kuti ikhoza kugwiritsidwa ntchito pazovuta zodalira insulin. Kukula kwa mankhwalawa kumakulira chifukwa cha kukhudzidwa kwa kapamba. Ali ndi contraindication ambiri, malire oletsa kugwiritsa ntchito. Pofuna kuthana ndi zovuta zomwe zimachitika ndikuwonjezera mphamvu, mankhwalawa amayenera kumwa nthawi yochepa.
Dzinalo Losayenerana
Glimepiride.
Ntchito yayikulu ya glimepiride ndi momwe amapangira insulin.
ATX
A10BB12.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwala amaperekedwa m'mitundu yosiyanasiyana, mosiyanasiyana muyezo wa yogwira: 2, 3 ndi 4 mg. Mutha kugula mugule olimba. Mapiritsi ali ndi chophatikizika cha dzina lomweli. Kapangidwe kake kamaphatikizanso zinthu zina:
- lactose;
- ma cellcose a microcrystalline;
- wowuma pregelatinized;
- sodium lauryl sulfate;
- magnesium wakuba.
Kuphatikiza apo, mankhwalawa amatha kukhala ndi utoto. Komabe, siali onse amitundu yonse ya glimepiride, koma ali m'mapiritsi okhala ndi gawo lalikulu la 3 mg. Mankhwala amaperekedwa m'matumba a 30 ma PC.
Zotsatira za pharmacological
Mankhwalawa amayimira othandizira a hypoglycemic a gulu la sulfonamides. Amati mankhwala osokoneza bongo a m'badwo wachitatu. Mfundo yakugwirira ntchito idakhazikitsidwa ndi zomwe zimapangitsa kuti insulini izitulutsidwe. Izi zimatheka polimbikitsa maselo ena a endocrine mbali ya kapamba. Amagwira ntchito zingapo: yambitsa kutulutsa insulini, nthawi yomweyo amathandizira kuchepa kwa shuga wamagazi.
Mankhwala ali ndi amadalira mlingo. Chifukwa chake, ndi kuchepa kwa kuchuluka kwa glimepiride, kuchuluka kwa kutulutsidwa kwa insulin kumachepa. Komabe, ndi izi zoyambirira zamankhwala, mankhwalawa amakhalanso ndi shuga wofanana ndi plasma monga ena ofananirana nawo waukulu. Izi zimatheka chifukwa chakuwonjezeka kwa insulin.
Mankhwala amapangidwa. Chifukwa chakuchepetsa zovuta zomwe wodwala ali nazo pamene zotsatira za insulin sizili zokwanira, amagwiritsidwa ntchito posagwirizana ndi matenda a shuga a shuga komanso mtundu II wa matenda a shuga. Amayendedwe a activation a insulin kupanga multistage. Zimakhazikitsidwa ndikupereka shuga ku ma cell a beta a kapamba, zomwe zimapangitsa kuti pakuwonjezereka kwa ntchito yopanga AFT. Ma molekyulu a enzyme amatseka njira za calcium zotsalira za calcium.
Glimepiride imagwiritsidwa ntchito posagwiritsa ntchito inshuwaransi yodalira shuga komanso mtundu II matenda a shuga.
Izi zimayambitsa kusokonezeka kwa njira yotulutsidwa kwa potaziyamu cell. Kenako kukomoka kwa nembanemba kwamaselo kumayamba. Pakadali pano, njira za calcium zomwe zimadalira calcium zimatsegulidwa, zomwe zimapangitsa kuchuluka kwa calcium pama cytoplasm of cell a beta. Pa gawo lotsiriza, kusunthira kwa insulin kuzinthu zam'mimba kumathandizira, chifukwa chake, zovuta za insulin zimalumikizana ndi membrane wa cell.
Ubwino wa mankhwalawa umakhala wochepa kwambiri pakayambitsa kutulutsa insulin, motero kuchepetsa chiopsezo cha hypoglycemia. Malo ena: kutsika kwa mayamwidwe a insulin ndi chiwindi, kuchepa kwamphamvu pakupanga shuga m'mizimba ya chiwalo ichi. Kuphatikiza apo, kuletsa kwa njira zingapo zamitundu mitundu zomwe zimatsogolera pakupanga kwa magazi kumadziwika. Izi zimapereka antithrombotic.
Katundu wina ndi kuthekera kwa Glimepiride kuwonetsa anti-atherogenic effect. Izi zikutanthauza kuti chifukwa cha izo chitukuko cha matenda amtima wamitsempha umapewedwa. Zotsatira zake zimatheka ndikusintha zomwe zili za lipid. Kuphatikiza apo, kuchepa kwa mulingo wa aldehyde yaying'ono kumadziwika.
Chifukwa cha izi, kuchuluka kwa lipid oxidation kumachepa. Mankhwala omwe amafunsidwanso amakhudzanso njira zina zamankhwala am'magazi, makamaka, amachotsa mawonekedwe a oxidative nkhawa omwe amayenda ndi odwala matenda a shuga.
Pharmacokinetics
Mankhwala amachita mwachangu. Pambuyo pa mphindi 120, ntchito yayitali kwambiri. Zotsatira zake zimasungidwa kwa 1 tsiku. Zitatha izi, kugwiritsidwa ntchito kwa zinthu zomwe zimayamba kugwira ntchito kumayamba kuchepa. Kukhazikika kwa njira zamankhwala am'magazi zomwe zimakhudzidwa ndi gawo lazomwe zimachitika mumasabata awiri.
Ubwino wa malondayo umapezeka mwachangu komanso mokwanira. Mankhwala omwe amafunsidwa ndi 100% bioavava. Ikafika m'chiwindi, makulidwe a oxidation amayamba. Pankhaniyi, metabolite yogwira imamasulidwa, yomwe imakhala yofooka pang'ono kuposa glimepiride malinga ndi kuchuluka kwa thupi. Njira ya metabolic ikupitirirabe. Zotsatira zake, gulu lomwe silikugwira ntchito limamasulidwa.
Kutha kwa theka la moyo kumapangitsa maola 5-8. Kutalika kwake kumatengera mkhalidwe wamthupi ndi kupezeka kwa ma pathologies ena. Gawo logwira ntchito likuwonetsedwa mu mawonekedwe osinthidwa. Komanso, zinthu zambiri zimachotsedwa m'thupi pakukodza, ndalama zotsalazo.
Hafu ya moyo wa glimepiride kuchokera m'thupi ndi maola 5-8.
Zizindikiro zogwiritsidwa ntchito
Mankhwalawa ali ndi malo ochepa owgwiritsira ntchito. Chifukwa chake, amalembera mtundu wachiwiri wa matenda ashuga. Ngati achire alibe mphamvu zokwanira, amasintha kuchokera ku chithandizo chamankhwala chovuta kwambiri. Pankhaniyi, owonjezera a Insulin kapena Metformin (250 mg) akhoza kulimbikitsidwa.
Contraindication
Ndi koletsedwa kugwiritsa ntchito chida chofunsidwa pazinthu zotere:
- metabolic acidosis, limodzi ndi kuphwanya kagayidwe kachakudya;
- matenda a shuga;
- mtundu 1 matenda a shuga;
- ma pathologies omwe chakudya chimatha kumizidwa kapena njirayi imadzaza zovuta.
- zovuta zoyipa zomwe zimakhudzana ndi kapangidwe kamankhwala awa ndi ena othandizira kuchokera ku gulu la sulfonamides ndi sulfonylurea;
- chiopsezo chachikulu cha hypoglycemia;
- Zotsatira zoyipa za lactose, kuperewera kwa lactase, shuga-galactose malabsorption.
Ndi chisamaliro
Matenda a wodwalayo ayenera kuyang'aniridwa pakumwa mankhwala ndi mankhwalawa pakafunika thandizo la insulin:
- kuwotcha ndi zowonongeka zambiri pazithunzi zakunja;
- opaleshoni yayikulu;
- kuvulala kambiri;
- matenda omwe chiopsezo cha malabsorption chakudya chimachuluka, mwachitsanzo, kutsekeka kwamatumbo kapena paresis yam'mimba.
Momwe mungatengere glimepiride
Mapiritsiwo adapangira pakamwa. Satha kutafunidwa, koma tikulimbikitsidwa kuti timize ndi madzi. Mankhwala amatengedwa pamimba yopanda chakudya, musanadye.
Ndi matenda ashuga
Nthawi zambiri, pa gawo loyamba, 1 mg ya mankhwala imakhazikitsidwa 1 nthawi patsiku. Kenako, pakupuma kwa masabata 1-2, kuchuluka kumachulukiratu mpaka 2 mg, kenako mpaka 3 mg. Pamapeto omaliza, 4 mg ndi mankhwala. Kuchuluka kwa tsiku lililonse kwa mankhwalawa ndi 6 mg.
Mapiritsiwo sangathe kutafuna, koma amalimbikitsidwa kuti amame ndi madzi.
Malingana ndi mfundo imodzimodziyo, ndikofunikira kuchita ngati akukonzekera kumwa mankhwalawo nthawi imodzi ndi Metformin. Mutha kusamutsa wodwala kuchokera ku Metformin kupita ku insulin. Poterepa, pitilizani maphunziro anu ndi kumwa komwe mankhwalawo adasokoneza. Izi zikuyenera kukhazikitsidwa. Mlingo wa insulin ukuwonjezeka pang'onopang'ono. Yambirani maphunziro a mankhwalawa ndi ndalama zochepa.
Pamafunika kusamutsa wodwala kuchokera ku mtundu umodzi wa hypoglycemic kupita ku mankhwala omwe mukufunsidwa, milingo yocheperako ya glimepiride imaperekedwanso koyamba. Kuchuluka kwantchito yogwiritsidwa ntchito ndi 1 mg. Kenako imakulitsidwa mpaka kufika pamlingo wofunikira.
Zotsatira zoyipa za gliperimide
Mankhwalawa amatha kuthandizira pakukula kwa njira zambiri za pathological, zomwe ziyenera kuganiziridwa posankha.
Pa mbali ya gawo la masomphenyawo
Zowonongeka (njira yosinthira).
Matumbo
Kuchepetsa msana, kusanza pamayendedwe a m'matumbowa, zotupa zotayidwa, kupweteka kwa epigastric, chiwindi cholakwika, chomwe chikuwonetseredwa ndi jaundice, hepatitis, kusintha kwa zikuluzikulu za ntchito ya chiwindi pakapita maphunziro.
Hematopoietic ziwalo
Matenda angapo omwe amabwera chifukwa cha kusintha kwa kapangidwe ka magazi, monga leukopenia, etc.
Kuchokera kumbali ya kagayidwe
Hypoglycemic zimachitika. Nthawi zambiri, amakula pambuyo pa kumapeto kwa maphunziro chifukwa cha kusintha kwa zakudya. Nthawi zina chifukwa chake ndi kuphwanya mlingo wa mankhwalawa panthawi ya mankhwala.
Matupi omaliza
Nthawi zambiri, urticaria imayamba, koma zizindikiro zofananira zimatha: kufooka kwa thupi, dyspnea, mantha a anaphylactic.
Zokhudza mphamvu pakuwongolera njira
Sikulimbikitsidwa kuchita nawo ntchito zina zofunika kwambiri. Izi ndichifukwa choti pamayambiriro a mankhwalawa kapena mukamasintha mankhwala kuchokera ku hypoglycemic kupita ku imzake, zizindikiro zotsatirazi zitha kuwoneka: kulephera chidwi, kuchepa kwa kuchuluka kwa zochitika zama psychomotor.
Mukatha kugwiritsa ntchito mankhwalawa, mantha a anaphylactic amatha.
Malangizo apadera
Ndikulimbikitsidwa kumwa mankhwalawa nthawi. Chifukwa cha izi, kukhazikika kwa chikhalidwe cha wodwalayo kumatheka mofulumira. Ngati mukuphonya nthawi yofunsidwa, ndizoletsedwa mwakufuna kwanu kuti muonjezere mankhwala. Funsani dokotala.
Ngati zizindikiro za hypoglycemia zimagwiritsidwa ntchito piritsi limodzi ndi kuchuluka kwa 1 mg ya glimepiride, ndiye kuti kuchuluka kwa glucose kumatha kusinthidwa pokhapokha zakudya zapadera.
Mukalandira mankhwala omwe akufunsidwa, kufunikira kwake kumachepa. Izi ndichifukwa cha kuwonjezeka kwapang'onopang'ono kwa kumva kwa insulin.
Tiyenera kukumbukira kuti odwala omwe apezeka ndi matenda amtundu wa endocrine, chiopsezo chokhala ndi kusakwanira kwa adrenocortical ukuwonjezeka.
Popeza kuti phindu la glimepiride limasungidwa kwa milungu ingapo, kupuma kungafunike pakusintha kuchokera ku mankhwala ena a hypoglycemic kupita ku wina.
Ndikumamwa Glimepiride, ndikofunikira kuti nthawi zonse muzichita mayeso kuti muone kuchuluka kwa shuga m'magazi, komanso glycated hemoglobin.
Ngakhale mukumwa mankhwalawo, ndikofunikira kuchita mayeso pafupipafupi. Pankhaniyi, kuchuluka kwa shuga m'magazi, komanso hemoglobin wa glycated, akuyerekezedwa.
Gwiritsani ntchito mu ukalamba
Ma pharmacological a mankhwalawa sasintha mwa odwala a gululi. Chifukwa chake, kusintha kwa mlingo sikofunikira.
Kupatsa ana
Sanapatsidwe.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Mankhwala ndi oletsedwa kugwiritsidwa ntchito. Pa gawo lokonzekera kukhala ndi pakati kapena poyamwitsa, mkazi amasamutsidwa ku insulin.
The ntchito aimpso kuwonongeka
Sanapatsidwe.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Sichikulimbikitsidwa kugwiritsa ntchito mankhwalawa chifukwa chogwira nawo ntchito mthupi lanu popanga mankhwala osokoneza bongo.
Mankhwala osokoneza bongo a glimepiride
Ngati mankhwalawa akachuluka, hypoglycemia imayamba msanga. Matenda amtunduwu amasungidwa kwa maola 12-72. Zizindikiro: kusokonezeka kwa mtima, kuda nkhawa, matenda oopsa, kupweteka pachifuwa, kufooka, kutsukidwa, kutsatiridwa ndi kusanza, kulakalaka kudya komanso mutu. Ma Adsorbents, ma laxatives amathandizira kuthetsa zizindikiro.
Ngati mulingo waukulu wa mankhwalawo utatengedwa, kupendekera kwa chapamimba kotsatiridwa ndi dextrose ndikofunikira. Izi zimachitika mu chipatala. Kuphatikiza apo, ndikofunikira kuyendetsa kuchuluka kwa glucose m'magazi.
Kuchita ndi mankhwala ena
Kuwonjezera mphamvu ya glimepiride ankaziona pamene ntchito insulinosoderzhaschih wothandizira, mankhwala hypoglycemic, Ace zoletsa, anabolic mankhwala, coumarin ofanana nawo, allopurinol, chloramphenicol, cyclophosphamide, disopyramide, Feniramidola, fenfluramine, fluoxetine, Dizopiramidona, mankhwala a ifosfamide, guanethidine, miconazole, Pentoxifylline, phenylbutazone, njira magulu a salicylates, quinolones, tetracyclines, sulfonamides.
Kuwonjezeka kwa mphamvu ya glimepiride kumadziwika ndi munthawi yomweyo kugwiritsa ntchito mankhwala okhala ndi insulin, mankhwala a hypoglycemic, zotumphukira za coumarin.
Mankhwala ena, m'malo mwake, amachepetsa mphamvu ya glimepiride. Izi zikuphatikiza: Acetazolamide, barbiturates, corticosteroids, diuretics, Epinephrine, Diazoxide, nicotinic acid, sympathomimetics, mankhwala othandizira, Glucagon, estrogen- ndi ma progesterone okhala ndi mahomoni a chithokomiro.
Kuyenderana ndi mowa
Sitikulimbikitsidwa kumwa zakumwa zoledzeretsa zokhala ndi mowa ndi glimepiride, chifukwa ndizovuta kuneneratu zomwe zingachitike. Mowa umatha kukulitsa mphamvu ya wothandizirayo.
Analogi
M'malo glimepiride zotchulidwa:
- Glibenclamide;
- Glianov;
- Amaryl;
- Diabetes, etc.
Kupita kwina mankhwala
Mankhwala ndi mankhwala.
Kodi ndingagule popanda kulandira mankhwala?
Palibe mwayi wotere.
Mtengo
Mtengo umasiyanasiyana kutengera mlingo wa glimepiride ndipo ndi ma ruble a 190-350.
Zosungidwa zamankhwala
Ana sayenera kulandira mankhwalawo. Kutentha kovomerezeka mkati - mpaka + 25 ° ะก.
Tsiku lotha ntchito
Mankhwalawa amatha kugwiritsidwa ntchito patatha zaka ziwiri kuchokera tsiku lomwe wamasulidwa.
Wopanga
"Pharmstandard - Leksredstva", Russia
Ndemanga
Alice, wazaka 42, Kirov
Mapiritsi a anthu odwala matenda ashuga ndiwabwino kuposa jakisoni, chifukwa ndichopepuka kwambiri, simuyenera kukhala ndi luso la jakisoni. Ndipo si aliyense amene angalekerere mtundu wa magazi. Chifukwa chake, ndidafunsa adotolo kuti asankhe mankhwalawa mu mawonekedwe olimba. Anayesa kuthetsa zizindikiro. Zotsatira zoyipa sizinachitike.
Elena, wazaka 46, St. Petersburg
Ngati chiwindi chayamba kugwira ntchito, palibe mankhwala omwe amakupatsani. Pazifukwa izi, ndinayenera kusintha. Ali ndi zaka 45, kulephera kwa hepatic kunapezeka. Koma ndimakonda zochita za Glimepiride, zimapereka chithandizo mwachangu, zotsatira zomwe zimapezeka zimasungidwa kwanthawi yayitali.
