Gliclazide - malangizo angagwiritsidwe ntchito, ndemanga za anthu odwala matenda ashuga komanso madokotala

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Mellitus wosadalira insulin ndiye mtundu wa matenda (90-95% ya matenda onse a shuga). Kugwiritsa ntchito bwino kwa matenda osachiritsika sikufuna kokha kusintha kwa moyo, komanso chithandizo chamankhwala chokhazikika. Derivatives of sulfonylureas (SM) imaphatikizidwanso mndandanda wazamankhwala omwe amafunikira munthu wodwala matenda ashuga - imodzi mwamankhwala omwe ali odziwika kwambiri pa algorithm iliyonse.

Kuyambira 1950, kalasi ya mankhwala a SM yakhala ikugwiritsidwa ntchito moyenera pachipatala pochiza matenda amtundu wa 2 padziko lonse lapansi, ndipo amagwiritsidwa ntchito modzipereka pamapulogalamu azofufuza zamankhwala.

Kuchita bwino kwambiri komanso kulekerera bwino komanso kuthekera kwachuma komwe kumaloledwa kwa nthawi yayitali kugwiritsa ntchito zotumphukira za SM monga gulu lalikulu la othandizira am'magazi a hypoglycemic, amawasunga mu regimens yochizira ngakhale atasintha insulin.

Mankhwala abwino a antiidiabetes masiku ano ayenera kukhala osavuta kuwongolera, omwe ali ndi chiopsezo chambiri (komanso osati hypoglycemia), yotsika mtengo, yodalirika komanso yotetezeka. Imakwaniritsa zonsezi Gliclazide (mu Latin Gliclazide) ndi mankhwala oyambirira a gulu la CM.

Pharmacology Glycaside

Gliclazide, chithunzi chake chomwe chitha kuwoneka m'ndime iyi, ndi mankhwala omwe akuimira gulu la zotumphukira za m'badwo wachiwiri.

Mphamvu yayikulu (koma osati yokhayo) ya mankhwalawa ndi hypoglycemic: imawonjezera kupanga kwa insulin kwina ndi ma pancreatic b-cell. Mwa kulimbikitsa minofu ya glycogen synthase, gliclazide imathandizira kugwiritsidwa ntchito kwa glucose. Mankhwala amabwezeretsa magawo a glycemic mwachangu, kuphatikiza ndi matenda a shuga a metabolic.

Kuchokera pakulandila chakudya m'mimba m'matumbo mpaka nthawi yopanga insulin ndi mapiritsi, nthawi yochepa imadutsa kuposa popanda iwo. Hyperglycemia, wokwiyitsidwa ndi kudya zamafuta, okhala ndi gliclazide alibe vuto.

Mankhwalawa amawonjezera kuphatikiza kwa maselo ambiri, heparin ndi fibrinolytic. Nthawi yomweyo, kulolerana kwa heparin kumachulukanso, mankhwalawa amakhalanso ndi dongosolo la antioxidant.

Pharmacokinetics wa mankhwala

Kuchokera pamimba yodyera, mankhwalawa amamwetsa nthawi yomweyo komanso kwathunthu. Mulingo wambiriwo umakwaniritsidwa kuyambira 2 mpaka 6 maola, komanso mapiritsi omwe amakhala ndi mphamvu yayitali - kuyambira maola 6 mpaka 12. Kutalika kwawonetsedwa ndi tsiku lapakati. Ndi mapuloteni amwazi, mankhwalawa amagwirizanitsidwa ndi 85-99%. Mankhwala ndi biotransformed mu chiwindi, kupanga metabolites, amene amathandiza microcirculation.

Kutha kwa theka-moyo kumakhazikika mu maola 8-12. Gliclazide MV - maola 12-16. Nthawi yomweyo, 65% ya mankhwalawa amachotsedwa mu mawonekedwe a metabolites mu mkodzo, 12% kudzera m'matumbo.

Kodi mankhwalawa amawerengedwa liti?

Mankhwalawa adakonzedwa kuti azitha kuyendetsa matenda a shuga a mtundu wa 2, onse monga monotherapy komanso kuphatikiza pamodzi ndi mankhwala ena amkamwa a antiidiabetes kapena kukonzekera kwa insulin.

Malangizo a Gliclazide ogwiritsira ntchito amalimbikitsanso kugwiritsidwa ntchito ngati gawo la zovuta zochizira matenda am'mimba. Pofuna kupewa, mankhwala amalepheretsa kukula kwa zovuta kuchokera ku matenda ashuga - retinopathy, neuropathy, nephropathy, stroko komanso mtima.

Contraindations a Gliclazide

Mndandanda wa contraindication sugwira ntchito kwa Glyclazide okha, komanso kwa mitundu yake yonse (yodziwika ndi chinthu chimodzi).

Mwa zoletsa zonse:

  • Mtundu woyamba wa shuga;
  • Ketoacidosis (mawonekedwe a matenda ashuga);
  • Hypersmolar kapena matenda ashuga;
  • Hypersensitivity kwa zosakaniza za formula;
  • Hepatic ndi aimpso pathologies;
  • Kuvulala kwakukulu;
  • Leukopenia;
  • Hyper- ndi hypothyroidism;
  • Matumbo kutsekereza;
  • Paresis wam'mimba;
  • Matenda omwe amaphatikizidwa ndi kuchepa kwa michere.

Zoletsa ntchito

Choletsa chokha ndi zaka za ana, popeza chitetezo ndi kuchita bwino kwa gulu ili la odwala sichinakhazikitsidwe.

M'mikhalidwe yina ya pathological (opaleshoni yomwe idakonzedwa, maphunziro a radiopaque), kusintha kwakanthawi kwa insulin kumafunika (nthawi zambiri maola 48 asanafike komanso maola 48 atatha njirayi).

Mankhwalawa ndi mankhwalawa amatsutsana panthawi yomwe ali ndi pakati, ndipo ngati chithandizo chikuchitika mkaka wa m`mawere, mwanayo amapititsidwa ku zakudya zosafunikira.

Zotsatira zoyipa

Posachedwa, zofalitsa zakhala zikuwoneka ku Europe ndi USA zokhudzana ndi kuyanjana pakati pa kayendedwe ka zotumphukira za SM ndi kukonzekera kwa insulini komanso mwayi wa kapamba ndi khansa ya kapamba. Zambiri zopanda umboni, popeza gliclazide ndiye mankhwala oyambirirawa, yakhala ikuwunikira mosamala kwambiri.

Mavuto akulu kwambiri ndi chiwopsezo chowonjezeka cha zochitika za hypoglycemic (pomwe glucose m'thupi imakhala yochepera 3 mmol / l) komanso phindu lolemera chifukwa chogwiritsa ntchito mankhwalawa kwa nthawi yayitali.

Mndandanda wathunthu wazotsatira zomwe sizinachitike ndizomwe zili pagome.

Kodi mbali yake ndi yotaniZosankha Zaothekera Mbali Zowopsa
Matumbomavuto a dyspeptic mawonekedwe a mseru, kusanza, kupweteka m'mimba
Kupendahypoglycemic zochitika
Njira yozunguliraeosinophilia, cytopenia, kuchepa magazi
ChikopaZiwengo, chithunzi
Zosangalatsakusintha kwa kukoma, kusowa kwa mgwirizano, kupweteka kwa mutu, kusweka

Chifukwa cha chiwopsezo cha machitidwe a hypoglycemic, musapereke mankhwala a Gliclazide okalamba omwe ali ndi matenda ashuga omwe ali ndi vuto losakwanira komanso osagwirizana ndi anthu, makamaka mtima ndi aimpso.

Zochita Zamankhwala

Gliclazide imatha kupititsa patsogolo ma ACE inhibitors, anabolic steroids, β-blockers, fluoxidine, cimetidine, salicylates, miconazole, MAO inhibitors, fluconazole, theophylline, pentoxifylline, tetracyclines.

Mphamvu ya glycoside imafooka ndi kugwiritsa ntchito komweko kwa barbiturates, glucocorticoids, sympathomimetics, saluretics, kulera pamlomo, rifampicin, estrogens.

Mankhwala okhala ndi ethanol ndi NSAIDs amayambitsa matenda osokoneza bongo komanso hypoglycemia.

Momwe mungagwiritsire ntchito

Glycloside amatengedwa pakamwa ndi chakudya. Piritsi limamezedwa lonse, popanda kuphwanya, kutsukidwa ndi madzi. Dotolo amasankha mankhwalawa payekhapayekha, poganizira momwe matendawa amachitikira komanso momwe wodwala matenda ashuga amvera. Zomwe zimayambira nthawi zambiri sizidutsa 80 mg, ngati sizigwira ntchito mokwanira, mlingo umakulitsidwa pang'onopang'ono.

Zomwe zimachitika tsiku lililonse zimachokera ku 30 mg mpaka 120 mg, poganizira gawo la matenda ashuga komanso kuletsa zaka. Nthawi zina, mpaka 200 mg akhoza kutchulidwa.

Ngati nthawi yolandila ikusowa, simungathe kuwirikiza kawiri. Mankhwalawa amayenera kumwedwa nthawi yoyamba.
Kugwiritsa ntchito kosakanikirana kosasinthika ndikotheka osati kokha ndi metformin, yomwe yokha imagwiritsidwa ntchito kwambiri kuposa oimira a SM, komanso maulendo atatu okhazikika.

Chakudya cham'mawa, chomwe chimagwiritsa ntchito mankhwalawa, chimayenera kukhala chokwanira, chokhala ndi chakudya pang'ono. Kufa ndi njala masana, makamaka ndi kuchuluka kwa thupi, kumayambitsa hypoglycemia. Zofananazo zimatha kumwa mowa.

Anthu odwala matenda ashuga akamakula amakhudzidwa kwambiri ndi Glyclazide, chifukwa amatha kukhala ndi glycemia. Gulu ili la odwala ndiloyenera kwambiri kwa mankhwala osakhalitsa monga Glyclazide wamba.

Mapiritsi osinthidwa amasinthidwa amagwiranso ntchito tsiku lonse, kuphatikiza mankhwala ngati amenewo ndi amodzi. Mlingo wa Gliclazide MV ndi theka theka la mtundu wamba. Mankhwalawa amagwira ntchito kwa zaka 3-5, ndiye kuti kukana kumawonjezeka - pang'ono kapena kusakwanira kwake. Zikatero, endocrinologist amasintha njira yochizira.

Mankhwala oyambirirawa, monga ma generics ake, amagwira ntchito pokhapokha akasinthidwe - zakudya zochepa za chakudya chamafuta, okwanira komanso olimbitsa thupi nthawi zonse, kuwunika momwe akumvera, ndikuwonera kugona komanso kupuma.

Chofunikanso ndikuwunika glycemia masana ndikujambulitsa zotsatira zakudwala kwa odwala matenda ashuga. Pambuyo pa kupsinjika kwakukulu, kulimbitsa thupi, kuperewera kwa zakudya, kuchepetsedwa kwa mlingo kungakhale kofunikira. Kuwunikira momwe muliri komanso kulumikizana ndi dokotala pafupipafupi kudzakuthandizani kupewa zovuta.

Njira zopewera

Popewa kuthana ndi vuto la hypoglycemic, ndikofunikira kudya chakudya cham'mawa bwino pambuyo piritsi, kupewa kugona ndi njala masana, komanso osapatula zakumwa zoledzeretsa. Kugwiritsanso ntchito kwa ma b-blockers kumatha kuphimba zizindikiro za hypoglycemic. Ndikofunikira kuti odwala matenda ashuga azitsatira zakudya zamafuta ochepa.

Chifukwa cha zovuta zomwe sizinachitike, ndikofunikira kumwa mosamala madalaivala komanso anthu omwe ali ndi magwiridwe antchito oopsa.

Thandizani wovutitsidwa ndi bongo wambiri

Ngati zovomerezeka ndizopambana, zizindikilo za mankhwala osokoneza bongo zitha kuwonekera:

  1. Kudzimva kutopa;
  2. Kuchuluka kwa kuthamanga kwa magazi;
  3. Mutu;
  4. Kusagona, kusokonekera;
  5. Zoletsa;
  6. Zowonongeka kwakanthawi;
  7. Kusokonekera kwa ntchito;
  8. Kupindika;
  9. Kukhumudwitsa.

Ngati glycemia watenga mawonekedwe owopsa ndipo wovutikayo sangayang'anire mkhalidwe wake, ayenera kuchipatala mwachangu. Kuletsa kuukira m'maola oyamba, ndikofunikira kupaka 50 mg ya glucose (30% r) m'mitsempha ndikukoka - dextrose (10% r) mu mtsempha. Ndikofunikira m'masiku oyambirira kuyang'anira glycemia pafupipafupi. Kutsegula ndi mankhwala osokoneza bongo a gliclazide sikuthandiza.

Mlingo wa mawonekedwe ndi kapangidwe kake

Ponena za kuchuluka, kukonzekera kwa SM kumakhala kachiwiri kwa Metformin. Chimodzi mwazabwino za mankhwala ndikupezeka: kwa Gliclazide, mtengo wophatikizira m'mapiritsi siuposa 160 ma ruble. 30 ma PC. Pamaukonde a mankhwala, mankhwala amaperekedwa pansi pa mayina osiyanasiyana ogulitsa: Glyclazide-Akos, Glyclazide Canon, Glidiab-MV. Mankhwalawa amapangidwa m'mitundu yosiyanasiyana, pali njira yomwe ingasinthidwe ndi gawo loyambira.

Mapiritsi ali ndi zonona zokongoletsa komanso pang'ono pang'ono. M'maselo a aluminiyamu mbale akhoza kukhala 10, 20 kapena 30 ma PC. mapiritsi. Matumba adayikika m'mabokosi 10, 20, 30, 60 ngakhale 100.

Piritsi lililonse lili ndi gliclazide yogwira, yomwe imathandizira ndi cellulose, hypromellose, colloidal silicon dioxide, magnesium stearate.

Zosinthika ndi mphamvu yayitali ya Glycaside MV zimagulitsidwa m'mapaketi ofanana a mapiritsi 15 kapena 30 mumtsuko kapena bokosi.

Kubwezera kwakukulu kwa gululi la mankhwalawa ndi mwayi wokhala ndi kukana: malinga ndi ziwerengero, 5% ya anthu odwala matenda ashuga omwe amamwa zochokera kwa SM kwakanthawi yayitali kuti atenge insulin pakapita nthawi.

Glyclazide ndi mawonekedwe ake amakonzanso kuchuluka kwa magazi ndi kuchuluka kwa magazi, zimakhudza kwambiri homeostasis. Kwa odwala matenda ashuga omwe ali ndi matenda amtundu wa 2, uwu ndi mwayi wofunikira kwambiri. Ndi zabwino komanso zovuta zonse za Gliclazide, dokotala ayenera kusankha analog m'malo mwake.

Generic Glyclazide

Gliclazide - mankhwala oyamba, mankhwala ena onse omwe ali ndi ntchito yomweyo kapena mankhwala ena, ma analogues. Glidiab ali ndi mtengo wabwino komanso wabwino kwambiri pakati pa ma Gliclazide analogu okwera ruble 13 mpaka 137. Kutamandidwa kwakukulu kumaperekedwa kwa madokotala ndi mankhwalawa Diabeteson ndi Diabeteson MV. Mtengo wa mankhwalawa umachokera ku ruble 250 mpaka 320.

Mwa mankhwala ena omwe amafanana ndi code 4 ya ATX level 4, otchuka kwambiri ndi awa:

  • Glurenorm;
  • Glimepiride;
  • Konza;
  • Glibenclamide;
  • Amaryl;
  • Maninil.

Ngati mwapereka mankhwala a Glyclazide atsopano, osamveka bwino, auzeni dokotala. Mwina, atamuwonjezera, amachepetsa mlingo kapena kusankha analogue oyenera. Kudziyesa nokha zamagetsi kumakhala koopsa ku thanzi lanu.

Gliclazide - ndemanga za odwala matenda ashuga ndi madokotala

Andrey Sergeevich, Saratov. Gliclazide MV - mankhwala abwino, ngati agwiritsidwa ntchito mwanzeru, palibe mavuto. Kugwiritsa ntchito kamodzi patsiku ndikosavuta, ndisanayiwale kumwa mankhwalawa panthawi. Shuga amawongolera bwino, komabe, mankhwalawa samakwanira. Ndikofunikira kwa ine kuti mtengo ukhale wotsika mtengo. Ndipo adotolo adanena kuti ali ndi phindu pakubwera kwa magazi, amachepetsa chiopsezo cha zovuta za matenda ashuga.

Alekseev I.G., endocrinologist, Bryansk. Glyclazide - mankhwala a m'badwo wachiwiri wa zotumphukira za SM; Poyerekeza ndi mankhwala akale, mphamvu yake ya hypoglycemic imatchulidwanso. Kuyanjana kwa maselo a b-cell kumakhala kuchulukirapo ka 2-5, kotero polemba, nditha kumadutsa pang'ono. Mankhwalawa amalekeredwa bwino ndi odwala anga, amakhala ndi chophimba cha tsiku ndi tsiku, amabwezeretsa kagayidwe kachakudya m'masiku ochepa, makamaka ngati matenda a shuga ayamba kupezeka. Ngakhale sindipereka mankhwala a anti-atherogenic, mawonekedwe a lipid mu kusanthula bwino amawonekera bwino. Ndimaona gliclazide chovomerezeka kwambiri mgulu la zomwe zimachokera ku sulfonylurea: kutsatira kwambiri kwa wodwala, kuchepa kwakukulu (mpaka 2%) mu hemoglobin ya glycated.

Mankhwala amakono a hypoglycemic amakono a mtundu wachiwiri wa shuga ayenera kusinthidwa payekhapayekha, kuti "agwirizane" ndi zosowa za wodwala wina, akuyenera kuganizira zaka zake komanso mawonekedwe ake azachipatala kuti achepetse kulumala, kusintha zotsatira zoyipa za matenda ndikulimbikitsa moyo wa odwala matenda ashuga.

Zachidziwikire, Glyclazide sioyenera aliyense, komanso othandizira ena ochepetsa shuga, koma titha kunena kuti mankhwalawa ndi mawonekedwe ake amagwirizana kwathunthu ndi zomwe zanenedwa zamakono, kukhalabe oyenera ndikupitilizabe kuthandiza odwala matenda ashuga kusamalira bwino matenda oyipirawo.

About chithandizo chamankhwala a shuga 2-goth chidziwitso pa kanema

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