Ciprolet 500 ndi imodzi mwamankhwala othandiza kwambiri pa fluoroquinolone omwe amagwiritsa ntchito mitundu yambiri. Itha kugwiritsidwa ntchito pochiza komanso kupewa matenda osiyanasiyana othandizira komanso opatsirana, koma musanayambe chithandizo, tikulimbikitsidwa kuti zitsimikizire kuti chiwopsezo cha tizilombo toyambitsa matenda ndichipatala.
ATX
Mankhwalawa ndi a gulu la mankhwala a quinolones ndipo ali ndi code ya ATX ya J01MA02.
Ciprolet 500 ndi imodzi mwamankhwala othandiza kwambiri pa fluoroquinolone omwe amagwiritsa ntchito mitundu yambiri.
Kutulutsa mafomu ndi kapangidwe kake
Cyprolet amapangidwa motere:
- mapiritsi okhala ndi kanthu;
- kulowetsedwa njira;
- Diso likugwera.
Monga yogwira mankhwala, ciprofloxacin imagwiritsidwa ntchito mwa iwo.
Mlingo wa 500 mg uli ndi mtundu wa piritsi wokha. Mapiritsiwo ndi oyera, ozungulira, onunkhira mbali zonse ziwiri. Gawo logwira ntchito ngati hydrochloride limapezeka mu 0,25 kapena 0,5 g. Pakatikati mulinso:
- croscarmellose sodium;
- microcellulose;
- magnesium wakuba;
- silicon dioxide;
- mankhwala talc;
- wowuma chimanga.
Kuphimba kwamafilimu kumapangidwa kuchokera ku osakaniza a hypromellose, dimethicone, titanium dioxide, macrogol, talc, sorbic acid ndi polysorbate.
Mapiritsi 10 gawirani m'matumba. Katakitala wakunja. 1 mbale yodzala ndi malangizo ogwiritsira ntchito amaikidwamo.
Ciprolet imagwiritsidwa ntchito ngati antibacterial drug.
Zotsatira za pharmacological
Ciprolet imagwiritsidwa ntchito ngati antibacterial drug. Gawo lake logwira ntchito ndi ciprofloxacin, mankhwala opanga mankhwala a fluoroquinolone. Makina a zochita za panganoli ndi zoletsa za topoisomerases a mtundu II ndi IV, omwe amachititsa kuti michere ya DNA yapangidwe.
Maantibayotiki amawonetsa katundu wa bactericidal. Mothandizidwa ndi iye, kubereka kwa DNA kumatsekedwa, kukula ndi kubereka kwa tizilombo tating'onoting'ono timayimitsidwa, zimagwira ndi ma membala am'mimba timawonongeka, zomwe zimayambitsa kupha kwa mabakiteriya. Izi zimakuthandizani kuti muwononge tizilombo toyambitsa matenda a gramu-negative omwe ali mgawo lochita komanso pakupuma. Mankhwalawa amagwiranso ntchito pamafakiteriya okhala ndi gramu, koma pokhapokha ngati ali pagawo la kubereka.
Ciprofloxacin sikuwonetsa kukana kwa ma cell ndi penicillin, aminoglycosides, tetracyclines, cephalosporins ndi maantibayotiki ena omwe satseketsa gyrase ya DNA. Chifukwa chake, imagwira bwino ntchito pomwe mankhwalawa amalephera. Imagwira ntchito yolimbana ndi matenda ambiri, kuphatikizapo:
- Moraxella catarrhalis;
- Salmonella
- Shigella
- zamisala;
- Klebsiella;
- Proteus
- mndandanda;
- brucella;
- entero ndi cytobacteria;
- ma vibrios;
- matumbo, hemophilic, Pseudomonas aeruginosa;
- chlamydia
- ena staph ndi streptococci.
Fecal enterococcus ndi Mycobacterium avium amafuna kuti mankhwalawa agwiritsidwe ntchito kwambiri. Sichothandiza pneumococcus, treponema, ureaplasma, mycoplasma, bacteroids, flavobacteria, Pseudomonas maltophilia, Clostridium Hardile, Nocardia asteroides, anaerobes ambiri, saphwanya matumbo achilengedwe komanso ukazi.
Kutsutsa kumatha kusintha pakapita nthawi komanso zimadalira geolocation. Kulimbana ndi chidwi kumayamba pang'onopang'ono.
Pharmacokinetics
Yogwira pophika imatengedwa kuchokera m'matumbo ang'onoang'ono, mpaka kufika pakulimbitsa magazi ambiri patatha maola 1-2 mutatha kumwa mapiritsi. Chakudya chimachepetsa mayamwidwe, koma sichikhudza kukhudzana kwa bioavailability, komwe kumatha kufika 80%. Maantibayotiki amalowa m'madzi osiyanasiyana (peritoneal, ophthalmic, bile, mkodzo, malovu, zamitsempha, zotsekemera, masempha am'mimba), amagawidwa m'misempha:
- chiwindi
- chikhodzodzo;
- ziwalo zoberekera zazikazi;
- matumbo;
- peritoneum;
- Prostate;
- mapapu ndi pleura;
- impso ndi kwamikodzo;
- mafupa amitsempha;
- minofu ndi mafupa khungu.
Nthawi yomweyo, zopanga minofu ndizambiri kangapo (mpaka 12) ndizokwera kuposa plasma.
Mankhwalawa amadutsa mkaka wa m'mawere, kudutsa placenta ndi chotchinga chamagazi. Zomwe zili za ciprofloxacin m'magazi a cerebrospinal osagwirizana ndi njira yotupa imatha kuchuluka kwa 8% m'magazi, ndipo ndimankhwala oyaka amatha kulowa 37%. Kuyankhulana ndi mapuloteni amwazi - 20-40%.
Kukonzekera pang'ono pang'ono kwa mankhwala a Ciprolet 500 amapangidwa ndi chiwindi, metabolites amawonetsa zochitika zina.
Kukonzekera pang'ono kwamankhwala kumachitika ndi chiwindi, metabolites amawonetsa zochitika zina. Mpaka 70% ya mlingo wotengedwa amawonetsedwa mwanjira yake yoyambirira. Chipsinjo chachikulu cha zotupa chimagwera impso. Kutha kwa theka-moyo ndi maola 3-6. Pakulephera kwa impso, chizindikirochi chimatha kuwirikiza, koma mankhwalawa samaphatikizika, chifukwa mawonekedwe ake kudzera m'mimba amatenda. Ndi ntchito yabwinobwino impso, ndowe zimasamutsidwa 1% ya voliyumu yoyambayo.
Zomwe zimathandiza
Mankhwala omwe akufunsidwa akufuna kuthana ndi microflora ya pathogenic, yomwe imakhudzidwa ndi ciprofloxacin. Zisonyezero zosankhidwa kwa Cyprolet:
- Matenda opatsirana kudzera m'mapapo: pachimake kupuma, bronchitis, bronchiectasis, chibayo, ngati siayambitsidwa ndi chibayo, zovuta za cystic fibrosis, legionellosis, kuperekera mphamvu ndi mapapo.
- Matenda a Otolaryngological: sinusitis, otitis media, mastoiditis, pharyngitis, agranulocytic tonsillitis.
- Matenda a urogenital: pyelonephritis, cystitis, tubulointerstitial nephritis, oophoritis, endometritis, salpingitis, orchitis, epididymitis, prostatitis, balanoposthitis, gonorrhea.
- Peritonitis ndi zotupa zina zam'mimba. Pano, maantibayotiki amagwiritsidwa ntchito ngati gawo la zovuta mankhwala.
- Cholecystitis, kuphatikizapo, yosadziwika, cholangitis, kupindika kwa ndulu.
- Matumbo a dongosolo la matenda, kuphatikiza shigellosis, typhoid fever, kutsekula m'mimba.
- Matenda opatsirana pogundika ndi zigawo zikuluzikulu: ma abscesses, phlegmon, furunculosis, mabala, zilonda zam'mimba, kutentha ndi zizindikiro za matenda opatsirana.
- Matenda a musculoskeletal: myositis, bursitis, tendosynovitis, osteomyelitis, nyamakazi yopatsirana.
- Sepsis, bacteremia, mphumu, anthrax, amatenga odwala omwe ali ndi chitetezo chofooka (ndi neutropenia kapena mankhwala a immunosuppressive).
- Kupewa matenda, kuphatikizapo Neisseria meningitidis ndi Bacillus anthracis.
Tsiprolet 500 singagwiritsidwe ntchito pobereka mwana.
Contraindication
Mankhwalawa sayenera kugwiritsidwa ntchito ngati mapangidwe ake ali osalolera kapena ali ndi mbiri ya hypersensitivity kwa mankhwala a fluoroquinolone. Zotsutsa zina zazikulu zimaphatikizapo:
- pseudomembranous enterocolitis;
- kumwa tizanidine chifukwa choopseza kwambiri hypotension;
- ubwana ndi unyamata (amaloledwa kugwiritsa ntchito Ciprolet kwa ana azaka 5 kuti apondereze zochita za Pseudomonas aeruginosa pamaso pa cystic fibrosis, komanso kuti athetse komanso kupewa matenda a Bacillus anthracis);
- kubereka mwana;
- kuyamwa.
Ndi chisamaliro
Kuwongolera kwapadera ndikofunikira kwa odwala okalamba, odwala omwe ali ndi chiwopsezo chaimpso, kuchepa kwa magazi m'thupi, pamaso pa khunyu.
Momwe mungatenge Ziprolet 500
Mankhwalawa amagwiritsidwa ntchito pokhapokha ngati akuwongoleredwa ndi dokotala. Mapiritsi amatha kumwedwa mosasamala chakudya. Ngati mumamwa pamimba yopanda kanthu, ndiye kuti adzachitapo kanthu mwachangu. Amameza athunthu ndikutsukidwa ndi madzi. Kugwiritsa ntchito munthawi yomweyo kwamankhwala kumapangidwa limodzi ndi timadziti ta zipatso tothiriridwa ndi mchere, komanso zinthu zamkaka (kuphatikiza yogati m'mabotolo ngati probiotic).
Mankhwala a Ciprolet amagwiritsidwa ntchito pokhapokha ngati akuwongolera dokotala.
Mlingo umatsimikiziridwa payekhapayekha kutengera zomwe zikuwonetsa, kufalikira kwa pathogen, kuopsa ndi malo a chotupa. Akuluakulu amatenga mapiritsi a 500 mg kawiri pa tsiku. Ngati ndi kotheka, limodzi mlingo ukuwonjezeka. Mlingo wa tsiku ndi tsiku sayenera kupitirira 1.5 g Ngati mukufunikira, mankhwalawa amaperekedwa ndikusinthira kwa pakamwa. Jakisoni wamkati alibe.
Mlingo woyambira ndi kukonza akukonzedwa kwa odwala omwe ali ndi vuto laimpso. Ndi creatinine chilolezo pansipa 30 ml / mphindi, nthawi pakati Mlingo ukuwonjezeka mpaka maola 24. Kwa ana ndi achinyamata, maantibayotiki amaikidwa ngati pakufunika, chifukwa angayambitse arthropathy. Mlingo amawerengedwa kutengera kulemera kwa mwana.
Zilonda zina zopatsirana komanso zotupa (matenda a mafupa a cartilage, ziwalo zam'mimba, ndi mafupa a m'mimba) zimafuna kugwiritsa ntchito mankhwala ena a antibacterial. Nthawi yayitali ya mankhwala ndi milungu iwiri. Nthawi zina njira yochizira imatenga miyezi ingapo.
Kodi ndizotheka kumwa mankhwalawa chifukwa cha matenda ashuga
Palibe zotsutsana pakugwiritsa ntchito Ciprolet ndi odwala matenda ashuga. Kuthekera kwa mankhwalawa poyambitsa kusinthasintha kwa misempha ya shuga mbali imodzi kapena imodzi kuyenera kukumbukiridwa.
Mukamatenga Ciprolet, chopinga cha hematopoietic ntchito ndikusintha kwama cell a magazi ndikotheka.
Zotsatira zoyipa
Mankhwalawa amalekeredwa bwino, koma nthawi zina amatha kuyambitsa zovuta zingapo.
Matumbo
Odwala amadandaula chifukwa cha mseru, kusanza, kukula kwa m'mimba, kupweteka kwam'mimba, kugona. Pafupipafupi, candidiasis ya mucosa ya pamlomo, laryngeal edema, kutupa kwa kapamba, kusagwira bwino ntchito kwa chiwindi (kuphatikizapo chiwindi), hepatitis, minofu necrosis, cholestasis, kuchuluka kwa michere ya chiwindi, pseudomembranous enterocolitis.
Hematopoietic ziwalo
Kuletsa kwa hematopoietic ntchito ndi kusintha kwa ma cell a magazi, kuphatikiza leukocytosis ndi pancytopenia, ndizotheka.
Pakati mantha dongosolo
Chizungulire, migraines, kutopa kwambiri, asthenia, nkhawa kwambiri, kusowa tulo, kukhumudwa, malingaliro osokoneza bongo, mavuto ndi mgwirizano wamatenda, kunjenjemera, kuwonekera kosagwirizana, paresthesia, neuropathy, kulawa ndi kununkhiza, kulira m'makutu, kusinthanso kwamva, kusinza komanso zonyansa zina zowoneka.
Kuchokera kwamikodzo
Kumwa mankhwala ochepetsa mphamvu ya kachilombo ka HIV kungayambitse matenda a impso, mawonekedwe amtsempha wamagazi mumkodzo, kukulira kwa crystalluria, komanso kuchuluka kwa ndende ya creatinine.
Mukatenga Cyprolet 500, chizungulire, migraine, ndi kutopa zimachitika.
Kuchokera pamtima
Kutheka kwa tachycardia, hypotension, kutentha kwa thupi, kufalikira kwa nkhope, kutalika kwa gawo la QT mu mtima, pirouette arrhythmia, vasculitis.
Matupi omaliza
Nthawi zambiri, zimachitika pakhungu: zotupa, zotupa, hyperemia, kuyabwa, urticaria. Nthawi zina kuzungulira kwamiyendo. Photosensitization, erythema yoyipa, necrolysis ya zopindika, bronchospasm, anaphylactic mantha, malungo, kupweteka kwa minofu ndi mafupa.
Malangizo apadera
Zilonda zoopsa, matenda a streptococcal, matenda oyambitsidwa ndi tizilombo toyambitsa matenda a anaerobic, chithandizo ndi Tsiprolet ziyenera kuthandizidwa ndi othandizira ena okhudzana ndi antimicrobial.
Kutsegula m'mimba chifukwa chomwa mankhwala osokoneza bongo sikungathetsedwe mothandizidwa ndi mankhwala omwe amapondereza matumbo a motor.
Ciprofloxacin ingayambitse kupindika kwa tendon, khunyu, komanso kukula kwa mphamvu.
Kuyenderana ndi mowa
Ngakhale mukumwa maantibayotiki, zakumwa zoledzeretsa komanso mankhwala omwe ali ndi mowa sayenera kumwa.
Zokhudza mphamvu pakuwongolera njira
Zotsatira zoyipa kuchokera ku dongosolo lamanjenje ndi ziwalo zam'maganizo ndizotheka, chifukwa chake, poyendetsa galimoto ndikuwongolera njira zoopsa, chisamaliro chiyenera kutengedwa.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Amayi oyembekezera ndi amayi oyamwitsa popanda kuletsa mwana kuyamwa, kumwa mankhwalawa ndi otsutsana.
Kulembera Cyprolet kwa ana 500
Zaka zake ndi zaka 18. Mankhwalawa angagwiritsidwe ntchito muubwana pokhapokha pothana ndi kupewa matenda a m'mapapo kapena kuthana ndi Pseudomonas aeruginosa odwala ndi cystic fibrosis. Koma muzochitika izi, ndikosavuta kugwiritsa ntchito mlingo wa 250 mg, m'malo 500 mg.
Bongo
Zizindikiro za bongo:
- mutu
- vertigo;
- kukokana
- kugwedezeka
- kupweteka pamimba;
- kuyerekezera;
- aimpso chiwindi kuwonongeka;
- krystalluria;
- magazi mkodzo.
Ndikofunikira kutulutsa m'mimba ndikuchita zochizira. Ndikofunikira kuyang'anira ntchito ya impso ndikutsatira njira yowonjezera yakumwa. Kutsegula m'mimba sikothandiza.
Amayi oyembekezera ndi amayi oyamwitsa popanda kuletsa mwana kuyamwa, kumwa mankhwala opha ziwalo zamkaka ndi zotsutsana.
Kuchita ndi mankhwala ena
Ciprolet imawonjezera zolembedwa za Theophylline mu plasma yamagazi, zimachepetsa kuchotsedwa kwa antidiabetesic oral agents, xanthines ndi NSAIDs (kupatula Aspirin), zimathandizira nephrotoxicity ya cyclosporin komanso magwiridwe antchito a Warfarin. Kukonzekera kwa magnesium, chitsulo, aluminium ndi zinc zimachepetsa kuyamwa kwa ciprofloxacin, chifukwa chake muyenera kuzigwiritsa ntchito pakapita maola 4.
Mankhwala omwe amafunsidwa ndiogwirizana ndi mankhwala ena a antibacterial:
- Metronidazole;
- Vancomycin;
- cephalosporins;
- penicillin;
- aminoglycosides;
- manzeru.
Kuchotsa kwake kumachepetsa pamaso pa Probenecid, ndipo kuphatikiza ndi NSAIDs, chiwopsezo chowonetsedwa motsimikiza chikuwonjezeka.
Analogs a Tsiprolet 500
Analogi ake mankhwala:
- Ciprofloxacin.
- Cyprocinal.
- Afenoksim.
- Tsiprosan.
- Tsiproksin.
- Medociprine.
- Ciprinol.
- Quintor et al.
Mankhwala osakanikirana ndi antioxotic ena omwe amapezeka, mwachitsanzo, Ciprolet A wokhala ndi tinidazole, angagwiritsidwe ntchito.
Kupita kwina mankhwala
Yoperekedwa ndi mankhwala.
Mtengo
Mtengo wa mapiritsi a 500 mg amachokera ku ma ruble 54. phukusi lililonse (ma PC 10).
Mkhalidwe wa Tsiprolet 500
Mankhwalawa amasungidwa pamtambo wakuda mpaka 25 + C m'malo osavomerezeka ndi ana.
Tsiku lotha ntchito
Zaka zitatu
Mankhwalawa amasungidwa pamtambo wakuda mpaka 25 + C m'malo osavomerezeka ndi ana.
Ndemanga za Tsiprolet 500
Mankhwalawa amalandila zambiri kuchokera kwa madotolo ndi odwala.
Madokotala
Kartsin N.S., Urologist, Tver
Mankhwala othandizira awa a fluoroquinolone ndi othandizika makamaka pakukhumudwa kwamtundu wa genitourinary thirakiti. Ndikofunika kuti kubzala musanadze.
Turimova O. N., wothandizira, Krasnodar
Mankhwalawa ali ndi zochitika zosiyanasiyana. Imagwira ntchito mwachangu. Zotsatira zoyipa ndizochepa.
Odwala
Lyudmila, wazaka 41, mzinda wa Kerch
Ndinamwa mapiritsi a angina. Masiku oyamba anali ovuta kumeza. Koma zotsatira zake zidakondwera: pakhosi labwino komanso palibe mavuto.
Anatoly, wazaka 37, Ryazan
Ndimamwa mankhwalawa ndikuwonjezera kukomoka kwa masiku 5, ngakhale kuti matendawa amayamba kale masiku atatu. Dokotala akangopereka mankhwala enanso, chifukwa cha matenda otsekula m'mimba omwe adayamba. Chifukwa chake ndimangopatsidwa chithandizo ndi Cyprolet. Thupi lake limawona bwino.
