Mankhwala a antihypertensive Losacor amagwiritsidwa ntchito pochiza matenda oopsa komanso kupewa mtima wamankhwala kwa odwala omwe ali pachiwopsezo. Ndemanga zambiri zabwino za mankhwalawa zimachitika chifukwa chogwiritsa ntchito kwambiri mankhwala osokoneza bongo komanso mtengo wotsika mtengo.
Dzinalo Losayenerana
Losartan (mu Chilatini - Lozartanum).
Dzinalo losagwirizana ndi mayiko ena la mankhwala Losacor ndi Losartan.
ATX
C09CA01.
Kutulutsa mafomu ndi kapangidwe kake
Wogulitsa, mankhwalawa ali piritsi. Piritsi lililonse lili ndi 12.5 mg wa losartan potaziyamu, womwe umakhala ngati maziko (othandizira) a mankhwalawa. Kupanga Kwachiwiri:
- wowuma chimanga;
- wowuma pregelatinized;
- ma cellcose a microcrystalline;
- magnesium wakuba;
- anhydrous aerosil (colloidal silicon dioxide);
- mapadi (kuphatikiza kwa selulosi ndi lactose monohydrate).
Kuphatikiza piritsi kumaphatikizapo utoto wa quinolone chikasu, titanium dioxide, propylene glycol, talc ndi hypromellose.
Pamalo okhala ndi mapiritsi 7, 10 kapena 14. Pazithunzi zamatoni a 1, 2, 3, 6 kapena 9.
Kuphatikiza piritsi kumaphatikizapo utoto wa quinolone chikasu, titanium dioxide, propylene glycol, talc ndi hypromellose.
Zotsatira za pharmacological
Mankhwalawa ali ndi hypotensive zotsatira ndipo amatsutsana ndi angiotensin 2, omwe amamangiriza minofu yambiri ndipo amagwira ntchito zambiri kuchokera pamalingaliro azachipatala, kuphatikizapo kutulutsidwa ndi vasoconstriction ya aldosterone ndi kukondoweza kwa kufalikira kwa minyewa.
Kuphatikiza apo, mankhwalawa amachepetsa kuthamanga kwa magazi, kupewa madzi ndi sodium m'thupi, komanso kumawonjezera kukana kuchita zolimbitsa thupi kwa odwala omwe ali ndi vuto la mtima (aakulu mtima kulephera).
Pharmacokinetics
Losartan amatengeka bwino pambuyo pakamwa. Thupi limatha kugwiritsidwa ntchito "njira yoyamba" kudzera m'chiwindi.
Chifukwa cha njirayi, metabolite yogwira (carboxylated) ndi angapo osagwira metabolites amapangidwa. Gawoli lili ndi bioavailability wa 33%. Kuchuluka kwa plasma ndende kumafikira ola limodzi pambuyo pakulowetsa. Chakudya sichimakhudza kwambiri mbiri ya pharmacokinetic ya antihypertensive mankhwala.
Losartan amapanga mgwirizano wolimba ndi mapuloteni a plasma (mpaka 99%). Pafupifupi 14% ya mlingo womwe umatengedwa umasinthidwa kukhala mtundu wa metabolite wogwira.
Zinthu zimapukutidwa ndi impso ndi matumbo.
Zizindikiro zogwiritsidwa ntchito
Mapiritsi amatha kulembedwa kwa odwala milandu:
- pamaso pa ochepa matenda oopsa;
- kuti muchepetse chiwopsezo cha kufa ndi kusakhazikika kwa odwala omwe ali pachiwopsezo (kumanzere kwamitsempha yamagazi, matenda oopsa);
- mankhwalawa proteinuria ndi hypercreatinemia (ndi chiŵerengero cha creatinine ndi albumin kwamikodzo woposa 300 mg / g) mwa odwala omwe ali ndi matenda a shuga 2 oopsa komanso ochepa matenda oopsa;
- CHF posakhala zotsatira za mankhwala ndi ACE zoletsa;
- kupewa zotupa a mtima mu opareshoni.
Contraindication
Chipangizocho sichigwiritsidwa ntchito pakulephera kwamphamvu kwa chiwindi (kupitirira mfundo za 9 mu Child-Pugh), kutseka kwa lactose, mkaka wa m`mawere, kutenga pakati, ubwana, komanso hypersensitivity kuti losartan ndi zina zowonjezera zamankhwala.
Ndi chisamaliro
Wothandizira antihypertgency amalembedwa mosamala ndi kuchepetsedwa kwa BCC, ochepa hypotension, kuchepa kwa magazi mosiyanasiyana, kuphatikiza digoxin, diuretics, warfarin, lithiamu carbonate, fluconazole, erythromycin ndi mankhwala ena ambiri.
Momwe mungatenge Losacor
Mapiritsi amatha kumwa mosasamala chakudya, kumeza lonse ndikusambitsidwa ndi madzi ambiri. Kugwiritsa ntchito pafupipafupi - 1 nthawi patsiku.
Matenda oopsa amathandizidwa mu 50 mg / tsiku.
Nthawi zina mlingo umatha kuwonjezeka mpaka 100 mg kawiri pa tsiku. Mlingo waukulu kwambiri ndi 150 mg / tsiku.
Pofuna kupewa matenda a mtima.
Ndi matenda ashuga
Pofuna kuteteza impso mwa odwala omwe ali ndi matenda a shuga a 2 omwe amakhala ndi proteinuria yofanana, Mlingo wa 50 mg / tsiku ndi mankhwala.
Mlingo wa mankhwala osokoneza bongo ungathe kuchuluka kwa 100 mg tsiku lililonse, poganizira kuopsa kwa kuphwanya magazi.
Mlingo utha kuwonjezeka mpaka 100 mg tsiku lililonse, poganizira kusokonezeka kwa kuthamanga kwa magazi.
Zotsatira zoyipa za Losacor
Nthawi zambiri, mankhwalawa amaloledwa modekha. Zomwe zimayambitsa zovuta zimafanana ndi izi mukamagwiritsa ntchito placebo.
Matumbo
Kupweteka mseru, kupweteka kwa epigastric, kulimbikitsa kusanza. Nthawi zina, chiwindi chimayamba.
Pakati mantha dongosolo
Mutu, kusokonezeka kwa kugona, komanso chizungulire chofatsa chingachitike.
Pa khungu
Malo ofiira amatha kuwoneka pakhungu.
Kuchokera pamtima
Kusweka mtima kwakukulu ndikotheka.
Kumwa mankhwala kungayambitse mtima.
Kuchokera kumbali ya kagayidwe
Nthawi zina, kuchepa mphamvu kwa madzi m'thupi ndi kuwonjezeka kwa kuchuluka kwa creatinine kapena urea m'madzi am'magazi kumawonedwa.
Matupi omaliza
Kutupa, zotupa, ndi kuyabwa ndizotheka. Nthawi zina, edema ya Quincke imayamba ndipo zimakhudza mphuno, pakamwa komanso ziwalo zina za thupi.
Zokhudza mphamvu pakuwongolera njira
Sipanakhale zoyesera zapadera pazakuwunikira mphamvu ya mankhwalawa pazomwe zimachitika mu psychomotor komanso kuthekera koyendetsa galimoto.
Malangizo apadera
Odwala omwe ali ndi BCC yochepetsedwa, Hypotension hypotension imayamba. Zinthu ngati izi zimafuna kugwiritsa ntchito milingo yotsika.
Potengera momwe mankhwalawa amathandizira, muyenera kuwunika mosamala mulingo wa potaziyamu mu seramu yamagazi, makamaka odwala okalamba komanso omwe ali ndi vuto laimpso.
Anthu okalamba safuna kusintha kwa mankhwalawo.
Gwiritsani ntchito mu ukalamba
Gulu ili la odwala silitenga kuti munthu asinthe mlingo.
Kupatsa ana
Kwa ana ochepera zaka 18, mankhwalawa satumizidwa.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Mankhwala a antihypertensive adatsutsana kuti agwiritsidwe ntchito m'gulu la odwala.
The ntchito aimpso kuwonongeka
Kulephera kwambiri kwa impso, antihypertgency sikulimbikitsidwa.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Ngati vuto la kuperewera kwa magazi ndi chiwindi china chitha kuchepa (kuphatikizapo matenda enaake), ndiye kuti mlingo wofunikira ndi womwe umaperekedwa.
Mankhwala osokoneza bongo a Losacor
Zambiri zokhudzana ndi mankhwala osokoneza bongo a antihypertensive ndi ochepa.
Ndi mankhwala osokoneza bongo a Losacor, kuthamanga kwa magazi kumatha kuchepa.
Zizindikiro: kuchepa kwakukulu kwa kuthamanga kwa magazi, tachycardia. Hemodialysis siyothandiza.
Kuchita ndi mankhwala ena
Mankhwala amawonjezera zotsatira za sympatholytics ndi beta-blockers.
Kuphatikizidwa kwa mankhwalawa ndi ma diuretic othandizira kungayambitse kuwonjezera.
Fluconazole ndi rifampin amachepetsa kuchuluka kwa plasma yogwira metabolite.
NSAIDs itha kuchepa mphamvu ya antihypertensive mankhwala. Pogwiritsa ntchito munthawi yomweyo mankhwalawa, kusintha kwa mankhwalawa kumafunikira.
Losacor imawonjezera mphamvu ya achifundo komanso a beta-blockers.
Kuyenderana ndi mowa
Akatswiri salimbikitsa kumwa mowa mukamagwiritsa ntchito mankhwala a antihypertensive.
Analogi
Zotsika mtengo komanso zogwira ntchito za mankhwala a antihypertensive:
- Vasotens;
- Vasotens N;
- Losartan;
- Lozap;
- Xarten;
- Cantab;
- Edarby
- Angiakand;
- Hyposart;
- Sartavel.
Kupita kwina mankhwala
Kodi ndingagule popanda kulandira mankhwala?
Ndizosatheka kugula mankhwala popanda mankhwala.
Mtengo wa Losacor
Kuyambira 102 rub. mapiritsi 10.
Zosungidwa zamankhwala
Pamalo otetezedwa ku chinyezi chambiri, pa kutentha pang'ono.
Tsiku lotha ntchito
Zaka zitatu
Wopanga
Kampani yaku Bulgaria "Adifarm EAT".
Muyenera kusunga mankhwalawo pamalo otetezedwa kuti asakhale ndi chinyezi chambiri, kutentha pang'ono.
Ndemanga za Losacore
Victoria Zherdelyaeva (wamtima), wazaka 42. Ufa
Kuchiritsa kwabwino. Zotsatira zake zowonera zimawonedwa tsiku loyamba. Mankhwala amathandizidwa nthawi zambiri ndi ochepa matenda oopsa. Mtengo wotsika mtengo. Musanagwiritse ntchito mankhwalawa, onetsetsani kuti mukumane ndi katswiri wazachipatala.
Valentina Struchkova, wazaka 23, Moscow
Mapiritsiwo adawalembera bambo anga ndi dokotala wamtima kuti athe kupewa matenda a mtima. Poyerekeza ndi zotsatira za mayeso omwe adadutsa posachedwa kuchipatala, "mankhwalawa" amagwira ntchito.
