Atorvastatin 10 amatanthauza ma enzyme enhibitors omwe amakhudza mosagwirizana ndi momwe amapangira cholesterol. Nthawi zambiri amalembera matenda a mtima omwe amayamba chifukwa cha kuwonongeka kwa lipid metabolism, komanso kuwonjezera mphamvu ya njira zochizira zochokera pakudya.
Dzinalo Losayenerana
Atorvastatin (mu Chilatini - atorvastatin).
ATX
C10AA05
Kutulutsa mafomu ndi kapangidwe kake
M'mafakitare mungapeze mankhwala amtundu umodzi wokha - mawonekedwe a mapiritsi. Chidacho chimanena za mankhwala amodzi. Atorvastatin imathandizira kuchepa kwa zam'mapid, ndipo zinthu izi zimaphatikizidwa pakukonzekera kwa mawonekedwe a calcium calcium (calcium trihydrate). Pazomwe mankhwala amafunsidwa, mulingo wa gawo lomwe limagwira ntchito umasungidwa - 10 mg. Ndalamayi ili ndi piritsi limodzi. Mankhwala samawonetsa zoyipa chifukwa cha kupezeka kwa nembanemba.
Atorvastatin itha kugulidwa m'mapaketi amtundu. Iliyonse ili ndi mapiritsi 10. Chiwerengero chonse cha matuza m'bokosi la makatoni ndi 1, 2, 3, 4, 5, kapena 10 ma PC.
Atorvastatin 10 amatanthauza ma enzyme enhibitors omwe amakhudza mosagwirizana ndi momwe amapangira cholesterol.
Zotsatira za pharmacological
Mankhwalawa ndi cholepheretsa cha enzyme hydroxymethylglutaryl-CoA reductase. Ili ndi kusankha kosankha. Chidacho chimakhudza kwambiri njira zomwe zimathandizira kuti pakhale cholesterol. Atorvastatin imalepheretsa kusintha kwina kwa zinthu zina mthupi mokwanira kwambiri.
HMG-CoA enzyme imayambitsa kuphatikizika kwa cholesterol, koma pokhapokha koyambira. Makina ake ochitapo kanthu amatengera luso la kusintha HMG-CoA kukhala chinthu (mevalonic acid), komwe cholesterol imamasulidwa. Chifukwa cha kulepheretsa kugwira ntchito kwa enzyme iyi, atorvastatin imalepheretsa kuchuluka kwa mafuta a cholesterol.
Kafotokozedwe kameneka ndi kamene kakuthandizira kuwonjezeka kwa ntchito ya otsika kachulukidwe lipoprotein receptors. Zotsatira zake, kutulutsa kwa LDL kuchokera ku plasma kumathandizira. Zotsatira zake, kuchuluka kwa apolipoprotein B, cholesterol ya LDL ndi cholesterol yathunthu yafupika. Chifukwa cha izi, pali kuchepa kwa chiwopsezo cha kukulitsa matenda a mtima.
Mankhwalawa amathandiza thupi chifukwa cha kulepheretsa kapangidwe kake ka maselo mkati mwa ziwiya.
Kuphatikiza apo, mankhwalawa amathandizira thupi chifukwa cha kulepheretsa kwa kapangidwe ka maselo mkati mwa ziwiya. Zotsatira zake, kuunikira kwa mitsempha ndi mitsempha kumatha kuchepa, komwe kumakhudza mwachangu kuthamanga kwa magazi, kulimba kwa magazi kupita ku ziwalo zamkati, boma la ubongo, malingaliro ndi thupi. Kuchepetsa thupi komanso kuwonjezereka kwa ntchito yamtima - chifukwa chakuwonjezeka kwa kuchuluka kwa HDL, lembani A apolipoproteins.
Mankhwala omwe amawaganizira ndi a gulu la ma statins; m'magazi am'magazi panthawi ya mankhwala, zomwe zimapezeka mu zinthu zingapo zimasinthidwa. Komabe, atorvastatin imadziwonetsera ngati chida chapamwamba cha antiplatelet. Chifukwa cha izo, kuchuluka kwa kuphatikizana kwa magazi m'thupi ndi mkati mwa mitsempha ya magazi kumachepa. Komabe, pali kuchepa kwamitsempha yamagazi, komwe kumathandizanso kuti magazi azithamanga.
Pamodzi ndi njira zomwe zafotokozedwazo, microphage metabolism imabwezeretseka. Nthawi yomweyo, ntchito zawo zimaletsedwa. Zotsatira zake, chiopsezo chotumphukira cholembera cha atherosulinotic chimachepetsedwa.
Mukamamwa mankhwalawo, kuchepa kwa magazi m'magazi kumadziwika, zomwe zimathandizanso kuti magazi azithamanga.
Pharmacokinetics
The bioavailability wa mankhwalawa ndi ochepa (osaposa 14%). Atorvastatin imalowa mwachangu. Njira imeneyi imayambitsidwa pakatha maola awiri mutamwa mankhwalawa. Ngakhale pharmacokinetics yabwino, mankhwalawa amachita pang'onopang'ono. Chifukwa chake, zochiritsidwazo zimawoneka posachedwa kuposa masabata awiri pambuyo pake. Muyezo wambiri wa atorvastatin amakwaniritsidwa masabata 4 pambuyo pa kuyamba kwa mankhwala ndi kugwiritsa ntchito mankhwala.
Odwala omwe ali osiyana zaka komanso msinkhu, pharmacokinetics samasiyana kwenikweni, zomwe zikutanthauza kuti palibe chifukwa chofotokozera kuchuluka kwa mankhwalawa popereka mankhwala kwa odwala a magulu awa. Mlingo wa kumanga ma atorvastatin kupita ku mapuloteni a seramu ndiwokwera - umafika 98%. Kugwiritsa ntchito bwino kwa mankhwalawa kumachitika chifukwa chakumasulidwa kwa metabolites yogwira, yomwe imathandizanso pakupanga cholesterol.
Kuchotsa hafu ya moyo wa chinthu chachikulu ndi maola 14. Atorvastatin amachotsedwa m'thupi limodzi ndi bile. Gawo lalikulu limapukusidwa pakuyenda matumbo. Mankhwala ochepa ndikamakodza.
Kuchotsa hafu ya moyo wa chinthu chachikulu ndi maola 14. Atorvastatin amachotsedwa m'thupi limodzi ndi bile.
Kodi amatchulidwa?
Magawo ofunikira:
- kuwonjezera mphamvu ya mankhwala omwe zochita zawo zimafuna kutsitsa cholesterol milingo (Atorvastatin imafotokozedwa ngati gawo la chithandizo chovuta), kukwaniritsa zotsatira zofunika ndi mankhwala;
- mankhwala a mtima dongosolo, kupewa kukula kwa mavuto chifukwa magazi kuchuluka kwamitsempha, mafuta ambiri, kuchepetsa mitsempha.
Contraindication
Atorvastatin sagwiritsidwa ntchito nthawi zingapo:
- tsankho kwa chigawo chilichonse;
- kuchuluka kwa hepatic transaminases;
- kusowa kwa lactase, wina zoipa zimachitika lactose, shuga-galactose malabsorption.
Ndi chisamaliro
Pankhaniyi, mankhwalawa adapangidwa ngati zotsatira zoyipa zikupitilira kuvulaza kwakukulu. Zotsutsana:
- uchidakwa;
- mbiri ya matenda a chiwindi;
- zinthu zomwe zingayambitse chiwopsezo cha myopathy, pomwe njira yakuwonongeka kwa maselo imayamba.
Kuchepa kwa zizindikiro za myopathy kumawonjezereka mu ukalamba, ndimatenda a chiwindi, matenda a pathological, owonetsedwa ndi kuphwanya minofu ntchito, motsutsana ndi maziko a uchidakwa.
Momwe mungatenge atorvastatin 10?
Pharmacodynamics sikudalira chakudya, mutha kumwa mankhwala pamimba yopanda kanthu kapena mutatha kudya. Malangizo ogwiritsira ntchito:
- tsiku mlingo - 10 mg;
- mankhwalawa amayenera kumwedwa kamodzi.
Mukamamwa mankhwalawa, muyenera kuyang'anira milomo ya lipids, ndipo kuyesedwa kwa labotale kumachitika nthawi imodzi pakatha milungu iwiri iliyonse.
Mukamamwa mankhwalawa, muyenera kuyang'anira milomo ya lipids, ndipo kuyesedwa kwa labotale kumachitika nthawi imodzi pakatha milungu iwiri iliyonse. Mlingo wosiyanasiyana womwe umayambitsa zovuta zimatengera mtundu wamatenda:
- ndi homozygous hypercholesterolemia, mabanja amasankha 80 mg wa atorvastatin (kapena mapiritsi 8) patsiku;
- heterozygous hypercholesterolemia ndimabanja: nthawi yoyamba ya chithandizo - 10 mg patsiku, ndiye kuti mankhwalawa amawonjezeka mpaka 40 mg patsiku, kuchuluka kwa mankhwalawa kumayenera kuwonjezeka pang'onopang'ono (machitidwe a mankhwalawa amasintha pakadutsa milungu 4 iliyonse).
Kumwa mankhwala a shuga
The mankhwala zotchulidwa muyezo Mlingo wa - 10 mg pa tsiku. Ndi chithandizo, mankhwalawa amathandizira kusintha, kutengera mtundu wa wodwalayo.
Zotsatira zoyipa
Kuchulukitsa kwa ntchito kwa creatine phosphokinase (CPK), aminotransferases. Matenda ofooka amatha kuyamba, nthawi zambiri kutopa kumachitika.
Mu shuga mellitus, mankhwala zotchulidwa muyezo Mlingo wa -10 mg pa tsiku.
Matumbo
Kuchuluka kwa mpweya wopanga, mseru, kusanza, kuvunda, kapenanso, ndowe zamadzimadzi. Ululu pamimba umadziwika. Pancreatitis sichimakula.
Pakati mantha dongosolo
Kusokonekera kwa misempha, kupweteka mutu, chizungulire, kusokonezeka kwa mitsempha, kusintha kwa kakomedwe, kuchepa kwa mitsempha, kuwonongeka kwa kukumbukira, komanso milandu yayikulu, kutayika kwathunthu.
Kuchokera ku kupuma
Matenda am'mapapo, omwe amawonekera ndi kutupa, kuphwanya kapangidwe ka makoma a alveoli. Maonekedwe a nosebleeds amadziwika.
Pa khungu
Zowombana, kumachitika kumene kumayendetsedwa ndi kuyabwa. Kawirikawiri amawonetsa erythema, alopecia, necrolysis, matenda a Stevens-Johnson.
Kuchokera pamtima dongosolo, mukamamwa mankhwalawa, kupweteka pachifuwa kumatha kuchitika.
Kuchokera ku genitourinary system
Kulephera kwina.
Kuchokera pamtima
Kupweteka pachifuwa.
Kuchokera ku minculoskeletal system
Zilonda zam'mimba, kumbuyo, kutupa kwa mafupa, myopathy, genopathy, minofu yofewa.
Matupi omaliza
Urticaria, angioedema.
Malangizo apadera
Musanayambe chithandizo ndi Atorvastatin, zakudya zimayikidwa, zomwe zimapangitsa kuchepa kwa ndende ya lipid. Kuphatikiza apo, odwala omwe ali ndi kunenepa kwambiri amalimbikitsidwa kuti azichita zolimbitsa thupi, chifukwa chomwe kulemera kwa thupi kumachepa, ndizotheka kuwongolera zizindikiro ngati hypercholesterolemia.
Kuunika kwa KFK ndikofunikira ngati pali zinthu zomwe zingayambitse chiwopsezo cha chiwindi.
Musanayambe chithandizo ndi Atorvastatin, zakudya zimayikidwa, zomwe zimapangitsa kuchepa kwa ndende ya lipid.
Poganizira kuti kuopsa kwa zizindikiro za myopathy kumawonjezeka ndi kugwiritsa ntchito mankhwala a Atorvastatin, tikulimbikitsidwa kuti mukaonane ndi dokotala nthawi yomweyo ngati kupweteka kwamisempha kumachitika.
Kuyenderana ndi mowa
Simuyenera kuphatikiza mankhwalawa ndi zakumwa zoledzeretsa.
Zokhudza mphamvu pakuwongolera njira
Palibe choletsa chokhwima, ngakhale chiwopsezo chachikulu chotenga matenda amkati wamanjenje (chizungulire), kuiwalika. Amaloledwa kuyendetsa galimoto ndi chithandizo cha Atorvastatin, koma kusamala kuyenera kuchitidwa.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Osakupatsani mankhwala mukambereka mwana. Mukamayamwitsa, mankhwalawa sagwiritsidwa ntchito chifukwa chosazindikira zambiri zakulowa kwake mkaka wa mayi.
Ana a Atorvastatin 10
Mankhwala angagwiritsidwe ntchito pochiza odwala osaposa zaka 18 pokhapokha ngati achibale a hypercholesterolemia a heterozygous atakula. Pankhaniyi, malinga ndi momwe mankhwalawo amasankhidwira bwino, mankhwala a pharmacokinetic amatha kukhala ofanana ndi chithandizo cha akuluakulu. Chipangizocho chimaletsedwa kugwiritsidwa ntchito ngati mwana sanafike zaka 10.
Chipangizocho chimaletsedwa kugwiritsidwa ntchito ngati mwana sanakwanitse zaka 10.
Gwiritsani ntchito mu ukalamba
The kuchuluka kwa mankhwalawa ndi apamwamba kuposa odwala achinyamata. Izi zimachitika chifukwa chakuchepa kwambiri pakuchotsa atorvastatin ndi ma metabolites. Komabe, pankhaniyi, palibe chifukwa chosinthira mankhwala.
The ntchito aimpso kuwonongeka
Njira ya mankhwala yolimbana ndi matenda ndi chotupa cha zotupa mu chiwalo chino sichimasintha. Izi zimachitika chifukwa chakuti impso zazing'ono zimatenga gawo la metabolism ya atorvastatin.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Mankhwala saloledwa cirrhosis chiwindi ndi matenda ena limodzi ndi owopsa zizindikiro kuwonongeka kwa chiwalo. Chiwonetsero chachikulu cha atorvastatin chimaposa nthawi yofananira ndi nthawi 11-16.
Mankhwalawa dongosolo motsutsana matenda ndi kufalikira kwa zotupa mu impso sasintha.
Bongo
Ndi kuwonjezeka kwa tsiku ndi tsiku mlingo, kuchuluka kwa chiwonetsero cha zotsatira zoyipa kumawonjezeka. Pofuna kusintha matupi a thupi, chithandizo chamankhwala chimachitika. Hemodialysis sichimapereka zotsatira zomwe mukufuna.
Kuchita ndi mankhwala ena
Pali kuwonjezeka kwa lipid-kutsitsa zotsatira pamodzi ndi othandizira ndi zinthu:
- maantibayotiki
- anti-HIV proteinase inhibitors;
- mankhwala opangidwa ndi mankhwala a mycoses;
- Nefazodon.
Makonzedwe omwewo a atorvastatin okhala ndi ezetimibe ndi omwe amachititsa kuti pakhale zovuta.
Kuchepa kwa kuchuluka kwa mankhwalawo chifukwa chodziwikiridwa ndi gulu la amtundu wa CYP3A4 isoenzyme. Zoletsa za isoenzyme iyi, m'malo mwake, zimathandizira kuwonjezeka kwa kuchuluka kwa atorvastatin.
Mankhwala omwe amafunsidwa akhoza kukhudza ma mahomoni a steroid.
Pochita mankhwala ndi Atorvastatin, kuyamwa kwa njira zakulera zamkamwa kumawonjezereka.
Kuphatikizika kwa mankhwalawa kumawonjezereka pamodzi ndi munthawi yomweyo kugwiritsa ntchito madzi a mphesa.
Kuphatikizika kwa mankhwalawa kumawonjezereka pamodzi ndi munthawi yomweyo kugwiritsa ntchito madzi a mphesa.
Analogi
Mankhwala otsatirawa amagwiritsidwa ntchito ngati othandizira:
- Atoris;
- Teorvastatin Teva;
- Atorvastatin Canon;
- Atorvox;
- Torvakard.
Ma Analogs amatha kukhala ndi mitundu yosiyanasiyana yotulutsira: jakisoni, lyophilisate, makapisozi. Ngati kapangidwe ka wogwirizira ndi Atorvastatin ndi kosiyana, kutembenuka kwa mlingo kungafunike.
Maulendo atchuthi Atorvastatin 10 ochokera ku malo ogulitsa mankhwala
Mankhwala ndi a gulu la mankhwala omwe amapezeka.
Kodi ndingagule popanda kulandira mankhwala?
Kuikidwa kwa dokotala ndikofunikira.
Mtengo
Mtengo wapakati: 135-265 rubles.
Zosungidwa zamankhwala
Kutentha kwakanthawi kanyumba sikokwanira kuposa + 25 ° ะก.
Tsiku lotha ntchito
Mankhwalawa sataya katundu kwa zaka 2 kuyambira tsiku lotulutsidwa.
Wopanga Atorvastatin 10
Krka (Slovenia).
Atorvastatin 10 Ndemanga
Madokotala
Zafiraki V.K., wazaka 42, Saratov
Ndikupangira kutenga atorvastatin monga gawo la mankhwala a Liprimar opangidwa ndi Pfizer. Makampani ena amatulutsanso chinthu ichi, koma nthawi zambiri kuchuluka kwa mavuto kumawonjezeka. Mwa zotengera zomwe ndimatha kusiyanitsa Atoris. Pankhani ya katundu ndi kuchuluka kwa kuchitira mwankhanza thupi, mankhwalawa ndi apamwamba kuposa olowa m'malo ena a Atorvastatin.
Gubarev I.A., wazaka 35, Tula
Pa chithandizo, kuyezetsa magazi pafupipafupi kumafunikira. Ngati malingaliro awa sanatsatidwe, chiopsezo cha zovuta zimachuluka. Atorvastatin ena onse ndi mankhwala abwino kwambiri, chifukwa ndiotsika mtengo komanso ogwira ntchito kwambiri.
Odwala
Eugenia, wazaka 38, Vladimir
Dokotala adapereka mankhwalawa motsutsana ndi maziko a cholesterol wamkulu. Ndinayenera kutenga nthawi yayitali, chifukwa mankhwalawa samapereka mwachangu zotsatira zake.
Galina, wazaka 35, Samara
Chidacho chimathandiza ngati chakudya chatsatiridwa. Kusunga zakudya zoyenera ndikovuta, chifukwa chake cholesterol yanga imachulukirachulukira. Nthawi iliyonse ndikamalandira chithandizo ndi Atorvastatin. Ubwino wa mankhwalawa ndi wotsika mtengo.
