Rosinsulin: ndemanga pakugwiritsa ntchito insulin, malangizo

Rosinsulin C imayendetsedwa mobwerezabwereza 1-2 pa tsiku, pafupifupi theka la ola musanadye. Nthawi iliyonse, tsamba la jakisoni liyenera kusinthidwa.

Nthawi zina, endocrinologist angafotokozere wodwalayo mu mnofu jakisoni wa mankhwala.

• ndi matenda a shuga a mellitus 1 ndi 2;
• mu gawo la kukana hypoglycemic m`kamwa mankhwala;
• ndi kuphatikiza mankhwala (pang'ono kukana hypoglycemic mkamwa mankhwala);
• ndi mono - kapena kuphatikiza mankhwala munthawi ya opaleshoni;
• ndi matenda wamba;
• ndi shuga mwa amayi apakati, pamene chithandizo cha zakudya sichimapereka zotsatira zomwe mukufuna.

Mlingo ndi makonzedwe

Kuyimitsidwa kwa jekeseni wa subcutaneous. Contraindication ndi hypoglycemia, hypersensitivity.

Rosinsulin C imayendetsedwa mobwerezabwereza 1-2 pa tsiku, pafupifupi theka la ola musanadye. Nthawi iliyonse, tsamba la jakisoni liyenera kusinthidwa. Nthawi zina, endocrinologist angafotokozere wodwalayo mu mnofu jakisoni wa mankhwala.

Tcherani khutu! Mtsempha wa magazi insulin ya sing'anga nthawi yoletsedwa! Munthawi zonse, dokotala amasankha payekha mlingo, womwe umatengera mawonekedwe a matendawa komanso zomwe zili m'magazi ndi mkodzo.

Mlingo wamba ndi 8-24 IU, womwe umaperekedwa nthawi imodzi patsiku, chifukwa mumatha kugwiritsa ntchito insulini ndi singano yochotsa.
Mwa ana ndi akulu omwe ali ndi chidwi chachikulu ndi mahomoni, mlingo umatha kuchepetsedwa mpaka 8 IU patsiku, ndipo, mosiyana, kwa odwala omwe ali ndi chidwi chokwanira - kuchuluka kwa 24 IU patsiku kapena kupitilira.

Ngati mlingo wa tsiku lililonse wa mankhwalawa uposa 0.6 IU / kg, umathandizidwa kawiri patsiku m'malo osiyanasiyana. Ngati mankhwalawa amaperekedwa mu 100 IU patsiku kapena kuposerapo, wodwalayo ayenera kuchipatala. Kusintha kwa insulin imodzi kupita kwina kuyenera kuchitika moyang'aniridwa ndi madokotala.

Pharmacokinetics

Mankhwala ndi a inshuwaransi yapakatikati, yomwe imayendetsedwa:

1. kuchepetsa magazi;
2. kuwonjezera mayamwidwe a shuga ndi minofu;
3. kupititsa patsogolo glycogenogeneis ndi lipogeneis;
4. Kuchepetsa kuchuluka kwa shuga m'magazi;
5. kaphatikizidwe kazakudya zama protein.

Zotsatira zoyipa

Zotsatira zoyipa:

• angioedema;
• kupuma movutikira
• urticaria;
• kutsika kwa kuthamanga kwa magazi;
• malungo.

Zizindikiro za Hypoglycemic:

1. thukuta;
2. kutsekeka kwa khungu;
3. kumverera kwa njala;
4. palpitations
5. Kuda nkhawa
6. thukuta;
7. wokongola
8. kugwedezeka
9. paresthesia mkamwa;
10. kugona
11. kukhumudwa;
12. machitidwe osazolowereka;
13. kusokonekera;
14. kusatsimikizika kwa mayendedwe;
15. mantha
16. malankhulidwe osokoneza;
17. kusowa tulo
18. mutu.

Ndi jakisoni wosaiwalika, mlingo wotsika, motsutsana ndi matenda kapena kutentha thupi, ngati zakudya sizikutsatiridwa, matenda ashuga acidosis ndi hyperglycemia atha:

• kuchepa kwa chakudya;
• ludzu
• kugona
• Hyperemia ya nkhope;
• kuda nkhawa mpaka kukomoka;
• kuchepa kwakanthawi kowoneka koyambirira kwamankhwala.

Malangizo apadera

Musanatolere vutoli kuchokera ku vial, onetsetsani kuti yankho likuwonekera. Ngati matope kapena vuto lazindikirika pakukonzekera, ndiye kuti singathe kugwiritsidwa ntchito.

Kutentha kwa yankho la makonzedwe kuyenera kufanana ndi kutentha kwa chipinda.

Chofunikira! Ngati wodwala ali ndi matenda opatsirana, matenda a chithokomiro, hypopituitarism, matenda a Addison, kulephera kwa impso, komanso kwa anthu azaka zopitilira 65, kusintha kwa insulin ndikofunikira.

Zomwe zimayambitsa hypoglycemia zitha kukhala:

1. M'malo mankhwalawa.
2. Bongo.
3. Kudumpha chakudya.
4. Matenda omwe amachepetsa kufunika kwa mankhwalawa.
5. Vomiting, kutsegula m'mimba.
6. Hypofunction wa adrenal kotekisi.
7. Kupsinjika kwakuthupi.
8. Kusintha kwa dera la jakisoni.
9. Kuchita ndi mankhwala ena.

Posamutsa wodwala kuchokera ku insulin ya nyama kupita ku insulin yaumunthu, kuchepa kwa ndende yamagazi ndikotheka.

Kufotokozera za ntchito ya mankhwala a Rosinsulin P

Rosinsulin P amatanthauza mankhwala omwe ali ndi chifupifupi hypoglycemic. Kuphatikiza ndi cholandirira cha membrane wakunja, yankho limapanga zovuta za insulin. Izi:

• kumawonjezera kaphatikizidwe ka cyclic adenosine monophosphate mu chiwindi ndi maselo amafuta;
• imapangitsa njira zamkati mwa intracellular (pyruvate kinases, hexokinases, glycogen synthases ndi ena).

Kuchepa kwa ndende ya magazi kumachitika chifukwa cha:

1. kuwonjezera intracellular mayendedwe;
2. kukondoweza kwa glycogenogeneis, lipogeneis;
3. kaphatikizidwe wa mapuloteni;
4. kukonza mayamwidwe a mankhwala ndi zimakhala;
5. kuchepa kwa kuwonongeka kwa glycogen (chifukwa cha kuchepa kwa kupanga kwa chiwindi ndi chiwindi).

Pambuyo subcutaneous makonzedwe, mphamvu ya mankhwala amapezeka 20-30 mphindi. Kuchuluka kwa ndende m'magazi kumachitika pambuyo pa maola 1-3, ndipo kupitiriza kwa chochitikacho kumadalira malo ndi njira yoyendetsera, mlingo ndi mawonekedwe a wodwala.

Zizindikiro zogwiritsidwa ntchito

Rosinsulin P imagwiritsidwa ntchito motere:

1. Matenda a shuga a 1 ndi 2.
2. Kukana pang'ono kwa mankhwala amkamwa a hypoglycemic.
3. Kuphatikiza mankhwala
4. Ketoacidotic ndi hyperosmolar chikomokere.
5. Matenda a shuga ketoacidosis.
6. Matenda a shuga amapezeka nthawi yoyembekezera.

Ntchito pang'onopang'ono:

• pakubala, kuvulala, maopareshoni omwe akubwera;
• musanayambe jakisoni ndi kukonzekera kwa insulin yayitali;
• ndi kagayidwe kachakudya matenda;
• ndi matenda omwe amatsatiridwa ndi kutentha thupi kwambiri.

Contraindication dnyanja

Contraindication ndi hypoglycemia, hypersensitivity.

Njira yoyendetsera mankhwala ndi mlingo muzochitika zonse zimatsimikiziridwa payekhapayekha. Chomwe chimapangitsa kudziwa kuchuluka kwa shuga ndi zomwe zimapezeka m'magazi musanadye komanso pambuyo pake, mawonekedwe a matendawa komanso kuchuluka kwa glucosuria.

Rosinsulin P idapangidwa kuti ikhale yachilendo, yamitsempha yama cell ndi minyewa. Jakisoni amachita pambuyo mphindi 15-30 asanadye. Nthawi zambiri, yankho limaperekedwa mwachangu.

pa opaleshoni, matenda a shuga a ketoacidosis ndi chikomokere, rosinsulin P imayendetsedwa ndi intramuscularly, chifukwa chake ndikofunikira kudziwa momwe mungabayire insulin molondola komanso molondola.

Ndi monotherapy, kuchuluka kwa jakisoni patsiku ndi katatu. Ngati ndi kotheka, akhoza kuchuluka mpaka nthawi 5-6. Popewa kukula kwa lipodystrophy, hypertrophy of adipose minofu, atrophy, ndikofunikira kusintha malo a jekeseni nthawi iliyonse.

Zotsatira zoyipa:

• angioedema;
• kupuma movutikira
• kutsika kwa kuthamanga kwa magazi;
• urticaria;
• malungo.

Zizindikiro za hypoglycemia:

1. thukuta;
2. tachycardia;
3. wokongola
4. kugona
5. kutsekeka kwa khungu;
6. kumverera kwa njala;
7. kumverera kwa nkhawa;
8. thukuta;
9. kugwedezeka
10. paresthesia mkamwa;
11. malankhulidwe osokoneza;
12. kusatsimikizika kwa mayendedwe;
13. Kukhumudwa
14. machitidwe achilendo;
15. kusokonekera;
16. mphwayi
17. kusowa tulo
18. mutu.

Poyerekeza ndi matenda kapena kutentha thupi, jakisoni wosaiwalika, mlingo wochepa, ndipo ngati zakudya sizitsatiridwa, wodwalayo atha kudwala matenda ashuga ndi hyperglycemia:

• kusowa kwa chakudya
• ludzu
• kugona
• kutupa kwa nkhope;
• kuda nkhawa mpaka kukomoka;
• kuchepa kwakanthawi kowoneka koyambirira kwamankhwala.

Malangizo apadera

Musanisonkhanitse rosinsulin C kuchokera pambale, onetsetsani kuti yankho ndi lomveka. Ngati phokoso kapena phokoso lazindikirika ndi insulin, silingagwiritsidwe ntchito. Kutentha kwa jekeseni kuyenera kukhala kutentha.

Tcherani khutu! Ngati wodwala ali ndi matenda opatsirana, kusokonezeka kwa chithokomiro cha chithokomiro, hypopituitarism, matenda a Addison, kulephera kwaimpso, komanso kwa anthu azaka zopitilira 65, kuyenera kwa insulin kuyenera.

Zotsatira za hypoglycemia zitha kukhala:

1. Kusintha kwa mankhwala.
2. Mlingo wowonjezera.
3. Kudumpha chakudya.
4. Matenda omwe amachepetsa kufunika kwa mankhwalawa.
5. Kholingo, m'mimba.
6. Ntchito yosakwanira ya adrenal cortex.
7. Zochita zolimbitsa thupi.
8. Kusintha kwa dera la jakisoni.
9. Kuchita ndi mankhwala ena.

Mukasamutsa wodwala kuchokera ku insulin ya nyama kupita ku insulin ya anthu, kuchepa kwa shuga m'magazi ndikotheka.