Mulingo wa insulin m'magazi mwa anthu

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Chikondamoyo ndi gawo la endocrine. Gawo lirilonse la iwo limatulutsa mahomoni ake, omwe amafunikira munthu.

M'maselo a beta a thupi, insulin imapangidwa - timadzi timene timagwira ntchito zambiri zofunika mthupi.

Kuperewera kwake, komanso mopitilira muyeso, kumabweretsa matenda osiyanasiyana.

Tanthauzo ndi ntchito zazikulu za insulin

Poyamba, kapamba amapanga timadzi tomwe timagwira. Kenako, podutsa magawo angapo, amapita kukonzekera. Pulogalamu yamapuloteni ndi mtundu wa fungulo lomwe glucose amalowerera minofu yonse ndi ziwalo zonse.

Glucose amalowa muubongo, maso, impso, mitsempha ya adrenal ndi mitsempha yamagazi yopanda insulin. Ngati sikokwanira m'magazi, ndiye kuti ziwalo zimayamba kupanga shuga ochulukirapo, motero zimadziwonetsa kupsinjika kambiri. Ndiye chifukwa chake mu shuga, ziwalozi zimawerengedwa kuti "zotha" ndipo zimakhudzidwa koyamba.

Tiziwalo totsala timadutsa glucose kokha ndi insulin. Mukakhala pamalo oyenera, glucose amasinthidwa kukhala mphamvu ndi minofu. Homoni imapangidwa mosalekeza tsiku lonse, koma pakudya, zotulukazo zimakhala zochulukirapo. Izi ndikuti tilewe shuga.

Ntchito za Insulin:

  1. Zimathandizira shuga kulowa mkati mwa minofu ndikupanga mphamvu.
  2. Kuchepetsa katundu pachiwindi, komwe amapanga shuga.
  3. Zimalimbikitsa kulowerera kwa ma amino acid ena mu minofu.
  4. Amatenga nawo kagayidwe, makamaka kagayidwe kazakudya.
  5. Ntchito yayikulu ya chinthu ndi hypoglycemic. Kuphatikiza pa chakudya chomwe anthu amadya, thupi limapanganso mahomoni ambiri omwe amalimbikitsa kuchuluka kwa shuga m'magazi. Izi zimaphatikizapo adrenaline, mahomoni okula, glucagon.

Kuzindikira ndi chizolowezi molingana ndi zaka

Kuti mudziwe kuchuluka kwa mahomoni anu, ndikofunikira kukonzekera bwino magazi.

Kukonzekera kusanthula:

  1. Magazi ayenera kumwedwa pamimba yopanda kanthu.
  2. Tsiku lotsatira liyenera kukhala chakudya chamadzulo, pafupifupi maola 8 musanayesedwe.
  3. M'mawa amaloledwa kumwa madzi owiritsa.
  4. Brush ndi rinsing sizikulimbikitsidwa.
  5. Masabata awiri musanafike mayeso, wodwalayo ayenera kusiya kumwa mankhwala onse. Kupanda kutero, adotolo ayenera kuwonetsa chithandizo chomwe munthu akalandira.
  6. Masiku angapo musanafike mayeso, ndikofunikira kukana zakudya zovulaza: mafuta, okazinga, osankhidwa ndi mchere, komanso zakumwa zoledzeretsa ndi chakudya mwachangu.
  7. Tsiku lisanafike phunziroli, muyenera kudzitchinjiriza pamasewera ndi pazovuta zambiri.

Zotsatira zomwe zimapezeka mukamayesa magazi a insulin sizingatheke popanda kuyesa magazi. Zizindikiro zonse ziwiri zokha zimapereka chithunzi chonse cha thupi. Pachifukwa ichi, wodwalayo amakumana ndi zovuta komanso mayeso oyipitsa.

Kuyesedwa kwa nkhawa kumawonetsa momwe insulin imayankhira mwachangu mu glucose yemwe amalowa m'magazi. Ikachedwa, kuzindikira kwa matenda am'mbuyomu kumakhazikitsidwa.

Kuyesaku kumachitika motere. Mimba yopanda kanthu imatenga magazi kuchokera mu mtsempha. Kenako wodwalayo amamwa shuga wina wabwino. Kukonzanso shuga kwa magazi kumapangidwa patatha maola awiri mutachita masewera olimbitsa thupi.

Tebulo la kuwunika zotsatira:

Pamimba yopanda kanthu
NormOsakwana 5.6 mmol / l
Matenda a glycemia5.6 mpaka 6.0 mmol / L
Matenda a shugaWokwezeka kwambiri kuposa 6.1 mmol / l
Pambuyo 2 maola
NormZochepera 7.8 mmol / l
Kuleza mtimaKuyambira 7.9 mpaka 10.9 mmol / L
Matenda a shugaPamwamba pa 11 mmol / L

Chiyeso choyambitsa kapena kuyesa ndi njala chimakhala choposa tsiku limodzi. Choyamba, wodwalayo amapereka magazi pamimba yopanda kanthu. Kenako samadya kanthu tsiku lina, ndipo nthawi ndi nthawi amapereka magazi. Zizindikiro zomwe zimatsimikizidwa mu zitsanzo zonse: insulin, glucose, C-peptide. Mwa amayi ndi abambo, chizolowezi chimakhala chimodzimodzi.

Gome lounikira zotsatira za kuchuluka kwa insulin m'magazi:

M'badwo ndi chikhalidweMitundu (μU / ml)
Mwana wosakwana zaka 12Mpaka 10
Munthu wathanzikuyambira 3 mpaka 25
Mkazi woyembekezera6-27
Mdalampaka 35

Kodi okwera amati chiyani?

Hyperinsulinemia nthawi zambiri imawonedwa pakudya. Koma ngakhale zili choncho, mulingo wake suyenera kupitilira malire.

Miyezo yambiri ya mahomoni m'magazi imakhala ndi zotsatirazi:

  • kumangokhalira kumva njala, limodzi ndi nseru;
  • kukoka kwamtima;
  • thukuta kwambiri;
  • manja akunjenjemera;
  • kukhumudwa pafupipafupi.

Matenda omwe amaphatikizidwa ndi kuwonjezeka kwa insulin m'magazi:

  1. Insulinoma - chisonyezo ya kapamba. Zimakhudzanso zisumbu za Langerhans komanso zimapangitsa kupanga insulin yambiri. Popanga matenda amtunduwu, wodwalayo amapatsidwa mankhwala opangira opaleshoni. Kuchotsa chotupacho, anthu 8 mwa khumi amachira kwathunthu.
  2. Shuga mtundu 2 shuga. Cholinga chake chachikulu ndikukula kwa insulin. Maselo amasiya kumva kukhudzidwa kwa mahomoni ndikuwonetsa kwa kapamba kuti mulibe magazi pang'ono. Amayamba kuphatikiza mahomoni ambiri, omwe amachititsa hyperinsulinemia.
  3. Acromegaly kapena gigantism. Matendawa amaphatikizidwa ndikupanga mahomoni ambiri okula.
  4. Cushing's Syndrome limodzi ndi kuchuluka kwa glucocorticosteroids m'mwazi, poyankha izi, kapamba amatulutsa timadzi tambiri tambiri.
  5. Polycystic Ovary - Nthenda yodziwika ndi kuperewera kwa mahomoni m'thupi, zomwe zimapangitsa kukula kwa mahomoni m'magazi. Hyperinsulinemia ndiyomwe imayambitsa kulemera kwambiri, kuthamanga kwa magazi, cholesterol yambiri, komanso kukula kwa zotupa, chifukwa mahomoni amalimbikitsa kukula kwawo.
  6. Kunenepa kwambiri Nthawi zina, zimakhala zovuta kudziwa ngati matendawa ndi chifukwa cha kuchuluka kwa mahomoni m'magazi kapena chifukwa chake. Ngati poyamba pali insulini yambiri m'magazi, munthu amakhala ndi vuto lanjala, amadya kwambiri ndipo amayamba kulemera kwambiri. Mwa anthu ena, kunenepa kwambiri kumayambitsa kukana insulini, chifukwa chomwe hyperinsulinemia imayamba.
  7. Matenda a chiwindi.
  8. Mimba Itha kuchitika popanda zovuta, koma ndi chidwi chambiri.
  9. Fructose ndi Galactose Kusagwirizanacholowa.

Ngati hyperinsulinemia yapezeka, muyenera kuyang'ana chomwe chimayambitsa matendawa, chifukwa palibe mankhwala omwe angachepetse kuchuluka kwa mahomoni.

Kuti muchepetse chizindikiro, tikulimbikitsidwa:

  • Idyani katatu patsiku osagwiritsa;
  • konzani tsiku losala kudya kamodzi pa sabata;
  • sankhani zakudya zoyenera, gwiritsani ntchito zakudya zokhala ndi chindapusa chochepa komanso chapakati;
  • masewera olimbitsa thupi;
  • CHIKWANGWANI chiyenera kupezeka mu chakudya.

Zotsatira za kusowa kwa mahomoni

Pali mtheradi ndi insulin kuchepa. Kukwanira kwathunthu kumatanthauza kuti kapamba satulutsa timadzi tating'onoting'ono ndipo munthu amakula matenda amtundu woyamba.

Kusakwanira kwachibale kumayamba pamene mahomoni m'magazi amapezeka mokhazikika kapena mopitilira muyeso, koma samatengedwa ndi maselo amthupi.

Hypoinsulinemia ikuwonetsa chitukuko cha matenda a shuga 1. Ndi matendawa, zisumbu za ma Langerhans a kapamba zimakhudzidwa, zomwe zimayambitsa kuchepa kapena kutha kwa kupanga kwa mahomoni. Matendawa ndi osachiritsika. Kwa moyo wabwinobwino, odwala amapatsidwa jakisoni wautali wa insulin.

Zoyambitsa hypoinsulinemia:

  1. Zinthu zamtundu.
  2. Kuzunza. Kudya zophika nthawi zonse ndi maswiti kungapangitse kuchepa kwa kupanga kwa mahomoni.
  3. Matenda opatsirana. Matenda ena amakhala ndi zowononga pama zisumbu za Langerhans, zomwe zimapangitsa kuchepa kwa kupanga kwa mahomoni.
  4. Kupsinjika Mitsempha yambiri ya m'magazi imakhala ndi shuga wambiri, motero insulin m'magazi imatha kugwa.

Mitundu ya Artificial Insulin

Odwala ndi matenda a shuga amatchulidwa subcutaneous makonzedwe a timadzi.

Zonsezi zimagawidwa potengera nthawi yochita:

  • Degludec amatanthauza insulin zazitali kwambiri, zomwe zimakhala maola 42;
  • Glargin amakhala ndi nthawi yayitali ndipo amakhala kwa maola 20 mpaka 36;
  • Humulin NPH ndi Bazal ndi mankhwala a nthawi yayitali, zotsatira zawo zimangoyambira maola atatu pambuyo pa jekeseni ndikutha pambuyo pa maola 14.

Mankhwalawa amadziwika kuti ndiwo maziko othandizira odwala matenda ashuga. Mwanjira ina, wodwalayo amapatsidwa mankhwala oyenera, omwe amaba jakisoni kamodzi kapena kawiri pa tsiku. Jakisoniyu sakukhudzana ndi zakudya zomwe amapeza.

Pazakudya, wodwala amafunika jakisoni wamfupi ndi wa ultrashort:

  1. Oyamba akuphatikiza Actrapid NM, Insuman Rapid. Pambuyo pa jakisoni, timadzi timene timayamba kugwira ntchito m'mphindi 30-45, ndikutsiriza ntchito yake patatha maola 8.
  2. Ultrashort jakisoni Humalog ndi Novorapid amayamba zochita zawo mphindi zochepa atabayidwa ndikugwira ntchito kwa maola 4 okha.

Tsopano, pochiza matenda amtundu wa shuga 1, mankhwalawa a nthawi yayitali ndi ultrashort amagwiritsidwa ntchito. Jekeseni woyamba mwa wodwala ayenera kukhala atangodzuka nthawi yayitali - kuchitapo kanthu kwa nthawi yayitali. Nthawi zina anthu amasintha jakisoniyo masana kapena madzulo, kutengera mtundu wa moyo ndi chidwi cha munthu payekha.

Insulin yochepa imayikidwa pamaso pa chakudya chachikulu, katatu pa tsiku. Mlingo amawerengedwa payekhapayekha kwa wodwala aliyense. Wodwala wodwala matenda ashuga azitha kuwerengetsa kuchuluka kwa mkate ndi mndandanda wa glycemic, ndipo amafunikiranso kudziwa kuchuluka kwa insulini ku mkate umodzi.

Mwachitsanzo, ngati mulingo wake uli pa 1: 1, ndiye kuti izi zikutanthauza kuti pakudya m'mawa m'magawo 5 a mkate wodwalayo amayenera kudula magawo asanu. Ngati kuchuluka kwake ndi 1: 2, ndiye kuti pa kadzutsa komweko munthu ayenera kubayidwa mayunitsi 10 kale. Zonsezi zimasankhidwa mosiyanasiyana payekhapayekha kwa wodwala aliyense.

Amakhulupirira kuti kuchuluka kwakukulu kwamahomoni m'mawa, ndipo pofika madzulo amachepetsa. Koma musatenge mawu awa ngati axiom. Thupi la munthu aliyense payekha, motero, wodwalayo ayenera kuthana ndi kusankha kwa mankhwalawa limodzi ndi endocrinologist. Kuti muphunzire thupi lanu mwachangu ndikusankha mlingo woyenera, muyenera kukhala ndi cholembera chodziletsa.

Aliyense ayenera kusamalira yekha zaumoyo. Ndi thanzi labwino, kuyesako kuyenera kuchitika kamodzi pachaka. Ngati muli ndi zizindikiro zilizonse za matendawa, muyenera kufunsa dokotala kuti akumuyezeni. Kuzindikira kwakanthawi kumathandizira kukhala wathanzi komanso kupewa kutulutsa zovuta zazikulu.

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