Orlistat: malangizo, kuwunika, kuchepetsa thupi, kuchuluka kwake

Orlistat ndi amodzi mwa mankhwala ovomerezeka ku Russia pochizira kunenepa kwambiri. Chipangizocho chiribe dongosolo, chifukwa chake ndichotetezedwa. Amagwira m'matumbo okha, kutsekereza kuyamwa kwamafuta pazakudya. Kudya calorie kumachepetsa basi. Kugwiritsa ntchito zakudya zamafuta kwambiri nthawi imodzi monga kumwa Orlistat kumapangitsa kuti mafuta azituluka limodzi ndi ndowe, motero odwala amalangizidwa kuti azitsatira zakudya mukamalandira chithandizo.

Orlistat amatumizidwira chiyani?

Kunenepa kwambiri kumatchedwa imodzi mwazovuta zazikulu zamankhwala amakono. Malinga ndi deta ya 2014, anthu 1.5 biliyoni ndi onenepa kwambiri, 500 miliyoni a iwo akupezeka ndi kunenepa kwambiri. Ziwerengerozi zikukula chaka chilichonse, kuchuluka kwamphamvu kwa anthu kwatengera vuto la mliri. Chifukwa chachikulu chakuwonekera kwa kunenepa kwambiri, madokotala amatcha chakudya chopanda thanzi komanso chokhala pansi. Udindo wa cholowa ndi chochepa kwambiri kuposa momwe anthu ambiri amakhulupirira. Odwala ambiri sanyalanyaza zakudya zomwe amapatsa mphamvu ndi zakudya zochuluka. Ndipo owerengeka okha ndi omwe ali okonzeka kuvomereza kuti kunenepa kwambiri ndi matenda osachiritsika omwe amafunikira kudziletsa pamoyo wonse.

Njira yothetsera kunenepa kwambiri imakhudza kusintha pang'onopang'ono njira zomwe wodwalayo amadya, kuthetseratu ubale womwe umakhalapo pakati pa zakudya ndi chakudya, komanso kupewa kukhala moyo wongokhala. Monga lamulo, endocrinologists amatcha cholinga choyambirira kukhala 10% kuwonda m'miyezi isanu ndi umodzi yoyambirira. Ngakhale ma kilogalamu 5-10 otayika kwambiri amakhudza thanzi la kuchepetsa thupi. Malinga ndi ziwerengero ,imfa imachepa ndi 20%, mwa odwala matenda ashuga - pafupifupi 44%.

Monga chithandizo, odwala ena amatha kupatsidwa mankhwala. Chofunikira chachikulu cha mankhwalawa omwe amagwiritsidwa ntchito mu kunenepa kwambiri ndi kusapezeka kwa vuto lakumtima. Mwa mankhwala omwe adalembetsedwa ku Russia, ndi Orlistat okha ndi analogue omwe ali otetezeka pamalingaliro awa.

Zowonetsa kugwiritsa ntchito, zomwe zikuwonetsedwa mu malangizo:

Matenda a shuga ndi kupsinjika kudzakhala chinthu chakale

• Matenda a shuga -95%
• Kuthetsa kwa mitsempha thrombosis - 70%
• Kuthetsa kwa kugunda kwamtima kwamphamvu -90%
• Kuthana ndi kuthamanga kwa magazi - 92%
• Kuwonjezeka kwa mphamvu masana, kukonza kugona usiku -97%

• kulemera kwamisempha kwamthupi pamtunda wa 30;
• BMI ikulu kuposa 27, wodwalayo ali ndi matenda a mtima, matenda a shuga kapena matenda oopsa.

M'magawo onse awiri, chithandizo cha nthawi yayitali chikuyenera kuchepetsa kulemera. Mukamamwa Orlistat, chakudya chochepetsedwa cha kalori chimafunika. Mafuta sayenera kupitirira 30% yama calories onse.

Pakufufuza zakuyenda bwino ndi chitetezo cha Orlistat, anthu opitilira 30,000 adatenga nawo gawo. Zotsatira za maphunziro awa:

1. Zotsatira zapakati pazakudya za Orlistat m'miyezi 9 ndizochepa makilogalamu 10.8.
2. Kutsika kwapakati kwazungulira m'chiuno pachaka kunali 8 cm.
3. Ndemanga zonse za kuchepetsa thupi za Orlistat zimavomereza kuti kuchepa kwambiri kwa thupi kumachitika m'miyezi itatu yoyambirira.
4. Chizindikiro chakuti mankhwalawa ndi othandiza ndipo muyenera kupitiliza chithandizo ndikuchepetsa kuposa 5% ya kulemera m'miyezi itatu. Kuchepetsa kwambiri odwala mu gulu lino patatha chaka ndi 14% ya kulemera koyamba.
5. Mankhwala sataya mphamvu kwa zaka zosachepera 4 za ntchito mosalekeza.
6. Nthawi yomweyo monga kuchepa thupi, odwala onse adawonetsa kusintha kwa thanzi, makamaka, kuchepa kwa mavuto ndi cholesterol.
7. Mu odwala matenda ashuga, insulin sensitivity imachulukitsa, mlingo wa mankhwala a hypoglycemic amachepa.
8. Mwa anthu omwe ali ndi metabolism ya carbohydrate ambiri, chiwopsezo cha matenda a shuga chimachepetsa ndi 37%, mwa omwe ali ndi prediabetes - ndi 45%.
9. Odwala omwe adapangidwira zakudya ndi placebo adataya 6.2% ya kulemera kwawo chaka chimodzi. Kuchepetsa thupi, omwe adatsatira zakudya ndipo adatenga Orlistat - 10,3%.

Kodi mankhwalawa amagwira ntchito bwanji?

Orlistat amatchedwa blocker wamafuta. Zotsatira zake ndi kuponderezedwa kwa lipases - michere, chifukwa chomwe mafuta amawonongeka kuchokera ku chakudya. Kupanga kwamachitidwe kukufotokozedwa mwatsatanetsatane mu malangizo: zomwe zimagwiritsidwa ntchito pa mankhwalawa zimamangiriza kupita ku lipases m'matumbo am'mimba, pambuyo pake amatha kuthana ndi triglycerides mu monoglycerides ndi mafuta acids. Fomu yopanda, ma triglycerides sangathe kumizidwa, chifukwa chake, amawapaka ndowe masiku awiri. Orlistat ilibe mphamvu pa michere ina yam'mimba.

Mankhwala amatha kuchepetsa kuyamwa kwa pafupifupi 30%. Mafuta ndi chakudya chamafuta kwambiri, mu 1 g yamafuta - oposa 9 kcal (poyerekeza, mumapuloteni ndi chakudya - pafupifupi 4). Kutayika kwawo kumabweretsa kutsika kwakukulu mu zopatsa mphamvu za calorie ndipo, monga chotsatira, kuwonda.

Orlistat imangokhala m'matumbo ochepa ndi m'mimba. Osapitirira 1% ya mankhwalawa imalowa m'magazi. Mu ndende yocheperako, ilibe gawo lalikulu mthupi lonse. Orlistat ilibe poizoni kapena zowopsa. Simalumikizana ndi mankhwala ambiri omwe amaperekedwa kwa matenda oopsa, matenda ashuga, matenda amtima. Orlistat ilibe vuto lililonse m'matumbo. Malinga ndi malangizo, mankhwala omaliza atatha kumwa, ntchito ya lipases imabwezeretseka kwathunthu patatha maola 72.

Kuphatikiza pa chithandizo chamankhwala mwachindunji, Orlistat imapangitsa kuti anthu achepetse thupi m'njira yovomerezeka kwambiri pakudya komwe adakonzera. Odwala amayenera kuyang'anira nthawi zonse pakudya mafuta, chifukwa pakudya mafuta okwanira magalamu 70 kapena kuposerapo patsiku kapena chakudya chokhala ndi mafuta opitilira 20% atatha kugwiritsa ntchito mankhwalawa, zovuta zam'mimba zimachitika: kukondwerera, kukakamira pafupipafupi kwa zovuta, zovuta zogwira ndowe, kutsekula m'mimba ndizotheka. Popondapo amakhala mafuta. Ndi zoletsedwa zamafuta, zoyipa ndizochepa.

Kupanga ndi mawonekedwe a kumasulidwa

Opanga omwe angagulitse mankhwala awo ku Russia:

Orlistat imapangidwa makamaka mawonekedwe a makapisozi. Gawo lolimbikira ndi orlistat, ndipo gawo lina ndi microcrystalline cellulose, talc, gelatin, povidone, utoto, sodium lauryl sulfate. Zosankha zokwanira muyezo ndi 60 kapena 120 mg. Mlingo wake umatengera kuti mankhwalawo adzagulitsidwa kwa inu ndi mankhwala. Orlistat 120 mg - mankhwala mosamalitsa; Orlistat 60 mg (Mini) yotsika mtengo imagulitsidwa mwaulere.

Ndalama zochuluka motani:

• Polish Orlistat 120 mg - ruble 1020. pa paketi iliyonse ya makapisozi 42, 1960 rub. - kwa ma PC 84. Mlingo wa 60 mg umadya ma ruble 450. ma 42 ma PC;
• Mtengo muma pharmacies a Orlistat Canon ndi wotsika pang'ono, kuchokera ku ma ruble 900. kwa ma CD ochepa mpaka 1700 rubles. zambiri;
• Mapiritsi a Orlistat Mini amagulitsidwa pamtengo wa 460 rubles. mapiritsi 60;
• Orlistat kuchokera ku Atoll adalembetsedwa mu 2018, sanayambe agulitsidwa.

Momwe mungatenge Orlistat

Ndondomeko yoyenera kutenga Orlistat imakhala katatu patsiku, 120 mg iliyonse. Mankhwala ayenera kuledzera mkati mwa ola limodzi kuyambira nthawi yakudya. Ngati chakudyacho chidatha kapena kulibe mafuta mmenemu, malangizowo akutsimikizira kudumpha chigawo chotsatira, mphamvu yochepetsera thupi sikuchepa chifukwa cha izi.

Orlistat ndi mankhwala okhawo a kunenepa kwambiri omwe angatengedwe kwa nthawi yayitali, maphunziro atsimikizira chitetezo cha kudya kwa zaka 4 popanda zosokoneza. Njira yothandizira mankhwalawa ndiyothekanso kuteteza kunenepa kwambiri kwa odwala omwe atopa kale.

Orlistat imatha kuonedwa ngati mtundu woyesera wamafuta ochulukirapo m'zakudya. Mankhwala, kuchepetsa kunenepa kumayenera kutsatira zakudya zamafuta ochepa. Komabe, iye sangapulumutse ku zopatsa mphamvu kuchokera ku zakudya zam'thupi. Ngati mumakonda mbatata, makeke, mchere, kuchepetsa thupi ku Orlistat sikungathandize.

Kuti chithandizo cha Orlistat chithandizike, malangizo ogwiritsidwira ntchito amalimbikitsa kuphatikiza zomwe mumamwa ndi kapisozi ndikusintha kamoyo:

1. Zakudya zosankhidwa payekha. Ngati atherosulinosis samachotsedwa makamaka mafuta amanyama, pang'ono zochepa kusiya nsomba ndi mafuta a masamba. Ndi matenda ashuga, mafuta onse othamanga amachotsedwa.
2. Calorie chiletso. Chakudyacho chikuyenera kupereka zosowa patsiku pafupifupi 600 kcal. Kuchepetsa thupi pazinthu ngati izi kumachokera ku 0,5 mpaka 1 kg pa sabata. Kuthamanga mwachangu kumatha kukhala koopsa.
3. Kuwonetsetsa kugwira ntchito kwamatumbo. Kuti muchite izi, chakudyacho chimalemezedwa ndi CHIKWANGWANI, mulibe momwemo amachepetsa madzi, ngakhale pamaso pa edema. Ndikosatheka kusintha machitidwe a Orlistat, onse akumwa othandizira ndi mankhwala otsekemera, komanso kuyambitsa kusanza.
4. Kuchepetsa mowa, kukanidwa kwa chikonga.
5. Kukonzanso kwamalingaliro azakudya. Kukometsa mbale zowoneka ndi kununkhira, kampani yabwino, phwando lokondwerera siliyenera kukhala chifukwa cha chakudya china. Kuchepetsa thupi kuchepetsa, chifukwa chokha chakudyacho chizikhala njala.
6. Kukula kwa zochitika zolimbitsa thupi. Kukula kwa katundu kumatsimikiziridwa ndi dokotala. Pamaso pa kunenepa kwambiri, nthawi zambiri amakhala ndi malire oyenda (makamaka ndi masitepe) komanso kusambira kokuangalika.

Pakhoza kukhala bongo

Chofotokozerachi chikuti kuyesa kuwonjezera kuchuluka kwa Orlistat kuti achepetse thupi msanga sikungathandize. Mphamvu ya lipase inhibition sichingakulire, kuchotsedwa kwamafuta sikungasinthe. Zowona, bongo wambiri sudzachitika. Zinapezeka kuti 6-mwezi kutumikiridwa kwa mankhwalawa kawiri muyezo komanso kugwiritsa ntchito kamodzi kwa makapisozi 6 nthawi imodzi ndi otetezeka ndipo osachulukitsa pafupipafupi.

Kulekerera kwa Orlistat kumayesedwa ndi madokotala kuti ndizokwanira. Malinga ndi odwala, 31% idati mafuta onyumba, 20% - kuchuluka kwamatumbo. Mu 17%, ndi mafuta ochulukirapo, panali zotupa zamafuta pang'ono zomwe sizimalumikizidwa ndi kayendedwe ka matumbo. Anakana chithandizo chifukwa cha zovuta zoyipa za 0,3%.

Contraindication

Popeza mphamvu za Orlistat ndizochepa m'mimba, kupatsirana kwa chithandizo chamankhwala sikokwanira. Mankhwalawa amaletsedwa chifukwa chokhala ndi malabsorption a michere (malabsorption) ndi cholestatic syndrome. Contraindication ndi tsankho kwa chilichonse cha zigawo za makapisozi. Wopanga amayesa chiwopsezo cha ziwengo kukhala zotsika (zochepera 0,1%), mwa iwo omwe amachepetsa thupi, kuzungulira, kuyabwa, ndi angioedema samachotsedwa.

Kwa odwala matenda ashuga omwe amatenga Orlistat ndipo amayamba kuchepa thupi, kayendedwe ka shuga ka magazi kamalimbikitsidwa ndi malangizo omwe angagwiritsidwe ntchito. Ndi kuchepa kwa thupi, milingo ya mankhwala osokoneza bongo imakhala yayikulu kwambiri, yomwe imayambitsa hypoglycemia.

Analogs ndi choloweza

Zofananira zonse za Orlistat ndimankhwala okha omwe ali ndi mphamvu yomweyo. Mu Russian Federation amalembetsa:

Mankhwala oyamba ndi Xenical. Kuyambira mu 2017, ufulu wake ndi wa kampani yaku Germany a Chelapharm. M'mbuyomu, gulu la Roche la makampani linali ndi satifiketi yolembetsa. Xenical ndi mankhwala okwera mtengo kwambiri a orlistat. Mtengo wa makapisozi 21 - kuchokera ku ma ruble 800., makapisozi 84 - kuchokera ku ruble 2900.

Pakati pa mankhwala ochepetsa thupi ndi chinthu china chogwira ntchito ku Russia, sibutramine imagwiritsidwa ntchito (Reduxin, kukonzekera kwa Goldline). Ili ndi tanthauzo lapakati: imathandizira kukhuthala, kumachepetsa chilakolako chofuna kudya. Ndi matenda amtima, kutenga sibutramine ndiwakufa, chifukwa chake amagulitsidwa mosamala ndi mankhwala.

Ndemanga za kuchepetsa kunenepa