Presartan ndi mankhwala osokoneza bongo a antihypertensive malinga ndi zochita za losartan. Zomwe zimagwiritsidwa ntchito sizili m'gulu la zoletsa zoletsa za ACE, popeza zimakhala zotsutsana ndi angiotensitive receptors. Mankhwalawa angagwiritsidwe ntchito poyerekeza ndi matenda a shuga komanso poperekanso mankhwala ena omwe ali ndi hypotensive. Mankhwalawa amathandizira kuthetsa kuthamanga kwa magazi ndi ochepa matenda oopsa komanso kumanzere kwamitsempha yamagazi.
Dzinalo Losayenerana
Losartan.
Presartan wa mankhwala angagwiritsidwe ntchito pa matenda a shuga.
ATX
C09CA01.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwalawa amapezeka mu mawonekedwe apiritsi, yokutidwa-filimu. Piritsi lililonse lili ndi 25 kapena 50 mg ya losartan potaziyamu ngati gawo logwira. Opezekapo ndi monga:
- wowuma wopanda madzi;
- talc;
- ma cellcose a microcrystalline;
- colloidal silicon dioxide;
- methylene chloride;
- sodium wowuma glycolate.
Piritsi lililonse la Presartan limakhala ndi 25 kapena 50 mg ya losartan potaziyamu ngati gawo logwira.
Mapiritsiwa ndi a pinki chifukwa cha utoto wofiirira, okhala ndi mawonekedwe a biconvex. Kusiyana pakati pa mapiritsi okhala ndi Mlingo wa 50 mg kuchokera ku mankhwala 25 mg ndikusowa kwa kugawa zowopsa kumbali yakutsogolo.
Mtolo wa makatoni okhala ndi matuza 1, 2 kapena 3.
Mapiritsi 10 kapena 14 amayikidwa m'matumba a aluminium blister.
Zotsatira za pharmacological
Mankhwalawa ndi a gulu la otsutsa a AT-1 (angiotensin receptors). Mankhwalawa ali ndi mphamvu ya antihypertensive. Zomwe zimagwiritsidwa ntchito ndi losartan ndizotsutsana za angiotensin II zolandilira. Pulogalamu yamankhwala, yosiyana ndi ACE inhibitors (angiotensin-converting enzyme), sichimaletsa kugwira ntchito kwa kinase II, yofunikira pakuwonongeka kwa vasodilating bradykinin.
Chifukwa cha kuponderezana kwa ma receptor a AT-1, zotumphukira zonse za mtima ndi magazi zimachepa. Pali kuchepa kwa katundu pambuyo pamtima. Mankhwalawa amachepetsa matenda oopsa a m'mapapo chifukwa cha kuchepa kwa kuthamanga kwa magazi m'magazi a m'mapapo.
Pharmacokinetics
Akamamwa pakamwa, losartan imatulutsidwa piritsi chifukwa cha matumbo am'mimba, omwe amaphwanya nembanemba, ndipo amadziunjikira kukhoma lamatumbo ndi zombo zophukira. Kuchokera khoma lamatumbo, chinthu chogwira ntchito chimalowa m'magazi, pomwe chimafika m'magazi a ola limodzi. Bioavailability limodzi mlingo ukufika 33%.
Mankhwala amayamba kusintha pomwe akudutsa maselo a chiwindi ndikupanga ma metabolites.
Panthawi ya mayesero azachipatala, kukondoweza kwa mankhwala mu minofu sikunakonzeke. Hafu ya moyo ndi maola 2. Zinthu zopanga thupi za losartan ndi yogwira ntchito palokha zimamangika ku albumin ndi 92-99% ndipo, chifukwa cha zovutazi, zimayamba kugawidwa m'thupi. Mankhwalawa amathandizidwa kudzera mu kwamikodzo pogwiritsira ntchito kusefera ndipo pang'onopang'ono amachoka m'thupi kudzera mu ndulu.
Zizindikiro zogwiritsidwa ntchito
Mankhwala amathandizidwa kuti athetse matenda oopsa oopsa komanso matenda a mtima (CHD), omwe amadziwika ndi zilembo zakulephera kwa mtima.
Presartan ndi gawo limodzi la mankhwala othandizira kuphatikiza okodzetsa ndi mtima wama glycosides.
Mwakutero, mapiritsi a Presartan ndi gawo la mankhwala othandizira osakanikirana ndi okodzetsa ndi mtima glycosides.
Contraindication
Wothandizila antihypertgency ndi woletsedwa kutenga mawonedwe akuwonjezereka a ziwalo ndi minyewa yogwira ntchito ndi mankhwala othandizira. Mankhwalawa sanatchulidwe kwa amayi apakati komanso ana mpaka atakwanitsa zaka 18.
Ndi chisamaliro
Chenjezo umalimbikitsidwa pakachitika zosokoneza m'madzi-electrolyte kagayidwe chifukwa cha kusowa kwa magnesium, sodium, ions wa potaziyamu m'thupi kapena motsutsana ndi maziko a hypochloremic alkalosis. M'pofunika kuwongolera zinthu motere:
- bilatal stenosis ya mitsempha mu impso;
- matenda a shuga;
- mtima pathologies;
- kuchuluka plasma ndende ya calcium;
- gout
- magazi ochepa ozungulira, okwiyitsidwa ndi kutaya kwamadzi.
Sikulimbikitsidwa kuti mtima wama glycosides aikidwa munthawi yomweyo mukamamwa mankhwala oopsa.
Momwe mungatenge Presartan
Kuti muchepetse kuthamanga kwa magazi, muyezo wa 25 mg wa tsiku ndi tsiku umapangidwira gawo loyambirira la mankhwala. M'masiku otsatira a mankhwalawa, mlingo umawonjezeka mpaka 50 mg ndikukwera pamwamba. Mankhwalawa amagwiritsidwa ntchito 1 nthawi patsiku.
Poyerekeza ndi kufooka kwa mtima kosatha, pafupifupi tsiku lililonse mankhwalawa ali 12,5 mg wa limodzi.
Kwambiri achire zotsatira zimawonedwa masabata 3-6 pambuyo pa kuyamba kwa mankhwala. Ndi kuchepa kwenikweni kwa thupi ku antihypertensive mankhwala, mulingo umachulukitsidwa mpaka 100 mg ndi pafupipafupi makonzedwe 2 pa tsiku.
Poyerekeza ndi kufooka kwa mtima kosatha, avareji ya tsiku ndi tsiku ndi 12,5 mg wa limodzi. Mlingo umachulukitsidwa mlungu uliwonse ndi 12,5 mg ndi njira yovomerezeka - 50 mg - pa mlingo umodzi.
Ndi matenda ashuga
Ndi shuga wololedwa, muyenera kusamala ndikuwonetsetsa kuti shuga ya m'magazi iyendera. Pankhani ya matenda oopsa a shuga, mankhwalawa amasiya.
Zotsatira zoyipa Presartana
Kwenikweni, mankhwalawa amalekeredwa bwino, chifukwa chake, zovuta zoyipa zimachitika mwa 85% ya milandu chifukwa cha mulingo woyenera kapena kulolera pang'ono pa mlingo woyenera.
Mwina kukula kwa kutupa, kuchuluka kwa potaziyamu m'madzi am'magazi, kupezeka kwa kupweteka kwa minofu.
Kusintha kwakanthawi kochepa kumadzichitira lokha mankhwalawo ukasiya kapena kuti tsiku ndi tsiku lithe.
Zotsatira zoyipa pambuyo potenga Presartan pokhudzana ndi gawo logaya chakudya lomwe limatuluka ngati chopondera (m'mimba).
Matumbo
Zotsatira zoyipa zamagayidwe am'mimba zimawonekera mwa mawonekedwe ampando wam'mimba (m'mimba) ndi dyspepsia. Nthawi zina, kukula kwa hyperbilirubinemia ndi kuchuluka kwa hepatic aminotransferase ndikotheka.
Pakati mantha dongosolo
Mankhwalawa amatha kuyambitsa chizungulire, chisokonezo, kupweteka mutu komanso kugona. Zotsalazo zimawoneka ngati kusowa tulo kapena kugona.
Kuchokera ku kupuma
Nthawi zina, mankhwalawa amakhala ndi poizoni kupuma, ndichifukwa chake wodwalayo amayamba kutsokomola komanso kulephera kupuma.
Matupi omaliza
Odwala omwe amakonda kuwonetsa anaphylactic zimachitika, kapena mwa anthu omwe ali ndi hypersensitivity kwa zigawo zomwe zimapangidwa, mawonekedwe a angioedema, anaphylactic mantha, Quincke edema, urticaria amatha.
Wodwala yemwe akutenga Presartan ayenera kusamala poyendetsa galimoto.
Zokhudza mphamvu pakuwongolera njira
Pali chiopsezo cha zovuta m'magazi amanjenje (kugona, chizungulire), chifukwa chomwe wodwalayo ayenera kusamala poyendetsa galimoto, polumikizana ndi zida zovuta komanso pochita zinthu zina zomwe zimafunikira chidwi chochulukirapo.
Malangizo apadera
Pamaso pa kuchepa kwa madzi m'thupi kwakanthawi kokhala ndi kuchuluka kwa okodzetsa koyambirira koyamba kugwiritsidwa ntchito kwa Presartan, orthostatic hypotension. Pofuna kupewa kuchepa kwa kuthamanga kwa magazi, ndikofunikira kuti muchepetse kuchepa kwa madzi mthupi musanamwe mankhwala a antihypertensive kapena kuyamba mankhwala osokoneza bongo ndi mlingo wotsika.
Odwala omwe ali ndi vuto la chiwindi amalimbikitsidwa kuti asankhe 12,5-25 mg tsiku lililonse.
Makamaka ndi kuchepa kwamafuta a hepatocytes. Cirrhosis imadzetsa kuchuluka kwa plasma ndende ya losartan, yomwe imatsimikiziridwa ndi maphunziro a labotale.
Chiwopsezo chokhala ndi matenda a mankhwalawa mukamamwa mankhwalawa chimawonjezeka ndi matenda a impso.
Nthawi zina, mukamamwa mankhwala omwe amakhudzanso dongosolo la renin-angiotensin, ndizotheka kuwonjezera serum creatinine ndi kuchuluka kwa urea m'magazi. Chiwopsezo cha kupangika kwa ma processic chimachulukana ndikusokonekera kwa magwiridwe antchito a impso.
Gwiritsani ntchito mu ukalamba
Anthu opitilira 65 safuna kukonzanso njira.
Kupatsa ana
Chifukwa cha kusowa kwa chidziwitso pazomwe zimapangidwira mankhwala a Presartan pakukula ndi kukula kwa thupi laumunthu muubwana ndi unyamata, mankhwalawo amaletsedwa kugwiritsidwa ntchito mpaka zaka 18.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Mankhwala sayenera kuperekedwa kwa amayi apakati, chifukwa pali mwayi wolowa mkati mwa losartan mwa chotchinga chotchinga ndi magazi a amayi. Kafukufuku wazamasamba mu zinyama sanawululire zotsatira za losartan, koma zinthu zomwe zimagwira zimatha kusokoneza chizindikiro chachikulu. Chifukwa chake, mankhwalawa amagwiritsidwa ntchito kuchepetsa kuthamanga kwa magazi kwa amayi apakati pokhapokha povuta, pamene chiopsezo ku moyo wa mayi chimaposa mwayi wakukula kwa mwana wosabadwayo.
Pa mankhwala ndi antihypertensive mankhwala, tikulimbikitsidwa kusiya kuyamwitsa.
Pa mankhwala ndi antihypertensive mankhwala, tikulimbikitsidwa kusiya kuyamwitsa.
The ntchito aimpso kuwonongeka
Ndikulimbikitsidwa kusamala ndi ntchito yosayenera ya impso ndikuyamba mankhwalawa ndi mankhwala ochepa.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Mankhwalawa amaletsedwa kuti chiwindi chisale kwambiri.
Overdose wa Presartan
Ndi gawo limodzi lalikulu la mankhwala, ochepa hypotension imayamba, kugunda kwa mtima kumawonjezereka ngati chiphuphu cha thupi. Wogwiritsa ntchito bongo mopitirira muyeso amafunika thandizo. Asanafike ambulansi, ndikofunikira kusamutsa wodwalayo pamalo opingasa ndikukweza miyendo yake kuyesera kukhazikika pakukakamizika. Pokhazikika, chithunzi cha mankhwala osokoneza bongo amachotsedwa. Hemodialysis chifukwa cha kuchuluka kwambiri kwa kumumanga kwa losartan kupita ku albin sikuthandiza.
Hemodialysis chifukwa cha kuchuluka kwa kumanga kwa Presartan kupita ku albin sikuthandiza.
Kuchita ndi mankhwala ena
Ndi munthawi yomweyo makonzedwe a Perzartan ndi diuretic ndi potaziyamu-yosungirako zotsatira, mankhwala okhala potaziyamu ndi m'malo mwake, hyperkalemia ikhoza kuchitika.
Mankhwala ena a antihypertgency amapanga synergistic zotsatira, momwe achire zotsatira zake zonse zimakhazikika. Mphamvu yowononga kwambiri imawonedwa.
Mankhwala osapatsirana omwe amaletsa kutupa ndi Indomethacin, akaperekedwa limodzi ndi losartan, amatha kufooketsa mphamvu ya achire.
Mukamamwa mankhwala okodzetsa panthawi ya mayeso a chipatala, kutsika kwa magazi kunapezeka.
Ndi kufanana kwa Perzartan ndi diuretic yokhala ndi potaziyamu wokulirapo, hyperkalemia ingachitike.
Kuyenderana ndi mowa
Panthawi yamankhwala, mumaletsedwa kumwa mowa. Mowa wa Ethyl umalepheretsa kugwira ntchito kwamkati wamanjenje ndipo umawonjezera poizoni m'maselo a chiwindi. Pazinthu zowonjezereka, hepatocytes sangathe kuchotsa poizoni ku cytoplasm munthawi yake, ndichifukwa chake amafa en masse. Madera a Necrotic amasinthidwa ndi minofu yolumikizana. Kuchepetsa mphamvu ya antihypertensive ya mankhwala kumawonedwa.
Analogi
Zofanana makulidwe a mankhwala omwe ali ndi kufanana kwa pharmacological amaphatikizapo:
- Lorista
- Cozaar;
- Losartan teva;
- Vasotens;
- Lozap.
Substartan imasinthidwa pakachitika zoipa, pomwe kutsitsa kwa mankhwalawa sikothandiza, kapena pakalibe chithandizo chowonjezera. Analogue imasankhidwa ndi adotolo kutengera mtundu wa wodwalayo.
Kupita kwina mankhwala
Mankhwalawa sagulitsidwa popanda chiwonetsero chachipatala mwachindunji.
Kodi ndingagule popanda kulandira mankhwala?
Kugulitsa kwaulere kumakhala kochepa chifukwa cha chiwopsezo chokhala ndi bongo wambiri ngati Presartan ikuzunzidwa kapena kuyambitsa kwambiri hypotension.
Mtengo wa Presartan
Mtengo wamba wamapiritsi umafika ku ruble 200.
Zosungidwa zamankhwala
Ndikulimbikitsidwa kusunga mapiritsi a Presartan pamtunda wa + 15 ... + 25 ° C pamalo otetezedwa ndi dzuwa, wokhala ndi chinyezi chocheperako.
Tsiku lotha ntchito
Zaka zitatu
Analogue ya Presartan - mankhwala a Lorista ayenera kusungidwa pa kutentha kwa + 15 ... + 25 ° C.
Wopanga
Ipka Laboratories Limited, India.
Ndemanga za madotolo za Presartan
Ivan Korenko, wothandizira, Lipetsk
Mankhwala othandiza ndi wofatsa kwambiri. Mtundu woyenera wa mankhwala. Muzochita zamankhwala, zotsatira zoyipa zimawonedwa mwa mawonekedwe a kufatsa kwamphamvu. Ndikofunika kutsatira mankhwalawa. Mosiyana ndi izi, chithandizo chamankhwala chimakhala chovuta kukwaniritsa ndipo zovuta zazotsatira zimatha kuwonjezereka. Mankhwalawa ndi njira yabwino yothanirana ndi mavuto a impso. Ndikulembera odwala matenda ashuga a 2 kuti muchepetse nkhawa pa impso.
Vasily Izyumenko, katswiri wamtima, Tomsk
Odwala omwe ali ndi matenda osokoneza bongo omwe samadalira insulin, mankhwalawa amachepetsa chiopsezo cha proteinuria. Ndinaona kugwira ntchito kwa okalamba - tachycardia ndi kupanikizika kumachepa pang'ono ndi pang'ono. The achire zotsatira zimawonekera monga losartan amadziunjikira mu thupi, kotero mkati mwa masabata 3-6 amafunikira kuti apereke kudya komwe kwa antihypertensive wina wamavuto. Mankhwala amachepetsa kutupa, kumawonjezera kukana kwa myocardium kulimbitsa thupi. Ndi mlingo woyenera, umagwirizana bwino ndi wodwalayo.
Mndandanda wa mankhwalawa womwe ukufunsidwa - Mankhwala a Cozaar sogulitsa popanda kuwonetsa mwachindunji kuchipatala.
Ndemanga za Odwala
Veniamin Gerasimov, wazaka 54, Yekaterinburg
Ndili ndi mavuto obwera ndi magazi komanso matenda ashuga, choncho si mankhwala aliwonse omwe ali oyenera. Dokotala wopezekapo analimbikitsa mapiritsi a Presartan, omwe sanayambe kuchitapo kanthu mwachangu. Pakati pa masabata awiri, kupanikizika kunakhalabe komweku ndipo sikunachepe. Zotsatira zake zimawonekera kwa masabata atatu okha. Pambuyo pa miyezi iwiri, kupanikizika kunabwereranso kwawoko ndipo ngakhale zinthu zonse zinasintha. Ataleka kumwa mankhwalawo, kupanikizika kunabwereranso kwambiri. Mankhwalawa samachiritsa, koma amathandizanso kuunika. Chifukwa chake, muyenera kusamala mukamatenga.
Alexandra Vlasova, wazaka 60, Arkhangelsk
Atamuchita opaleshoni ya mtima, mwamunayo amayenera kuwunika mayendedwe ake nthawi zonse. Pa kuthamanga kwa magazi kwa 180/120, Zizindikiro mu mwezi zidatsikira mpaka 120/100, kugunda kwa mtima kuchokera pa 120 kutsika mpaka kumamenya 72 / mphindi. Panalibe zotsatirapo zoyipa kapena zoyipa, koma panali zovuta m'masiku oyamba oyang'anira. Mwamunayo anali m'chipatala, ndipo adotolo adati izi zinali zotsatira zoyipa za opaleshoniyo. Kupanikizika ndikukhazikika.
