Indapamide - mankhwala otsimikiziridwa a kuthamanga kwa magazi

Indapamide ndi yachiwiri, yamakono kwambiri, yamtundu wa thiazide-ngati okodzetsa. Chotsatira chachikulu cha mankhwalawa ndi kuchepa msanga, kosasunthika komanso kosakhalitsa kwa kuthamanga kwa magazi. Imayamba kugwira ntchito pambuyo pa theka la ola, pambuyo pa maola 2 zotsatira zake zimakhala zochuluka ndikukhalabe pamalo okwera kwa maola osachepera 24. Ubwino wofunika wa mankhwalawa ndi kusakhudzidwa kwa kagayidwe kazinthu, kuthekera kukonza impso ndi mtima. Monga ma diuretics onse, Indapamide ikhoza kuphatikizidwa ndi njira zotchuka komanso zotetezeka: sartans ndi ACE inhibitors.

Kwa omwe indapamide adalembedwa

Odwala onse omwe ali ndi matenda oopsa amathanso kulandira chithandizo cha moyo wonse, chomwe chimakhala ngati munthu akumwa mankhwala tsiku lililonse. Mawu awa akhala asakufunsidwa m'magulu azachipatala azachipatala. Zinapezeka kuti kuwongolera kuthana ndimankhwala osachepera 2 nthawi kumachepetsa mwayi wamatenda amtima, kuphatikizapo oopsa. Palibe kutsutsana pamakakamizidwe oyambira kumwa mapiritsi. Padziko lonse lapansi, kuchuluka kofunikira kwa odwala ambiri kumawerengedwa kuti ndi 140/90, ngakhale kupanikizika kukwera mosadukiza ndipo sikubweretsa kusokonezeka kulikonse. Pewani kumwa mapiritsi okha ndi matenda oopsa. Kuti muchite izi, muyenera kuchepetsa thupi, kusiya fodya ndi mowa, kusintha zakudya.

Chizindikiro chokhacho chogwiritsira ntchito Indapamide chomwe chikuwonetsedwa mu malangizowo ndi matenda oopsa. Kuthamanga kwa magazi nthawi zambiri kumaphatikizidwa ndi matenda a mtima, impso, mitsempha yamagazi, chifukwa chake, mankhwala omwe amalembedwa kuti achepetse, amayenera kuyesedwa kuti ateteze komanso kuchita bwino m'magulu awa odwala.

Zomwe zimathandiza Indapamide:

1. Kutsika kwapakati pa kupanikizika mukamatenga Indapamide ndi: kumtunda - 25, kutsika - 13 mm Hg
2. Kafukufuku wasonyeza kuti ntchito ya antihypertensive ya 1.5 g ya indapamide ndi ofanana 20 mg ya enalapril.
3. Kupanikizika kwa nthawi yayitali kumabweretsa kuwonjezereka kwa mtima wamanzere wamtima. Kusintha kwa ma pathological koteroko kumakhala kodzaza ndi kusokonezeka kwa miyendo, kugunda, kulephera mtima. Mapiritsi a Indapamide amathandizira kuchepa kwa lamanzere yamitsempha yama cell, kuposa enalapril.
4. Kwa matenda a impso, Indapamide siigwira ntchito kwenikweni. Kuchita kwake kungaonedwe ndi kugwa kwa 46% pamlingo wa albumin mkodzo, womwe umadziwika kuti ndi chimodzi mwazizindikiro zakulephera kwa impso.
5. Mankhwalawa alibe zotsatira zoyipa za shuga, potaziyamu ndi mafuta m'thupi, motero, angagwiritsidwe ntchito kwambiri kwa matenda ashuga. Zochizira matenda oopsa mu diabetes, diuretics zotchulidwa mankhwala ochepa, pamodzi ACE zoletsa kapena Losartan.
6. Katundu wapadera wa Indapamide pakati pa okodzetsa ndiwowonjezera mulingo wa "wabwino" cholesterol wa HDL ndi pafupifupi 5.5%.

Kodi mankhwalawo amagwira ntchito bwanji?

Chuma chachikulu cha okodzetsa ndi kuwonjezeka kwa mkodzo. Nthawi yomweyo, kuchuluka kwamadzimadzi mu minyewa ndi mitsempha yamagazi kumatsika, ndipo kupsinjika kumachepa. M'mwezi wa chithandizo, kuchuluka kwamadzi am'mimba amayamba kuchepa ndi 10-15%, kulemera chifukwa cha kuchepa kwa madzi kumachepa pafupifupi 1.5 makilogalamu.

Indapamide pagulu lake limakhala malo apadera, madokotala amachitcha kuti diuretic popanda diuretic. Izi ndizovomerezeka pamalingaliro ang'onoang'ono. Mankhwalawa samakhudza kuchuluka kwa mkodzo, koma amakhala ndi kupuma kwamitsempha yamagazi pokhapokha akagwiritsidwa ntchito mu mlingo wa ≤ 2,5 mg. Ngati mutenga 5 mg, kutulutsa mkodzo kumawonjezeka ndi 20%.

Chifukwa cha kupsinjika komwe kumagwa:

1. Misewu ya calcium imatsekedwa, zomwe zimapangitsa kuchepa kwa kuchuluka kwa calcium m'makoma amitsempha, kenako ndikukulira kwamitsempha yamagazi.
2. Njira za potaziyamu zimayendetsedwa, motero, kulowa kwa calcium m'maselo kumatsika, kaphatikizidwe ka nitric oxide m'mitsempha yamitsempha imakulanso, ndipo zombo zimatsitsika.
3. Kapangidwe ka prostacyclin kumakhudzidwa, chifukwa chomwe kuthekera kwa ma protein kupangira zigawo zamagazi ndikutsamira kumakoma amitsempha yamagazi kumachepa, kamvekedwe ka minofu ya makoma am'thupi amachepa.

Kutulutsa mawonekedwe ndi mlingo

Mankhwala oyamba omwe ali ndi indapamide amapangidwa ndi kampani yopanga zamankhwala Server pansi pa dzina la Arifon. Kuphatikiza pa choyambirira cha Arifon, ma genetic ambiri okhala ndi indapamide adalembetsedwa ku Russia, kuphatikiza pansi pa dzina lomwelo la Indapamide. Ma analogi a Arifon amapangidwa mwa mawonekedwe a makapisozi kapena mapiritsi okhala ndi filimu. Posachedwa, mankhwala osokoneza bongo omwe amasinthidwa a indapamide kuchokera pamapiritsi adadziwika.

Matenda olembetsa magazi komanso kukakamizidwa kukhala zinthu zakale - zaulere

Matenda a mtima komanso mikwingwirima ndizomwe zimayambitsa pafupifupi 70% ya imfa zonse padziko lapansi. Anthu asanu ndi awiri mwa anthu khumi amafa chifukwa chotseka mitsempha ya mtima kapena ubongo. Pafupifupi nthawi zonse, chifukwa chakumapeto kowopsa ndichofanana - kuthamanga kwa magazi chifukwa cha matenda oopsa.

Ndikotheka komanso kofunikira kuti muchepetse kukakamizidwa, osatero ayi. Koma izi sizichiritsa matendawa, koma zimangothandiza kuthana ndi kafukufuku, osati zomwe zimayambitsa matendawa.

• Matenda a kukakamizidwa - 97%
• Kuthetsa kwa mitsempha thrombosis - 80%
• Kuthetsa kwa kugunda kwamtima kwamphamvu - 99%
• Kuchotsa mutu - 92%
• Kuwonjezeka kwa mphamvu masana, kukonza kugona usiku - 97%

Kodi Indapamide imapangidwa m'mitundu iti?

Malinga ndi akatswiri a mtima, ndikofunikira kugula Indapamide wamba m'mapiritsi. Mankhwalawa amasungidwa m'mabotolo nthawi yayitali, ali ndi bioavailability yambiri, amakamizidwa mwachangu, ali ndi zinthu zochepa zothandizira, zomwe zikutanthauza kuti amayambitsa ziwengo pafupipafupi.

Mtundu wamakono kwambiri wa indapamide ndi mapiritsi okhala ndi nthawi yayitali. Zomwe zimagwira kuchokera kwa iwo zimamasulidwa pang'onopang'ono chifukwa chaukadaulo wapadera: kuchuluka kwa indapamide komwe kumagawidwa mothandizidwa ndi cellulose. Mukangolowa m'mimba, pang'onopang'ono cellulose imasanduka gel. Zimatengera pafupifupi maola 16 kupasuka piritsi.

Poyerekeza ndi mapiritsi amchikhalidwe wamba, indapamide yomwe imakhala nthawi yayitali imapereka mphamvu yokhazikika komanso yolimba ya antihypertensive, kusinthasintha kwatsiku ndi tsiku kumatenga pang'onopang'ono. Malinga ndi mphamvu yakuchitapo kanthu, 2.5 mg ya wamba Indapamide ndi 1.5 mg kutalika. Zotsatira zoyipa zambiri zimadalira mlingo, ndiye kuti, kuchuluka kwawo komanso kuopsa kwake kumawonjezeka ndi kumwa mankhwala. Kutenga mapiritsi a Indapamide nthawi yayitali kumachepetsa chiopsezo cha mavuto, makamaka kutsika kwa magazi a potaziyamu.

Kusiyanitsidwa kwakutali kwa indapamide kumatha kukhala pa 1.5 mg. Phukusili likhale chizindikiro cha "zochita nthawi yayitali", "kusinthidwa kusinthidwa", "kutulutsidwa kolamulidwa", dzinalo likhoza kukhala ndi "retard", "MV", "long", "SR", "CP".

Momwe angatenge

Kugwiritsa ntchito indapamide kuti muchepetse kupanikizika sikutanthauza kuchuluka kwa pang'onopang'ono. Mapiritsi yomweyo amayamba kumwa muyezo. Mankhwalawa amadziunjikira m'magazi pang'onopang'ono, kotero ndizotheka kuweruza kugwira ntchito kwake pokhapokha sabata 1 la chithandizo.

Malamulo okuvomerezedwa kuchokera kuzomwe mungagwiritse ntchito:

Chonde dziwani: musanayambe mankhwala ndi ma diuretics aliwonse, ndikofunikira kuyang'anira magawo ena a magazi: potaziyamu, shuga, creatinine, urea. Ngati zotsatira zoyeserera zikusiyana ndi zofunikira, funsani dokotala wanu, chifukwa kutenga mankhwala okodzetsa kumakhala kowopsa.

Ndingatenge nthawi yayitali bwanji osapuma

Mapiritsi oponderezedwa a Indapamide amaloledwa kumwa nthawi yopanda malire, malinga ndi momwe amapereka gawo lomwe akukakamizidwa ndipo amaloledwa bwino, ndiye kuti, samayambitsa zovuta zomwe zimakhala zowopsa thanzi. Osasiya kumwa mankhwalawo, ngakhale atakukakamizani kuti abwerere mwakale.

Osachepera 0,01% ya odwala matenda oopsa omwe amakhala ndi mapiritsi a Indapamide ndi mapiritsi ake, kusintha kwa kapangidwe ka magazi kumawonekera: kuchepa kwa leukocytes, mapulateleti, hemolytic kapena aplastic anemia. Kuti mudziwe zoyenera kuchita panthawi imeneyi, malangizowo amayeserera kuti mukayezetsedwe magazi miyezi isanu ndi umodzi iliyonse.

Indapamide, pamlingo wocheperako kuposa zida zina zamagetsi, amalimbikitsa kuchotsedwa kwa potaziyamu m'thupi. Komabe, odwala matenda oopsa omwe ali pachiwopsezo chogwiritsa ntchito mapiritsi nthawi yayitali amatha kukhala ndi hypokalemia. Zomwe zimayambitsa ngozi zimaphatikizapo ukalamba, matenda enaake, edema, matenda amtima. Zizindikiro za hypokalemia ndi kutopa, kupweteka kwa minofu. Mu kuwunika kwa odwala omwe adakumana ndi vuto ili, amanenanso za kufooka kwambiri - "osagwira miyendo", kudzimbidwa pafupipafupi. Kupewera kwa hypokalemia ndiko kumwa zakudya kwambiri mu potaziyamu: nyemba, masamba, nsomba, zipatso zouma.

Zotsatira zoyipa

Zochita zosafunikira za Indapamide ndi pafupipafupi zomwe zimachitika:

Malangizo ogwiritsira ntchito akuwonetsa kuti kuthekera kwa kusokonezeka kwakutali ndikwambiri ndi mapiritsi a Indapamide, otsika ngati mukugwiritsa ntchito fomu yayitali.

Contraindication

Mndandanda wamilandu ya Indapamide ndi yochepa kwambiri. Mankhwala sangathe kumwa:

• ngati chimodzi mwa zinthu zake chikukhumudwitsani;
• ndi ziwengo kuti sulfonamide zotumphukira - nimesulide (Nise, Nimesil, etc.), celecoxib (Celebrex);
• kwambiri aimpso kapena kwa chiwindi kusakwanira;
• ngati hypokalemia yakhazikitsidwa;
• ndi hypolactasia - mapiritsi ali ndi lactose.

Mimba, ubwana, kuyamwitsa sizimaganiziridwa kuti ndi contraindication. Muzochitika izi, kumwa Indapamide sikofunikira, koma ndikotheka poika komanso moyang'aniridwa ndi dokotala.

Malangizo ogwiritsira ntchito Indapamide samawonetsa kuthekera kowatenga pamodzi ndi mowa. Komabe, powunika kwa madotolo, kuyenderana kwa mowa ndi mankhwalawa kumawonetsedwa kuti ndi owopsa thanzi. Kugwiritsidwa ntchito kamodzi kwa ethanol kungayambitse kuchepa kwa mavuto. Kuchitiridwa nkhanza pafupipafupi kumawonjezera chiopsezo cha hypokalemia, kumachepetsa mphamvu ya hypotensive ya Indapamide.

Analogs ndi choloweza

Mankhwala amabwerezedwa kwathunthu mu kapangidwe ndi Mlingo, ndiye kuti, mankhwala otsatirawa omwe adalembedwa ku Russian Federation ali ndi chithunzi chonse cha Indapamide:

Zitha m'malo mwa Indapamide popanda kuonana ndi adokotala. Malinga ndi ndemanga ya odwala omwe amamwa mankhwalawo, apamwamba kwambiri pamndandandawu ndi mapiritsi a Arifon ndi Indap.

Yerekezerani ndi mankhwala ofanana

Pakati pa thiazide ndi thiazide-ngati diuretics, indapamide imatha kupikisana ndi hydrochlorothiazide (mankhwala Hydrochlorothiazide, Hypothiazide, Enap complication, Lorista ndi mankhwala ena ambiri a antihypertensive) ndi chlortalidone (mapiritsi a Oxodoline, amodzi mwa magawo a Tenorik ndi Tenoretik).

Zofanana poyerekeza ndi mankhwalawa:

• mphamvu ya zochita za 2,5 mg ya indapamide ndi wofanana ndi 25 mg ya hydrochlorothiazide ndi chlortalidone;
• hydrochlorothiazide ndi chlortalidone sizingatheke m'malo mwa indapamide mu matenda a impso. Amadziwitsidwa kuti impso zisasinthidwe, motero, ndi kulephera kwaimpso, mankhwala osokoneza bongo amatha kuthekera kwambiri. Indapamide imapukusidwa ndi chiwindi, osapitilira 5% amachotsedwa mu mawonekedwe othandizira, motero amatha kuledzera mpaka pakulephera kwakukulu kwa impso;
• Poyerekeza ndi hydrochlorothiazide, indapamide imateteza kwambiri impso. Kwa zaka ziwiri za kumwa kwake, GFR imawonjezeka ndi 28%. Mukamamwa hydrochlorothiazide - yochepetsedwa ndi 17%;
• chlortalidone imatenga masiku atatu, kotero ingagwiritsidwe ntchito mwa odwala omwe sangathe kumwa mankhwalawo pawokha;
• Mapiritsi a Indapamide samakhudza kagayidwe kazakudya, chifukwa chake amatha kugwiritsidwa ntchito pa matenda ashuga. Hydrochlorothiazide imathandizira kukana insulin.

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