NovoNorm: malangizo, ntchito, maupangiri, ndemanga zamankhwala

Zowonjezera za pancreatic zopanga zawo za insulin zimatenga malo oyamba muyezo wa mankhwala antidiabetes. Mu gululi - sulfonylurea kukonzekera mndandanda (Maninil, Diabetes, Amaryl) ndi dongo.

Mankhwala amakono a NovoNorm, othandizira a hypoglycemic omwe ali ndi mphamvu yogwira ntchito mwachangu, nawonso ali m'gulu lomaliza. Iyenera kugwiritsidwa ntchito mosamala, ndipo mapiritsi sakhala oyenera kwa odwala matenda ashuga onse omwe ali ndi mtundu wachiwiri wa matenda, chifukwa chake ndikofunikira kudziwa malangizo (osachepera ndi mtundu wake wosinthika).

Kuphatikizika ndi mankhwala

NovoNorma, chithunzi chake chomwe chikuwonetsedwa mu gawo ili, chili ndi gawo loyambira la repaglinide, lophatikizidwa ndi cellulose, wowuma wa chimanga, potaziyamu polacryline, glycerin, povidone, calcium hydrogen phosphate, magnesium stearate, iron oxide, poloxamer, meglumine, utoto.

Mankhwalawa amatha kuzindikiridwa ndi mawonekedwe ake (mapiritsi a convex ozungulira), mtundu (wachikasu pa 1 mg ndi bulauni, wokhala ndi pinki tint pa 2 mg) ndikulemba chizindikiro cha kampani - Novo Nordisk. Mapiritsi okhala ndi matuza m'matumba 15.

Mu bokosi lambale oterowo amatha kukhala awiri kapena asanu ndi mmodzi. Ku Novonorm, mtengo ndi imodzi mwazinthu zopanga bajeti ya mankhwala antidiabetes: 177 rubles. mapiritsi 30. Mankhwala omwe mumalandira amamasulidwa. Wopanga Danish adatsimikiza moyo wa alumali wa repaglinide pasanathe zaka zisanu. Mankhwala safuna mikhalidwe yapadera kuti asungidwe.

Pharmacology

Pansi pophika Repaglinide ndi chofunikira kwambiri chothandizira kupanga amkati insulin. Kulimbitsa ntchito ya kapamba, mankhwalawa amatulutsa glycemia mwachangu. Mphamvu zake zimagwirizana mwachindunji ndi kuchuluka kwa ma cell a b omwe amachititsa kuti pakhale kuphatika kwa mahomoni.

Mutatha kumwa piritsi, repaglinide mu plasma mu diabetes amakumana mu theka la ola. Izi zimakuthandizani kuti muzilamulira glycemia panthawi yotsatira kudya komanso kukonza chakudya. Momwemo katundu wam'mimba utachepa, kuchuluka kwa mankhwalawo kumachepa, osachepera 4 ma mankhwalawa atatha kulowa m'matumbo am'mimba.

Chitetezo cha mankhwalawa chinayesedwa munthawi yamankhwala. Kutsika komwe amadalira mlingo wa glycemic kudalembedwa ndikugwiritsa ntchito 0.5-4 mg NovoNorm. Zotsatira zimatsimikiza kuthekera kwa kudya kwa prrandial (15-30 mphindi musanadye) kumwa mankhwalawa.

Pharmacokinetics

Repaglinide imatengeka mwachangu kuchokera m'mimba. Kuwerengera kwamphamvu kwambiri kwa magazi kumawonedwa ola limodzi atatha kumeza kenako amachepetsa mwachangu ndi bioavailability yokwanira 63% yokhala ndi mgwirizano wa 11%.

NovoNorm imachotsedwa mu maola 4-6 ndi theka la moyo pafupifupi ola limodzi. Mankhwalawa amapukusidwa kwathunthu, koma ma metabolites ake satha ntchito. Gawo laling'ono lazinthu zomwe zidagwiritsidwa ntchito linapezeka mumkodzo ndi ndowe - mpaka 8% ndi 2%, motero. Kukula kwakukulu kwa metabolites kumatha ndi bile.

Mphamvu ya mankhwalawa imatchulidwa kwambiri mu odwala matenda ashuga komanso kwa onse omwe ali ndi vuto la impso. Pambuyo masiku 5 kumwa NovoNorm muyezo wa 3 p. / Tsiku. 2 mg mu mitundu yayikulu ya aimpso kukanika AUC ndi TЅ.

Ana ashuga sanatenge nawo ziyeso. Kafukufuku wazinyama sanawonetse zotsatira za teratogenic mu repaglinide, koma adapeza zoopsa za kubereka. Pa mlingo waukulu wa mankhwalawo, kusokonezeka kwa makoswe kumawonedwa, mankhwalawo amalowerera mkaka wa amayi wa akazi.

Zizindikiro

Mankhwalawa amaphatikizidwa ndi mankhwala othandizira odwala matenda opatsirana pogwiritsa ntchito njira ina - - metformin, thiazolidinediones, kotero angagwiritsidwenso ntchito povuta.

Contraindication for Repaglinide

Kuphatikiza pa hypersensitivity pazosakaniza za formula, repaglignide sichinatchulidwe:

1. Ndi matenda a shuga 1 amtundu wa shuga ndi C-peptide
2. Mu mkhalidwe wa matenda a shuga a ketoacidosis (ngakhale pakalibe chikomokere);
3. Amayi oyembekezera komanso oyembekezera;
4. Anthu odwala matenda ashuga omwe ali ndi vuto losokoneza bongo la hepatic;
5. Momwemonso kugwiritsidwa ntchito kwa gemfibrozil.

Malangizo ogwiritsira ntchito

Dokotala amasankha payekha mankhwalawa, mwakuganizira zotsatira za mayeso, gawo la matendawa, matenda amtunduwu, msinkhu, komanso momwe thupi limayankhira mankhwala. Pakupita milungu iwiri iliyonse, imayang'anira kuyendera bwino kwa njira yomwe idasankhidwira kumveketsa mlingo, muyezo wa hemoglobin umaperekedwa.

Kuwunikira ndikofunikira kuti muchepetse glycemia pamlingo wofunikira kwambiri (kulephera kwakukulu) ndikuzindikira kusakhalapo koyenera pambuyo pake pakumwa mankhwala (yachiwiri kulephera).

Kwa NovoNorma, malangizo omwe angagwiritsidwe ntchito amalimbikitsa muyeso wa 0,5 mg. Kwa theka la mwezi ndikotheka kale kuwunika momwe thupi limayendera ndikumayendetsa. Ngati matenda a shuga a NovoNorm asamutsidwa kuchokera kwa wothandizira wina wa hypoglycemic, ndiye kuti mlingo woyambira uyenera kukhala mkati mwa 1 mg.

Njira yothandizira pakukonzekera imaphatikizanso kugwiritsa ntchito repaglinide mpaka 4 mg / tsiku. 15-30 mphindi asanadye. Muyenera kumwa piritsi musanadye chilichonse, chifukwa mphamvu ya mankhwalawa m'mimba pakapita nthawi ndiyochepa. Mlingo woyenera wa mankhwalawa ndi 16 mg / tsiku. mapiritsiwo amagawidwa kawiri kapena katatu.

Ndi chithandizo chovuta ndi metformin kapena thiazolidinediones, mlingo woyambirira wa reaglinide sudutsa 0.5 mg, mlingo wa mankhwala ena umasinthidwa.

Palibe deta pa chitetezo ndi kugwira ntchito kwa NovoNorm kwa ana.

Mankhwala osokoneza bongo osokoneza bongo komanso osafunika

Mwa zolinga za sayansi, kwa masabata 6, repaglinide idaperekedwa kwa odzipereka mu 4-20 mg / tsiku. Pamene ntchito anayi. Hypoglycemia mikhalidwe ya kuyesera idayendetsedwa ndi zopatsa mphamvu za zakudya, chifukwa chake, palibe zoyipa zomwe zidalembedwa.

Ngati kunyumba pali zizindikiro za kuchuluka kwa thukuta, kuchuluka kwa thukuta, kunjenjemera, migraines ndi kutayika kwa mgwirizano, ndikofunikira kupatsa wodwalayo zakudya zamafuta ambiri othamanga. Ngati vutoli lakhala lalikulu ndipo wodwalayo atha kuzindikira, amadzipaka ndi glucose ndikumutumiza kuchipatala.

Hypoglycemia ndi imodzi mwamtundu wa zoopsa zomwe sizinachitike. Pafupipafupi mawonekedwe ake amawonetseredwa ndi moyo wa odwala matenda ashuga: zakudya, mulingo wa minofu ndi kupsinjika, mulingo komanso mankhwala. Ziwerengero za milandu yotereyi zimawonetsedwa patebulo.

Pewani zosafunika zomwe zingakulowetseni pang'ono pang'onopang'ono, kumwa matenda, matenda, uchidakwa, anthu odwala matenda ashuga ayenera kulimbikitsidwa.

Kodi ndingasinthe bwanji NovoNorm

Kwa NovoNorm, ma analogu amasankhidwa malinga ndi dongosolo lapadziko lonse lapansi la kapangidwe ka mankhwala ATS (anatomical, achire komanso gulu la mankhwala). Repaglinide mu kapangidwe kake imakhala ndi mankhwala ena awiri - Repodiab ndi Insvada.

Malinga ndi zomwe zikuwonetsa komanso momwe angagwiritsire ntchito, ma repaglinides ndi ofanana:

• Guarem;
• Baeta;
• Victoza;
• Lycosum;
• Forsyga;
• Saxenda;
• Jardins
• Attokana.

Amaril, Bagomet, Glibenclamide, Glibomet, Glyukofazh, Glurenorm, Glyclazid, Diabeteson, Diaformin, Metformin, Maninil, Ongliza, Siofor, Yanumet, Yanuviya ndi ena ambiri ali pafupi ndi code 3 ATC code (kapangidwe kake ndi kosiyana).

Pazosiyanasiyana zamankhwala amakono a hypoglycemic, madokotala omwe amagwiritsa ntchito mankhwala samakhazikika nthawi zonse, ndipo sizovomerezeka kuti odwala matenda ashuga azitha kugwiritsa ntchito mankhwala osaphunzitsidwa zachipatala. Zomwe zili m'nkhaniyi zimangoperekedwa kuti zingochitika zonse.

Ndemanga za Mankhwala

Za ndemanga za NovoNorm za madokotala ndi odwala matenda ashuga kwambiri. Mankhwalawa amapangidwa ku Denmark ku kampani ya NovoNordisk, komwe chitetezo choyambirira chimayang'aniridwa.

Upangiri wa akatswiri pakuwongolera matenda a shuga a 2 - mu pulogalamu yapa TV "Piritsi" - pa kanemayu.