Diabeteson MV ndi mankhwala apadera amtundu wake. M'magawo ake othandizira pamakhala chinthu china chapadera - hypromellose. Amakhala ngati maziko a hydrophilic matrix, omwe, akamagwirizana ndi madzi am'mimba, amasintha kukhala gel. Chifukwa cha izi, pali yosalala, tsiku lonse, kumasulidwa kwa chinthu chachikulu yogwira - gliclazide. Matenda a shuga amakhala ndi vuto lalikulu kwambiri ndipo amatha kumwedwa kamodzi patsiku. Palibe zovuta pa metabolism yamafuta, ndiotetezeka kwa okalamba ndi anthu omwe ali ndi vuto laimpso.
Zolemba
- 1 Kuphatikizika ndi mawonekedwe a kumasulidwa
- 2 Kodi a Diabeteson MV ali bwanji
- 2.1 Pharmacokinetics
- 3 Zizindikiro zogwiritsidwa ntchito
- 4 Kutsutsana
- 5 Mimba ndi kuyamwitsa
- 6 Malangizo ogwiritsira ntchito
- 7 mavuto
- 8 Mankhwala osokoneza bongo
- 9 mogwirizana ndi mankhwala ena
- Malangizo apadera
- 11 Analogs a Diabeteson MV
- 12 Nchiyani chingalowe m'malo?
- Maninil, Metformin kapena Diabeteson - ndibwino bwanji?
- 14 Mtengo mumafakisi
- 15 Ndemanga za Amayi
Kupanga ndi mawonekedwe a kumasulidwa
Diabeteson MV imapangidwa ngati mapiritsi okhala ndi notch komanso cholembedwa "DIA" "60" mbali zonse ziwiri. The yogwira ndi gliklazid 60 mg. Zothandiza: magnesium stearate - 1.6 mg, anhydrous colloidal silicon dioxide - 5.04 mg, maltodextrin - 22 mg, hypromellose 100 cP - 160 mg.
Makalata "MV" m'dzina la Diabeteson adawonetsedwa ngati kumasulidwa kosintha, i.e. pang'onopang'ono.
Wopanga: Les Laboratoires Serviceier, France
Kodi a Diabeteson MV ali bwanji
A diabetes akutanthauza sulfonylureas a m'badwo wachiwiri. Imayendetsa kapamba ndi ma cell a cell omwe amachititsa kuti apange insulin. Kugwira ntchito ngati maselo agwira ntchito mwanjira inayake. Mankhwalawa adapangidwa pambuyo pa kusanthula kwa c-peptide, ngati zotsatira zake ndizosakwana 0.26 mmol / L.
Kutulutsidwa kwa insulin mukamamwa gliclazide kumayandikira pafupi ndi kuthekera kwa thupi: nsonga ya katulutsidwe imabwezeretseka poyankha dextrose, yomwe imalowa m'magazi kuchokera ku chakudya, kupangika kwa mahomoni mu gawo lachiwiri kumatheka.
Pharmacokinetics
Pambuyo pakukonzekera pakamwa, Diabeton imatha. Kuwonjezeka kwa kuchuluka kwa zinthu zogwira ntchito m'magazi kumatha kwa maola 6 ndipo kumatha kusungidwa pamlingo womwe wakwaniritsidwa mpaka maola 12.
Kuyankhulana ndi mapuloteni a plasma kumafika pa 95%, voliyumu yogawa ndi 30 l. Kuti mukhalebe ndi plasma nthawi zonse kwa maola 24, mankhwalawa ndi okwanira kumwa piritsi 1 imodzi patsiku.
Kuwonongeka kwa zinthu kumachitika m'chiwindi. Kupeputsidwa ndi impso: metabolites amatulutsidwa, <1% imatuluka mu mawonekedwe ake apoyamba. Diabeteson MV amachotsedwa m'thupi ndi theka m'maola 12−20.
Zizindikiro zogwiritsidwa ntchito
- Diabeteson MV (60 mg) amalembedwa ndi dokotala wa matenda amtundu wa II, pamene zakudya zopangidwira ndi zolimbitsa thupi sizithandiza.
- Amagwiritsidwanso ntchito kupewa zovuta za matenda ashuga: kuchepetsa chiopsezo cha macrovascular (stroke, myocardial infarction) ndi zovuta za microvascular (retinopathy, nephropathy) kwa odwala omwe ali ndi matenda a shuga a 2.
Contraindication
- Mtundu I shuga
- tsankho kwa gliclazide, sulfonylurea ndi sulfonamide zotumphukira, lactose;
- galactosemia, shuga-galactose malabsorption;
- kuthamanga kwa magazi ndi matupi a ketone;
- woopsa mitundu ya aimpso ndi kwa chiwindi kuchepa, shuga.
- ubwana ndi unyamata
- nthawi yapakati;
- kuyamwitsa;
- zikhalidwe za odwala matenda ashuga khoma.
Mimba komanso yoyamwitsa
Kafukufuku wokhudza azimayi omwe ali ndiudindo sanachitepo kanthu; palibe zidziwitso za zotsatira za gliclazide pa mwana wosabadwa. Panthawi yoyesera nyama zoyeserera, palibe kusokonezeka kwakutukuka kwa embryonic komwe kudadziwika.
Ngati mimba yachitika pamene mukumwa Diabeteson MV, ndiye kuti imatha ndipo imasinthidwa kupita ku insulin. Zomwezo zimapita kukonzekera. Izi ndizofunikira kuti muchepetse mwayi wokhala ndi vuto lakubadwa mwa mwana.
Gwiritsani ntchito nthawi yoyamwitsa
Palibe chidziwitso chokwanira chokhudzana ndi kumeza kwa Diabeteson mkaka ndi chiopsezo chokhala ndi mtundu wa hypoglycemic wakhanda, ndizoletsedwa panthawi ya mkaka wa m'mawere. Pakanakhala kuti palibenso chifukwa china, amasinthidwira ku chakudya chakupanga.
Malangizo ogwiritsira ntchito
Diabeteson MV imaloledwa kutengedwa ndi akulu okha. Phwando ikuchitika 1 nthawi patsiku m'mawa ndi chakudya. Mlingo wa tsiku ndi tsiku womwe umayikidwa ndi adokotala, kuchuluka kwake kungafikire 120 mg. Piritsi kapena theka lake limatsukidwa ndi kapu yamadzi oyera. Osabera komanso kupera.
Mukadumpha mlingo umodzi, mlingo wovomerezeka suvomerezeka.
Mlingo woyambirira
Kumayambiriro kwa chithandizo, ndi theka piritsi, i.e. 30 mg Ngati ndi kotheka, mlingo wa Diabeteson MV pang'onopang'ono umakwera mpaka 60, 90 kapena 120 mg.
Mlingo watsopano wa mankhwalawa sudanenedwe kale kuposa mwezi umodzi atapereka yapita. Chosiyana ndi anthu omwe kuchuluka kwa shuga m'magazi sikusintha pambuyo pa masabata awiri kuchokera pa kipimo choyamba. Kwa odwala otere, mlingo umachulukitsa pambuyo masiku 14. Kwa odwala omwe ali ndi zaka zopitilira 65, kusintha sikofunikira.
Chikuonetseratu pambuyo mankhwala ena antidiabetes
Mlingo wamankhwala am'mbuyomu komanso kutalika kwa kutuluka kwawo kumawaganiziridwa. Poyamba, mlingo wake ndi 30 mg, umasinthidwa molingana ndi shuga m'magazi.
Ngati Diabeteson MV atalowa m'malo mwa mankhwalawa wokhala ndi nthawi yayitali, mlingo womaliza umayimitsidwa kwa masiku awiri. Mlingo woyamba ulinso 30 mg. Anthu omwe ali ndi matenda a impso ofunika safuna kusintha kwa Mlingo.
Gulu lamavuto:
- Hypoglycemic mkhalidwe chifukwa choperewera m'thupi.
- Kuperewera kwachilengedwe komanso adrenal, kuchepa kwakutalika kwa mahomoni a chithokomiro.
- Lekani kumwa corticosteroids mukatha kulandira chithandizo.
- The chachikulu coronary mtsempha wamagazi, mawonekedwe a cholesterol zolembedwa pa makoma a carotid mitsempha.
Zotsatira zoyipa
Mukamamwa Diabeteson limodzi ndi kudya kosamveka, hypoglycemia imatha kuchitika.
Zizindikiro zake:
- kupweteka mutu, chizungulire, kusokonezeka kwa kuzindikira;
- kumangokhalira kumva njala;
- kusanza, kusanza
- kufooka wamba, manja akunjenjemera, kukokana;
- kusasangalala kwazifukwa, chisangalalo chamanjenje;
- kusowa tulo kapena kugona kwambiri;
- kusokonezeka kwa chikumbumtima chomwe chingatheke.
Zotsatira zotsatirazi zomwe zimatha mutatha kutsekemera zitha kupezekanso:
- Kuchita thukuta kwambiri, khungu limakhala lomata kukhudza.
- Matenda oopsa, palpitations, arrhythmia.
- Zowawa kwambiri m'chifuwa chifukwa chosowa magazi.
Zotsatira zina zosafunikira:
- Zizindikiro za dyspeptic (kupweteka kwam'mimba, nseru, kusanza, kutsekula m'mimba kapena kudzimbidwa);
- thupi lawo siligwirizana pamene akutenga matenda ashuga;
- kuchepa kwa chiwerengero cha leukocytes, mapulateleti, kuchuluka kwa ma granulocytes, hemoglobin concentration (kusintha kumakhala kusintha);
- kuchuluka kwa hepatic michere (AST, ALT, zamchere phosphatase), milandu ya chiwindi;
- Kusokonezeka kwa mawonekedwe owoneka ndi kotheka kumayambiriro kwa matenda a Diabetesone.
Bongo
Ndi mankhwala osokoneza bongo a Diabetesone, matenda a hypoglycemic akhoza kuyamba. Ngati chikumbumtima sichikumangika ndipo palibe zizindikiro zoopsa, ndiye kuti muyenera kumwa madzi otsekemera kapena tiyi ndi shuga. Kuti hypoglycemia isabwezenso, muyenera kuwonjezera kuchuluka kwa chakudya m'thupi kapena kuchepetsa kuchuluka kwa mankhwalawa.
Kugonekedwa kuchipatala kumafunika ngati vuto lalikulu la hypoglycemic layamba. 50 ml 40% shuga yothetsera shuga imaperekedwa kwa wodwala. Kenako, kuti tisunge glucose yambiri pamtunda wa 1 g / l, 10% dextrose imayendetsedwa.
Kuchita ndi mankhwala ena
Mankhwala omwe amawonjezera mphamvu ya gliclazide
Wothandizira antifungal Miconazole amatsutsana. Amaonjezera ngozi yotenga gawo la hypoglycemic, mpaka kukomoka.
Kugwiritsira ntchito Diabeteson ndi mankhwala osagwiritsa ntchito mankhwala a Phenylbutazone ayenera kuphatikizidwa mosamala. Ndi kugwiritsidwa ntchito kwadongosolo, kumachepetsa kuchotsa kwa thupi. Ngati kumwa kwa matenda a shuga ndikofunikira ndipo ndikosatheka kuisintha ndi china chilichonse, kusintha kwa gliclazide kumachitika.
Mowa wa Ethyl umakulitsa mkhalidwe wa hypoglycemic ndikulepheretsa kulipidwa, zomwe zimapangitsa kuti pakhale chipwirikiti. Pachifukwa ichi, ndikofunikira kupatula mowa ndi mankhwala omwe amakhala ndi ethanol.
Komanso, kukhazikika kwa dziko la hypoglycemic ndikugwiritsa ntchito mosalamulirika ndi matenda a shuga kumathandizira:
- Bisoprolol;
- Fluconazole;
- Captopril;
- Ranitidine;
- Moclobemide;
- Sulfadimethoxine;
- Phenylbutazone;
- Metformin.
Mndandandawo umawonetsa zitsanzo zenizeni zokha, zida zina zomwe zili m'gulu lomwelo zomwe zidatchulidwazo zikufanana.
Mankhwala ochepetsa matenda a shuga
Osatenga Danazole, monga imakhala ndi matenda ashuga. Ngati phwando silithetsedwa, kukonza kwa gliclazide ndikofunikira nthawi yayitali komanso pambuyo pake.
Kuwongolera mosamala kumafuna kuphatikiza ndi ma antipsychotic mu Mlingo waukulu, chifukwa amathandizira kuchepetsa katulutsidwe ka mahomoni ndi kuwonjezera shuga. Kusankhidwa kwa mlingo wa Diabeteson MV kumachitika onse munthawi ya mankhwala ndi pambuyo pake.
Mankhwalawa ndi glucocorticosteroids, kuchuluka kwa shuga kumawonjezeka ndi kutsika kwa kulekerera kwa chakudya.
Intravenous β2-adrenergic agonists amalimbikitsa kuchuluka kwa glucose. Ngati ndi kotheka, wodwalayo amapatsidwa insulin.
Zophatikiza siziyenera kunyalanyazidwa
Pogwiritsa ntchito mankhwala a warfarin, odwala matenda ashuga atha kuwonjezera zotsatira zake. Izi zikuyenera kukumbukiridwa ndi kuphatikiza uku ndikusintha mlingo wa anticoagulant. Kusintha kwa mlingo womaliza kungafunike.
Malangizo apadera
Hypoglycemia
Ndikofunika kuti mutenge Diabeteson MV kokha kwa anthu omwe amadya mokhazikika komanso nthawi zonse osadumpha chakudya chofunikira - chakudya cham'mawa. Zakudya zamafuta m'zakudya ndizofunikira kwambiri, chifukwa chiopsezo chokhala ndi boma la hypoglycemic limachulukana ndendende ndi zosagwiritsidwa ntchito mosasamala, komanso kudya zakudya zopatsa mphamvu zochepa.
Zizindikiro za Hypoglycemic zimatha kubwereranso. Ndi zizindikiro zazikulu, ngakhale ngati pakhale kusintha kwakanthawi pambuyo pa chakudya chama chakudya, chithandizo chofunikira chimafunikira, nthawi zina mpaka kuchipatala.
Kuti izi zisachitike, muyenera kuyandikira kusankha kwa odwala matenda ashuga.
Milandu yomwe imawonjezera chiopsezo cha vuto la hypoglycemic:
- Kusafuna ndi kulephera kwa munthu kutsatira malangizo a dokotala.
- Zakudya zoperewera, kudya chakudya, kuthawa.
- Zosafunika zolimbitsa thupi ndi chakudya chamagulu ambiri.
- Kulephera kwina.
- Mankhwala osokoneza bongo a gliclazide.
- Matenda a chithokomiro.
- Kumwa mankhwala.
Kulephera kwamkati ndi chiwindi
Mphamvu ya thunthu limasintha chifukwa cha hepatic komanso kulephera kwambiri kwaimpso. Matenda a hypoglycemic amatha kupitiliza, chithandizo chadzidzidzi ndikofunikira.
Zidziwitso Zodwala
Muyenera kuchita masewera olimbitsa thupi pafupipafupi ndikuwunika glucose anu, kumamatira ku menyu wapadera, komanso kudya osadumpha. Wodwalayo ndi abale ake ayenera kudziwa za hypoglycemia, zizindikiritso zake ndi njira zoletsa.
Kusakwanitsa kuyang'anira glycemic
Wodwala akakhala ndi malungo, matenda opatsirana, njira zazikulu zochitira opaleshoni zimayikidwa, kuvulala kumalandiridwa, kuyendetsa glycemic kumafooka. Nthawi zina zimakhala zofunikira kusinthana ndi insulin ndikutha kwa Diabeteson MV.
Kukana kwachiwiri kwa mankhwalawa kumatha kuchitika, komwe kumachitika pamene matendawa apita kapena poyankha kwa thupi kumankhwala amachepa. Nthawi zambiri, chitukuko chake chimachitika pambuyo povomerezeka kwa mankhwala a pakamwa a hypoglycemic. Kutsimikizira kukana kwachiwiri, endocrinologist imawunika kulondola kwa Mlingo wosankhidwa ndikutsatira wodwala pazakudya zomwe zimayikidwa.
Zokhudza mphamvu pakutha kuyendetsa magalimoto ndi zida
Mukamagwira ntchito mukamayendetsa kapena ntchito iliyonse yomwe imafuna kusankha zochita mwachangu, muyenera kusamala makamaka.
Analogs a Diabeteson MV
Dzina la malonda | Mlingo wa glyclazide, mg | Mtengo, pakani |
Glyclazide CANON | 30 60 | 150 220 |
Glyclazide MV OZONE | 30 60 | 130 200 |
Glyclazide MV PHARMSTANDART | 60 | 215 |
Diabefarm MV | 30 | 145 |
Glidiab MV | 30 | 178 |
Glidiab | 80 | 140 |
Diabetesalong | 30 60 | 130 270 |
Gliklada | 60 | 260 |
Chingalowe m'malo ndi chiyani?
Diabeteson MV ikhoza m'malo mwa mankhwala ena omwe atenga muyezo womwewo komanso mankhwala ena othandizira. Koma pali zinthu monga bioavailability - kuchuluka kwa zinthu zomwe zimakwaniritsa cholinga, i.e. kuthekera kwa mankhwalawa kuzamwa. Kwa ma analogu ena otsika mtengo, ndizochepa, zomwe zikutanthauza kuti mankhwalawa satha ntchito, chifukwa Zotsatira zake, kuchuluka kwake kungakhale kolakwika. Izi zimachitika chifukwa cha kusakhala bwino kwa zinthu zopangira, zinthu zothandizira, zomwe sizimalola kuti chinthu chogwira ntchito chizamasulidwa kwathunthu.
Kuti mupewe mavuto, m'malo onse mumachitika pokhapokha mukaonana ndi dokotala.
Maninil, Metformin kapena Diabeteson - ndibwino?
Kuyerekeza zomwe zili bwino, ndikofunikira kulingalira mbali zoyipa za mankhwalawo, chifukwa Onsewa amafanana ndi matenda amodzimodzi. Zambiri pa mankhwala a Diabeteson MV amaperekedwa pamwambapa, chifukwa chake, Maninil ndi Metformin adzawonedwanso.
Maninil | Metformin |
Kuletsedwa pambuyo resection kapamba ndi zinthu limodzi ndi malabsorption chakudya, komanso matumbo. | Ndizoletsedwa chifukwa chomwa mowa kwambiri, mtima komanso kupuma, magazi m'thupi, matenda opatsirana. |
Kukwera kwakukulu kwa kudzikundikira kwa yogwira thupi m'thupi mwa odwala ndi aimpso. | Mosasamala amakhudza mapangidwe a fibrin kuvala, zomwe zikutanthauza kuwonjezeka kwa nthawi yamagazi. Kuchita opaleshoni kumawonjezera ngozi yotaya magazi kwambiri. |
Nthawi zina pamakhala zowonongeka zowoneka ndi pogona. | Choyipa chachikulu ndikukula kwa lactic acidosis - kudzikundikira kwa lactic acid mu minofu ndi magazi, komwe kumayambitsa kukomoka. |
Nthawi zambiri kumayambitsa kuwoneka kwamatumbo. |
Maninil ndi Metformin ali m'magulu osiyanasiyana a mankhwalawa, chifukwa chake mfundo ndiosiyana kwa iwo. Ndipo iliyonse ili ndi zopindulitsa zake zomwe ndizofunikira kumagulu ena a odwala.
Zabwino:
Maninil | Metformin |
Imathandizira ntchito ya mtima, sikuti imachulukitsa myocardial ischemia mwa odwala matenda amitsempha ya m'matumbo ndi arrhythmia ya ischemia. | Pali kusintha pakulidwe ka glycemic pakukulitsa chidwi cha zotumphukira zama cell kuti insulini. |
Amawerengera chifukwa chosagwira ntchito zina zochokera ku sulfonylurea. | Poyerekeza ndi gulu la zotumphukira za sulfonylurea ndi insulin, hypoglycemia sichimakula. |
Imawonjezera nthawi pakufunika kwa insulini chifukwa chachiwiri cha kusuta kwa mankhwala osokoneza bongo. | Amachepetsa cholesterol. |
Amachepetsa kapena kukhazikika pamanja. |
Ndi pafupipafupi makonzedwe: Diabeteson MV amatengedwa kamodzi patsiku, Metformin - katatu, Maninil - 2-4.
Mtengo mumafakisi
Mtengo wa Diabeteson MV 60 mg umasiyana ndi ma ruble 260. mpaka 380 rub. pa paketi 30 yamapiritsi.
Ndemanga Zahudwala
Katherine. Posachedwa, dokotala wandipatsa Diabeteson MV kwa ine, ndimatenga 30 mg ndi Metformin (2000 mg patsiku). Shuga adatsika kuchokera ku 8 mmol / L mpaka 5. Zotsatira zake zimakhala zokhutira, palibe mavuto, hypoglycemia nawonso.
Valentine Ndakhala ndikumwa diabeteson kwa chaka chimodzi, shuga wanga ali bwinobwino. Ndili pa chakudya, ndikuyenda madzulo. Zinali zakuti ndayiwala kudya nditamwa mankhwalawo, kunjenjemera kunawoneka m'thupi, ndinamvetsetsa kuti kunali hypoglycemia. Ndinkadya maswiti pambuyo pa mphindi 10, ndinamva bwino. Zitachitika izi ndimadya pafupipafupi.