Lisinopril ndi enalapril nthawi zambiri amapatsidwa mankhwala othamanga kwambiri a mtima ndi mtima. Mankhwala onsewa amaphatikizidwa ndi gulu la pharmacological la angiotensin lotembenuza enzyme inhibitors. Chifukwa cha zomwe anachita, mapangidwe a enzyme yotereyi amachedwa, zomwe zimapangitsa kuti mitsempha ya magazi ikhale yochepa, chifukwa chomwe kupanikizika kumabwereranso kwazonse.
Chikhalidwe cha Lisinopril
Ndi choletsa ACE chokhala ndi katundu wa antihypertensive. Chosakaniza chachikulu chogwira ntchito ndi lisinopril. Kutulutsa mawonekedwe - mapiritsi. Mankhwala ali ndi izi:
- amachepetsa kwathunthu zotumphukira kukana;
- kutsitsa magazi;
- amachepetsa katundu pamtima ndi kupanikizika kwa mapapu;
- kumawonjezera voliyumu ya magazi yotulutsidwa ndi mtima;
- kumawonjezera kukana kwa minofu ya mtima ku nkhawa, makamaka kwa odwala omwe ali ndi vuto la mtima.
Lisinopril ndi enalapril nthawi zambiri amapatsidwa mankhwala othamanga kwambiri a mtima ndi mtima.
Mankhwala nthawi zambiri samakulitsa mitsempha, koma mitsempha. Kugwiritsidwa ntchito kwakanthawi kochepa kumachepetsa hypertrophy ya myocardial, kukonza thanzi la minofu ya mtima, ndikuwonjezera chiyembekezo cha moyo wa odwala omwe adakumana ndi vuto la myocardial infarction. Matenda a wodwalayo amakula bwino m'masiku oyamba kugwiritsa ntchito mankhwalawa, ndipo zotsatira zake zimakhazikika mu miyezi 1-2.
Zisonyezero zogwiritsidwa ntchito:
- mitundu yosiyanasiyana ya matenda oopsa;
- matenda ashuga nephropathy;
- kuphatikiza mankhwala ena mankhwalawa aakulu mtima kulephera ndi pachimake myocardial infarction.
Zoyipa:
- hypersensitivity kwa ACE zoletsa;
- mimba ndi mkaka wa m`mawere;
- mbiri ya angioedema;
- cholowa cha edincke's edema;
- wazaka 18.
Imwani mankhwalawa kamodzi patsiku, kutsatira malangizo omwe analimbikitsidwa. Chitetezo cha mankhwalawa chatsimikiziridwa ndi maphunziro osiyanasiyana. Koma ngati bongo wambiri, zotsatirazi zingakhale ndi izi:
- kwambiri hypotension, palpitations, myocardial infarction, kukula kwa mtima kulephera, kupweteka pachifuwa, tachycardia, orthostatic hypotension;
- jaundice, hepatitis, kapamba, vuto la kukoma, kukanika, pakamwa lowuma;
- asthenic syndrome, kugwedeza kwamphamvu kwa minofu yolimba, kuchuluka kwa kutopa, kusokonezeka, kugona, kupweteka kwa mitsempha, kusokonezeka ndende, kukhudzika mtima;
- kuchepa magazi, thrombocytopenia, neutropenia, leukopenia;
- kupuma movutikira, bronchospasm, chifuwa chowuma;
- utachepa potency, mapuloteni mu mkodzo, kuwonongeka kwa impso, anuria, oliguria, kulephera kwaimpso;
- arthralgia, myalgia;
- urticaria, zotupa pakhungu, edema ya Quincke;
- kuchuluka kwa bilirubin, creatine, urea m'magazi, kuchuluka ESR, eosinophilia, kuchuluka kwa hepatic transaminases.
Kuphatikiza kwa mankhwalawa ndi mowa ndi zero. Analogs akuphatikizapo: Lisinopril-Teva, Diroton. Opanga mankhwalawa ndi Teva, Stada, Sofarma, Lupine, Krka, Avant, Ratiopharm, Astrafarm, Grindeks ndi ena.
Makhalidwe a Enalapril
Izi ndi othandizira okhudzana ndi ACE zoletsa. Chofunikira chachikulu ndi enalapril. Kukonzekera kuli ngati mapiritsi. Pansi pa ntchito yake, mitsempha ndipo, pang'ono, mitsempha imakulitsidwa. Mankhwalawa amasintha kayendedwe kazinthu zamagazi ndi aimpso. Chifukwa chogwiritsa ntchito mankhwalawa kwa nthawi yayitali, hypertrophy yamitsempha yamanzere yam'mimba imachepetsedwa ndikukula kwa kulephera kwa mtima kumalepheretsedwa.
Mothandizidwa ndi mankhwalawa, myocardium imayamba kupatsidwa magazi mokwanira. Kuphatikizana kwamapulogalamu amachepetsa. Enalapril imachepetsa kukula kwa vuto lakumanzere kwamatumbo mwa anthu omwe adakumana ndi myocardial infarction. Mankhwalawa ali ndi mphamvu yokhudza kukodzetsa.
Kuti achepetse kuthamanga kwa magazi, odwala ambiri amatenga mankhwalawo kwa milungu ingapo. Njira ya mankhwala kwa odwala matenda a mtima akhoza kukhala osachepera miyezi isanu ndi umodzi.
Mankhwala akuwonetsedwa pazochitika zotsatirazi:
- chachikulu mawonekedwe a ochepa matenda oopsa;
- kumanzere kwamitsempha yamagazi ndi kusakhazikika kwa mtima;
- yachiwiri matenda oopsa, kuchitika motsutsana maziko a matenda a impso.
Enalapril ndi mankhwala ochititsa chidwi ogwirizana ndi ACE inhibitors.
Zoyipa:
- angioedema oyambitsidwa ndi enalapril;
- tsankho limodzi pazigawo za mankhwala;
- mimba ndi mkaka wa m`mawere;
- porphyria.
Mankhwalawa amatha kuyambitsa kuchepa kwambiri kwa kukakamizidwa, kotero, amatengedwa mosamala pakuchepetsa minyewa ya impso, zamkati mwa mitsempha ya impso, mitundu ya matenda a mtima, matenda amitsempha yamagazi ndi matenda ena omwe amateteza kutuluka kwa magazi kuchokera kumanzere kumanzere.
Zotsatira zoyipa zimaphatikizapo:
- chifuwa chowuma chosabereka;
- pharyngitis;
- kuvutika kupuma
- kupweteka kwam'mimba
- kutsegula m'mimba
- nseru
- cholestasis;
- zilonda zam'mimba;
- matenda a anorexia;
- matumbo kutsekeka;
- zotupa pakhungu;
- Hyperkalemia
- Kukhumudwa
- masomphenya osalala, kugona, mutu, chizungulire;
- bradycardia, ochepa hypotension;
- palpitations, kupweteka pachifuwa;
- myositis, myalgia, vasculitis, malungo.
Analogs akuphatikizapo: Enap, Korandil, Renitek, Miopril, Enam, Berlipril, Invoril, Vasolapril. Opanga - Pharmstandard-Leksredstva OAO, Russia, Gedeon Richter, Hungary.
Kuyerekezera Mankhwala
Kufanana
Lisinopril ndi enalapril ali ndi zotsatira zofanana ndi thupi, amachepetsa kuthamanga kwa magazi ndikuthandizira kuchepetsa chiopsezo cha stroke. Amapangidwa mu mtundu umodzi wa mlingo, ndipo momwe amawagwiritsira ntchito amakhala tsiku limodzi. Mankhwala amatha kugwiritsidwa ntchito ngati njira yokhayo, kapena kuphatikiza ndi mankhwala ena a antihypertensive.
Kodi pali kusiyana kotani?
Kuphatikizidwa kwa mankhwala kumaphatikizapo magawo osiyanasiyana othandiza komanso othandiza. Enalapril amatha kwambiri kulowa mkaka wa m'mawere kudzera mu chotchinga chachikulu, ndipo Lisinopril ndi wotsika. Amakhala ndi mawonekedwe osiyanasiyana ogwiritsira ntchito, contraindication ndi mavuto. Mankhwala osokoneza bongo amapangidwa ndi makampani osiyanasiyana.
Zomwe zimakhala zamphamvu
Kusankha kuti ndi mankhwala ati omwe ali ndi mphamvu - Lisinopril kapena Enalapril, madokotala amayerekezera momwe amachitira mankhwala, zikuwonetsa, magwiridwe antchito, komanso kuwunika machitidwe a thupi la wodwalayo. Odwala ena amakhudzidwa ndimankhwala oyamba, ena ndi wachiwiri.
Zomwe zimakhala zotsika mtengo
Mtengo wapakati wa enalapril ndi ma ruble 70, Lisinopril ndi ma ruble 110.
Zomwe zili bwino - Lisinopril kapena Enalapril
Madokotala zimawavuta kuyankha funso kuti ndi mankhwala ati ali bwino. Ndiwothandizanso pa matenda a mtima osakhazikika, ndipo kuti mupeze zotsatira zochizira, ndikofunikira kuwamwa pafupipafupi.
Ngati chiwindi ntchito, enalapril sayenera kumwedwa, ndipo ndi kulephera aimpso, lisinopril.
Kuchokera pamavuto
Pochiza odwala matenda oopsa, zotsatira zabwino zimatha kuchitika - kupanikizika kumabwereranso kwina. Chizindikiro ichi chimakhala kwa nthawi yayitali odwala omwe akutenga Lisinopril, choncho mankhwalawa ndi othandiza kwambiri.
Itha kupangitsa kuti enalapril isinthidwe ndi lisinopril
Nthawi zina, ndi enalapril tsankho, akhoza m'malo ndi lisinopril. Imwani nawo muyezo womwewo ngati mankhwala oyamba. Mwachitsanzo, 10 mg ya lisinopril ndi wofanana ndi 10 ml ya enalapril.
Ndemanga za Odwala
Dmitry, wazaka 65, Oryol: "Miyezi ingapo yapitayo ndidadwala matenda opha ziwalo. Dotolo adamuuza Lisinopril kuti alandire matenda oopsa.
Alena, wazaka 33, Samara: "Zaka zambiri zapitazo adapunduka, chifukwa ndimadwala mphumu. Posachedwa, kuthamanga kwa magazi kunayamba kukwera. Sindinayesere kugwiritsa ntchito mankhwala aliwonse, koma Enalapril yekha adandithandizira. Chifukwa cha izi, kupsinjika kunabwelera ndipo kunakhala kosavuta. pumira. "
Odwala omwe amatenga Lisinopril, kupsinjika kumabwereranso kwina, motero mankhwalawa amakhala othandiza kwambiri.
Ndemanga za Madotolo pa Lisinopril ndi Enalapril
Alexei, wa mtima wazaka 51, Sevastopol: "Lisinopril ndi chida chabwino kwambiri chomwe chimachepetsa kuthamanga kwa magazi. Imalekeredwa bwino, ndiyotheka kutenga, ndipo zotsatira zake zimasungidwa tsiku lonse. Sizotsika mtengo."
Elena, dokotala wamtima wazaka 38, ku Moscow: "Machitidwe anga, nthawi zambiri ndimapereka mankhwala a Enalapril kwa odwala omwe ali ndi matenda oopsa. Zakhala zikuwatsimikizira kuti ndizothandiza. Ziyenera kutengedwa muyezo wokhazikitsidwa ndi mankhwala chifukwa zotsatira zake zimatha."