Glyclazide MV 30 mg ndi MV 60 mg: malangizo ndi kuwunika kwa odwala matenda ashuga

Gliclazide MV ndi amodzi mwa mankhwala omwe amagwiritsidwa ntchito kwambiri pa matenda a shuga a 2. Ndi gawo lam'badwo wachiwiri wa kukonzekera kwa sulfonylurea ndipo ingagwiritsidwe ntchito onse mu monotherapy komanso mapiritsi ena ochepetsa shuga ndi insulin.

Kuphatikiza pa momwe magazi amasinthira, gliclazide imathandizanso pakupanga magazi, imachepetsa kupsinjika kwa oxidative, imakongoletsa ma microcirculation. Mankhwalawa alibe popanda zovuta zake: amathandizira kulemera, ndikugwiritsa ntchito nthawi yayitali, mapiritsi amatha mphamvu. Ngakhale kuphatikiza pang'ono kwa gliclazide kumakhala ndi vuto la hypoglycemia, kuopsa kwake kumakhala kwakukulukulu ukalamba.

Zambiri

Satifiketi yakulembetsa ku Gliclazide MV imaperekedwa ndi kampani yaku Russia Atoll LLC. Mankhwala omwe ali pansi pa mgwirizano amapangidwa ndi kampani yopanga mankhwala a Samara Ozone. Imapanga ndi kunyamula mapiritsi, ndikuwongolera mtundu wawo. Gliclazide MV silingatchulidwe ngati mankhwala apakhomo, chifukwa mankhwala azomweyo (gliclazide yomweyo) amagulidwa ku China. Ngakhale izi, palibe cholakwika chomwe chinganenedwe za mtundu wa mankhwalawa. Malinga ndi odwala matenda ashuga, palibe vuto lililonse kuposa French Diabeteson yofananira.

Mawu achidule a MV m'dzina la mankhwalawa akuwonetsa kuti chinthu chomwe chimagwira mwa iye chimasinthidwa. Glyclazide amasiya piritsi nthawi yomweyo komanso pamalo oyenera, omwe amawonetsetsa kuti salowa m'magazi nthawi yomweyo, koma m'magawo ang'onoang'ono. Chifukwa cha izi, chiwopsezo cha zotsatira zosafunikira chimachepetsedwa, mankhwalawa amatha kumwa pafupipafupi. Ngati mapangidwe a piritsi amaphwanyidwa, nthawi yayitali imatayika, motero, malangizo ogwiritsira ntchito silimbikitsa kuti azidula.

Glyclazide imaphatikizidwa pamndandanda wazamankhwala ofunikira, chifukwa chake ma endocrinologists ali ndi mwayi wopereka kwa odwala matenda ashuga kwaulere. Nthawi zambiri, malinga ndi zomwe wapatsidwa, ndi MV Gliclazide yomwe ndi analog ya Diabeteson woyambayo.

Matenda a shuga ndi kupsinjika kudzakhala chinthu chakale

• Matenda a shuga -95%
• Kuthetsa kwa mitsempha thrombosis - 70%
• Kuthetsa kwa kugunda kwamtima kwamphamvu -90%
• Kuthana ndi kuthamanga kwa magazi - 92%
• Kuwonjezeka kwa mphamvu masana, kukonza kugona usiku -97%

Zisonyezero zamankhwala Glyclazide

Glyclazide kuloledwa kugwiritsa ntchito kokha ndi mtundu 2 wa shuga komanso mwa odwala akuluakulu. Zimasankhidwa ngati kusintha kwa zakudya, kuchepa thupi komanso maphunziro akuthupi sikokwanira kwa glycemia wabwinobwino. Mankhwalawa amatha kuchepetsa shuga m'magazi, potero amachepetsa chiopsezo cha angiopathy komanso zovuta zophatikizana ndi matenda ashuga.

Kumayambiriro kwa matenda amtundu wa 2, pafupifupi munthu aliyense wodwala matenda ashuga ali ndi zinthu zomwe zimapangitsa kuyeretsa kwamitsempha yamagazi: glucose, kunenepa kwambiri, kusuntha kochepa. Pakadali pano, ndikokwanira kuti wodwalayo asinthe moyo wake ndikuyamba kutenga metformin. Palibe njira yodziwira matenda ashuga, gawo lalikulu la odwala limapita kwa dotolo pomwe thanzi lawo silili bwino. Pazaka 5 zoyambirira za matenda ashuga osakhwima, ntchito za maselo a beta omwe amapanga insulin zimachepa. Pofika pano, metformin ndi zakudya sizingakhale zokwanira, ndipo odwala amamulembera mankhwala omwe amathandizira kaphatikizidwe ndi kutulutsa insulin. Glyclazide MV ilinso yamankhwala otere.

Kodi mankhwalawo amagwira ntchito bwanji?

Ma gliclazide onse atakhudzidwa m'mimba amatayikiridwa m'magazi ndipo amaphatikizana ndi mapuloteni ake. Nthawi zambiri, shuga amalowa m'maselo a beta ndipo amathandizira zolandilira zapadera zomwe zimayambitsa kutulutsidwa kwa insulin. Glyclazide imagwiranso ntchito mofananamo, kupangitsa mwachilengedwe kuphatikizika kwa mahomoni.

Zotsatira pakupanga insulin sizingokhala machitidwe a MV Glyclazide. Mankhwala amatha:

1. Kuchepetsa kukana insulin. Zotsatira zabwino (kuchuluka kwa insulivivity mwa 35%) zimawonedwa.
2. Kuchepetsa kapangidwe ka shuga ndi chiwindi, potero kumapangitsa kusala kudya.
3. Pewani magazi kuundana.
4. Yambitsani kaphatikizidwe ka nitric oxide, yomwe imakhudzidwa pakukakamiza, kuchepetsa kutupa, komanso kukonza magazi kuti apange ziwalo zotumphukira.
5. Ntchito ngati antioxidant.

Kutulutsa mawonekedwe ndi mlingo

Piritsi Gliclazide MV ndi 30 kapena 60 mg yogwira ntchito. Zothandizira zothandizira ndi izi: cellulose, yomwe imagwiritsidwa ntchito ngati chochulukitsa, silika ndi magnesium stearate ngati emulsifiers. Mapiritsi amtundu woyera kapena kirimu, womwe umayikidwa mu matuza a 10-30 zidutswa. Mu paketi ya matuza a 2-3 (mapiritsi 30 kapena 60) ndi malangizo. Gliclazide MV 60 mg imatha kugawidwa pakati, chifukwa izi ndizowopsa pamapiritsi.

Mankhwala amayenera kuledzera pakudya cham'mawa. Gliclazide imagwira ntchito mosasamala kanthu za kupezeka kwa shuga m'magazi. Kuti hypoglycemia isachitike, palibe chakudya chomwe muyenera kudumpha, chilichonse chimayenera kukhala ndi chakudya chofanana. Ndikofunika kuti mudye mpaka katatu pa tsiku.

Malamulo akusankha:

Malangizo atsatanetsatane oti mugwiritse ntchito

Malinga ndi malingaliro azachipatala a Unduna wa Zaumoyo ku Russia, gliclazide iyenera kuyikidwa kuti ikulimbikitse insulin. Moyenerera, kusowa kwa mahomoni akeake kuyenera kutsimikiziridwa ndikuwunika wodwalayo. Malinga ndi ndemanga, izi sizimachitika nthawi zonse. Othandizira ndi ma endocrinologists amapereka mankhwala "ndi maso". Zotsatira zake, zochuluka kuposa kuchuluka kwa insulin komwe kumatulutsidwa, wodwalayo amafuna kudya nthawi zonse, kulemera kwake kukuwonjezeka pang'onopang'ono, ndipo kubwezeredwa kwa matenda ashuga sikokwanira. Kuphatikiza apo, maselo a beta okhala ndi njira yotereyi amawonongeka mwachangu, zomwe zikutanthauza kuti matendawo amapita gawo lina.

Mungapewe bwanji izi:

1. Yambani kutsatira zakudya za anthu odwala matenda ashuga (tebulo Na. 9, kuchuluka kwa chakudya kokhazikika kwa dokotala kapena wodwalayo malinga ndi glycemia).
2. Fotokozerani zochitika zatsiku ndi tsiku.
3. Kuchepetsa thupi kubwinobwino. Mafuta ochulukirapo amawonjezera shuga.
4. Imwani glucophage kapena mawonekedwe ake. Mulingo woyenera kwambiri ndi 2000 mg.

Ndipo pokhapokha ngati izi sizikwanira shuga wabwinobwino, mutha kuganiza za gliclazide. Musanayambe chithandizo, ndikofunikira kuyesedwa kwa C-peptide kapena insulin kuti muwonetsetse kuti kuphatikizika kwa mahomoni kumavulaza kwenikweni.

Ha glycated hemoglobin ndi yokwera kuposa 8.5%, MV Gliclazide imatha kuperekedwa limodzi ndi zakudya komanso metformin kwakanthawi, mpaka matenda a shuga amalipiridwe. Pambuyo pake, nkhani yosiya mankhwala imasankhidwa payekhapayekha.

Momwe mungatengere panthawi yoyembekezera

Malangizo ogwiritsira ntchito kuletsa kulandira mankhwala ndi Gliclazide pa nthawi ya pakati komanso mkaka wa m`mawere. Malinga ndi gulu la FDA, mankhwalawa ndi a gulu C. Izi zikutanthauza kuti zingasokoneze khwimbi la mwana wosabadwa, koma sizimayambitsa kusabereka. Glyclazide ndiyotetezedwa m'malo ndi mankhwala a insulin musanabadwe, ovuta kwambiri - kumayambiriro.

Kuthekera kwa kuyamwitsa ndi gliclazide sikunayesedwe. Pali umboni kuti kukonzekera kwa sulfonylurea kumatha kulowa mkaka ndikupangitsa hypoglycemia makanda, kotero kugwiritsa ntchito panthawiyi ndizoletsedwa.

Zotsatira zoyipa ndi bongo

Zotsatira zoyipa kwambiri za Gliclazide MV ndi hypoglycemia. Zimachitika pamene kupanga kwa insulin kwadutsa kofunikira pakufunikira. Cholinga chake chimatha kukhala kuti mwangozi mankhwala osokoneza bongo, kudumphadumpha chakudya kapena kusowa kwa chakudya m'thupi, komanso kuchita masewera olimbitsa thupi mopitirira muyeso. Komanso, kutsika kwa shuga kungayambitse kudzikundikira kwa gliclazide m'mwazi chifukwa cha kulephera kwaimpso ndi chiwindi, kuwonjezeka kwa ntchito ya insulin m'matenda ena a endocrine. Malinga ndi ndemanga, mankhwalawa sulfonylureas ndi hypoglycemia, pafupifupi onse odwala matenda ashuga. Madontho ambiri a shuga amatha kuthetseka mosavuta.

Monga lamulo, hypoglycemia imayendera limodzi ndi zizindikiro zosonyeza: njala yayikulu, kugwedezeka kwamphamvu, kukalamba, kufooka. Odwala ena pang'onopang'ono amasiya kumva izi, kutsika kwawo kwa shuga ndikuwopseza moyo. Amafunikira kuwongolera kwa glucose pafupipafupi, kuphatikiza usiku, kapena kusamukira kumapiritsi ena ochepetsa shuga omwe alibe zotsatira zoyipa.

Chiwopsezo cha zochita zina zosafunikira za Gliclazide zimayesedwa ngati zosowa komanso zosowa kwambiri. Chotheka:

• kugaya chakudya mu mawonekedwe a mseru, zovuta matumbo, kapena m'mimba. Mutha kuwathetsa potenga Glyclazide panthawi yazakudya kwambiri;
• ziwengo pakhungu, nthawi zambiri zimakhala ngati zotupa, limodzi ndi kuyabwa;
• kutsika kwa mapulosi, maselo ofiira a magazi, maselo oyera amwazi. Kapangidwe ka magazi kamabwerera mwakale pakokha atachotsedwa kwa Gliclazide;
• kuchuluka kwakanthawi kantchito ya chiwindi michere.

Yemwe Glyclazide MV wapatukana

Zitha kusintha

Gliclazide ya ku Russia ndiyotsika mtengo, koma m'malo mwake ndi mankhwala apamwamba, mtengo wa ma CD a Gliclazide MV (30 mg, 60 unit) ndi mpaka ma ruble 150. M'malo mwake ndi analogues pokhapokha ngati mapiritsi wamba sogulitsidwa.

Mankhwala oyamba ndi Diabeteson MV, mankhwala ena onse omwe ali ndi mawonekedwe omwewo, kuphatikiza Gliclazide MV ndi majenito, kapena makope. Mtengo wa matenda ashuga ndiwotsika pafupifupi 2-3 kuposa ma genetic ake.

Gliclazide MV analogues ndi olowa m'malo omwe adalembetsedwa ku Russian Federation (zosintha zakumasulidwa zokhazokha zikuwonetsedwa):

• Glyclazide-SZ yopangidwa ndi Severnaya Zvezda CJSC;
• Golda MV, Pharmasintez-Tyumen;
• Glyclazide Canon kuchokera ku Canonpharm Production;
• Gliclazide MV Pharmstandard, Pharmstandard-Tomskkhimfarm;
• Diabetesalong, wopanga MS-Vita;
• Gliclada, Krka;
• Glidiab MV kuchokera ku Akrikhin;
• Kampani ya Diabefarm MV Pharmacor Production.

Mtengo wa analogues ndi ma ruble 120-150 pa phukusi lililonse. Gliklada yopangidwa ku Slovenia ndiye mankhwala okwera mtengo kwambiri kuchokera pamndandandawu, paketi imadya pafupifupi ma ruble 250.

Ndemanga Zahudwala