Captopril 25 ndi zoletsa za ACE zomwe zimagwiritsidwa ntchito pakuchiritsa kovuta kwa kuthamanga kwa magazi. Mankhwalawa ali ndi kanthu kanthawi kochepa ndipo samagwiritsidwa ntchito pochizira matenda oopsa.
Dzinalo Losayenerana
Captopril (Kaptopril).
Captopril 25 ndi zoletsa za ACE zomwe zimagwiritsidwa ntchito pakuchiritsa kovuta kwa kuthamanga kwa magazi.
Ath
Co 9AA01 Captopril.
Kutulutsa mafomu ndi kapangidwe kake
Mapiritsiwo ali ndi utoto woyera, fungo lapadera, mawonekedwe a lathyathyathya. Mwa blockers, mankhwalawa akuwoneka kuti amatha kuchepetsa mtima kukana komanso kutulutsa mphamvu m'makoma a mitsempha.
The yogwira mankhwala ali kuchuluka 25 mg.
Kutulutsa mawonekedwe - mapiritsi, 25 mg, 10 ma PC. Kulongedza contour, khungu, yokhala ndi malangizo ogwiritsa ntchito. 20 ma PC. mapiritsi amatayikidwa mumtsuko woyikidwa mu katoni.
Mankhwala amapangidwa pa mlingo wa 12,5 mg ndi 50 mg. Mankhwalawa ali ndi gulu la sulfhydryl lomwe limalepheretsa kuwonongeka kwa myocardium.
Mankhwalawa ali ndi gulu la sulfhydryl lomwe limalepheretsa kuwonongeka kwa myocardium.
Zotsatira za pharmacological
Mankhwalawa amathetsa ntchito ya ACE, chifukwa chake, kuchuluka kwa kusintha kwa enzyme I kupita ku angiotensin II, komwe kumatanthauza vasoconstrictor athari, kumachepa.
Mu adrenal cortex, kupanga aldosterone kumawonjezeka. Mankhwala amakhudza kinin-kallikrein dongosolo, kusunga bradykinin.
Pharmacokinetics
Mutagwiritsa ntchito limodzi mlingo wa mankhwala othandizira, 75% ya mankhwalawo amachotsedwa pamimba. Kudya kumakhudza mayamwidwe a mankhwalawa, kuchepetsa zotsatira zake ndi 40%.
Mu madzi a m'magazi, mankhwalawa amamangidwa kumapuloteni (albumin) ndipo amamuchotsa mkaka wa m'mawere.
Mankhwala amaphulika m'maselo a chiwindi, ndikupanga zotsatirazi:
- disulfide dimer ya yogwira mankhwala;
- cysteine disulfide.
Zinthu zowola sizikugwira ntchito. Hafu ya moyo wa mankhwala sichidutsa 3 hours. Ndi kulephera kwa aimpso, mankhwalawa amadziunjikira mthupi, chifukwa chake, kuchuluka kwa urea ndi creatinine mu seramu yamagazi kumawonjezeka.
Zomwe Captopril zimathandizira 25
Wothandizira mankhwala amasonyezedwa matenda monga:
- ochepa matenda oopsa (monga gawo la mankhwala osakanikirana);
- kusintha kwa ntchito yamanzere yamitsempha yamagazi chifukwa cha kulowetsedwa kwa myocardial;
- matenda ashuga nephropathy;
- kulephera kwa mtima.
Malangizo ogwiritsira ntchito othandizira achire amasonyeza kuti anti-ischemic, mtima wa blocker. Mankhwalawa amagwiritsidwa ntchito popereka chisamaliro chadzidzidzi pakuwonjezera kuthamanga kwa magazi pamalo oyambira.
Mankhwalawa amagwiritsidwa ntchito popereka chisamaliro chadzidzidzi pakuwonjezera kuthamanga kwa magazi pamalo oyambira.
Kuchuluka kwake kumatsikira
ACE zoletsa mpaka 150 mg patsiku, ogwiritsidwa ntchito pazachikhalidwe limodzi ndi mtima glycosides komanso okodzetsa, amachepetsa kufa ndi 40%.
Mlingo woyambira wa 6.25 mg pang'onopang'ono umakwera mpaka 25 mg 2-3 kawiri pa tsiku. Poletsa kutsika kwa magazi, kuchuluka kwa mankhwala omwe amwedwa kumachitika masiku angapo (kuchuluka kwa mankhwalawa ndikololedwa kwa magazi a systolic pamtunda wa 90 mm Hg komanso osapitirira 1 nthawi sabata).
Zigawo zikuluzikulu za mankhwalawa zimachepetsa kuthamanga kwa magazi, koma zimayambitsa kukulitsa zotsatira zoyipa, mpaka kumayambiriro kwa myocardial kapena stroke.
Contraindication
Mankhwala samatchulidwa ngati chidziwitso cha matenda monga:
- anaphylactic mantha (mbiri);
- aimpso kuwonongeka;
- magazi akulu a nayitrogeni;
- kuchitira impso opaleshoni;
- kupendekera pakamwa pa msempha;
- mitral valavu stenosis;
- hepatitis;
- matenda a chiwindi;
- ochepa hypotension;
- Cardiogenic mantha ndi myocardial infarction.
Mankhwala samatchulidwa ngati chidziwitso cha kufooka kwa impso chikuwoneka m'mbiri yamankhwala.
Hypotension ndi chiwonetsero choyambirira cha kukanika kwaimpso sikuti ndi zotsutsana kwathunthu chifukwa cha kuperekedwa kwa mankhwala.
Mlingo wa Captopril 25
Mankhwala amatengedwa pakamwa pa 6.25-12.5 mg katatu patsiku. Ngati sizingatheke kukwaniritsa zowoneka bwino, kuchuluka kwa mankhwalawa kumawonjezereka mpaka 25-30 mg ndi kumwa katatu pa tsiku. Mlingo wapamwamba tsiku lililonse ndi 150 mg.
Ndi myocardial infaration
Mankhwala wolembedwa koyambirira, amakhala ndi zotsatirazi:
- amachepetsa nkhawa pamtima;
- amachepetsa chiopsezo cha fibrosis;
- normalizing endothelial ntchito;
- imayendetsa ma receptor a peptide omwe amapanga mitsempha yamagazi.
Mankhwalawa aledzera moyang'aniridwa ndi kuthamanga kwa magazi kwa masabata asanu. Pambuyo kumwa mankhwalawa, nsonga za hypotensive zotsatira zimawonedwa pambuyo maola 3-5.
Mlingo woyambirira wa mankhwalawa ndi 6.25 mg.
Mankhwalawa amatchulidwa 3-16 patatha pachimake myocardial infarction. Pambuyo pa maola awiri, mlingo wa ACE inhibitors umakulitsidwa mpaka 12,5 mg ndi kumwa 3 katatu patsiku.
Mankhwalawa ndiwotalikirapo, ochitika mothandizidwa ndi kuthamanga kwa magazi (magazi a wodwalayo sayenera kugwa pansi pa 100 mm Hg. Art.).
Captopril, yoperekedwa koyambirira, imathandiza kuchepetsa kupsinjika kwa mtima.
Pakanikizidwa
Mlingo woyambirira wa mankhwalawa 25 mg 2 kawiri pa tsiku. Ngati pakufunika thandizo, kuchuluka kwa mankhwalawa kumawonjezereka kwa masiku 14-28 mpaka zotsatira zamankhwala zimatheka.
Ndi matenda oopsa a digiri ya I-II, chithandizo chikuchitika pogwiritsa ntchito ACE zoletsa pa 25 mg 2 kawiri pa tsiku. Kuchuluka kwa tsiku lililonse kwa mankhwalawa ndi 100 mg.
Pa matenda oopsa kwambiri, mankhwala a 30 mg katatu patsiku amaloledwa. Popereka mankhwala, chiwopsezo cha kutsika kwa magazi chikuwonjezereka ngati wodwala akudwala kwambiri mtima, amakhala ndi magazi ochepa.
Kulephera kwa mtima kosatha
Zochizira kulephera kwa mtima, mankhwalawa amalimbikitsidwa ngati mankhwala omwe ali ndi diuretics alibe matenda. Mlingo woyambirira ndi 6.25 mg katatu patsiku.
Kuchuluka kwa mankhwalawa sikudutsa 25 mg katatu pa tsiku.
Mulingo waukulu wa blocker ndi 150 mg patsiku.
Ndi matenda ashuga nephropathy
Ngati aimpso kuwonongeka ntchito, amene amapezeka wodwala matenda a shuga, ndi creatinine chilolezo cha 30 ml / mphindi, mankhwala zotchulidwa pa mlingo wa 75-100 mg / tsiku.
Mankhwalawa aledzera pakukakamiza kwa ola limodzi asanadye.
Momwe mungatengere 25
Mankhwalawa aledzera pakukakamiza kwa ola limodzi asanadye. Njira yogwiritsira ntchito othandizira achire imadalira momwe wodwalayo alili.
Piritsi silikulimbikitsidwa kupera kapena kuluma.
Mankhwalawa amatsukidwa ndi 125 ml ya madzi owiritsa.
Pansi pa lilime kapena chakumwa
Pokhala ndi vuto la kuthamanga kwa magazi, mutha kuyika piritsi ili pansi pa lilime. Mutatenga 6.25 mg kapena 12.5 mg ya mankhwalawa, kuthamanga kwa magazi kumayeza pambuyo pa mphindi 30 kwa maola atatu. Ndi kuchuluka Mlingo, tikulimbikitsidwa kuthana ndi kukakamiza 1 ora pambuyo makonzedwe.
Ndingamwe kangati
Rimage regimen imakhazikitsidwa ndi adokotala. Kuchuluka kwa mankhwalawa sikupitirira 300 mg patsiku. Kuchulukitsa kwa mankhwalawa kumabweretsa kuwonongeka kwa wodwala komanso kukulitsa mavuto.
Zimatenga nthawi yayitali bwanji
Kupanikizika kumacheperachepera maola 1-1,5 mutatha kugwiritsa ntchito mlingo umodzi wa mankhwalawa. Kupitiliza kwakanthawi kachipatala kumachitika pakatha masabata 8 mutatha kugwiritsa ntchito mankhwala a antihypertensive.
Mlingo wa Captopril 25 watsimikiza.
Zotsatira zoyipa
Zotsatira zofananira zam'mapiritsi sizikhudzanso kuphatikizidwa kwake mndandanda wa mankhwala ofunikira, chifukwa mankhwalawo akutchulidwa mu database ya Pubucol nthawi 12,500.
Matumbo
Mukamagwiritsa ntchito mankhwalawa, mutha kukumana ndi zovuta monga:
- nseru
- kusowa kwa chakudya;
- kusintha kwa kukoma;
- kupweteka kwa epigastric;
- kudzimbidwa
- hepatitis;
- kutupa kwa kapamba;
- kuphwanya kapangidwe ka bile;
- Khungu;
- kupweteka mu hypochondrium yoyenera.
Hematopoietic ziwalo
Zomwe zimachitika mutagwiritsa ntchito mankhwalawa zimadziwika kuti:
- kuchepa magazi;
- kuchepa kwa maselo a mapulateleti;
- magawo ochepa a neutrophils m'magazi.
Mulingo waukulu wa mankhwalawa kwa anthu opitilira 65 umayambitsa kuchepa kwa maselo oyera a magazi, kuwonjezereka kwa chiwopsezo cha matenda oyamba ndi fungus, komwe ndi koopsa kwambiri kwa odwala omwe ali ndi matenda a autoimmune.
Pakati mantha dongosolo
Pa mankhwala, mawonekedwe a machitidwe amodzimodzi:
- Chizungulire
- kutopa
- kusowa kwa mgwirizano;
- kusintha kwa khungu.
Mwa odwala okalamba, kuwonongeka kwa mawonekedwe, kugona, kupweteka kwa mutu, kuzindikira kwazomwezo, kapena kugwa kwa orthostatic ndizotheka.
Pa chithandizo, chizungulire chimadziwika.
Kuchokera kwamikodzo
Zosakwanira zimachitika mthupi monga:
- aimpso kuwonongeka;
- polyuria;
- kuchuluka kwa mapuloteni mumkodzo;
- kuchuluka sclerotic njira mu zimakhala za kwamikodzo chiwalo.
Odwala omwe amalephera kupweteka aimpso, chiopsezo chokhala ndi microalbuminuria chikuwonjezeka, kuchuluka kwa creatinine kumawonjezeka kuposa 30% kuchokera ku gawo loyamba. Odwala ena, aimpso amayamba kugwira ntchito, ndipo ischemic nephropathy imayamba.
Kuchokera ku kupuma
Pa mankhwala, mawonekedwe a machitidwe amodzimodzi:
- bronchospasm;
- chifuwa chowuma;
- kugwedezeka kwa mawu ndi kuwunda kwa mawu;
- kusapeza bwino pakhosi;
- kupuma movutikira atagona.
- laryngeal stenosis;
- pulmonary edema.
Makanda obadwa kumene amakhala ndi vuto la oliguria ndi mitsempha.
Captopril ikhoza kuyambitsa chifuwa chowuma, chopweteka.
Pa khungu
Mukamagwiritsa ntchito choletsa ACE, wodwala amatha kukumana ndi zovuta monga:
- kulowetsedwa mapepala oyenda;
- kuyabwa kowawa;
- mabala a pinki.
Mawonekedwe amtundu wa pakhungu amachitika pakadutsa mphindi zochepa atamwa mankhwalawo, Zizindikiro zimayambiranso pambuyo pa kumwa mankhwala.
Kutupa kumachitika motsutsana ndi msana wa edema yodontha, kutentha kumawoneka, khungu limalimbikira, lomwe limasunthika bwino, fossa siliwongola kwa nthawi yayitali ndikukanikiza ndi chala.
Kuchokera ku genitourinary system
Mankhwalawa atagwiritsidwa ntchito kwa nthawi yayitali amatha kubweretsa kusabereka, kuwonongeka kwa impso.
Matupi omaliza
Mawonetsedwe pawokha atatha kumwa mankhwalawa amakhala ndi mtima wa edema ndi urticaria. Kukula kwa anaphylactoid zimachitika limodzi ndi maonekedwe a kuyabwa kwa chapamwamba ndi m'munsi malekezero, nkhope, pakamwa patsekeke, mzere wosanjikiza chapamwamba kupuma thirakiti ndi m'mimba thirakiti.
Mawonetsedwe pawokha atatha kumwa mankhwalawa amadziwika ndi mawonekedwe a kukhathamira.
Wodwala ali ndi izi:
- aphonia;
- kupuma kwamphamvu;
- kuthamangitsa;
- zotsatira zakupha.
Zokhudza mphamvu pakuwongolera njira
Mankhwalawa ndi antihypertensive agent, ndikofunikira kupewa kuyendetsa galimoto ndi njira zina zomwe zimafunikira chidwi chochulukirapo.
Malangizo apadera
Pa mankhwala, kusamala ndikofunikira kwa odwala omwe ali ndi matenda a impso. Anthu omwe akuvutika ndi vuto la mtima nthawi yamankhwala amayang'aniridwa ndi dokotala. Chenjezo lapadera limagwira ntchito kwa odwala omwe ali ndi matenda othandizira minofu ngati atenga Allopurinol kapena Cyclophosphamide.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
M'tsogolo mayi, chithandizo cha matenda oopsa chimachitika pogwiritsa ntchito mankhwala Methyldopa.
Oletsa sikuti amatchulidwa, chifukwa akuyimba:
- kulephera kwaimpso wakhanda;
- kupindika kwa miyendo ndi nkhope
- kukula kwa mapapo;
- Imfa ya mwana wosabadwa.
Mankhwala mu mkaka wa m'mawere amakhala ndi zotsatira zoyipa pa thanzi la mwana.
Kuyenderana ndi mowa
Mankhwalawa sangatengedwe nthawi imodzi ndi zakumwa zomwe zimakhala ndi ethyl mowa, kuti mupewe kukulitsa zovuta.
Pankhani ya poizoni wa Captopril, wodwalayo amayamba kuwonongeka.
Bongo
Pothetsa poyizoni ndi ACE inhibitor, wodwalayo amakula:
- hypotension;
- myocardial infarction;
- sitiroko;
- thromboembolism;
- kulephera kwaimpso;
- kuwonongeka kwamawonekedwe.
Mankhwala, tikulimbikitsidwa kuyeretsa matumbo, mankhwala jekeseni wa mankhwala a vasoconstrictor. Mankhwala, njira za colloidal, mankhwala Dopamine ndi Norepinephril amagwiritsidwa ntchito.
Kuchita ndi mankhwala ena
Kuphatikizana kwa mankhwalawa ndi vasodilator kumapangitsa kuwonjezeka kwa hypotensive.
Kugwiritsa ntchito kwa ACE inhibitor yokhala ndi mankhwala osapweteka a antiidal kapena clonidine kumapangitsa kuchepa kwa mphamvu ya mankhwalawa.
Kugwiritsa ntchito mankhwala osokoneza bongo kumayambitsa bongo wa potaziyamu.
Chenjezo liyenera kuchitidwa nthawi yomweyo kugwiritsa ntchito mchere wa lithiamu ndi othandizira ena, popeza kuchuluka kwa ma cell omwe amapezeka mu seramu ya magazi kumawonjezeka.
Kugwiritsa ntchito kwa Captopril ndi mankhwala osagwiritsa ntchito mankhwala a anti-yotupa kumabweretsa kuchepa kwa mphamvu ya mankhwalawa.
Odwala omwe akutenga Allopurinol ndi choletsa ACE ali pachiwopsezo chokhala ndi chizindikiro cha Stevens-Johnson.
Analogi
Monga cholowa m'malo mwa mankhwala othandizira, gwiritsani ntchito:
- Angiopril;
- Blockordil;
- Normopress;
- Capril;
- Kapoten;
- Burlipril;
- Lowetsani;
- Renetek.
Inhibitor ya kampani Sandoz (Germany) ili ndi 6.25 mg yogwira piritsi 1 piritsi. Mankhwalawa amagwiritsidwa ntchito pochiza matenda osokoneza bongo, kulephera kwa mtima, matenda a shuga.
Alkadil amatha kukhala ngati cholowa m'malo mwa mankhwalawa ndipo ndiwothandiza. Mankhwalawa amalembedwa chifukwa cholephera kwa muyezo.
Angiopril ali ndi vuto lofananalo ndi ACE inhibitor. Mankhwalawa amathandizidwa kuti ayambe kugwira ntchito ya mtima, pambuyo pofufuza m'mitsempha, ndi albuminuria osapitirira 30 mg / tsiku.
Mutha kusintha mankhwalawa ndi mankhwala monga Kapoten. Mankhwala amatengedwa monga adanenera dokotala ola limodzi musanadye.
Kupita kwina mankhwala
Mankhwalawa amaperekedwa ndi mankhwala.
Kodi ndingagule popanda kulandira mankhwala?
Mankhwalawa sangagulidwe popanda chilolezo cholembedwa ndi dokotala.
Mtengo wa captopril 25
Mapiritsi 25 mg, 40 ma PC. gulitsani pamtengo wa ma ruble 12. (kupanga OZON OO, Russia). ACE inhibitor, mapiritsi 25 mg, 20 ma PC. mtengo 8 rubles. (kupanga OZON OO, Russia).
Zosungidwa zamankhwala
Mankhwalawa amasungidwa pamalo owuma, komanso otsekemera, kutentha pamunsi pa 30 ° C.
Tsiku lotha ntchito
Mankhwalawa ndi oyenera kugwiritsidwa ntchito kwa zaka zitatu.
Mankhwalawa ndi oyenera kugwiritsidwa ntchito kwa zaka zitatu.
Wopanga
Mankhwalawa amapangidwa:
- Ozone OO, (Russia);
- Borisov chomera cha mankhwala (JSC "BZMP"), Belarus.
Ndemanga za Captopril 25
Vasily, wazaka 67, Voronezh
Ndimadwala matenda othamanga magazi. Chaka chatha, panali vuto lalikulu kwambiri la matenda oopsa. Kupsinjika sikunatayike ndi kalikonse, ngakhale atabayidwa jekeseni kuchipatala sikunakhale kosavuta. Ndinakumbukira mankhwalawo, ndikuyika piritsi la 25 mg pansi pa lilime langa, ndipo patatha mphindi 30 kupanikizika kunachepa. Nthawi zonse ndimasunga mankhwalawo mu kabati ya mankhwala.
Margarita, wazaka 55, Cheboksary
Usiku, kupanikizika kunali 230 mpaka 115. Ndinaika mapiritsi awiri a mankhwalawo pansi pa lilime langa, kenako usiku wina 2. M'mawa, kukakamiza kunatsikira mpaka 160 pa 100. Ndikhulupirira kuti ndibwino kugwiritsa ntchito mankhwala oyamba a Kapoten pamankhwala.
Tamara, wazaka 57, Derbent
Ndimatenga inhibitor ya ACE kwa zaka 15, piritsi limodzi 0,25 mg kamodzi patsiku. Zochita za tsiku ndi tsiku zasintha, ntchito zamagalimoto zachepa, motero ndimamwa mapiritsi awiri a mankhwalawa patsiku. Palibe mavuto. Mankhwala ndi othandiza.
