Trazhenta mankhwala: malangizo, ndemanga za anthu odwala matenda ashuga komanso mtengo

Trazhenta ndi mankhwala atsopano pochepetsa shuga wamagazi m'matenda a shuga, ku Russia adalembedwa mu 2012. Chosakaniza chogwira cha Trazhenta, linagliptin, ndi imodzi mwamagulu otetezeka kwambiri othandizira a hypoglycemic - DPP-4 inhibitors. Amalekeredwa bwino, alibe zotsatira zoyipa, ndipo samayambitsa hypoglycemia.

Trazenta pagulu la mankhwala omwe ali ndi pafupi amayimirira. Linagliptin ali ndi mphamvu kwambiri, motero piritsi lokha 5 mg yokha. Kuphatikiza apo, impso ndi chiwindi sizitenga nawo gawo pazakudya zake, zomwe zikutanthauza kuti odwala matenda ashuga omwe ali osakwanira ziwalozi amatha kutenga Trazhentu.

Zizindikiro zogwiritsidwa ntchito

Malangizowo amalola kuti Trazent akhazikitsidwe kokha kwa odwala matenda ashuga omwe ali ndi matenda amtundu wa 2. Monga lamulo, ndi mzere wachiwiri wa mankhwalawa, ndiye kuti, umalowetsedwa mu njira yothandizira pakukonzanso zakudya, kuchita masewera olimbitsa thupi, metformin pakulondola kapena mulingo wokwanira kusiya kuperekera chokwanira chokwanira chifukwa cha matenda ashuga.

Chizindikiro chovomerezeka:

1. Trazhent itha kufotokozedwa ngati hypoglycemic yokhayo ngati metformin silivomerezedwa bwino kapena kugwiritsa ntchito ikaphatikizidwa.
2. Itha kugwiritsidwa ntchito ngati gawo lachithandizo chokwanira ndi mankhwala a sulfonylurea, metformin, glitazones, insulin.
3. Chiwopsezo cha hypoglycemia mukamagwiritsa ntchito Trazhenta ndi chocheperako, chifukwa chake, mankhwalawa amakonda kuti odwala omwe amakonda kutsika ndi shuga.
4. Chimodzi mwazinthu zoyipa kwambiri komanso zovuta zomwe zimachitika chifukwa cha matenda ashuga chimayambitsa matenda a impso - nephropathy yokhala ndi kulephera kwa aimpso. Kufika pamlingo wina, izi zimachitika mu 40% ya anthu odwala matenda ashuga, nthawi zambiri amayamba asymptomatic. Kuchulukana kwa zovuta kumafunika kukonza njira yochiritsira, popeza mankhwala ambiri amatsitsidwa ndi impso. Odwala ayenera kuletsa metformin ndi vildagliptin, kuchepetsa kuchuluka kwa acarbose, sulfonylurea, saxagliptin, sitagliptin. Kutumiza kwa adotolo, ndi glitazones okha, glinids ndi Trazhent omwe atsalira.
5. Pafupipafupi pakati pa odwala matenda a shuga komanso kuwonongeka kwa chiwindi, makamaka mafuta a hepatosis. Pankhaniyi, Trazhenta ndiye mankhwala okhawo ochokera ku DPP4 inhibitors, omwe malangizowo amalola kugwiritsa ntchito popanda zoletsa. Izi ndizowona makamaka kwa odwala okalamba omwe ali pachiwopsezo cha hypoglycemia.

Kuyambira ndi Trazhenta, mutha kuyembekezera kuti hemoglobin ya glycated idzachepa pafupifupi 0.7%. Kuphatikiza ndi metformin, zotsatira zake zimakhala bwino - pafupifupi 0.95%. Umboni wa madotolo uwonetsa kuti mankhwalawa ndi othandizanso kwa odwala omwe ali ndi matenda a shuga okha komanso omwe ali ndi matenda opitilira zaka 5. Kafukufuku wochitidwa zaka zopitilira 2 atsimikizira kuti kuthandizira kwa mankhwala a Trazent sikuchepa pakapita nthawi.

Matenda a shuga ndi kupsinjika kudzakhala chinthu chakale

• Matenda a shuga -95%
• Kuthetsa kwa mitsempha thrombosis - 70%
• Kuthetsa kwa kugunda kwamtima kwamphamvu -90%
• Kuthana ndi kuthamanga kwa magazi - 92%
• Kuwonjezeka kwa mphamvu masana, kukonza kugona usiku -97%

Kodi mankhwalawa amagwira ntchito bwanji?

Ma mahomoni amtundu wa incretin amathandizira mwachindunji kuchepetsa glucose kukhala gawo lanyama. Kuphatikizika kwawo kumawonjezeka poyankha kulowa kwa glucose m'matumbo. Zotsatira za ntchito ya ma insretins ndikuwonjezereka kwa kapangidwe ka insulin, kuchepa kwa glucagon, komwe kumapangitsa kutsika kwa glycemia.

Ma incretins amawonongeka mwachangu ndi ma enzymes apadera DPP-4. Mankhwala Trazhenta amatha kumangiriza ma enzyme awa, amachepetsa ntchito, chifukwa chake, amakhalanso ndi moyo wa ma insretin ndikuwonjezera kutuluka kwa insulin m'magazi a shuga.

Ubwino wosakayika wa Trazhenta ndikuchotsa chinthu chomwe chimagwira makamaka ndi bile kudzera m'matumbo. Malinga ndi malangizo, osapitilira 5% ya linagliptin amalowa mkodzo, amachepetsa kwambiri mu chiwindi.

Malinga ndi anthu odwala matenda ashuga, zabwino za Trazhenty ndi:

• kumwa mankhwalawa kamodzi patsiku;
• odwala onse amupatsa mlingo umodzi;
• kusintha kwa mankhwala sikofunikira pa matenda a chiwindi ndi impso;
• palibe mayeso owonjezera omwe amafunikira kuti asankhe Trazenti;
• mankhwalawa alibe poizoni;
• Mlingo sasintha mukamamwa Trazhenty ndi mankhwala ena;
• mogwirizana ndi mankhwala a linagliptin pafupifupi sikuchepetsa mphamvu yake. Kwa odwala matenda ashuga, izi ndi zowona, chifukwa amayenera kumwa mankhwalawa nthawi imodzi.

Mlingo ndi mawonekedwe

Trazhenta wa mankhwalawa amapezeka mu mawonekedwe a mapiritsi okhala ndi mtundu wofiyira. Kuti muteteze motsutsana ndi zinthu zabodza, mbali imodzi ya makampani opanga, gulu la makampani a Beringer Ingelheim, limapanikizika, mbali inayo - zizindikiro za D5.

Piritsi ili mu chipolopolo cha filimu, magawo ake samaperekedwa. Phukusi lomwe linagulitsidwa ku Russia, mapiritsi 30 (matuza atatu a ma PC 10.). Piritsi lililonse la Trazhenta limakhala ndi 5 mg linagliptin, wowuma, mannitol, magnesium stearate, utoto. Malangizo ogwiritsira ntchito amapereka mndandanda wathunthu wazinthu zothandizira.

Malangizo ogwiritsira ntchito

Pankhani ya matenda a shuga a shuga, mlingo woyenera watsiku ndi tsiku ndi piritsi limodzi. Mutha kumwa nthawi iliyonse yabwino, osagwirizana ndi zakudya. Ngati mankhwala a Trezhent adalembedwa kuwonjezera pa metformin, mlingo wake umasinthidwa.

Mukasowa piritsi, mutha kumwa tsiku lomwelo. Kumwa Trazhent muyezo wapawiri ndizoletsedwa, ngakhale kulandilidwa kunakusowa tsiku lakale.

Mukagwiritsidwa ntchito limodzi ndi glimepiride, glibenclamide, gliclazide ndi analogues, hypoglycemia ndiyotheka. Kuti mupewe, Trazhenta aledzera monga kale, ndipo mlingo wa mankhwala ena umachepetsedwa mpaka standardoglycemia itakwaniritsidwa. Pakupita masiku atatu kuyambira pomwe Trazhenta adayamba kudya, magazi amayamwa mwachangu, chifukwa mphamvu ya mankhwalawo imayamba pang'onopang'ono. Malinga ndi ndemanga, mutasankha mtundu watsopano, pafupipafupi komanso kuopsa kwa hypoglycemia kumakhala kocheperako kuposa chithandizo cha Trazhenta.

Mankhwala omwe mungathe kuchita mogwirizana ndi malangizo:

Mankhwala ena, kuyanjana ndi Trazhenta sikunapezeke.

Zomwe zitha kuvulaza

Zotsatira zoyipa zomwe zimachitika Trazenti amayang'aniridwa panthawi yoyesedwa ndipo atagulitsa mankhwalawo. Malinga ndi zotsatira zawo, Trazhenta anali m'modzi wa otetezeka kwambiri a hypoglycemic. Kuopsa kwa zovuta zomwe zimakhudzana ndikumwa mapiritsi sikochepa.

Chosangalatsa ndichakuti pagulu la odwala matenda ashuga omwe adalandira placebo (mapiritsi osagwira ntchito iliyonse), 4,3% adakana kulandira chithandizo, chifukwa chake panali zotsatirapo zoyipa. Mu gulu lomwe linatenga Trazhent, odwala awa anali ocheperako, 3,4%.

Mu malangizo ogwiritsira ntchito, mavuto onse azaumoyo omwe amakumana ndi odwala matenda ashuga panthawi ya kafukufuku amatengedwa patebulo lalikulu. Apa, komanso matenda opatsirana, ndi mavairasi, komanso matenda a parasitic. Ndi kuthekera kwakukulu Trazenta sichomwe chidayambitsa kuphwanya izi. Chitetezo ndi monotherapy ya Trazhenta, komanso kuphatikiza kwake ndi othandizira odwala matenda ashuga, adayesedwa. Muzochitika zonse, palibe zotsatira zoyipa zomwe zidapezeka.

Kuchiza ndi Trazhenta ndi kotetezeka komanso pankhani ya hypoglycemia. Ndemanga zikuwonetsa kuti ngakhale odwala matenda ashuga omwe ali ndi vuto la madontho a shuga (okalamba omwe akudwala matenda a impso, kunenepa kwambiri), pafupipafupi hypoglycemia sapitilira 1%. Trazhenta siyikusokoneza ntchito ya mtima ndi mitsempha yamagazi, sikuti imabweretsa kuwonjezeka pang'onopang'ono, monga sulfonylureas.

Bongo

Mlingo umodzi wa 600 mg wa linagliptin (mapiritsi 120 a Trazhenta) amalolera bwino ndipo samayambitsa mavuto azaumoyo. Zotsatira za Mlingo wapamwamba pamthupi sizinaphunzire. Kutengera ndi mankhwalawa supretion wa mankhwala, chinthu chothandiza ngati bongo ndi kuchotsedwa kwa mapiritsi osaphatikizika kuchokera m'mimba thirakiti (la m'mimba). Chithandizo cha zizindikiro ndi kuwunika kwa zizindikiro zofunika kumachitidwanso. Kutsegula vuto la bongo wa Trazhenta sikothandiza.

Contraindication

Mapiritsi osamala sagwirira ntchito:

1. Ngati wodwalayo alibe maselo a beta omwe amatha kupanga insulin. Choyambitsa chimatha kukhala matenda a shuga 1 kapena kapamba.
2. Ngati mumadwala zilizonse zomwe zimapanga piritsi.
3. Mu pachimake hyperglycemic zovuta za shuga. Chithandizo chovomerezeka cha ketoacidosis ndi insulin kudzera mu insulin kuti muchepetse glycemia ndi saline kuti athetse kusowa kwamadzi. Mapiritsi aliwonse amakonzedwa amathetsedwa mpaka mkhalidwewo ukhazikika.
4. Ndi kuyamwitsa. Linagliptin imatha kulowa mkaka, m'mimba mwa mwana, imakhudza kagayidwe kake ka chakudya.
5. Pa nthawi yoyembekezera. Palibe umboni wonena za kuthekera kwa linagliptin kulowetsedwa mwa placenta.
6. Pa anthu odwala matenda ashuga osakwana zaka 18. Zokhudza thupi la ana sizinaphunzire.

Pokhapokha powonjezera chidwi chaumoyo, Trazhent amaloledwa kusankha odwala omwe ali ndi zaka zopitilira 80, omwe ali ndi pancreatitis yovuta komanso yopweteka. Gwiritsani ntchito molumikizana ndi insulin komanso sulfonylurea kumafuna kuwongolera shuga, chifukwa zingayambitse hypoglycemia.

Zomwe analogues zitha kusintha

Trazhenta ndi mankhwala atsopano, chitetezo cha patent chikugwirabe ntchito polimbana nacho, chifukwa chake ndizoletsedwa kupanga fanizo ku Russia ndi mawonekedwe omwewo. Pankhani ya magwiridwe antchito, chitetezo ndi kagwiridwe kake ka zochita, magulu omwe ali ngati gulu ali pafupi kwambiri ndi Trazent - DPP4 inhibitors, kapena glisitins. Zinthu zonse kuchokera pagululi nthawi zambiri zimatchedwa kutha ndi -gliptin, kotero zimatha kusiyanitsidwa ndi mapiritsi ena ambiri odwala matenda ashuga.

Zofanana poyerekeza ndi ma glissins:

Kukonzekera kwa Sulfonylurea (PSM) ndi njira zotsika mtengo za Trazhenta. Zimathandizanso kaphatikizidwe ka insulin, koma kapangidwe ka kayendedwe ka maselo ka beta kamasiyana. Trazenta amagwira ntchito atatha kudya. PSM imalimbikitsa kutulutsidwa kwa insulini, ngakhale shuga m'magazi ndi yabwinobwino, chifukwa chake nthawi zambiri amayambitsa hypoglycemia. Pali umboni kuti PSM imasokoneza bwino mtundu wa maselo a beta. Mankhwala Trazhenta pankhaniyi ndi otetezeka.

Opanga zamakono kwambiri komanso zopanda vuto lililonse ku PSM ndi glimepiride (Amaryl, Diameride) komanso glycazide (Diabeteson), Glidiab ndi ma analogu ena). Ubwino wa mankhwalawa ndi mtengo wotsika, mwezi woyendetsera ndalama umakhala ndi ma ruble a 150-350.

Malamulo osungira ndi mtengo

Kuyika Trazhenty kumawononga ma ruble 1600-1950. Mutha kugula kokha ndi mankhwala. Linagliptin akuphatikizidwa pamndandanda wazamankhwala ofunikira (Vital and Essential Diction), ngati pali zisonyezo, odwala matenda ashuga omwe adalembetsedwa ndi endocrinologist atha kumalandira.

Tsiku lotha ntchito kwa Trazenti ndi zaka 3, kutentha m'malo osungirako sikuyenera kupitirira 25 digiri.

Ndemanga