Kukonzekera kwa Hypoglycemic Glibomet kwa odwala matenda ashuga a 2

Glibomet ndi imodzi mwazodziwika zophatikizika za metformin ndi zotengera za sulfonylurea, glibenclamide. Zinthu izi zimakhala ndi magwiritsidwe osiyanasiyana, chifukwa chake kuphatikiza piritsi limodzi kumakupatsani mwayi wambiri wolimbitsa magazi, kupewa zovuta za matenda ashuga.

Berlin-Chemie Glibomet anali kuphatikiza koyamba kwa mankhwala awiri ochepetsa shuga omwe adalembetsedwa ku Russia. Kwazaka 15 zapitazi, mankhwalawa sanaathere kutchuka, chifukwa chogwira ntchito kwambiri, bwino, mtengo wotsika. Pokhala ndi chiphuphu chokwanira cha matenda ashuga, Glibomet imatha kuwonjezeredwa ku mankhwala ochokera m'magulu ena mu regimen yothandizira.

Zizindikiro zogwiritsa ntchito Glibomet

Chimodzi mwazochita za mankhwalawa ndikulimbikitsa kupanga kwake insulin. Izi ndizotheka pokhapokha ngati wodwala ali ndi maselo a beta mu kapamba, chifukwa chake mapiritsi a Glibomet ndi omwe amapatsidwa kokha ndi mtundu 2 wa shuga. Ndi matenda amtundu 1, mankhwalawa ndi osathandiza.

Zisonyezero zogwiritsidwa ntchito:

1. Odwala omwe amawonetsedwa chithandizo ndi zovuta ziwiri (ndi glycated hemoglobin yopitilira 8%) kapena atatu (HH> 9%) othandizira a hypoglycemic.
2. Odwala omwe ali ndi zakudya, masewera, komanso metformin kapena glibenclamide omwe adatchulidwa kale samapereka kuchepetsedwa kwa shuga.
3. Anthu odwala matenda ashuga osalolera mpaka Mlingo wambiri wa metformin.
4. Kusintha mankhwala awiri ndi mmodzi mwa odwala omwe ali ndi shuga yayitali.

Mapiritsi onse a sulfonylurea antidiabetesic angayambitse hypoglycemia. Glibomet sichoncho. Glibenclamide, yomwe ndi gawo lake, ndi mankhwala amphamvu kwambiri m'gululi, zomwe zikutanthauza kuti lilinso loopsa kwambiri pankhani ya hypoglycemia.

Matenda a shuga ndi kupsinjika kudzakhala chinthu chakale

• Matenda a shuga -95%
• Kuthetsa kwa mitsempha thrombosis - 70%
• Kuthetsa kwa kugunda kwamtima kwamphamvu -90%
• Kuthana ndi kuthamanga kwa magazi - 92%
• Kuwonjezeka kwa mphamvu masana, kukonza kugona usiku -97%

Odwala omwe ali ndi lingaliro lakuchepa kwambiri kwa shuga kapena ndi zizindikiro zochepa za Glybomet amayesetsa kuti asalembe. Anthu odwala matenda ashuga atsopano ndi oyenera kwa odwala matenda ashuga.

The zikuchokera ndi tanthauzo la mankhwala

Zotsatira zamankhwala zimachitika chifukwa cha zinthu zomwe zimapanga zomwe zimapangidwa. Piritsi limodzi la Glibomet lili ndi 400 mg ya metformin, 2.5 mg ya glibenclamide.

Metformin imagwira metabolism wama carbohydrate kudzera m'njira zingapo. Palibe wa iwo omwe amakhudza mwachindunji kapamba. Metformin imachepetsa kutulutsa shuga m'magazi ndi chiwindi, zomwe zimathandizira kukula kwa shuga. Imawonjezera kuyankha kwa maselo ku insulini, yomwe imapangitsa kuti shuga igwiritsidwe ntchito ndi minyewa yokhala ndi insulin - minofu, mafuta, komanso chiwindi. Popeza metformin sikukhudza maselo a beta, singayambitse hypoglycemia.

Mwa zina zowonjezereka za chinthu ichi, chofunikira kwambiri mu matenda osokoneza bongo ndi zotsatira za metformin pakutha kwa magazi kusungunuka kwamagazi omwe ayamba kumene kupanga. Awa ndi mankhwala okhawo omwe ali ndi vuto la antiidiabetes omwe adatsimikiziridwa kuti achepetse chiopsezo cha zovuta zazikulu za matenda ashuga. Metformin imachepetsa imfa ndi 42%, kugunda kwa mtima ndi 39%.

Ntchito yachigawo chachiwiri cha Glibomet, glibenclamide, ndikupititsa patsogolo katulutsidwe ka insulin yake. Kuti muchite izi, zimagwirizanitsa ndi beta-cell receptors ndipo, monga glucose, imalimbikitsa ntchito yawo. Mu gulu lake, glibenclamide ndi mankhwala amphamvu kwambiri pazotsatira za hypoglycemic. Amathandizanso kuwonjezera masitolo a glycogen mu minofu minofu. Malinga ndi madotolo, kutenga glibenclamide mwa odwala omwe ali osakwanira kapangidwe ka insulin kumatha kusintha njira ya shuga ndikuchepetsa kuchuluka kwa zovuta za 25vas.

Chifukwa chake, mankhwalawa Glybomet amakhudza zomwe zimayambitsa hyperglycemia: imabwezeretsa insulin yopanga komanso imachepetsa kukana kwa insulin.

Ubwino wa Glibomet:

• kugwiritsa ntchito mosavuta. M'malo mapiritsi 6, atatu ndi okwanira;
• kuchepetsa shuga musanayambe kudya komanso mutatha kudya;
• kuthekera kuchepetsa kuchuluka kwa mapiritsi a 1-2 ngati kubwezeretsedwa kwa matenda a shuga;
• kuchitapo kanthu - kukonza lipid mawonekedwe amwazi, kuchepetsa kuchepa thupi, kuchepetsa kuthamanga;
• inachepetsa njala. Malinga ndi odwala matenda ashuga, izi zimakuthandizani kuti muzitha kumamatira ku chakudya;
• kupezeka - Glybomet itha kugulika pafupifupi mankhwala aliwonse pamtengo wotsika mtengo. Kuchiza ndi mankhwala awiri omwe ali ndi mawonekedwe omwewo, mwachitsanzo Maninil ndi Siofor, adzagula ndalama zambiri kuposa kumwa Glibomet wophatikizidwa.

Malingaliro a Katswiri

Arkady Alexandrovich

Endocrinologist wodziwa zambiri

Funsani katswiri funso

Powonjezera Glibomet ku regimen yothandizira mankhwalawa kumalola kuchepetsa kuthamanga kwa shuga ndi 3 mmol / L, glycated hemoglobin ndi 2,5%.

Momwe angatenge

Kuchepetsa shuga mutamwa Glibomet kumayamba mu 2 hours ndipo kumatenga maola 12, chifukwa chake malangizo omwe angagwiritsidwe ntchito amalimbikitsa kumwa mankhwalawa kawiri pa tsiku. Imwani piritsi ndi chakudya.

Mlingo wa mankhwalawa umatsimikiziridwa ndi endocrinologist. Pankhaniyi, kuchuluka kwa shuga, zaka, kulemera kwa wodwalayo, chakudya chake, chizolowezi cha hypoglycemia ziyenera kukumbukiridwa.

Momwe mungasankhire mlingo woyenera:

1. Kuyamba kwa mapiritsi 1-3. Kukwera kwa glycemia, mapiritsi ambiri amafunikira. Ngati wodwala sanamwe mankhwala omwe ali ndi zomwezi, ndi bwino kuyamba ndi piritsi limodzi. Anthu odwala matenda ashuga omwe sanamwe kale metformin amwanso piritsi 1 limodzi masabata awiri oyamba. Izi nthawi zambiri zimayambitsa kusokonekera mu chakudya cham'mimba. Kuzolowera, thupi limatenga nthawi pang'ono.
2. Kuchulukitsa muyezo ndi chiphuphu chosakwanira cha matenda a shuga kungakhale masiku atatu aliwonse. Ndi kulekerera bwino kwa metformin - milungu iwiri iliyonse.
3. Mlingo wambiri tsiku lililonse malinga ndi malangizo ndi mapiritsi 5. Kupitilira muyeso kumatha kuyambitsa matenda osokoneza bongo komanso hypoglycemia. Ngati mapiritsi 5 akukwana kulipirira shuga, chithandizo chimathandizidwa ndi mankhwala ochokera m'magulu ena.

Mlingo wa metformin ku Glibomet ndi wocheperako. Pa mlingo wambiri watsiku ndi tsiku wa mapiritsi 4, odwala matenda ashuga amalandira 1600 mg ya metformin, pomwe mlingo wake wabwino ndi 2000 ndipo mlingo waukulu ndi 3000 mg. Ngati wodwala yemwe ali ndi matenda am'mimba amadziwika ndi kunenepa kwambiri pamimba, kuthekera kapena kulekerera kwakanthawi kochita masewera olimbitsa thupi, kukana insulini yayikulu, shuga wamagazi, amalimbikitsidwa kuti atenge mankhwala owonjezera a metformin asanagone.

Zotsatira zoyipa ndi bongo

Zina mwazotsatira zoyipa za mankhwala Glibomet, zomwe zimadziwika kwambiri ndi hypoglycemia, yomwe imatha kukulitsidwa mpaka kukomoka kwa hypoglycemic. Gawo lalikulu la hypoglycemia ndi mapapu, omwe amafunikira kulowererapo kochepa kwa wodwala matenda a shuga. Choyambitsa kutsika kwa shuga chimatha kukhala chowonjezera cha Glibomet mlingo, kuphwanya zakudya, kuchita masewera olimbitsa thupi mopitirira muyeso kapena osakonzekera.

Mankhwala osokoneza bongo amachititsa kuti matenda ashuga achulukane - lactic acidosis. Nthawi zambiri, zinthu zofananira zimafunikira pakukula kwake: matenda a impso, chiwindi, ziwalo zopumira, kuchepa magazi, ndi zina zambiri.

Mndandanda wazotsatira zoyipa malinga ndi malangizo:

Kuopsa kwa zotsatira zosakhudzidwa, kuwonjezera pa hypoglycemia, kumayesedwa ndi malangizo ogwiritsira ntchito ngati osowa (ochepera 0,1%) komanso osowa kwambiri (ochepera 0,01%).

Contraindication

Kulandila kwa Glybomet ndi koletsedwa ndi malangizowa potsatira milandu:

• hypoglycemia. Piritsi sayenera kuledzera mpaka magazi abwerere mwakale;
• ketoacidotic chikomokere ndi zochitika zake zam'mbuyomu;
• Hypersensitivity ku zilizonse za mankhwala Glibomet;
• Mtundu umodzi wa matenda ashuga. Ngati mankhwala a insulin atchulidwa mtundu wa matenda 2, akhoza kuphatikizidwa ndi Glybomet;
• odwala matenda ashuga okalamba olimbika, ali ndi chiwopsezo chachikulu cha lactic acidosis;
• chakudya chomwe chili ndi zopatsa mphamvu zopitilira 1000;
• pakati ndi hepatitis B Glibenclamide imadutsa mkaka wa m'mawere, kudutsa chotchinga, ndipo imatha kuyambitsa hypoglycemia mwana;
• uchidakwa, uchidakwa.

Pankhani ya matenda oopsa a chiwindi ndi impso, matenda opatsirana owopsa, kulowererapo kwa maopaleshoni, mabala ambiri ndikuwotcha, kupuma komanso kulephera kwa mtima, kuphwanya myocardial, funso lakuvomerezedwa kuti mutenge Glibomet limasankhidwa ndi dokotala. Ntchito ya odwala matenda ashuga ndi abale ake ndi kudziwitsa ogwira ntchito zachipatala za kupezeka kwa odwala omwe ali ndi shuga ndi zomwe amamwa.

Pa kutentha kwambiri ndi vuto la endocrine, Glybomet imatha kuyambitsa hypoglycemia yosakonzekera, chifukwa chake malangizowo amalangizidwa kuti muzigwiritsa ntchito mosamala.

Analogs ndi choloweza

Ma analogi a Glibomet omwe ali ndi mlingo womwewo wa zinthu zofunikira (2,5 + 400) - Indian Gluconorm ndi Russian Metglib. Kuphatikiza kwina konse kwa glibenclamide ndi metformin kumakhala ndi Mlingo wa 2.5 + 500 ndi 5 + 500, kotero mukasinthira ku mankhwalawa, shuga wamagazi wamba angasinthe. Mwambiri, kusintha kwa mankhwala ofunikira kuyenera.

Ma Analogues ku Russia amapangidwa ndi makampani akuluakulu anayi azachipatala - Pharmasintez, Pharmstandart, Kanonfarma ndi Valeant. Malinga ndi ndemanga, mankhwala awo ndi othandiza monga Glibomet.

Ngati kuphatikiza mankhwala kulibe mankhwala, akhoza kusintha ndi metformin ndi glibenclamide padera. Ngati mutenga muyezo womwewo, malipiro a matenda a shuga sangakulitse.

Glimecomb ndi Amaril ali pafupi ndi Glibomet ndi makina amachitidwe. Zomwe zimagwira pophatikizika, gliclazide ndi glimepiride, ndizofanizira za gulu la glibenclamide. Amachepetsa shuga pang'ono bwino, koma ndi otetezeka m'maselo a beta.

Malamulo Osungira ndi Mtengo

Glybomet imasunga bwino kwa zaka 3, chinthu chokha chosungira ndicho kutentha osaposa 30 ° C.

Kuyika ma Glibomet kuchokera pamapiritsi 40 kumawononga ma ruble 280-350. Ma analogues a Chefer ndi Gluconorm Plus (mtengo ma ruble 150 ma mapiritsi 30), Gluconorm (ma ruble 220 pa mapiritsi 40), Metglib (210 rubles for 40 mapiritsi).

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