Forsiga - chida chatsopano chothandizira matenda a shuga

Posachedwa, gulu latsopano la othandizira a hypoglycemic omwe ali ndi vuto lina losiyana siyana apezeka kwa odwala matenda ashuga ku Russia. Mankhwala oyamba a Forsig a matenda a shuga a 2 adalembedwa m'dziko lathu, zidachitika mchaka cha 2014. Zotsatira za kafukufuku wa mankhwalawa ndizosangalatsa, kugwiritsa ntchito kwake kumatha kuchepetsa kwambiri mankhwalawa, ndipo nthawi zina ngakhale kupatula jakisoni wa insulin pazovuta zamatendawa.

Ndemanga za endocrinologists ndi odwala ndizosakanikirana. Wina amasangalala ndi mwayi watsopano, ena amakonda kudikirira mpaka zotsatira zake atamwa mankhwalawo kwa nthawi yayitali kuti adziwike.

Kodi mankhwala a Forsig amagwira ntchito bwanji

Zotsatira za mankhwala a Forsig zimatengera luso la impso kuti lisonkhanitse shuga m'magazi ndikuchotsa mkodzo. Mwazi m'thupi lathu umadetsedwa nthawi zonse ndi zinthu zopangidwa ndi metabolism komanso poizoni. Udindo wa impso ndikuwunika zinthu izi ndikuzichotsa. Chifukwa cha izi, magazi amadutsa mu mawonekedwe aimpso kangapo patsiku. Pachigawo choyamba, zigawo zama protein zokha za magazi sizidutsa mu fayilo, madzi ena onse amalowa glomeruli. Izi ndiye zotchedwa kuti mkodzo woyamba, makumi a malita amapangidwa masana.

Matenda a shuga ndi kupsinjika kudzakhala chinthu chakale

• Matenda a shuga -95%
• Kuthetsa kwa mitsempha thrombosis - 70%
• Kuthetsa kwa kugunda kwamtima kwamphamvu -90%
• Kuthana ndi kuthamanga kwa magazi - 92%
• Kuwonjezeka kwa mphamvu masana, kukonza kugona usiku -97%

Kuti mukhale wachiwiri ndikulowa chikhodzodzo, madzi osefedwa amayenera kuzikirapo. Izi zimatheka mu gawo lachiwiri, pamene zinthu zonse zofunikira - sodium, potaziyamu, ndi zinthu zamagazi - zimabwezeretsedwa m'magazi mu mawonekedwe osungunuka. Thupi limaganiziranso kuti shuga ndiyofunika, chifukwa ndi omwe amapatsa mphamvu minofu ndi ubongo. Mapuloteni apadera a SGLT2 amabweza magazi. Amapanga mtundu wamtoko mu thumba la nephron, lomwe shuga limadutsa m'magazi. Mwa munthu wathanzi, glucose imabweranso kwathunthu, mwa wodwala yemwe ali ndi matenda a shuga, amalowa mkodzo pang'ono pomwe mulingo wake umaposa gawo la impso la 9-10 mmol / L.

Mankhwala a Forsig adapezeka chifukwa chamakampani opanga mankhwala omwe amafunafuna zinthu zomwe zitha kutseka matanthwe amenewa ndikutchingira shuga mumkodzo. Kufufuza kunayamba m'zaka zapitazi, ndipo pomaliza, mu 2011, Bristol-Myers squibb ndi AstraZeneca anafunsanso kuti alembetsedwe ngati mankhwala atsopano a matenda a shuga.

Zomwe zimagwira ntchito ya Forsigi ndi dapagliflozin, ndizoletsa zama protein a SGLT2. Izi zikutanthauza kuti amatha kupondaponda ntchito yawo. Madzi amkati am'madzi amkodzo amachepa, amayamba kuphatikizidwa ndi impso zochulukirapo. Zotsatira zake, kuchuluka kwa magazi kumatsitsa glucose, mdani wamkulu wamitsempha yamagazi komanso chifukwa chachikulu cha zovuta zonse za shuga. Mbali yodziwika bwino ya dapagliflozin ndiyosavuta kusankha, ilibe gawo lililonse pama glucose omwe amayenda ndi minofu ndipo samasokoneza mayamwidwe ake.

Pa mulingo woyenera wa mankhwalawa, pafupifupi 80 g ya glucose imatulutsidwa mkodzo patsiku, kuwonjezera apo, kuchuluka kwa insulin yopangidwa ndi kapamba, kapena kupezeka ndi jakisoni. Zisakhudze mphamvu ya Forsigi ndi kukhalapo kwa insulin kukana. Komanso, kuchepa kwa shuga m'magazi kumathandizira kudutsa shuga otsala kudzera mwa michere.

Mulimonse momwe amaperekedwera

Forsyga sangathe kuchotsa shuga onse owonjezera panthawi yomwe kudya kosalekeza kwa chakudya. Monga othandizira ena a hypoglycemic, kudya ndi kuchita masewera olimbitsa thupi pakugwiritsa ntchito ndizofunikira. Nthawi zina, monotherapy ndi mankhwalawa ndizotheka, koma nthawi zambiri endocrinologists amalembera Forsig limodzi ndi Metformin.

Kukhazikitsidwa kwa mankhwala mu milandu yotsatirayi ndikulimbikitsidwa:

• kuwongolera kuchepa kwa odwala omwe ali ndi matenda a shuga 2;
• monga chida chowonjezera chodwala;
• kukonza zolakwa pafupipafupi m'zakudya;
• pamaso pa matenda omwe amalepheretsa zolimbitsa thupi.

Ngakhale adachita bwino kwambiri komanso kuwunika kwabwino, a Forsiga sanalandire zofalitsa zambiri. Pali zifukwa zingapo izi:

• mtengo wake wokwera;
• nthawi yokwanira yophunzira;
• kudziwonetsera kokha chizindikiro cha matenda ashuga, osakhudza zomwe zimayambitsa;
• zovuta za mankhwala.

Malangizo ogwiritsira ntchito mankhwalawa

Mankhwala amakhudza kuchuluka kwamkodzo kwamkodzo tsiku lililonse, kuti muchepetse 80 g shuga, pafupifupi 375 ml ya madzi amathandizanso. Uwu ndi pafupifupi ulendo wina wowonjezera kuchimbudzi tsiku lililonse. Madzi otaika amayenera kulowedwa m'malo kuti athetse kusowa kwamadzi. Chifukwa cha kuchotsedwa kwa gawo lina la glucose mukamamwa mankhwalawo, zopatsa mphamvu zonse za kalori zimachepetsedwa ndi zopatsa mphamvu 300 patsiku.

Zotsatira zoyipa za mankhwalawa

Polembetsa Forsigi ku US ndi Europe, opanga ake adakumana ndi zovuta, komitiyi sinavomereze mankhwalawa chifukwa choopa kuti ikhoza kuyambitsa zotupa mu chikhodzodzo. Panthawi ya mayeso azachipatala, malingaliro awa adakanidwa, katundu wa carcinogenic sanawululidwe ku Forsigi.

Mpaka pano, pali zambiri kuchokera ku kafukufuku woposa khumi ndi awiri omwe atsimikizira chitetezo cha mankhwalawa komanso kuthekera kwake kuchepetsa shuga. Mndandanda wazotsatira zoyipa ndi kupezeka kwake zimachitika. Zonse zomwe atengedwa zimachokera pakudya kwakanthawi kothana ndi Forsig - pafupi miyezi isanu ndi umodzi.

Palibe deta pazotsatira zakugwiritsa ntchito mankhwalawa kwa nthawi yayitali. Nephrologists akuwonetsa nkhawa kuti kugwiritsa ntchito mankhwalawa kwa nthawi yayitali kungasokoneze kugwira ntchito kwa impso. Chifukwa choti amakakamizidwa kuti azigwira ntchito mopitilira muyeso, kuchuluka kwa kusefera kwa madzi kumatha kuchepa ndipo kuchuluka kwa mkodzo kumatha kuchepa.

Zotsatira zoyipa zomwe zadziwika:

1. Mukapatsidwa chida chowonjezera, kuchepa kwambiri kwa shuga m'magazi ndikotheka. Hypoglycemia nthawi zambiri imakhala yofatsa.
2. Kutupa kwa genitourinary system yoyambitsidwa ndi matenda.
3. Kuwonjezeka kwamkodzo kwamikodzo ndikuposa kuchuluka komwe kumafunikira pochotsa shuga.
4. Kuchuluka kwa lipids ndi hemoglobin m'magazi.
5. Kukula kwa magazi a metabolinine komwe kumayenderana ndi kuwonongeka kwaimpso kwa odwala omwe ali ndi zaka 65.

Osakwana 1% ya odwala omwe ali ndi matenda ashuga, mankhwala amayambitsa ludzu, kuchepa kwa nkhawa, kudzimbidwa, thukuta lotuluka, kukodza pafupipafupi usiku.

Kukhala tcheru kwambiri kwa madokotala kumachitika chifukwa cha kukula kwa matenda opatsirana kwamtunduwu chifukwa chogwiritsa ntchito Forsigi. Zotsatira zamtunduwu ndizofala kwambiri - mwa 4.8% ya odwala matenda a shuga. Amayi 6.9% ali ndi vaginitis ya bakiteriya ndi fungus komwe amayambira. Izi zikufotokozedwa ndikuti shuga yowonjezereka imakwiyitsa kuchuluka kwa mabakiteriya mu urethra, mkodzo ndi nyini. Kuteteza mankhwalawa, titha kunena kuti matendawa amakhala ochepetsetsa kapena ochepa komanso amathandizira pakulandira chithandizo chokwanira. Nthawi zambiri zimachitika kumayambiriro kwa Forsigi, ndipo sizibwerezedwa kawirikawiri pambuyo pa chithandizo.

Malangizo ogwiritsira ntchito mankhwalawa amasintha mosinthasinthazimagwirizanitsidwa ndi kupezeka kwa zotsatira zoyipa ndi zotsutsana. Mwachitsanzo, muFebruary 2017, chenjezo lidaperekedwa kuti kugwiritsa ntchito SGLT2 inhibitors kumawonjezera chiopsezo chodulidwa zala zakumanzere kapena mbali ya phazi ndi katatu. Zosinthidwa zimawonekera mu malangizo a mankhwalawo pambuyo patsopano maphunziro.

Contraindication Forsigi

Zoyipa zotsutsana ndi:

1. Type 1 shuga mellitus, popeza kuthekera kwa hypoglycemia kwakukulu sikumachotsedwa.
2. Nthawi ya kubereka ndi mkaka wa m`mawere, zaka mpaka 18. Umboni wa chitetezo cha mankhwalawa kwa amayi apakati ndi ana, komanso kuthekera kwa kutulutsa kwake mkaka wa m'mawere, sikunachitike.
3. Zazaka zopitilira 75 chifukwa cha kuchepa kwa thupi mu ntchito ya impso komanso kuchepa kwa magazi mozungulira.
4. Lactose tsankho, ngati chinthu chothandizira ndi gawo la piritsi.
5. Thupi lawo siligwiritsidwa ntchito popanga miyala ya zipolopolo.
6. Kuchulukitsa kwamphamvu m'magazi a ketone matupi.
7. Matenda a shuga ndi nephropathy omwe amachepetsa kuchuluka kwa kusefera kwa 60 ml / mphindi kapena kulephera kwambiri kwaimpso komwe sikugwirizana ndi shuga.
8. Kulandilidwa kwa malupu (furosemide, torasemide) ndi thiazide (dichlothiazide, polythiazide) okodzetsa chifukwa cha kuchuluka kwa zomwe amachita, zomwe zimayamba chifukwa chakuchepa kwa kupsinjika ndi kuperewera kwa madzi m'thupi.

Kuvomerezedwa kumaloledwa, koma kusamala ndikuwunika kowonjezera kuchipatala kumafunikira: odwala okalamba omwe ali ndi matenda osokoneza bongo, anthu omwe ali ndi hepatic, mtima kapena kulephera kwa aimpso, matenda osachiritsika.

Kuyesedwa kwa zovuta zakumwa zoledzeretsa, nikotini ndi zakudya zosiyanasiyana zomwe zimachitika chifukwa cha mankhwala sikunachitikebe.

Kodi zingathandize kuti muchepetse kunenepa

Pakufotokozeratu mankhwalawo, wopanga Forsigi amadziwitsa za kuchepa kwa thupi komwe kumawonedwa pakumwa. Izi zimadziwika makamaka kwa odwala matenda a shuga omwe amakhala ndi kunenepa kwambiri. Dapagliflozin amagwira ntchito monga okodzetsa pang'ono, amachepetsa kuchuluka kwa madzi mthupi. Ndilemera kwambiri komanso kupezeka kwa edema, awa ndi madzi osachepera 3-5 kg ​​sabata yoyamba. Zofananazo zitha kuchitika mwa kusinthira ku chakudya chopanda mchere ndikuchepetsa kwambiri kuchuluka kwa chakudya - thupi limayamba kuchotsa chinyezi chosafunikira.

Chifukwa chachiwiri chakuchepetsa thupi ndi kuchepa kwama calories chifukwa kuchotsedwa kwa gawo la shuga. Ngati 80 g ya glucose imatulutsidwa mkodzo patsiku, izi zimataya kuchepa kwa zopatsa mphamvu 320. Kuti muchepetse kilogalamu yakulemera chifukwa cha mafuta, muyenera kuchotsa ma calories a 7716, ndiye kuti, kutaya 1 makilogalamu kumatenga masiku 24. Zikuwonekeratu kuti Forsig angachite pokhapokha ngati pali zakudya zopanda thanzi. Kuti mukhale okhazikika, kuchepa thupi kuyenera kutsatira zakudya zomwe simukudwala ndipo musaiwale za maphunziro.

Anthu athanzi sayenera kugwiritsa ntchito Forsigu pakuchepetsa thupi. Mankhwalawa amagwira ntchito kwambiri ndi misempha yayikulu yamagazi. Kuyandikira kwambiri kwachilendo, kumachepetsa mphamvu ya mankhwalawo. Musaiwale za kupsinjika mopitirira muyeso kwa impso komanso kusakwanitsa kugwiritsa ntchito mankhwalawa.

Ndemanga za Odwala

Kodi fanizo ndi chiyani

Mankhwala a Forsig ndi mankhwala okhawo omwe amapezeka m'dziko lathu ndi dapagliflosin. Zofananira zonse za Forsigi choyambirira sizipangidwa. Monga cholowa mmalo, mutha kugwiritsa ntchito mankhwala aliwonse kuchokera mgulu la glyphosines, machitidwe omwe amatengera zoletsa za SGLT2. Mankhwala awiri otere anapititsa kulembetsa ku Russia - Jardins ndi Invokana.

Mitengo yoyenerera ya Forsigu

Mwezi umodzi wothira mankhwala a Forsig udzagula pafupifupi ma ruble 5,000. Kuyika pang'onopang'ono, osati zotsika mtengo, makamaka mukamaganizira za othandizira a hypoglycemic, mavitamini, zakudya zam'magazi, komanso zina zotsekera shuga, zomwe ndizofunikira kwa matenda ashuga. Posachedwa, zinthu sizingasinthe, popeza mankhwalawo ndi atsopano, ndipo wopanga amafuna kuyambiranso ndalama zomwe adaziika pantchito zachitukuko ndi kafukufuku.

Kuchepetsa kwa mitengo kungayembekezeredwe pokhapokha kutulutsidwa kwa ma jenereta - ndalama ndi zomwe zimapangidwa ndi ena opanga. Zofanizira zotsika mtengo sizidzawonekeranso kale kuposa chaka cha 2023, chitetezo cha patent cha Forsigi chikadzatha, wopanga zinthu zoyambirira ataya ufulu wake.