Mankhwalawa angagwiritsidwe ntchito ngati muyezo waukulu wa mankhwala, komanso, ndi njira zina zamkati pamtima. Ichi ndi mankhwala a antihypertensive, koma nthawi yomweyo zinthu zina za pathological zimachotsedwa ndi thandizo lake. Amapangidwa monga mapiritsi. Mankhwala amadziwika ndi dera laling'ono logwiritsira ntchito.
Dzinalo Losayenerana
Losartan.
ATX
C09CA01 Losartan.
Mankhwalawa angagwiritsidwe ntchito ngati muyezo waukulu wa mankhwala, komanso, ndi njira zina zamkati pamtima.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwalawa amapangidwa molimba. Potaziyamu losartan amakhala ngati gawo lalikulu logwira ntchito. Kuphatikizika kwake piritsi limodzi ndi 50 mg. Zinthu zina zosagwira:
- lactose monohydrate;
- ma cellcose a microcrystalline;
- wowuma mbatata;
- povidone;
- magnesium wakuba;
- sodium carboxymethyl wowuma;
- silicon dioxide colloidal.
Mankhwalawa amapangidwa molimba.
Zotsatira za pharmacological
Ntchito yayikulu ya mankhwalawa ndi kuthekera kwachulukitsa magazi. Izi zitha kuperekedwa popewa kupezeka kwa zochitika zolimbitsa thupi zomwe zimayambitsa ndikumanga kwa agonists ndi angiotensin II receptors. Zomwe zimagwiritsidwa ntchito pakupanga kwa blocktran sizikhudza enzyme kinase II, yomwe imathandizira kuwonongeka kwa bradykinin (peptide chifukwa chomwe ziwiya zimakulira, kutsika kwa magazi kumachitika).
Kuphatikiza apo, izi sizikhudza ma receptor angapo (mahomoni, ma ion njira) omwe amathandizira kukulitsa kutupa ndi zotsatira zina. Mothandizidwa ndi losartan, kusintha kwa ndende ya adrenaline, aldosterone m'mwazi amadziwika. Kuphatikiza apo, mankhwalawa amayimira gulu la okodzetsa - amalimbikitsa kuchepa kwa madzi m'thupi. Chifukwa cha mankhwalawa, mwayi wokhala ndi hypertrophy ya myocardial umachepetsedwa, odwala omwe ali ndi vuto losakwanira la mtima amalolera zochitika zolimbitsa thupi.
Ntchito yayikulu ya mankhwalawa ndi kuthekera kwachulukitsa magazi.
Pharmacokinetics
Ubwino wa chida ichi ndi monga kuyamwa mwachangu. Komabe, bioavailability wake ndi wotsika kwambiri - 33%. Mulingo wofunikira kwambiri umatheka pambuyo pa ola limodzi. Pakusintha kwa chinthu chachikulu chogwira ntchito, metabolite yogwira imamasulidwa. Peak ya chithandizo chokwanira kwambiri imatheka pambuyo pa maola 3-4. Mankhwala amalowa m'madzi a m'magazi, chizindikiro cha mapuloteni ake - 99%.
Losartan sasintha pambuyo pa maola 1-2. Metabolite imachoka m'thupi pambuyo pa maola 6-9. Mankhwala ambiri (60%) amawachotsa m'matumbo, ena onse - pokodza. Kudzera m'maphunziro azachipatala, zidapezeka kuti kuchuluka kwa gawo lalikulu m'madzi a m'magazi kumawonjezeka. Mphamvu yayitali kwambiri ya antihypertensive imaperekedwa pambuyo pa masabata 3-6.
Pambuyo pa limodzi mlingo, zotsatira zofunika pa mankhwala zimapezeka pambuyo maola ochepa. Masautso a losartan amayamba kuchepa. Kuchotsa kwathunthu kwazinthu izi kumatenga tsiku limodzi. Pachifukwa ichi, kuti mupeze zofunikira zochizira, ndikofunikira kumwa mankhwala pafupipafupi, kutsatira chiwembu.
Mankhwala ambiri (60%) amawachotsa m'matumbo, ena onse - pokodza.
Zizindikiro zogwiritsidwa ntchito
Wothandizila amamulembera matenda oopsa. Zizindikiro zina zogwiritsa ntchito Blocktran:
- kusakwanira kwa mtima mu mawonekedwe osakhazikika, bola ngati chithandizo cham'mbuyomu ndi ACE inhibitors sichinapereke zotsatira zomwe zingafunikire, komanso ngati milandu yomwe ACE inhibitors imathandizira kukulitsa zotsatira zoyipa ndipo sizingatheke kuzitenga;
- kukhalabe aimpso ntchito matenda a 2 matenda a shuga, kuchepetsa mphamvu ya chitukuko cha kuperewera kwa thupilo.
Chifukwa cha mankhwalawa, pali kuchepa kwa kupezeka kwa ubale wapakati pa matenda a mtima ndi kufa kwake.
Contraindication
Zoletsa kugwiritsa ntchito Blocktran:
- Hypersensitivity ku zilizonse za mankhwala;
- angapo matenda a chibadwa chikhalidwe: lactose tsankho, shuga-galactose malabsorption syndrome, kuchepa kwa lactase.
Wothandizila amamulembera matenda oopsa.
Ndi chisamaliro
Ngati matenda a coronary, impso, mtima kapena chiwindi kulephera (stenosis ya mitsempha ya impso, hyperkalemia, etc.) atapezeka, ndikofunikira kugwiritsa ntchito mankhwalawa moyang'aniridwa ndi dokotala, kuyang'anira thupi mosamala. Pakachitika zovuta, njira ya mankhwalawa imatha kusokonezedwa. Malangizowa akukhudzidwa ndi milandu yomwe angioedema yapanga kapena kuchuluka kwa magazi kwachepetsedwa.
Momwe mungatenge Blocktran
Mlingo wa tsiku ndi tsiku ndi piritsi limodzi lokhala ndi mphamvu ya 50 mg. Ndi matenda oopsa osagwirizana, ndizovomerezeka kuwonjezera kuchuluka uku mpaka 100 mg patsiku. Imagawidwa mu 2 Mlingo kapena kumwa kamodzi patsiku. Muli matenda osiyanasiyana, mankhwalawa tsiku lililonse amakhala ochepa:
- kulephera kwa mtima - 0,0125 g;
- Ndi munthawi yomweyo mankhwala okodzetsa, mankhwala zotchulidwa muyezo osapitirira 0,025 g.
Mwambiri, mankhwalawa amatengedwa sabata limodzi, ndiye kuti mlingo umakulitsidwa pang'ono. Izi ziyenera kupitilizidwa mpaka malire a tsiku lililonse a 50 mg afike.
Mlingo wa tsiku ndi tsiku ndi piritsi limodzi lokhala ndi mphamvu ya 50 mg.
Kumwa mankhwala a shuga
Ndikulimbikitsidwa kuti muyambe kuchiza ndi 0.05 g patsiku. Pang'onopang'ono, mlingo umakulitsidwa ku 0,1 g, koma muyenera kuyang'anira kuchuluka kwa kuthamanga kwa magazi.
Zotsatira zoyipa za Blocktran
Nthawi zambiri, mankhwalawa amalekeredwa bwino. Ngati zizindikiro zoyipa zikuwoneka, nthawi zambiri zimazimiririka zokha, pomwe palibe chifukwa choletsa mankhwalawo. Zotsatira zoyipa za ziwalo zam'maganizo zimatha kukhazikika: kuwonongeka kwamawonekedwe, tinnitus, maso oyaka, vertigo.
Matumbo
Ululu pamimba, chopondapo chovuta, chopondapo chamadzimadzi, chimasintha chimbudzi, kusanza ndi kusanza, kuchuluka kwa mapangidwe a gesi, njira zowonongeka m'mimba, pakamwa kowuma.
Hematopoietic ziwalo
Anemia, ecchymosis, Shenplein-Genoch wofiirira.
Pakati mantha dongosolo
Mutu, chizungulire, kukhumudwa m'maganizo, limodzi ndi kumva kutentha. Kupendekera, kusokera m'malingaliro (kusokonezeka, kuwopsezedwa ndi nkhawa ndi nkhawa), kusokonezeka kwa kugona (kugona kapena kugona tulo), kukomoka, kunjenjemera kwa malekezero, kuchepa kwa chidwi, kukhumudwa kukumbukira, kusokonezeka kwa malingaliro komanso kukhumudwa kumadziwikanso.
Pambuyo kumwa mankhwalawa, pamatha kupweteka m'mimba.
Kuchokera kwamikodzo
Kuwonongeka kwa kugonana mwa amuna, kuvuta kukodza, kukhala wamphamvu kuposa anthu athanzi, kuthana ndi matenda opatsirana.
Kuchokera ku kupuma
Chifuwa, rhinitis, mphuno, kukha magazi. Matenda angapo obwera amatchulidwanso: bronchitis, pharyngitis, laryngitis.
Pa khungu
Kuuma kwambiri pakhungu, kuyabwa, chikomokere, zotupa, kuthothoka kwa tsitsi, zomwe zimayambitsa dazi. Hyperhidrosis, totupa, dermatitis, komanso chidwi chowala pakuwala zimadziwikanso.
Kuchokera ku minculoskeletal system
Myalgia, kupweteka miyendo, kumbuyo, kutupa, kupindika minofu, nyamakazi, arthralgia, fibromyalgia.
Kuchokera pamtima
AV block (2 degrees), myocardial infarction, hypotension yamtundu wina (ochepa kapena orthostatic), kupweteka pachifuwa ndi vasculitis. Ambiri a zochitika zamatenda zimadziwika, limodzi ndi kuphwanya mtima: mtima wa angina pectoris, tachycardia, bradycardia.
Kuchokera pamtima wamatenda, pamatha kukhala kulowerera kwa mtima.
Matupi omaliza
Urticaria, kupuma movutikira chifukwa cha kukulira kwa kupuma kwa thirakiti, anaphylactic reaction.
Zokhudza mphamvu pakuwongolera njira
Palibe zoletsa mwamphamvu pakuyendetsa. Komabe, kusamala kumalangizidwa pankhaniyi chifukwa cha mwayi wokhala ndi ziwopsezo zowopsa (kusokonezeka kwa chikumbumtima, chizungulire, kulowetsedwa kwa myocardial, etc.).
Malangizo apadera
Asanayambe chithandizo, odwala amawonetsedwa kutopa. Ndikofunikira kuwunika pafupipafupi potaziyamu.
Ngati mumwa mankhwalawa panthawi yapakati (mu 2 ndi 3 trimester), chiopsezo cha kufa kwa mwana wosabadwa ndi wakhanda chimawonjezeka. Nthawi zambiri zimachitika ana.
Ngati madzi osunthika a electrolyte asokonekera, mwayi wama hypotension ukuwonjezeka.
Ngati mumwa mankhwalawa panthawi yapakati (mu 2 ndi 3 trimester), chiopsezo cha kufa kwa fetal chimawonjezeka.
Ndi matenda a shuga a 2, hyperkalemia imatha kuchitika.
Ngati wodwala wapezeka ndi hyperaldosteronism yoyamba, mankhwalawo saikidwa, chifukwa pankhaniyi zotsatira zabwino sizingatheke.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Mankhwala ndi oletsedwa kugwiritsidwa ntchito.
Lamulo la Blocktran la Ana
Popeza luso la Blocktran silinatsimikizidwe, ndipo chitetezo chake sichinakhazikitsidwe, muyenera kupewa kumwa mankhwalawa odwala omwe sanathe msinkhu.
Gwiritsani ntchito mu ukalamba
Pankhaniyi, sikofunikira kuchepetsa kuchuluka kwa mankhwalawa.
Mukalamba, sikofunikira kuchepetsa kuchuluka kwa mankhwalawa.
The ntchito aimpso kuwonongeka
Dozi silinawerengeredwe, chifukwa gawo lomwe limagwira ntchito kwa odwala omwe ali ndi matenda a chiwalochi komanso anthu athanzi lili m'magazi momwemonso.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Ngati pali mbiri yachipatala ya chiwalochi, mankhwalawa amayenera kumwedwa moperewera, chifukwa ali ndi chuma chambiri, zomwe zikutanthauza kuti mphamvu yakuchita ikula. Ndi ma pathologies akulu, palibe chochitika chogwiritsidwa ntchito, chifukwa chake ndi bwino kupewa kumwa mankhwalawo.
Blocktran bongo
Zizindikiro zimachitika:
- kuchepa kwamphamvu kwa kuthamanga kwa magazi;
- tachycardia;
- bradycardia.
Mankhwala osokoneza bongo a Blocktran amachititsa tachycardia.
Malangizo othandizira: diuresis, mankhwala omwe cholinga chake ndi kuchepetsa kwambiri kapena kuchotsa kwathunthu mawonekedwe owonetsa. Hemodialysis pankhaniyi siyothandiza.
Kuchita ndi mankhwala ena
Sizoletsedwa kumwa mankhwalawo nthawi yomweyo ndi alactiren ndi othandizira malinga ndi mankhwalawo, ngati wodwala wapezeka ndi matenda a shuga kapena kulephera kwa aimpso.
Sizoletsedwa kukonzekera zomwe zimakhala ndi potaziyamu panthawi ya mankhwala ndi Blocktran.
Palibe zoyipa zomwe zimachitika pakamodzi kugwiritsa ntchito mankhwalawa pogwiritsa ntchito hydrochlorothiazide, warfarin, digoxin, cimetidine, phenobarbital.
Mothandizidwa ndi Rifampicin, kuchepa kwa kugwiritsidwa ntchito kwa mankhwala mu blocktran kumadziwika. Fluconazole amachitanso chimodzimodzi.
Sizoletsedwa kukonzekera zomwe zimakhala ndi potaziyamu panthawi ya mankhwala ndi Blocktran.
Losartan amachepetsa ndende ya lithiamu.
Mothandizidwa ndi NSAIDs, mphamvu ya mankhwala omwe amafunsidwa amachepa.
Ndi matenda a shuga a mellitus komanso kulephera kwa aimpso, ndizoletsedwa kugwiritsa ntchito aliskiren ndi mankhwala ozikidwa pompopompo
Kuyenderana ndi mowa
The yogwira pophika mankhwala amafunsidwa zimabweretsa zovuta ngati ntchito imodzi ndi zakumwa zoledzeretsa.
Analogi
Mawu:
- Losartan;
- Losartan Canon;
- Lorista
- Lozarel;
- Presartan;
- Blocktran GT.
Ndizovomerezeka kuganizira mankhwala aku Russia (Losartan and Losartan Canon) ndi analoques achilendo. Ogwiritsa ntchito ambiri amakonda mankhwala opezeka m'mapiritsi, chifukwa ndiosavuta kugwiritsa ntchito: palibe chifukwa chotsatira malamulo aukhondo pakugwiritsira ntchito mankhwalawa, palibe chifukwa chofunikira pakulamulira, monga momwe zilili ndi yankho. Mapiritsi amatha kutengedwa ndi inu, koma mlingo umawerengedwa ngati mankhwala agwiritsidwa ntchito mwanjira ina.
Kupita kwina mankhwala
Mankhwala omwe mumalandira amaperekedwa.
Kodi ndingagule popanda kulandira mankhwala?
Palibe mwayi wotere.
Mtengo wa Blocktran
Mtengo wake ndi ma ruble 110.
Zosungidwa zamankhwala
Kutentha komwe kotsimikizika kuli mpaka + 30 ° ะก.
Mankhwala omwe mumalandira amaperekedwa.
Tsiku lotha ntchito
Sizoletsedwa kugwiritsa ntchito chida ichi patatha zaka zitatu kuyambira tsiku lopangidwa.
Wopanga
Pharmstandard-Leksredstva, Russia.
Ndemanga za blocktran
Kuunika kwa akatswiri ndi ogula ndi njira yofunika posankha mankhwala. Amaganiziridwa pamodzi ndi zomwe mankhwalawo amapanga.
Madokotala
Ivan Andreevich, katswiri wamtima, Kirov
Mankhwalawa amaletsa ma receptor ena okha, ndipo samakhudza kayendedwe kazinthu zosiyanasiyana zomwe zimatsimikizira kuyendetsa bwino kwa thupi. Mukakhazikitsa, mawonekedwe a wodwalayo komanso kupezeka kwa matenda oyanjana nawo amakumbukiridwa, popeza Blocktran ili ndi zotsutsana zambiri.
Odwala
Anna, wazaka 39, Barnaul
Ndili ndi kuthamanga kwa magazi m'moyo wanga. Ndikudzipulumutsa ndekha ndi chida ichi. Ndipo pamavuto, ndi mankhwala okhawo omwe amawathandiza. Nditathetsa chiwonetsero chachikulu cha matenda oopsa, ndikupitiliza kumwa ma piritsi kuti ndikhale ndi nkhawa nthawi zonse. Zotsatira zake ndi mankhwalawa ndi zabwino kwambiri.
Victor, wazaka 51, Khabarovsk
Ndili ndi matenda ashuga, motero ndikugwiritsa ntchito mankhwalawa mosamala. Mapiritsi amatha kuchepetsa kuthamanga kwa magazi ngati mutatenga mlingo wopitilira womwe umalimbikitsa. Koma pakadali pano sindinapeze njira ina pakati pa mankhwala omwe ali ndi mphamvu zambiri, ndimagwiritsa ntchito Blocktran. Ndinayesanso zakudya zamagulu owonjezera, koma samapereka zotsatira zoyenera konse.
