Orlistat - mankhwala ochepetsa thupi: malangizo, mtengo, ndemanga

Kupanga ndi mawonekedwe a kumasulidwa

Orlistat imapezeka mu mawonekedwe a makapisozi, mkati mwake momwe mumakhala ma pellets omwe ali ndi ntchito yogwira - orlistat. Izi zimapangitsa kuti mankhwalawa adutse m'malo ovuta pamimba ndipo osamasula zomwe zili mkati mwake isanakwane.

Mankhwalawa amapangidwira mumiyeso iwiri: 60 ndi 120 mg. Chiwerengero cha makapisozi pachikwama chilichonse chimasiyana 21 mpaka 84.

Mankhwala

Mu gulu lake la mankhwala, orlistat imalepheretsa zam'mimba lipase, zomwe zikutanthauza kuti imalepheretsa kwakanthawi ntchito ya enzyme yapadera yomwe imapangidwa kuti igwetse mafuta kuchokera ku chakudya. Imagwira mu lumen m'mimba ndi m'mimba yaying'ono.

Zotsatira zake ndikuti mafuta osakwanira sangatengeke m'makoma a mucous, ndipo zopatsa mphamvu zochepa zimalowa m'thupi, zomwe zimabweretsa kuwonda. Orlistat kwenikweni simalowa m'magazi apakati, amapezeka m'magazi nthawi zambiri komanso pamiyeso yotsika kwambiri, yomwe singayambitse zotsatira zoyipa.

Zambiri zakuchipatala zimawonetsa kuti anthu omwe ali ndi kunenepa kwambiri komanso amtundu wa 2 shuga athandiza kwambiri pakulimbana ndi glycemic. Kuphatikiza apo, ndi makina a orlistat, zotsatirazi zidawonedwa:

• kuchepetsa Mlingo wa othandizira a hypoglycemic;
• kuchepa kwa ndende kukonzekera insulin;
• kuchepa kwa insulin kukana.

Kafukufuku wazaka 4 adawonetsa kuti mwa anthu onenepa kwambiri omwe amakonda kukhala ndi matenda ashuga amtundu wa 2, chiopsezo cha kuyambitsidwa kwake chidachepetsedwa ndi 37%.

Kuchita kwa orlistat kumayamba patatha masiku 1-2 patatha mlingo woyamba, zomveka zomveka chifukwa cha mafuta omwe amapezeka mumalondowo. Kuchepetsa thupi kumayambira pakatha milungu iwiri ya kudya pafupipafupi komanso kupitilira miyezi 6 mpaka 12, ngakhale kwa anthu omwe sikuti amachepetsa thupi pazakudya zapadera.

Mankhwala sayambitsa kubweza kawirikawiri pambuyo kusiya mankhwala. Imasiya kutulutsa mphamvu pambuyo patha masiku 4-5 mutatenga kapisozi komaliza.

Zizindikiro ndi contraindication

Zowonetsa:

1. Njira yayitali yothandizira anthu onenepa kwambiri omwe BMI yawo imaposa 30.
2. Chithandizo cha odwala omwe ali ndi BMI yoposa 28 komanso zinthu zoopsa zomwe zimayambitsa kunenepa kwambiri.
3. Chithandizo cha anthu omwe ali ndi matenda a shuga a 2 komanso kunenepa kwambiri omwe amamwa mankhwala osokoneza bongo a hypoglycemic komanso / kapena insulin.

Malo omwe orlistat yaletsedwa kapena kuletsedwa:

• Hypersensitivity pazinthu zilizonse zomwe zimapanga.
• Zaka mpaka zaka 12.
• Nthawi ya pakati ndi kuyamwa.
• Kuyamwa kwa michere yaying'ono yamatumbo.
• Mavuto ndi mapangidwe ndi ndulu ya bile, chifukwa imalowa mu duodenum yaying'ono.
• Ntchito munthawi yomweyo cyclosporine, warfarin ndi mankhwala ena.

Ngakhale zotsatira za kafukufuku wazinyama sizinawululire vuto loyenera la orlistat pa mwana wosabadwayo, amayi oyembekezera amaletsedwa kugwiritsa ntchito mankhwalawa. Kutheka kwa chinthu chomwe chikulowa mkaka wa m'mawere sichinakhazikitsidwe, chifukwa chake, munthawi ya chithandizo, mkaka wa m'mawere uyenera kumalizidwa.

Malangizo ogwiritsira ntchito

Pali makapisozi 60 ndi 120 mg. Madokotala nthawi zambiri amapereka mankhwala okwanira 120, chifukwa amagwira bwino ntchito kunenepa kwambiri.

Mankhwalawa amayenera kuledzera kapisozi imodzi pachakudya chilichonse (kutanthauza kupumira kwathunthu, nkhomaliro ndi chakudya, osati zakudya zazing'ono). Orlistat imagwiritsidwa ntchito nthawi yomweyo isanachitike, nthawi, kapena osapitirira ola limodzi mutatha kudya. Ngati chakudyacho chinalibe mafuta, mutha kudumpha ndikumwa mankhwala.

Mlingo wambiri womwe umalimbikitsa ndi 120 mg katatu pa tsiku. Dokotala wokhoza kusintha amatha kusintha kayendedwe ka mankhwala ndi kumwa mwa kufuna kwake. Njira yochizira ndi orlistat imakhazikitsidwa payekhapayekha, koma nthawi zambiri imatha miyezi itatu, chifukwa nthawi imeneyi ndi yomwe mungathe kumvetsetsa momwe mankhwalawa amathandizira ndi ntchito yake.

Mankhwala osokoneza bongo komanso mavuto ambiri

Kuyesa kunachitika ndikugwiritsa ntchito milingo yayikulu ya Orlistat kwa nthawi yayitali, zotsatira zoyipa sizinapezeke. Ngakhale bongo utadzioneka mwadzidzidzi, zizindikiro zake zimakhala zofanana ndi zovuta zomwe zimachitika, zomwe zimachedwa.

Nthawi zina mavuto amabuka omwe amasintha:

1. Kuchokera m'mimba thirakiti. Kupweteka kwam'mimba, kusefukira kwam'mimba, kutsegula m'mimba, kuyenda pafupipafupi kupita kuchimbudzi. Zosasangalatsa kwambiri ndizakuti: kutulutsidwa kwamafuta osaphatikizika kuchokera ku rectum nthawi iliyonse, kutulutsa kwa mpweya ndi mpweya wochepa, fecal incontinence. Kuwonongeka kwa chingamu ndi mano nthawi zina kumadziwika.
2. Matenda opatsirana. Zowonekera: fuluwenza, wotsika komanso wapamwamba matenda opatsirana thirakiti, matenda amkodzo.
3. Kupenda. Kutsitsa kuchuluka kwa shuga m'magazi m'munsimu 3.5 mmol / L.
4. Kuchokera ku psyche ndi dongosolo lamanjenje. Mutu ndi nkhawa.
5. Kuchokera ku kubereka. Kuzungulira kosazungulira.

Kusokonezeka kochokera m'mimba ndi matumbo kumawonjezeka molingana ndi kuchuluka kwa zakudya zamafuta m'zakudya. Amatha kuwongoleredwa ndi zakudya zamafuta ochepa.

Orlistat yoyambirira itatulutsidwa m'misika yamankhwala, zodandaula zotsatirazi zamavuto zinayamba kufika:

• magazi otupa;
• kuyabwa ndi zotupa;
• kuyika kwa oxalic acid amchere mu impso, komwe kunayambitsa kulephera kwa impso;
• kapamba

Pafupipafupi pazotsatira izi sizikudziwika, atha kukhala mu dongosolo limodzi kapena osakhudzana mwachindunji ndi mankhwalawo, koma wopanga amayenera kuwalembetsa iwo pazomwe akuwatsata.

Malangizo apadera

Musanayambe chithandizo ndi Orlistat, ndikofunikira kuuza dokotala za mankhwala onse omwe amamwa mosalekeza. Zina mwa izo sizingafanane. Izi zikuphatikiza:

• Cyclosporin. Orlistat imachepetsa kukhazikika kwake m'magazi, zomwe zimapangitsa kuchepa kwa mphamvu ya immunosuppressive, yomwe ingasokoneze kwambiri thanzi. Ngati mukufunika kumwa onse awiri nthawi yomweyo, onetsetsani zomwe zili mu cyclosporine pogwiritsa ntchito mayeso a labotale.
• Mankhwala othandizira antiepileptic. Ndi makonzedwe awo omwewo, kukhumudwitsidwa nthawi zina kumawonedwa, ngakhale ubale wamphamvu pakati pawo sunawululidwe.
• Warfarin ndi zina zotero. Zomwe zili ndi mapuloteni amwazi, zomwe zimakhudzidwa ndi kuphatikizika kwake, nthawi zina zimatha kuchepa, zomwe nthawi zina zimasintha magawo a labotale.
• Mafuta mavitamini sungunuka (E, D ndi β-carotene). Kuyamwa kwawo kumachepa, komwe kumakhudzana mwachindunji ndi machitidwe a mankhwalawa. Ndikulimbikitsidwa kumwa mankhwalawa usiku kapena maola awiri mutatha kumwa Orlistat yomaliza.

Njira ya mankhwalawa ndi mankhwalawa iyenera kuyimitsidwa ngati, pambuyo pa milungu 12 yogwiritsidwa ntchito, kulemera kwacheperachepera ndi osakwana 5% a choyambirira. Mwa anthu omwe ali ndi matenda a shuga a 2, kuchepa thupi kumatha kuchepa.

Amayi omwe amamwa mapiritsi a piritsi amayenera kuchenjezedwa kuti ngati chimbudzi cha pafupipafupi chimawonekera pakumwa kwa Orlistat, chitetezo chowonjezera chimafunikira, chifukwa mphamvu ya mankhwala a mahormoni pamwambapa imachepa.

Ma Analogs a Orlistat

Mankhwala oyamba ndi Xenical. Linapangidwa ndi kampani yopanga mankhwala ku Switzerland kumapeto kwa zaka za m'ma 1900. Anthu opitilira 4,000 adatenga nawo mbali pazoyeserera.

Zofananira zina:

• Orliksen
• Orsoten;
• Leafa;
• Xenalten.

Makampani ena opanga amapanga mankhwala pansi pa dzina la chinthu chomwe chimagwira: Akrikhin, Atoll, Canonfarma, Polfarma, etc. Pafupifupi mankhwala onse omwe amakhazikitsidwa ndi orlistat amaperekedwa, kupatula Orsoten Slim, yomwe imakhala ndi 60 mg yogwira mankhwala.

Mankhwala ena ochepetsa thupi komanso mankhwalawa a matenda a shuga 2

Chidule Cha Mankhwala Ovuta

Mtengo mumafakisi

Mtengo wa orlistat umatengera mlingo (60 ndi 120 mg) ndi kuyika kwa makapisozi (21, 42 ndi 84).

Mankhwalawa amayenera kutumizidwa ndi adotolo ndipo pokhapokha ngati mankhwala othandizira adya komanso zolimbitsa thupi sanapereke zotsatira zomwe akufunazo. Anthu wamba opanda mavuto azaumoyo, salimbikitsidwa.

Ndemanga