Saxenda (Saxenda) ndi gulu la ndalama zomwe zochita zawo zimafuna kuchepetsa kulemera kwa wodwala. Amadziwika ndi gawo lopapatiza, chiwerengero chachikulu cha zoyipa ndi zoletsa kugwiritsa ntchito.
Dzinalo Losayenerana
Liraglutide
Saxenda (Saxenda) ndi gulu la ndalama zomwe zochita zawo zimafuna kuchepetsa kulemera kwa wodwala.
ATX
A10BJ02
Kutulutsa mafomu ndi kapangidwe kake
Mankhwalawa adapangira ma subcutaneous makonzedwe. Amaperekedwa ngati yankho la jakisoni. Mankhwalawa ndi amodzi. Izi zikutanthauza kuti kapangidwe kameneka ndikuphatikiza 1 yogwira - liraglutide. Kuphatikizika kwake mu 1 ml ya mankhwalawa ndi 6 mg. Mankhwalawa amapangidwa mu syringes yapadera. Kukula kulikonse ndi 3 ml. Chiwerengero chogwira ntchito mu syringe ndi 18 mg.
Kuphatikizikako kumaphatikizanso zinthu zomwe sizimakhudza kuchepa thupi:
- phenol;
- sodium hydrogen phosphate dihydrate;
- propylene glycol;
- hydrochloric acid / sodium hydroxide;
- madzi a jakisoni.
Mankhwalawa amaperekedwa phukusi lomwe lili ndi ma syringes asanu.
Mankhwalawa adapangira ma subcutaneous makonzedwe.
Zotsatira za pharmacological
Chida chija chikuyimira gulu la mankhwala a hypoglycemic, ndi analogue yopanga ya munthu glackey-peptide-1 kapena GLP-1. Zimapezeka potsatira biotechnology potengera kuphatikizika kwa DNA yomwe imapangidwanso komanso mtundu wamagulu a yisiti bowa, kusiyana komwe kumakhala kofanana kwambiri ndi kufanana kwa amino acid a GLP-1 (97%) ya anthu.
Ntchito yayikulu ya Saxenda imamangirira ku GLP-1 receptors ndi kupititsa patsogolo kwawo. Izi zimachepetsa kufunika kwa chakudya. Izi zikuchitika chifukwa chakuwonjezeka kwa chizindikiritso chokhudza kukwera kwa thupi. Nthawi yomweyo, pakhala kuchepa kwa kuchuluka kwa chizindikiro cha njala. Chifukwa cha izi, kuchepa kwa thupi, chifukwa munthu samamva kufunika kwa chakudya, chilakolako cha thupi chimafooka.
Choyamba, unyinji wa minofu ya adipose imachepetsedwa. Chimodzi mwa mankhwalawa ndiko kusatha kwawonjezera mphamvu zamagetsi tsiku ndi tsiku. Chithandizo chogwira ntchito pakuphatikizidwa chimakhudzidwa m'njira zambiri zamankhwala am'thupi. Mwachitsanzo, zikomo kwa iye, kuchuluka kwa mapangidwe a insulin kumawonjezeka. Komabe, pali kuchepa kwa kupanga kwa glucagon modalira shuga.
Ntchito yayikulu ya Saxenda imamangirira ku GLP-1 receptors ndi kupititsa patsogolo kwawo. Izi zimachepetsa kufunika kwa chakudya.
Zikondamoyo zimachitikanso bwino, chifukwa cha kuphatikiza kwa ntchito ya beta-cell. Zotsatira za njirayi ndikuchepa kwa kudya kwa glucose komanso mukatha kudya. Chifukwa cha izi, kutaya kwa m'mimba kumachepetsedwa pang'ono, zomwe zimapangitsa kukulira kwa nthawi, ndikuphatikizidwa ndi kumverera kwodzaza.
Amadziwika kuti mankhwala omwe amafunsidwa ndi okhawo omwe ali ndi fanizo omwe amapereka kwambiri kuchepetsa thupi (9%). Zotsatira zotere zimatsimikiziridwa ndi kafukufuku wazachipatala womwe wachitika kwa nthawi yayitali okhudza odwala osiyanasiyana omwe ali ndi kunenepa kwambiri kapena kunenepa kwambiri. Kufunika koyenera kunapezeka limodzi ndi zakudya (kwenikweni hypocaloric) komanso zolimbitsa thupi.
Pazithandizo, ntchito zingapo zimachitika nthawi imodzi: kulakalaka kudya ndikugwiritsa ntchito mphamvu kumachepetsedwa, kufunikira kwa ma calorie owonjezera kumachepetsedwa, ndipo kutsekeka kwa m'mimba kumakhala pang'ono. Tinkakhulupirira kuti zotulukazi zimatheka chifukwa chosintha chakudya komanso kuchuluka. Komabe, mankhwalawo omwe amafunsidwa ndi othandiza kwambiri kuposa placebo.
Amadziwika kuti mankhwala omwe amafunsidwa ndi okhawo omwe ali ndi fanizo omwe amapereka kwambiri kuchepetsa thupi (9%).
Pharmacokinetics
Mayamwidwe liraglutide pang'onopang'ono. The bioavailability wa chinthu ichi ndi 55%. Zochita zapamwamba za mankhwalawa zimachitika patatha maola 11 pambuyo pa mankhwalawa. Kutha kwake kumangiriza mapuloteni a plasma (98%) amadziwika. Zotsatira zamaphunziro, zidapezeka kuti pambuyo pa utsogoleri, piritsi la mankhwala likupitirirabe kukhala chinthu chokha chogwira ntchito.
Ikamamwa, liraglutide imasandulika. Zotsatira zake, ma metabolites a 2 amasulidwa, omwe amadziwika ndi ntchito zochepa. Chifukwa chake, machitidwe omwe amalimbikitsa kuchepa thupi, satenga nawo mbali. Mapeto a chochitikacho, chinthu chachikulu sichimachotsedwa m'thupi pakuyenda matumbo kapena kukodza.
Ziwalo zazikuluzikulu zomwe zimayambitsa kuchotsa zinyalala (impso, matumbo) pang'ono zimatenga nawo gawo pochita izi.
Zizindikiro zogwiritsidwa ntchito
Mankhwalawa amathandizidwa pokhapokha ngati njira yothandizira. Nthawi zambiri imagwiritsidwa ntchito limodzi ndi zakudya zochepa zopatsa mphamvu, zamasewera (zolimbitsa thupi pang'ono). Zisonyezero zogwiritsidwa ntchito ndi kunenepa kwambiri (BMI imaposa 30 kg / m²), kunenepa kwambiri (BMI yapamwamba kuposa 27 kg / m²). Mlandu wachiwiri, mankhwalawa amagwiritsidwa ntchito pochiza odwala omwe matenda a kunenepa kwambiri sanawatsimikizire, koma kuchuluka kwa kulemera kumawonedwa.
Chizindikiro chogwiritsidwa ntchito ndi kunenepa kwambiri.
Ndikulimbikitsidwa kugwiritsa ntchito Saxenda ngati pali chinthu chimodzi chokha chomwe chimapangitsa kuti thupi lizikula: matenda oopsa, cholesterol yowonjezera, mtundu 2 shuga mellitus.
Contraindication
Zambiri za matenda omwe amaletsa kugwiritsa ntchito mankhwalawa:
- kusachita bwino kwamunthu;
- khansa ya chithokomiro (mbiri ya ndikupanga);
- matenda endocrinological (endocrine neoplasia mtundu II);
- mkhalidwe wopsinjika, malingaliro odzipha;
- kulephera kwa mtima (kokha pa gawo la chitukuko cha zam'magawo a kalasi ya III-IV);
- kugwiritsa ntchito, pamodzi ndi njira zina zomwe zimakhudza kulemera kwa thupi, zilibe kanthu kuti ndi mankhwala kapena zikuyimira gulu lazakudya zowonjezera;
- ndi mtundu wa 2 wodwala mellitus, mankhwalawa sagwiritsidwa ntchito ndi insulin;
- yotupa njira m'mimba thirakiti, kuphwanya galimoto ntchito m'mimba.
Ndi chisamaliro
Pali matenda angapo omwe ndi bwino osagwiritsa ntchito Saxenda. Komabe, palibe malamulo okhwima ogwiritsira ntchito mankhwalawa. Zotsutsana:
- kulephera kwa mtima kwamakalasi a I-II;
- ukalamba (woposa zaka 75);
- matenda a chithokomiro;
- chizolowezi chokhala ndi kapamba.
Momwe mungatenge Saxenda
Mankhwalawa sagwiritsidwa ntchito kudzera m'mitsempha kapena m'mitsempha. Kuwongolera mozungulira kumachitika kamodzi patsiku. Nthawi yophera jakisoni itha kukhala iliyonse, pomwe palibe kudalira chakudya.
Madera olimbikitsidwa a thupi komwe mankhwalawa amaperekedwa bwino: phewa, ntchafu, pamimba.
Yambani maphunziro a mankhwala ndi 0,6 mg wa yogwira ntchito. Pambuyo masiku 7, kuchuluka kumachulukanso ndi 0,6 mg. Kenako, mlingo umapangidwanso sabata iliyonse. Nthawi iliyonse, 0,6 mg ya liraglutide iyenera kuwonjezeredwa. Kuchuluka kwa tsiku lililonse kwa mankhwalawa ndi 3 mg. Ngati, ngati atagwiritsidwa ntchito nthawi yayitali, adazindikira kuti kulemera kwa thupi kumatsika osaposa 5% ya kulemera konse kokwanira kwa wodwalayo, maphunzirowo amasokonezedwa kuti asankhe analogue kapena kufotokozeranso mlingo.
Kumwa mankhwala a shuga
Njira yodziwika yochiritsira imagwiritsidwa ntchito nthawi zina. Popewa hypoglycemia, tikulimbikitsidwa kuti muchepetse insulin yambiri.
Popewa hypoglycemia, tikulimbikitsidwa kuti muchepetse insulin yambiri.
Kukonzekera cholembera ndi singano kuti mugwiritse ntchito
Zolowera zimachitika m'magawo:
- chotsani kapu ku syringe;
- singano yotayika imatsegulidwa (chomata chimachotsedwa), kenako chitha kuyikiridwa pa syringe;
- musanagwiritse ntchito, chotsani kapu yakunja ndi singano, yomwe pambuyo pake idzabweranso, kuti musataye;
- ndiye chophimba chamkati chimachotsedwa, sichidzafunika.
Nthawi iliyonse mankhwalawa akagwiritsidwa ntchito, ma singano othandizira amagwiritsidwa ntchito.
Zotsatira zoyipa zimapitirira
Mankhwalawa amakhumudwitsa anthu ambiri omwe sanamve bwino. Komabe, sizichitika nthawi yomweyo. Zotsatira zoyipa zimasiyana, zomwe zimakhudzidwa ndi mtundu wa matenda, kupezeka kwa matenda ena, momwe wodwalayo alili.
Matumbo
Kusintha pakati pa mseru, chimbudzi, kapena kudzimbidwa. Kupukusa kumasokonekera, kuwuma pamkamwa kumakulirakulira. Nthawi zina pamakhala kuyenda kwamkati mwa m'mimba, kumeza, kupangidwa kwa mpweya kumakulirakulira, kupweteka kumachitika pamimba. Pancreatitis nthawi zina amakula.
Zotsatira zoyipa za mankhwalawa zimatha kusanza motsutsana ndi maziko amphuno.
Kuchokera ku chitetezo chamthupi
Odwala ena amapezeka ndi anaphylactic reaction.
Pakati mantha dongosolo
Chizungulire, kuchepa kugona, kusintha kukoma kapena kuwonongeka kwathunthu.
Kuchokera kwamikodzo
Ntchito ya impso imasokonekera. Nthawi zina kulephera kwa ntchito ya chiwalo kumayamba.
Pa khungu ndi subcutaneous minofu
Momwe thupi limasokoneza.
Kuchokera pamtima
Kusintha kwa mtima kumasintha (kuwonetsedwa ndi tachycardia).
Pa mbali ya chiwindi ndi biliary thirakiti
Mapangidwe a calculi. Pali kusintha kwa zizindikiro zamankhwala pakusanthula kwa chiwindi.
Matupi omaliza
Mwa mawonetseredwe ake omwe alipo, nthawi zambiri, chitukuko cha urticaria, anaphylactic mantha chimadziwika. Kutheka kwa mawonekedwe omaliza a zizindikirozo kumachitika chifukwa cha zinthu zingapo zam'machitidwe: hypotension, arrhythmia, kupuma movutikira, chizolowezi cha edema.
Mwa mawonekedwe omwe alipo a ziwengo pakumwa mankhwala nthawi zambiri, chitukuko cha urticaria chimadziwika.
Zokhudza mphamvu pakuwongolera njira
Popeza mankhwala omwe amafunsidwa ali ndi vuto pang'ono pamtima ndi mitsempha, ndizovomerezeka kuchita zochitika zomwe zimafunikira chidwi, kuphatikizapo kuyendetsa magalimoto. Komabe, kusamala kuyenera kuchitika powona zomwe zikuwonetsa.
Malangizo apadera
Amadziwika kuti mwa azimayi, chilolezo chogwira ntchito pambuyo pake ndizochepa kuposa amuna. Komabe, izi sizikhudza njira yochizira: kuchuluka kwa magazi sikumachitika.
Ngati pali zizindikiro za kapamba kapena kukula kwa mkhalidwe wofanana ndi chithunzi cha matenda ndi matendawa, muyenera kuyimitsa njira ya chithandizo mpaka matenda atatsimikiziridwa.
Kusintha kwa zakudya komanso vuto lakudya kumatha kuyambitsa calculi.
Poyerekeza ndi momwe mankhwalawa amathandizira odwala omwe ali ndi matenda a shuga 2, chiwopsezo chokhala ndi vuto la chithokomiro chikukula: kukula kwa goiter, kuchuluka kwa plasma calcitonin, ndi zina zambiri.
Ndi mankhwala a Saksenda, mwayi wokhala ndi madzi am'madzi umachulukanso, motero kudya tsiku lililonse kwamadzimadzi kumayenera kuwonjezeka.
Ndi mankhwala a Saksenda, mwayi wokhala ndi madzi am'madzi umachulukanso, motero kudya tsiku lililonse kwamadzimadzi kumayenera kuwonjezeka.
Poyerekeza ndi chithandizo cha mankhwalawa pogwiritsa ntchito mankhwalawa, odwala ochepa adayamba khansa ya m'mawere, malingaliro odzipha adawonekera.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Mankhwala ndi oletsedwa kugwiritsidwa ntchito.
Kusankhidwa kwa Saksenda kwa ana
Popeza kuti kafukufuku wa momwe mankhwalawa amathandizira thupi la ana sanachitike, sibwino kuti mupereke mankhwalawa kwa odwala omwe sanakwanitse zaka 18.
Gwiritsani ntchito mu ukalamba
Pa mankhwala, kukula kwa zoyipa, kusokonezeka kwa thupi sizichitika. Chifukwa chake, zaka sizikhudza pharmacodynamics ya mankhwala. Pazifukwa izi, kuchuluka kwa mlingo sikuchitika.
Kugwiritsa ntchito mu ukalamba ndikotheka, chifukwa nthawi ya mankhwalawa palibe chitukuko chosokoneza, kusokoneza thupi.
The ntchito aimpso kuwonongeka
Mankhwala sinafotokozedwe matenda a chiwalochi kwambiri mawonekedwe (kulengedwa kwa creatinine zosakwana 30 ml kwa mphindi). Ndi ntchito yochepa komanso yofooka yaimpso, ndizovomerezeka kugwiritsa ntchito Saxend. Komabe, mlingo wa mankhwalawa ungafotokozeredwe chifukwa cha kusintha kwa kugwiritsidwa ntchito kwa zinthu.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Sizoletsedwa kugwiritsa ntchito mankhwalawa. Ndi zovuta kapena zowonda za hepatic, ndizovomerezeka kugwiritsa ntchito. Komabe, pankhaniyi, mankhwalawa amawerengedwa. Ichi ndi chifukwa chosintha momwe zimakhalira pakuwonekera kwa chiwindi.
Mankhwala ochulukirapo a Saxend
Ndi kuwonjezeka kwa mlingo wa 72 mg, zotsatira zoyipa: nseru, kusanza, kusokonezeka kwa chopondapo. Komabe, chiopsezo chotenga zovuta zazikulu ndizochepa. Hypoglycemia nayenso samapezeka.
Ndi kuwonjezeka kwa mlingo wa 72 mg, zotsatira zoyipa, monga kusokonezeka kwa chopondapo, zimawonjezeka.
Kuchita ndi mankhwala ena
Pogwiritsa ntchito nthawi imodzi ya Saksenda ndi Warfarin, komanso zotumphukira zina za coumarin, pamakhala chiopsezo cha mgwirizano wamankhwala, koma palibe chidziwitso chotsimikizika.
The kuchuluka kwa digoxin yafupika kwambiri (16%) motsogozedwa ndi mankhwala omwe akufunsidwa. Zofananazo zimakwaniritsidwa pogwiritsa ntchito nthawi yomweyo Saxenda ndi Lisinopril. Pankhaniyi, kugwiritsidwa ntchito kwa otsiriza mwa njira kumachepa.
Ndi kuphatikiza kwa mankhwalawo mukufunsidwa ndi Paracetamol, palibe zosintha pantchito kapena kugwira ntchito koyambirira kwa mankhwalawo. Zotsatira zofananazo zimapezeka mukamagwiritsa ntchito Atorvastatin, Griseovulfine.
Kuyenderana ndi mowa
Sizoletsedwa kuphatikiza zakumwa zokhala ndi zakumwa zoledzeretsa ndi mankhwalawo. Izi zikuchitika chifukwa cha kuwonjezeka kwa katundu pa chiwindi, komwe kungathandize kuchepetsa kuyamwa kwa shuga.
Sizoletsedwa kuphatikiza zakumwa zokhala ndi zakumwa zoledzeretsa ndi mankhwalawo.
Analogi
M'malo mwa mankhwala omwe mukufunsidwa, njira zoterezi zimagwiritsidwa ntchito:
- Victoza;
- Baeta;
- Liraglutide.
Kupita kwina mankhwala
Mankhwalawa akhoza kungogulidwa ndi mankhwala.
Kodi ndingagule popanda kulandira mankhwala?
Palibe mwayi wotere.
Mtengo wa Saxenda
Mtengo wake ndi ma ruble 26,000 ndipo amatha kusiyanasiyana malinga ndi dera.
Mtengo wake ndi ma ruble 26,000 ndipo amatha kusiyanasiyana malinga ndi dera.
Zosungidwa zamankhwala
Syringe yomwe sinatsegulidwe iyenera kusungidwa mufiriji kutentha kwa + 2 ... + 8 ° C. N`zosatheka kuzimitsa mankhwala. Pambuyo pakutsegula, syringe imatha kusungidwa kutentha mpaka + 30 ° C kapena mufiriji. Iyenera kutsekedwa ndi chipewa chakunja. Ana sayenera kulandira mankhwalawo.
Tsiku lotha ntchito
Syringe yomwe sinatsegulidwe ikhoza kusungidwa kwa zaka ziwiri ndi miyezi isanu kuyambira tsiku lomasulidwa. Pamene kukhulupirika kwa phukusi kumaphwanyidwa, moyo wa alumali wa mankhwala osokoneza bongo umachepetsedwa mwezi umodzi.
Wopanga
Novo Nordisk A / S, Denmark.
Ndemanga za Saxend
Galina, wazaka 33, Tver
Ndinayenera kumwa mankhwalawo. Ndimanenepa kwambiri, koma sindinafikebe m'gulu la odwala onenepa. Sindikudziwa chifukwa chake, koma mankhwalawo sanathandize kuchotsa mafuta. Inde, panali kuchepa pang'ono mu kuchuluka kwake, koma osati mwamphamvu zokwanira.
Anna, wazaka 45Moscow
Mankhwala abwino. Mukamatsatira malangizo opanga, zotsatirapo zake zidzakhalapo, ngakhale zimakwaniritsidwa pang'onopang'ono.
