Malangizo tsatanetsatane wa mankhwala Glucofage - momwe angatengere kuti muchepetse kulemera ndikulembetsa matenda a shuga a 2?

Glucophage ndi mankhwala osokoneza bongo a hypoglycemic, omwe amaphatikiza metformin, chinthu chomwe chimatulutsa antidiabetesic.

Yogwira pophika mankhwala amachotsa hyperglycemia popanda kuchepa kwa pathological shuga. Simalimbikitsa insulin kupanga ndi hypoglycemic boma mwa athanzi.

Imathandizira kukonzanso kwa receptor ku peptide timadzi ndipo imathandizira kukonza kwa chakudya chosavuta. Imachepetsa kupanga shuga pang'onopang'ono pang'onopang'ono kagayidwe ndi kuphwanya kwa glycogen. Amalepheretsa mayamwidwe osavuta a chakudya chokwanira ndi m'mimba.

Metformin imayendetsa glycogeneis, imawonjezera kuchuluka kwamapuloteni a shuga, mtundu wa metabolidi ya lipid. Chifukwa chotenga Glucofage, kulemera kwa wodwalayo kumachepera. Kafukufuku watsimikizira prophylactic antidiabetic katundu wa Glucophage mwa anthu omwe akupitiliza kuwonjezeka kwa shuga wamagazi komanso zinthu zina zomwe zingayambitse ngozi.

Mankhwalawa akuwonetsedwa kwa odwala omwe, atasintha momwe amakhalira moyo wawo, sanafike pamlingo wawo wabwinobwino. Momwe mungatengere Glucofage kuti mupewe mankhwala osokoneza bongo ambiri komanso zoyipa zitha kupezeka pazambiri zomwe zaperekedwa pansipa.

Mawonekedwe ndi kipimo

Gawo lokangalika la mankhwalawa limakhala ndi metformin hydrochloride, ochepa maselo olemera polyvinylpyrrolidone, magnesium stearate.

Mapiritsi a Glucophage

Ponseponse, mapiritsi oyera a biconvex a 500 ndi 850 mg amaphatikizidwa ndi filimu ya hypromellose. Unyinji woyera oyera ukupezeka pamtanda.

Oval, mapiritsi oyera a 1000 mg oyera omwe ali ndi mbali zonse ziwiri ali ndi filimu ya opadra, mzere wogawa ndi mawu olembedwa "1000".

Zizindikiro zogwiritsidwa ntchito

Chithandizo chogwira mankhwalawa chimasintha kagayidwe ka mafuta, chimathandizira kuthetsa lipoprotein atherogenic ndi cholesterol.

Zizindikiro zazikulu zogwiritsa ntchito mankhwalawa ndi izi:

• matenda osagwirizana ndi shuga omwe amachititsa kuti munthu azinenepa kwambiri komanso osapeza zotsatira zamagulu azakudya kapena ntchito zolimbitsa thupi;
• odwala akulu ndi ana opitirira zaka 10 ngati njira yodziyimira payokha ya matenda a shuga a 2 kapena limodzi ndi mankhwala ena ochepetsa shuga;
• kupewa matenda a shuga a 2 m'malire a malire.

Contraindication

Monga mankhwala onse amachokera ku mankhwala, glucophage ali ndi malire.

Kumwa mankhwalawo ndizoletsedwa motere:

• Hypersensitivity kuti metformin, zinthu zina za mankhwala;
• chikhalidwe cha hyperglycemia, ketoanemia, precoma, chikomokere;
• zinchito aimpso matenda;
• kusintha kwa mchere wamchere;
• zotupa zopatsirana;
• kulephera kwakukulu kwa kayendedwe ka kayendedwe ka moyo;
• kuphwanya kusinthanitsa kwa mpweya m'mapapo;
• decompensated myocardial dysfunction ndi magazi osakhazikika;
• pachimake ischemic necrosis;
• ntchito zochulukirapo ndi kuvulala komwe kumafuna chithandizo cha insulin;
• magwiridwe antchito a chiwindi;
• mankhwala osokoneza bongo osagwirizana ndi zakumwa zoledzeretsa za ethanol;
• mimba
• kuchuluka magazi lactate;
• gawo la scintigraphy kapena radiology ndikuyambitsa mankhwala osiyana okhala ndi ayodini;
• kutsatira zakudya zochepa zopatsa mphamvu.

Glucophage imagwiritsidwa ntchito mosamala pazinthu zotsatirazi:

• kuchita masewera olimbitsa thupi atakalamba, komwe kungayambitse mapangidwe a lactic acidosis;
• aimpso kuwonongeka;
• Nthawi yonyamula mkaka.

Mlingo ndi njira yothandizira matenda ashuga

Mukakhala m'matumbo am'mimba, metformin imalowetsedwa kwathunthu.

Mtheradi bioavailability ukufika 60%. Pazitali ya plasma ndende imawonedwa patatha maola awiri atatha ntchito.

Kugwiritsa ntchito nthawi yomweyo kumachedwetsa kuyamwa kwa chinthucho. Metformin imadzaza matupi popanda mapuloteni.

Mankhwala a hypoglycemic amakhala ndi mphamvu yofooka. Imafufutidwa chifukwa cha kusefukira kwa impso ndi katulutsidwe ka njira. Kutha kwa theka-moyo ndi maola 6.5. Zovuta za impso zimawonjezera nthawi, zimayambitsa chiwopsezo chokhala ndi mankhwala.

Mankhwalawa amagwiritsidwa ntchito tsiku lililonse, osapumira.Kwa akuluakulu, kuchuluka koyamba tsiku lililonse kwa chinthucho - 500 kapena 850 mg amagawidwa pawiri kapena katatu. Imadyedwa ndi chakudya kapena itatha. Pakatha masabata awiri aliwonse, kuchuluka kwa shuga wamagazi kumayang'aniridwa. Kutengera ndi zomwe zapezedwa, kukonza kumachitika.

Kuwonjezeka kwapang'onopang'ono kwa mlingo kumalepheretsa zotsatira zoyipa za m'mimba. Mankhwala omwe amaperekedwa tsiku lililonse ndi 1500-2000 mg. Mlingo wovomerezeka ndi 3000 mg. Imagawidwa m'njira zitatu.

Kwa odwala omwe amagwiritsa ntchito metformin mu 2000-3000 mg tsiku lililonse, ndikofunika kusintha kuti mapiritsi a 1000 mg. Voliyumu ya tsiku ndi tsiku imagawidwa panjira zitatu.

Kuphatikiza kwa mankhwala omwe ali ndi insulin kumathandizira kuyendetsa shuga m'magazi. Chiwerengero choyamba cha mankhwalawa ndi 850 mg. Iagawika pawiri pa 2-3. Mlingo wa mahomoni a peptide amasankhidwa malinga ndi shuga m'magazi.

Glucophage amalembera ana azaka zopitilira 10. Kugwiritsanso ntchito kwa insulin ndikuloledwa. Voliyumu yoyambira tsiku lililonse ndi 500 kapena 850 mg. Tengani 1 nthawi patsiku chakudya kapena mutatha kudya. Pambuyo pa masabata awiri, kukonza chithandizo kumachitika. Kuchuluka kwatsiku ndi tsiku - 2000 mg amagawidwa pamtundu wa 2-3.

Zotsatira zoyipa

Nthawi zina glucophage imayambitsa zosakhudza thupi. Izi ndizotheka kupewa:

• lactic acidosis;
• kuyamwa kosakwanira kwa vitamini B 12;
• kusowa kwa masoka akumva;
• kuwonda m'mimba, kusanza, matumbo pafupipafupi, kupweteka kwam'mimba;
• kusintha kwa magawo a chiwindi, hepatitis.

Kafukufuku wazaka zapakati pa ana kuyambira zaka 10 mpaka 16 atsimikizira kupezeka kwa zotsatirapo zoyipa zomwe zimachitika mwa odwala akuluakulu.

Bongo

Kuchulukitsa kwakukulu kwa mulingo waukulu kapena zochitika zina zimabweretsa kuwonjezeka kwa lactate. Maonekedwe a kuwonjezeka kwa lactic acid kumafuna kuyimitsa chithandizo, kuchipatala mwachangu njira yoyeretsera magazi ndi chithandizo chamankhwala.

Kuyamwa kwa mowa

Kugwiritsa ntchito pamodzi mankhwala antidiabetesic ndi Mowa sikulimbikitsidwa.

Kuledzera kwa mowa kumayambitsa lactic acidosis pazinthu zotsatirazi:

• Zakudya zokwanira
• zakudya zochepa zopatsa mphamvu;
• magwiridwe antchito a chiwindi.

Mimba komanso kuyamwa

Kuperewera kwa mankhwala a antidiabetic munthawi yobereka mwana kumakhala chifukwa cha kusinthika kwa chiberekero cha mwana wosabadwayo ndi kufa kwa nthawi ya bere.

Zambiri pazakuwonjezereka kwa kuchepa kwa makanda pomwe amayi oyembekezera akutenga Glucofage sizikupezeka.

Ngati mayi wapezeka ndi pakati kapena ngati akukonzekera kukhala ndi pakati, mankhwalawo amachotsedwa. Metformin imadutsa mkaka wa m'mawere.

Zotsatira zoyipa za mankhwalawa mwa akhanda sizinadziwikebe, koma kuchuluka kwazomwe kumawonetsa kukugwiritsidwa ntchito kosayenera kwa nthawi imeneyi.

Zochita Zamankhwala

Kuphatikizidwa kowopsa ndikugwiritsa ntchito metformin yokhala ndi zinthu za radiopaque zokhala ndi ayodini. Poyerekeza ndi maziko a matenda a impso, kuphunzira koteroko kumathandizira kukulitsa lactic acidosis.

Kugwiritsa ntchito mankhwalawa kumatha masiku awiri kafukufukuyu asanachitike. Kuyambiranso pambuyo pa maola 48 pansi pa ntchito yachibadwa.

Kuphatikiza kwa Glucophage ndi mankhwala omwe alembedwa pansipa akuwonetsedwa motere:

• Danazole amakwiya ndi hyperglycemic zotsatira za metformin;
• Chlorpromazine mu voliyumu yayikulu imachulukitsa kuchuluka kwa chakudya chambiri, kumachepetsa kutulutsa kwa peptide timadzi;
• analoguo wa amkati amkaka amachepetsa kuchuluka kwa glucose, amachititsa kuphwanya kwamafuta osungidwa;
• diuretics kumapangitsa lactic acidosis pamaso pa zinchito aimpso kulephera;
• jakisoni wa beta2-adrenergic agonists kuwonjezera kuchuluka kwa shuga m'magazi;
• antihypertensive mankhwala, kupatula ACE blockers, kuchepetsa kuchuluka kwa shuga;
• munthawi yomweyo kugwiritsa ntchito mankhwala ndi sulfonylurea zotumphukira, ma peptide mahomoni, alpha-glucosidase zoletsa, salicylates amakhumudwitsa hypoglycemia;
• Nifedipine imawonjezera njira ya mayamwidwe yogwira mankhwala;
• cationic antibacterial othandizira amapikisana ndi metformin yama cell kayendedwe ka ma cell, kumawonjezera kuchuluka kwake.

Migwirizano yogulitsa ndikusunga

Mankhwala amaperekedwa pokhapokha ngati amupatsa mankhwala. Kutentha kosungira - mpaka 25 ° C. Pewani kufikira ana.

Kodi ndizotheka kuchepetsa thupi kuchokera ku mankhwalawa

Pali malingaliro oyenera kuti muchepetse kuwonda kwambiri popanda kuvulaza thanzi. Mlingo wa munthu aliyense amasankhidwa ndi adokotala.

Yambani ndi kupsinjika pang'ono, kulowera pang'onopang'ono. Gwiritsani ntchito othandizira a hypoglycemic poyerekeza ndi zakudya zabwino.

Makanema okhudzana nawo

Zokhudza zakudya za glucophage: