Momwe mungagwiritsire ntchito mankhwala Amaryl M?

Amaryl M - njira yochepetsera shuga wamagazi. Mankhwala ali ndi extrapancreatic ntchito, amalimbikitsa chinsinsi cha insulin. Perekani kwa odwala omwe ali ndi matenda a shuga 2 omwe amaphatikizidwa ndi zakudya komanso moyo wokangalika.

Dzinalo Losayenerana

Glimepiride + Metformin.

ATX

A10BD02.

Kutulutsa mafomu ndi kapangidwe kake

Kutulutsa mawonekedwe - mapiritsi. Zomwe zimagwira popanga ndi gliperide ndi metformin mu gawo la 1 mg + 250 mg kapena 2 mg + 500 mg.

Amaryl M - njira yochepetsera shuga wamagazi.

Zotsatira za pharmacological

Chidacho chili ndi vuto la hypoglycemic. Mothandizidwa ndi zigawo zikuluzikulu, insulin yochokera m'maselo a beta imatulutsidwa ndikulowera m'magazi. Tiziwopsezo timene timayambitsa chidwi ndi insulin, momwe amapangira shuga kuchokera ku zinthu zopanda mafuta zimayimitsidwa, mulingo wa LDL ndi triglycerides umachepa.

Pharmacokinetics

Kafukufuku wa Pharmacokinetic akuti 100% kumanga kwa glimepiride kumapuloteni a plasma. Ndi kumiza nthawi yomweyo, mayamwidwe ake amayamba kuchepa. Sichikundikira minofu, imapukusidwa mu chiwindi ndikupanga 2 metabolites, imatuluka m'matumbo ndi mkodzo (mawonekedwe a metabolites osagwira).

Metformin imagwira mwachangu komanso mwachangu. Osati biotransformed. Odwala ndi kulephera kwaimpso, amatha kudziunjikira mu minofu. Amathira mkodzo.

Zizindikiro zogwiritsidwa ntchito

Mankhwala amapatsidwa mtundu wa matenda a shuga a 2, ngati shuga sangakhalebe wolimba mothandizidwa ndi zakudya komanso zolimbitsa thupi.

Fomu yotulutsira ndi miyala, magawo omwe amagwira ntchito pophatikizidwa ndi gliperide ndi metformin mu gawo la 1 mg + 250 mg kapena 2 mg + 500 mg.

Contraindication

Kuvomerezeka kwa mankhwalawa kumapangidwa m'njira zina ndi matenda:

• Kulephera kwaimpso ndi zina zomwe zimalepheretsa impso;
• kwambiri matenda a chiwindi ntchito;
• uchidakwa wambiri;
• chikhalidwe pamaso chikomokere kapena chikomokere;
• mtundu 1 matenda a shuga;
• ziwengo kwa sulfonylureas, zigawo zikuluzikulu za mankhwala kapena Biguanides, sulfonamides;
• kulephera kupuma;
• matenda ashuga ketoacidosis, komanso pachimake komanso matenda a metabolic acidosis;
• kulephera kwa mtima;
• myocardial infarction;
• lactic acidosis;
• malungo
• kukhalapo kwa matenda oopsa;
• magazi poyizoni;
• minofu yamatumbo;
• kupsinjika kumbuyo kwa zovulala, kuwotcha, ntchito zovuta, kufa ndi njala;
• matumbo kutsekereza;
• kutsegula m'mimba
• poyizoni thupi ndi mowa;
• kuphwanya kusokonekera kwa shuga mkaka;
• zaka mpaka 18;
• galactosemia;
• mkaka wa m'mimba ndi pakati.

Kulephera kwamkati ndi vuto lina laimpso ndi kuphwanya kutenga Amaril M.

Kutenga Amaril M kumatsutsana ndi uchidakwa.

Ngati mtima wapezeka kuti mwapezeka, ndiye kuti kutenga Amaril M ndizoletsedwa.

Ndi poyizoni wamagazi, ndizoletsedwa kumwa mankhwalawo Amaril M.

Tengani mapiritsi mosamala ngati chithokomiro chikulephera.

Pogwira ntchito zolimbitsa thupi, Amaryl M amatengedwa mosamala.

Sichabwino kutenga Amaril M ndi chakudya chopatsa thanzi.

Mankhwalawa sayenera kuyamba pa hemodialysis.

Ndi chisamaliro

Nthawi zina, kumwa mapiritsi mosamala:

• zakudya zopanda pake;
• kusowa zolimbitsa thupi;
• chithokomiro chithokomiro;
• shuga-6-phosphate dehydrogenase akusowa;
• kukhalapo kwa matenda omwe amalumikizitsa njira ya matenda a shuga a 2;
• kulimbikira ntchito.

Mukakalamba, muyenera kuigwiritsa ntchito moyang'aniridwa ndi dokotala.

Momwe mungatenge Amaryl M

Mankhwala a pakamwa makonzedwe ayenera kumwedwa ndi chakudya. Kudumpha mosapatsa mlingo sikuyenera kupititsa patsogolo kuchuluka.

Ndi matenda ashuga

Mlingo watsimikiza ndi dokotala potengera kuchuluka kwa shuga m'magazi. Imwani mankhwala 1-2 pa tsiku. Mulingo waukulu ndi mapiritsi 4 patsiku.

Zotsatira zoyipa Amarila M

Mankhwalawa amalekeredwa bwino, koma nthawi zina amatha kuyambitsa mavuto kuchokera ku ziwalo zosiyanasiyana.

Mu shuga mellitus, mlingo amatsimikiza ndi dokotala potengera kuchuluka kwa shuga m'magazi.

Pa mbali ya ziwalo zamasomphenya

Pali kuwonongeka kwamawonedwe owonekera chifukwa cha kusinthasintha kwa kuchuluka kwa shuga m'magazi.

Matumbo

Zizindikiro zakugaya kwam'mimba: kusowa kwa chilakiko, kupuma kosakhazikika, mseru, kusanza, kupweteka pamimba, kuchuluka kwa mpweya.

Hematopoietic ziwalo

Kumwa mapiritsi kumatha kubweretsa kukula kwa pancytopenia (kuchepa kwa zinthu zofunika m'magazi a magazi), komanso thrombocytopenia, aplastic anemia ndi leukopenia.

Kuchokera kumbali ya kagayidwe

Zizindikiro zitha kuchitika zomwe zikuwonetsa kuchepa kwa kuchuluka kwa shuga m'magazi: migraine, chizungulire, thukuta, kuthamanga kwa magazi, tachycardia, kudzipereka kwa minofu, kunjenjemera, kusowa chidwi, kugona.

Pali kuwonongeka kwamawonedwe owonekera chifukwa cha kusinthasintha kwa kuchuluka kwa shuga m'magazi.

Zizindikiro zoyipa za m'mimba zomwe zimapezeka: kutaya chilimbikitso, kupumira pansi, nseru, kusanza.

Kumwa mapiritsi kungachititse kuti pancytopenia, komanso thrombocytopenia, aplastic anemia ndi leukopenia.

Zizindikiro zitha kuchitika zomwe zikuwonetsa kuchepa kwa magazi m'magazi a shuga: migraine, chizungulire.

Thukuta lamphamvu limawonetsa zotsatira za mankhwalawa Amaril M.

Zotsatira zoyipa zitha kuwoneka ngati uritisaria, totupa.

Mankhwala amatha kubweretsa kukula kwa hypoglycemia, chifukwa chake sikulimbikitsidwa kuyendetsa zinthu zovuta panthawi yamankhwala.

Matupi omaliza

Pali urticaria, zotupa. Mwakamodzikamodzi, vutoli limakhala lovuta chifukwa cha mantha anaphylactic.

Zokhudza mphamvu pakuwongolera njira

Mankhwala amatha kubweretsa kukula kwa hypoglycemia, chifukwa chake sikulimbikitsidwa kuyendetsa zinthu zovuta panthawi yamankhwala.

Malangizo apadera

Ndi kulephera kwa aimpso ndi matenda a chiwindi, lactic acid imatha kudziunjikira m'magazi ndipo zimakhala (lactic acidosis). Ndi kuchepa kwa kutentha kwa thupi, kupweteka kwam'mimba komanso kupuma movutikira, muyenera kusiya kumwa mankhwalawo. Imitsani kwakanthawi chithandizo musanachite opareshoni.

Pa mankhwala, tikulimbikitsidwa kuwunika kuchuluka kwa shuga m'magazi kuti mupewe kukula kwa hypoglycemia. Chofunikanso kwambiri ndikuwongolera kwa ndende ya hemoglobin, creatinine ndi vitamini B12. Kuthandizira glycemia pogwiritsa ntchito masewera olimbitsa thupi, zakudya.

Gwiritsani ntchito mu ukalamba

Chisamaliro chikuyenera kuonedwa kuti chikuyang'anira ntchito ya impso.

Kupangira Amaril M kwa ana

Mu ana osakwana zaka 18 ndi zoletsedwa.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Iwo contraindicated kuti ayambe mankhwala pa mimba ndi mkaka wa m`mawere. Kuyamwitsa kuyenera kuyimitsidwa.

The ntchito aimpso kuwonongeka

Kuchepa kwambiri kwaimpso komanso milingo yokwezeka ya satinine sikumadziwika.

Gwiritsani ntchito ntchito yolakwika ya chiwindi

Mophwanya kwambiri, ntchito ya chiwindi sichimasankhidwa.

Mukalamba, Amaryl M amayenera kutengedwa moyang'aniridwa ndi dokotala.

Mwa ana osakwana zaka 18, kutenga Amaril M ndizoletsedwa.

Amakanizidwa kuti ayambe mankhwala ndi Amaril M pa nthawi ya pakati.

Mukamamwa Amaril M, kuyamwitsa kuyenera kuyimitsidwa.

Aphwanya kwambiri chiwindi, Amaryl M sanalembedwe.

Overdose wa Amaril M

Mankhwala osokoneza bongo amatsogolera pakukula kosiyanasiyana ndi kukula kwa hypoglycemia. Zizindikiro za hypoglycemia zimayimitsidwa ndi shuga. Mankhwala othandizira amachita.

Kuchita ndi mankhwala ena

Mankhwala amakhudzana ndi mankhwala ena motere:

• kugwiritsa ntchito munthawi yomweyo kwa inducers kapena zoletsa za CYP2C9, ma tetracyclines, azapropazone, antimicrobial othandizira a gulu la quinolone, tritokvalin, Mao inhibitors ndi ACE inhibitors, fluconazole, coumarin anticoagulants, phenenecid, anabolic steroid, fenflaculin, fenflaculin, fenflaculin, fenflaculin, fenfidulin. tritokvalina, beta-blockers, aminosalicylic acid kumabweretsa kukula kwa hypoglycemia;
• sikofunikira kusakaniza makonzedwe a x-ray ndi kugwiritsa ntchito zinthu zomwe zimakhala ndi ayodini;
• nifedipine ndi furosemide kumawonjezera ndende ya Metformin m'magazi;
• kutenga histamine H2 receptor blockers, clonidine ndi reserpine kungayambitse hyperglycemia kapena hypoglycemia;
• ibuprofen sichikhudza magawo a pharmacokinetic;
• kuchepa kwa zotsatira za hypoglycemic kumatha kuchitika mchikakamizo cha okodzetsa, epinephrine, nicotinic acid, acetazolamide, diazoxide, estrogens, rifampicin, barbiturates, sympathomimetics, corticosteroids, mankhwala othandizira, phenytoin, mahomoni a chithokomiro.

Kuphatikiza apo, makonzedwe omwe munthawi yomweyo amakhala ndi mankhwalawa ayenera kupewedwa.

Kugwiritsa ntchito pamodzi kwa inducers kapena zoletsa za CYP2C9, ma tetracyclines, azapropazone kumabweretsa chitukuko cha hypoglycemia.

Ibuprofen sichikhudza magawo a pharmacokinetic.

Sikoyenera kuphatikiza makonzedwe a x-ray ndi kugwiritsa ntchito zinthu zomwe zimakhala ndi ayodini.

Chifukwa cha chiwopsezo cha hypoglycemia, kugwiritsa ntchito limodzi ndi mowa kumatsutsana.

Kuyenderana ndi mowa

Ethanol amatha kuwonjezera kapena kufooketsa mphamvu ya mankhwalawo. Chifukwa cha chiwopsezo cha hypoglycemia, kugwiritsa ntchito limodzi ndi mowa kumatsutsana.

Analogi

Mu mankhwala mungagule mankhwala ena a hypoglycemic ophatikizika:

• Glucovans.
• Glimecomb.
• Galvus Met.

Musanagwiritse ntchito, muyenera kufunsa dokotala kuti muchepetse kupezeka kwa mavuto.

Kupita kwina mankhwala

Yoperekedwa ndi mankhwala.

Kodi ndingagule popanda kulandira mankhwala?

Mutha kugula mukapereka mankhwala kwa dokotala.

Pamankhwala mutha kugula mankhwala ena a hypoglycemic omwe akuphatikizidwa, mwachitsanzo, a Glucovans.

Mtengo wa Amaryl M

Mtengo wa ma phukusi umachokera ku 800 mpaka 900 ma ruble.

Zosungidwa zamankhwala

Sungani mapiritsi m'malo otentha kwambiri mpaka kutentha + mpaka 25 ° C.

Tsiku lotha ntchito

Moyo wa alumali ndi zaka zitatu.

Wopanga

Handok Pharmaceuticals Co, Ltd., Korea.

Ndemanga za Amarila M

Anna Kazantseva, wothandizira

Njira ya mankhwalawa ndikutseka njira ndi potaziyamu ndikutsegula njira za calcium. Nthawi yomweyo, insulini imamasulidwa yaying'ono kuposa momwe amachokera ku zinthu zina za sulfonylurea. Chifukwa chake, chiwopsezo cha kukhala ndi hypoglycemia chimachepetsedwa.

Anatoly Romanov, endocrinologist

Zigawo za mankhwala zimaphatikizana bwino kwambiri. Chuma cha hypoglycemic cha metformin chimadziwonetsa pakumasulidwa kwa insulin m'maselo a beta. Metformin imathandizira mphamvu ya glimepiride ndipo imatsogolera kuchepa kwa cholesterol "yoyipa" m'magazi ndi triglycerides. M'pofunika kumwa mankhwala mosamala vuto la chithokomiro cha chiwindi ndi chiwindi.

Eugene, wazaka 38

Chida chimathandizira kuwongolera shuga. Ndimamwa piritsi limodzi m'mimba yopanda kanthu m'mawa ndipo sindingadandaule tsiku lonse. Ndinasinthira ku mankhwala ophatikiza monga adanenera dokotala. Chifukwa cha zotsatira zoyipa, chifukwa cha kusinthasintha kwa glucose m'magazi, mawonekedwe amawonongeka, nthawi zina amasanza. Popita nthawi, zizindikirizo zinazimiririka. Ndine wokhutira ndi zotsatira zake ndipo ndikupitiliza kulandira mankhwalawa.