Fendivia ndi gulu la ma narcotic analgesics. Monga yogwira mankhwala ili ndi opiate. Chifukwa cha gawo ili, kuchepa kwa kukula kwa kupweteka kwamawu kumaperekedwa.
Dzinalo Losayenerana
Fentanyl (mu Chilatini - Fentanyl).
Fendivia ndi gulu la ma narcotic analgesics.
ATX
N02AB03.
Kutulutsa mafomu ndi kapangidwe kake
Kukonzekera kumakonzedwa ngati njira yothetsera jakisoni (kutumikiridwa kudzera m'mitsempha ndi intramuscularly). Pakugulitsa mutha kupeza chigamba cha transdermal. Fentanyl amagwira ntchito ngati othandizira. Mitundu yosiyanasiyana ya mankhwalawa imaperekedwa. Mlingo wa zomwe zimagwiritsidwa ntchito zimatha kusiyanasiyana (mg): 1.38; 2.75; 5.5; 8.25; 11. Kuchuluka kwa kumasulidwa kwa fentanyl kumasiyananso (μg / h): 12.5; 25; 50; 75; 100.
Chigamba chidakutidwa ndi filimu yoteteza; Muli zinthu zina zomwe zili motengera:
- dimethicone;
- dipropylene glycol;
- hyprolose.
Zotsatira za pharmacological
Chofunikira kwambiri pakuphatikizidwachi ndi gulu la maopioid. Imakhala ndi mphamvu ya analgesic. Chifukwa chokhala ndi mankhwala osokoneza bongo a mankhwalawa, mankhwalawo amagwiritsidwa ntchito mosamala malinga ndi zomwe dokotala akuwonetsa. The pharmacological zochita zachokera kuthekera kusangalatsa opiate zolandilira chapakati mantha dongosolo, zimakhala, ndi msana. Mothandizidwa ndi fentanyl, kupundula kwanyengo kumakwera, chifukwa chomwe kukana kwa thupi pazinthu zakunja ndi zamkati kumawonjezeka.
Kukonzekera kumakonzedwa ngati njira yothetsera jakisoni (kutumikiridwa kudzera m'mitsempha ndi intramuscularly).
Kuthekera kwina kwa gawo logwiritsa ntchito ndikuphwanya kwa tchuthi cha kufalikira kwa zokondweretsa ku hypothalamus, thalamus, amygdala zovuta. Zomwe zimagwiritsidwa ntchito ndi mankhwalawa: analgesic komanso sedative. Mankhwalawa nthawi yomweyo amachepetsa kukula kwa ululu wa neuropathic ndipo amachepetsa mphamvu zowonjezera ndi zizindikiro zina zamavuto amanjenje.
Mothandizidwa ndi fentanyl, kusintha kwa kusintha kwa malingaliro kumadziwikiridwa. Kuphatikiza apo, mapiritsi ogona akuwonetsedwa. Kukula kwa mphamvu ya gawo lomwe limagwira wodwalayo zimatengera muyeso wa fentanyl komanso kuchuluka kwa chidwi cha thupi. Nthawi zina, pamodzi ndi mankhwala ochititsa chidwi, osokoneza zochita, amadziwika. Nthawi zambiri mankhwalawa akagwiritsidwa ntchito, ndiye kuti pamakhala chiwopsezo chokhala ndi chololera chogwirizana ndi zomwe zimagwira. Pambuyo pakugwiritsidwa ntchito mobwerezabwereza, kudalira pazomwe zimagwira kungachitike.
Mothandizidwa ndi fentanyl, zimayambitsa zovuta kupuma: ntchito ya kupuma imaletsa, ndipo malo ena (maliseche ndi masanzi), m'malo mwake, amasangalala. Zotsatira zina zowopsa ndikuwonjezera kamvekedwe ka minofu ya ma sphincters osiyanasiyana komanso urethra, komanso chikhodzodzo. Zotsatira zake, kusokonezeka kwa kwamikodzo kumawonekera. Nthawi yomweyo, chitukuko cha zotsatirazi zoyipa chimadziwika:
- Kuchepetsa chimbudzi chifukwa cha kuchepa kwa mphamvu ya matumbo mphamvu;
- magazi aimpso;
- madzi ochokera m'matumbo amatengeka kwambiri;
- kusintha kwa mtima;
- ochepa hypotension;
- kuchuluka kwa amylase, lipase m'magazi limachulukana.
Mothandizidwa ndi fentanyl, mapiritsi ogona amawonetsedwanso.
Pharmacokinetics
Chiwopsezo cha ntchitoyi chimatheka mkati mwa maola 12-14 mutalandira mlingo wa mankhwalawa. Achire zotsatira akupitilira 3 masiku otsatira. Ngati mankhwalawa amagwiritsidwa ntchito mobwerezabwereza, ndende imapitilizidwa mosalekeza. Ngati chigamba chikugwiritsidwa ntchito, kuchuluka kwa yogwira ntchito m'madzi a m'magazi mwachindunji kumadalira kukula kwake. Pankhaniyi, kuchuluka kwa kuyamwa ndikusiyana. Chifukwa chake, pochita ntchito pachifuwa, mayamwidwe sachepa.
Mapuloteni ambiri omangira m'mwazi amadziwika - mpaka 84%. Komanso, fentanyl imadutsa mkaka wa m'mawere, mwana wosabadwayo panthawi yoyembekezera. Ikalowa m'chiwindi, gawo lalikulu limasinthidwa ndikutulutsidwa kwazomwe zimagwira. Njira yochotsa fentanyl m'thupi imayamba kugwira ntchito pambuyo poti wachotsa. Hafu ya moyo ndi maola 17, odwala muubwana - motalika. Mothandizidwa ndi mtsempha wa magazi, chinthucho chimachotsedwa m'thupi mwachangu.
Kuchuluka kwina kumachotsedwa pakukodza. Gawo laling'ono la mankhwalawa limachotsedwa pakuyenda matumbo. Gawo lalikulu limapukusidwa mu mawonekedwe a metabolites.
Zizindikiro zogwiritsidwa ntchito
Cholinga chachikulu cha mankhwalawa ndikuchotsa zizindikiro zosasangalatsa mu zikhalidwe za pathological mu mawonekedwe osakhazikika, ngati atatsagana ndi kupweteka kwambiri. Amadziwika ngati chithandizo cha nthawi yayitali cha opioid chikufunika. Mwachitsanzo, Fendivia imatengedwa ngati nyamakazi, neuropathy, chikuku (chigamba).
Fendivia imatengedwa ngati nyamakazi.
Kukula kwa jakisoni ndiwofalikira: kuyambitsa opaleshoni isanachitike opaleshoni, kupweteka kwamtundu wosiyanasiyana (kuphwanya kwa mtima ntchito, kuchira kuchokera ku opareshoni, kuvulala kwamtundu wamatumbo, oncology), komwe sikumasiyana mu chikhalidwe chodwala. Komanso, mankhwala omwe ali mumadzi amadzimadzi amatha kupatsidwa mankhwala opha antipsychotic.
Contraindication
Zoyipa za chida ichi ndizambiri zoletsa kwathunthu kugwiritsa ntchito:
- zoipa zochita za munthu;
- kupuma ntchito;
- Kusintha kwa chivundikiro chakunja komanso munthawi yoyatsa, kuphatikiza (kwa chigamba);
- Kutulutsa chofufumitsa pamankhwala othana ndi ma penicillin, cephalosporins, lincosamides;
- m'mimba matenda a poizoni chikhalidwe;
- kuwonongeka kwakukulu kwa chapakati mantha dongosolo.
Ndi chisamaliro
Zilolezo zingapo pakugwiritsa ntchito zalembedwa:
- kuchuluka kwachuma chamkati;
- matenda a m'mapapo;
- bradyarrhythmia;
- kuvulala kwa ubongo kapena kutupa;
- kuchuluka kwa kuthamanga kwa magazi;
- colic mu chiwindi, impso;
- mapangidwe a calculi mu ndulu;
- matenda a chithokomiro (hypothyroidism);
- kupweteka kwam'mimba kwa etiology yosadziwika;
- chosaopsa hypertrophy ya zimakhala za prostate;
- kuchuluka kwa kutentha kwa thupi kwakanthawi, komwe kumayambitsa kutenthedwa (mwachitsanzo, poyendera sauna);
- mowa kapena mankhwala osokoneza bongo;
- kuchepa kwa lumen kwa urethra;
- ambiri zovuta mkhalidwe wodwala.
Momwe mungagwiritsire ntchito Fendivia
Mlingo wa gawo yogwira umatsimikiziridwa payekhapayekha. Kuchuluka kwa fentanyl kumatengera momwe wodwalayo alili, kupezeka / kusakhalapo kwa chidziwitso ndi kugwiritsidwa ntchito koyambirira kwa narcotic analgesics. Mukamagwiritsa ntchito chigamba, nsalu yakunja imatsukidwa ndikuuma. Zidole siziyenera kugwiritsidwa ntchito, madzi oyera ndi okwanira. Khungu sayenera kupunduka.
Mlingo woyamba ndi 12,5 kapena 25 mg. Kenako imakulitsidwa ndi chigamba chilichonse chatsopano. Kuchuluka kwa fentanyl tsiku lililonse ndi 300 mg. Ngati ndi kotheka kuwonjezera mlingo, lingalirani ndalama zamadzimadzi. Kuti mupewe zizindikiro zakuti muchoke, ndikofunikira kuti muchepetse kuchuluka kwa zinthu zomwe zimagwira pang'onopang'ono.
Kumata
Chosakaniza chophatikizacho chimatengeka bwino kumbuyo kumbuyo, mikono.
Momwe mungasinthire
Kutalika kwa kugwiritsa ntchito chigamba chimodzi ndi maola 72. Pambuyo pake, m'malo mwake amapangidwa. Ngati achire akakhala ofowoka, mankhwalawo amasinthidwa atatha maola 48. Komanso, chigamba chotsatira chimayikidwa m'malo atsopano. Ngati izi sizikumbukiridwa, kuchuluka kwa fentanyl kumachuluka. Pochotsa chigamba, ayenera kupindidwa ndi zomata mkati komanso kutaya.
Ndi matenda a shuga, mankhwalawa amatha kugwiritsidwa ntchito, koma monga momwe adanenera.
Kodi ndizotheka kudula
Kuti mupeze zotsatira zabwino, musaphwanye umphumphu wa chigamba.
Ndi odwala khansa angati omwe amakhala ku Fendivia
Mankhwalawa amagwiritsidwa ntchito mpaka othandizira atakwaniritsidwa. Zizindikiro zololera zikawoneka, zimasinthidwa kukhala njira ina.
Gwiritsani ntchito matenda a shuga
Mankhwalawa amatha kugwiritsidwa ntchito, koma monga adanenera dokotala komanso kuti khungu lake silinawonongeke.
Zotsatira zoyipa
Chidachi chimathandizira kuti pakhale zovuta zingapo.
Matumbo
Kuchepetsa mphuno kumatsatiridwa ndi kusanza, kupweteka kwam'mimba, kusokonezeka kwapachifuwa, kutsika kwa chimbudzi, kupweteka kwamkamwa pakamwa. Zizindikiro za matumbo otsekemera samachitika kawirikawiri.
Kutenga Fendivia kumatha kuwapangitsa kuti asakhale ndi chidwi chofuna kudya.
Pa gawo la kagayidwe ndi zakudya
Odwala ambiri amawonetsa zizindikiro za matenda a anorexia: kuchepa thupi, kuchepa kwa chakudya, kukula kwa matenda ammimba.
Pakati mantha dongosolo
Kugona, kupweteka mutu komanso chizungulire, miyendo itanjenjemera, kusokonezeka kukumbukira, kukokana, kusokoneza komanso kukomoka.
Kuchokera kwamikodzo
Pali kuchedwa kukodza.
Kuchokera ku kupuma
Kupuma movutikira, kupuma ntchito; kumangidwa kupuma sikumachitika kawirikawiri, mpweya wokwanira wamapapu umawonetsedwa.
Pa khungu
Hyperhidrosis, kuyabwa, erythema, zotupa pakhungu, chikanga.
Kutenga Fendivia kumatha kudzetsa eczema.
Kuchokera ku genitourinary system
Kuphwanya kugonana.
Kuchokera pamtima
Sinthani pamlingo wamtima, kupindika kwa chingwe chakunja.
Kuchokera musculoskeletal system ndi minofu yolumikizana
Kuluka minofu, kupindika.
Pa mbali ya chiwindi ndi biliary thirakiti
Colic.
Matupi omaliza
Thupi lawo siligwirizana, dermatitis. Zizindikiro: hyperemia, kuyabwa, zotupa.
Zokhudza mphamvu pakuwongolera njira
Mankhwalawa amakhudza ntchito zingapo zofunika za thupi. Pazifukwa izi, magalimoto sayenera kuyendetsedwa panthawi ya chithandizo. Komabe, palibe malamulo okhwima.
Malangizo apadera
Mankhwalawa amagwiritsidwa ntchito limodzi ndi mankhwala ena.
Popeza kuti mankhwalawa amalowa mkaka wa mayi komanso kudzera mwa placenta, chiopsezo chokhala ndi zovuta zoyipa mwa mwana ndichokwera kwambiri.
Ngati malingaliro osagwirizana ndi zomwe zachitika, wodwalayo ayenera kuyang'aniridwa kwa maola 24 otsatira, chifukwa chotsika fentanyl.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Mankhwala ndi mankhwala, koma monga chomaliza. Amagwiritsidwa ntchito pazifukwa zaumoyo, pomwe maubwino amakhala ochulukirapo kuposa kuvulaza komwe kungachitike. Ndi chithandizo chamankhwala panthawi yoyembekezera, pamakhala mwayi woti mwana akhanda atabadwa.
Popeza kuti mankhwalawa amalowa mkaka wa mayi komanso kudzera mwa placenta, chiopsezo chokhala ndi zovuta zoyipa mwa mwana ndichokwera kwambiri.
Kuikidwa kwa Fendivia kwa ana
Mankhwala amavomerezedwa kuti azigwiritsidwa ntchito. Ndizololedwa kupereka kuchokera zaka ziwiri. Ana opitirira zaka 16 amatha kugwiritsa ntchito mlingo wa akuluakulu. Odwala osakwana zaka 16 amafunsidwa ngati mankhwala akumwa a morphine adagwiritsidwapo ntchito kale (osachepera 30 mg patsiku).
Gwiritsani ntchito mu ukalamba
Pa mankhwala, njira yotsimikizika ya fentanyl imayamba kuchepa. Izi zimatsogolera kukuwonjezeka kwapang'onopang'ono kwa kupangika kwake. Pazifukwa izi, mlingo uyenera kuwunikiranso. Mankhwalawa amavomerezedwa kuti azigwiritsidwa ntchito pokhapokha ngati phindu liposa kuvulaza. Mankhwalawa amayenera kuyamba ndi mlingo wa 12,5 mg.
Mukakalamba, mankhwalawa amavomerezedwa kuti azigwiritsidwa ntchito pokhapokha ngati phindu liposa kuvulaza.
Ngati aimpso ntchito
Pali chiopsezo cha kuchuluka kwa seramu fentanyl. Pazifukwa izi, koyamba mlingo wa mankhwalawa panthawi ya mankhwala ndi 12,5 mg.
Ndi chiwindi ntchito
Chidachi chimagwiritsidwa ntchito mosamala, popeza kuchuluka kwa zinthu zomwe zimagwira m'magazi zimachulukanso. Njira ya mankhwalawa imayamba ndi kuchuluka kwa mankhwalawa - 12,5 mg.
Ndi matenda amtima
Chipangizocho chikuvomerezedwa kuti chigwiritsidwe ntchito, koma kuyang'anira akatswiri ndikofunikira.
Bongo
Ngati kuchuluka kwa chigawocho chikuchulukirachulukira, chigamba chimachotsedwa, chinthu chomwe ndi chotsutsa (naloxone) chimayendetsedwa. Mlingo woyambirira ndi 0.4-2 mg (kudzera m'mitsempha). Ngati ndi kotheka, chithandizo chimapitilizidwa ndi mobwerezabwereza makonzedwe atatu aliwonse 3. Njira ina ndiyo kuperekera yankho la lexone ndi dontho (2 g ya chinthu ichi ndi kusakanikirana ndi 500 ml ya sodium chloride 0,9%).
Njira ina ndiyo kuperekera yankho la lexone ndi dontho (2 g ya chinthu ichi ndi kusakanikirana ndi 500 ml ya sodium chloride 0,9%).
Kuchita ndi mankhwala ena
Kutengeka kwa chinthu chomwe chikuchitikacho kumawonjezeka motsogozedwa ndi cytochrome P450 3A4 inhibitors. Ndipo kugwiritsa ntchito ma cytochrome inducers, m'malo mwake, kumathandizira kuchepetsa zomwe zili m'magazi.
Osagwiritsa ntchito zoletsa za MAO, agonists osakanikirana ndi otsutsa, mankhwala a serotonergic limodzi ndi Fendivia.
Kuyenderana ndi mowa
Osamamwa zakumwa zoledzeretsa mukamamwa mankhwala omwe mukufunsidwa.
Analogi
Mankhwala othandiza:
- Dolforin;
- Durogezik;
- Fentanyl.
Zotsatira za tchuthi Fendivia kuchokera ku mankhwala
Mankhwala ndi mankhwala.
Pankhani ya nthenda ya mtima, mankhwalawo amavomerezedwa kuti agwiritse ntchito, koma kuyang'anira akatswiri ndikofunikira.
Kodi ndingagule popanda kulandira mankhwala?
Ayi.
Mtengo wa Fendivia
Mtengo umasiyanasiyana 4900 mpaka 6400 rubles.
Zosungidwa zamankhwala
Mtengo wolimbikitsidwa: + 25 ° С.
Tsiku lotha ntchito
Alumali moyo wa mankhwalawa ndi zaka 2 kuyambira tsiku lomwe amatulutsa.
Wopanga Fendivia
LTS Lohmann Therapie-Systeme, Germany.
Ndemanga za Fendivia
Kufufuza kwa ogula komanso akatswiri amakupatsani mwayi wambiri pazokhudza mankhwalawa.
Madokotala
Danilov I.I., oncologist, wazaka 49, Vladivostok
Chida chimagwira ntchito yake - chimachotsa kupweteka. Zoyipa zake zimaphatikizapo kuthamanga kothamanga, popeza fentonil imatulutsidwa pang'onopang'ono: choyamba imalowa mu kapangidwe ka kachipenthero kakunja ndipo kenako m'magazi. Ngakhale mawonekedwe ake, mankhwalawa amathanso kukhala owopsa chifukwa cha kusokonezeka kwa chitetezo chathupi (anaphylactoid reaction).
Verilova A.A., dokotala wa opaleshoni, wazaka 53, St.
Ndimagwiritsa ntchito mankhwalawa moyenera chifukwa cha mawonekedwe osagwirizana. Amachita pang'onopang'ono. Kuphatikiza apo, mtengo wake ndi wokwera. Ngati tilingalira zofunikira zake, ndiye kuti chida ichi sichothandiza poyerekeza mitundu ina.
Odwala
Eugene, wazaka 33, Penza
Mankhwalawa ndi owopsa, monga ma opiates ambiri. Nthawi yayitali atayamba chithandizo, adasiya kuthandiza. Ndidawerenga za kuthekera kwa kulekerera kwa chinthu chomwe chimagwira, koma sindinkaganiza kuti analcic ya narcotic ikhoza kusiya ntchito yake mwachangu. Ndidasinthira ku analogi.
Veronika, wazaka 39, Moscow
Ndi oncology, imathandizira bwino. Zotsatira zake ndizakanthawi kochepa, pambuyo pake ndikofunikira kusintha pang'ono, lomwe ndi vuto, chifukwa lingagwiritsidwe ntchito nthawi yopitilira 1 mkati mwa maola 48. Pazifukwa izi, adotolo adatumiza mankhwala ena.
