Ingavirin ali ndi katundu wa immunomodulatory ndipo amatha kupewetsa ma virus monga nkhumba chimfine komanso fuluwenza B. Kuphatikiza apo, mankhwalawa amatha kusokoneza thupi ndi matenda a adenoviral, parainfluenza ndi matenda ena oyambitsidwa ndi tizilombo. Mankhwalawa anapangidwa koyamba ndi A. Chuchalin.
Ingavirin amaloledwa kutengedwa ngati chiwopsezo cha matenda opezeka ndi mavairasi. Mankhwalawa ali ndi mphamvu yayikulu mthupi mumaola 36 oyambirira atatenga kachiromboka.
Kuphatikiza apo, ndizotheka kugwiritsa ntchito mankhwalawa pa oncology monga othandizira a hematopoiesis.
Mankhwala si mankhwala othana ndi mankhwalawa, sangagwiritsidwe ntchito pochiza matenda opatsirana a bakiteriya. Kusiyana pakati pa mankhwalawa ndi maantibayotiki ndikuthekera kwake kolimbikitsa chitetezo cha mthupi.
Khalidwe lotsirizali ndilofunika makamaka pakakhala zovuta zamagulu amunthu. Chimodzi mwazinthu izi zothandiza monga matenda a shuga.
Chowonadi ndi chakuti pakukula kwa shuga pali kuchepa kwa chitetezo cha mthupi, zomwe zimakweza chitukuko mthupi la matenda osiyanasiyana opatsirana a ma virus omwe amakhudza kupuma kwamunthu. Mankhwala ali ndi anti-kutupa.
Mlingo mawonekedwe ndi zikuchokera mankhwala
Ingavirin ndi dzina lachiwiri lomwe ndi lapadziko lonse lapansi komanso losagwirizana - imidazolylethanamide pentanedioic acid.
Njira yayikulu yomasulira mankhwalawa ndi makapisozi.
Wogwira ntchito popanga mankhwalawa ndi 2- (imidazol-4-yl) -ethanamide pentanedio-1,5 acid. Kutengera ndi ma phukusi, kapisozi imodzi imatha kukhala ndi 30 kapena 90 mg ya mankhwala othandizira.
Kuphatikiza pazinthu zogwira ntchito, kapisozi imodzi imakhala ndi mitundu yonse yazothandizira.
Zothandiza pazomwe zili kapisozi yamankhwala ndi:
- lactose;
- wowuma mbatata;
- colloidal silicon dioxide;
- magnesium wakuba.
Chigoba cha kapisozi chili ndi:
- Gelatin
- Titanium dioxide
- Utoto wapadera.
Kutengera ndi kuchuluka kwa ntchito yogwira, makapisozi amakhala ndi mtundu wina. Pa mlingo wa 90 mg, makapisozi amakhala ndi mtundu wofiirira, pamtengowo wa zigawo 30 mg wa makapisozi okhala ndi mtundu wamtambo wamtambo.
Makapisozi amakhala ndi granules kapena ufa wa yogwira mankhwala. Ufa umakhala ndi mtundu woyera, nthawi zina pamakhala ufa woyera wokhala ndi zonunkhira zonona.
Mankhwalawa atha kugulidwa ku malo ambiri ogulitsa mankhwala. Kukhazikitsa kwa mankhwalawa kumachitika malinga ndi mankhwala omwe adokotala amapita.
Mankhwalawa amayenera kusungidwa m'malo owuma ndikutetezedwa ndi kuwala kwa dzuwa osaposa 25 digiri Celsius.
Pewani kufikira ana. Alumali moyo wa mankhwala 2 zaka.
Sizoletsedwa kugwiritsa ntchito mankhwala atatha nthawi yosungirako.
Pharmacokinedics ndi pharmacodenamics ya mankhwala
Mankhwala ali sapha mavairasi oyambitsa. Zotsatira zoyipa zamafulufiyamu ndi mitundu yosiyanasiyana yamatenda oyambitsa kupuma imayikidwa mwa kupondereza kubereka komanso kugwiritsa ntchito mphamvu ya cytopathic pa ma virus ma virus.
Mothandizidwa ndi mankhwalawa, ntchito yotsatsira kachilombo ka HIV imaponderezedwa. Kuphatikiza apo, zinthu zomwe zimaphatikizidwa ndi kapisozi zimathandizira chitetezo cha wodwala.
Kugwiritsa ntchito mankhwalawa kumawonjezera kuchuluka kwa kuphatikizirana m'thupi, kumapangitsa kuti maselo oyera azitsekera m'magazi a wodwala.
Kulandira chithandizo m'thupi la wodwalayo sikungosinthidwa ndi metabolic, ndipo kuchoka kwa zinthu zogwirira ntchito m'thupi la wodwalayo kumachitika mosasintha.
Mafuta ambiri omwe amaphatikizidwa m'thupi la wodwalayo amafika mphindi 30 mutatha kumwa mankhwalawo. Mankhwala mwachangu pambuyo makonzedwe amalowa m'magazi kuchokera m'matumbo am'mimba.
Kuchuluka kwa mankhwalawa kumachotsedwa m'thupi pakatha maola 24. Ndi munthawi imeneyi yomwe gawo lalikulu la mankhwalawa limachotsedwa, zomwe zimapangitsa kuti 80% yazonse za mankhwalawo.
34% ya mankhwalawa amachotseredwa pakatha maola 5 atasiya kumwa mankhwalawa ndipo pafupifupi 46% amachotsedwa pakadutsa maola 5 mpaka 24. Kuchotsa unyinji wa mankhwalawa kudzera m'matumbo. Kuchuluka kwa mankhwala omwe amathandizidwa mwanjira imeneyi ndi pafupifupi 77%, pafupifupi 23% amamuwonjezera kudzera mu kwamikodzo.
Mukamagwiritsa ntchito mankhwalawa, palibe mphamvu yosinthira thupi. Ingavirin sichikhudza kuchuluka kwa zochitika zama psychomotor. Mankhwalawa amaloledwa kumwa ndi odwala omwe amayendetsa magalimoto ndi zida zovuta zomwe zimafuna kuthana kwakukulu ndikuwonetsetsa.
Chimodzi mwa mankhwalawa ndiko kusowa kwake kwa mutagenic, immunotoxic, allergenic ndi carcinogenic; kuphatikiza apo, mankhwalawa samakhumudwitsa thupi.
Mankhwalawa amadziwika ndi kawopsedwe kotsika kwambiri kwa thupi la munthu.
Malangizo ogwiritsira ntchito mankhwalawa
Kulandila kwa chipangizo chachipatala kumachitika mosasamala mtundu wa chakudya.
Zochizira matenda a virus, mankhwalawa amatengedwa pa mlingo wa 90 mg 1 nthawi patsiku. Kwa ana a zaka 13 mpaka 17, tikulimbikitsidwa kumwa mankhwalawa 60 mg kamodzi patsiku munthawi ya mankhwala.
Kutalika kwa mankhwalawa ndi masiku 5 mpaka 7. Kutalika kwa mankhwalawa kumatengera kuopsa kwa matendawa.
Kumwa mankhwalawa kuyenera kuyamba mukangoyamba kumene kwa zizindikiro zoyambirira.
Pa prophylactic makonzedwe a mankhwalawa akakumana pakati pa anthu athanzi ndi odwala, mankhwalawa amayenera kumwa kuchuluka kwa 90 mg, kamodzi patsiku, mankhwala ayenera kumwedwa kwa masiku 7.
Zizindikiro zazikulu pakugwiritsa ntchito mankhwalawa ndi izi:
- Mankhwala othandizira fuluwenza A ndi B, komanso matenda ena amtundu wa kupuma kwamphamvu mwa munthu wamkulu.
- Njira zodzitetezera poyambitsa fuluwenza A ndi B komanso matenda ena amtundu wa kupuma kwamphamvu mwa munthu wamkulu.
- Chithandizo cha fuluwenza A ndi B, komanso kupewa kwa ana azaka 13 mpaka 17.
Milandu ikuluikulu yomwe imagwiritsidwa ntchito ngati mankhwala ndi awa:
- kukhalapo kwa kuchepa kwa lactose mu thupi;
- lactose tsankho;
- kukhalapo kwa shuga-galactose malabsorption wodwala;
- nthawi yobereka mwana;
- nthawi yoyamwitsa;
- kukhalapo kwa hypersensitivity ku zigawo za mankhwala.
Kodi ndizotheka kutenga Ingavirin ngati wodwala matenda ashuga amagwiritsa ntchito insulin? Malinga ndi madotolo, ndizotheka kuphatikiza wothandizira antiviral ndi insulin. Izi sizowopsa.
Zotsatira zoyipa mukamagwiritsa ntchito mankhwalawa zimayambitsa matupi awo. Zotsatira zoyipa mukamagwiritsa ntchito mankhwalawa m'thupi la wodwala ndizosowa kwambiri.
Sipanakhalepo ndi vuto la kumwa mopitirira muyeso mukamamwa mankhwalawa.
Mukamachititsa maphunziro a milandu yogwirizana ndi mankhwala ena ndi mankhwala ena sizinapezekenso.
Pochiza matenda a viral, sikulimbikitsidwa kugwiritsa ntchito Ingavirin osakanikirana ndi mankhwala ena omwe ali ndi zotsatira zoyambitsa matenda.
Mtengo wa mankhwalawo, mawonekedwe ake ndi ndemanga zake
Ma analogi a Ingavirin amaimiridwa pamsika wamankhwala ambiri. Mankhwala amatha kusiyanasiyana kapangidwe kake ka mankhwala ndi mtengo wake, koma zimakhudzanso thupi.
Mukamasankha analogues, chisamaliro chapadera chiyenera kulipidwa pa mlingo wogwiritsidwa ntchito komanso mndandanda wa contraindication. Nthawi zambiri, mankhwala okhala ndi mtengo wotsikirapo amagwiritsidwa ntchito muyezo waukulu, womwe ungakhale wosavomerezeka mukamagwiritsa ntchito mankhwala kuchiza odwala muubwana.
Kuphatikiza apo, kugwiritsa ntchito mankhwalawa muyezo waukulu kungafune ndalama zowonjezera chifukwa chakuti kuchuluka kwa mankhwalawa kumatha.
Ndemanga za Ingavirin nthawi zambiri zimapezeka kuti zili ndi zabwino, ndemanga zoyipa zimakonda kugwiritsidwa ntchito chifukwa chakuti mankhwalawa amathandizanso pokonza mankhwala.
Ma fanizo ofala kwambiri ndi awa:
- Tiloron.
- Anaferon.
- Altabor.
- Amizon.
- Imustat.
- Kagocel.
- Hyporamine.
- Ferrovir
Mtengo wapakati wa Ingavirin ku Russia ndi pafupifupi ma ruble 450. Ngakhale kuti othandizira sathandizira amakhala otetezeka, tikulimbikitsidwa kupezeka ndi nthawi yovomerezeka ya ARVI. Kukhala kofunikira kugwiritsa ntchito maofesi a multivitamin, mwachitsanzo, Oligim kapena Doppelgerts kwa odwala matenda ashuga. Kanemayo munkhaniyi apitiliza kuthandizira matenda a shuga.
