Trazhenta ndi mankhwala a hypoglycemic ogwiritsira ntchito mkati. Mankhwalawa amapezeka mu mawonekedwe a mapiritsi ofiira owala, ozungulira. Gome louma lili ndi mbali komanso zopindika. Chizindikiro cha wopanga chimalembedwa mbali imodzi, ndipo chizindikiro cha "D5" chidalemba mbali inayo.
Malangizowo akuti gawo lalikulu la piritsi lililonse la Trazhenta ndi linagliptin, yomwe ili ndi voliyumu ya 5 mg. Zowonjezera ndi:
- 2,7 mg magnesium stearate.
- 18 mg pregelatinized wowuma.
- 130.9 mg wa mannitol.
- 5.4 mg wa Copovidone.
- 18 mg chimanga wowuma.
- Mapangidwe a chipolopolo chokongola amaphatikiza pinki opadra (02F34337) 5 mg.
Mankhwala a Trazent amapakidwa m'matumba a aluminium, mapiritsi 7 aliwonse. Malipenga, nawonso, ali m'makatoni a 2, 4 kapena 8. Ngati chithuacho chikhale ndi mapiritsi 10, ndiye kuti paphukusi limodzi pazikhala zitatu.
Pharmacological zochita za mankhwala
Chofunikira chachikulu cha mankhwalawa ndi choletsa enzyme dipeptidyl peptidase-4 (DPP-4). Vutoli limakhala ndi zowononga zamahomoni a incretin (GLP-1 ndi GUI), zomwe ndizofunikira kuti thupi laumunthu likhale ndi shuga yolondola.
Mukangodyera m'thupi, timadzi tambiri timene timachitika. Ngati kuchuluka kwa shuga m'magazi ndikwabwinobwino kapena kukokomeza pang'ono, mahomoni amenewa amafulumizitsa kupanga kwa insulin ndi kubisala kwake ndi parenchyma. Mahomoni GLP-1, kuwonjezera, amathandizanso kupanga shuga ndi chiwindi.
Mwachindunji mankhwalawo pawokha komanso mawonekedwe ake amawonjezera kuchuluka kwa ma insretin chifukwa cha kupezeka kwawo ndipo, kuchita nawo, kumawonjezera ntchito yawo yayitali.
Mukawunika Trazhent, munthu akhoza kupeza kuti mankhwalawa amachititsa kuti shuga azipanga shuga komanso zimachepetsa kupangika kwa glucagon. Chifukwa cha izi, kuchuluka kwa shuga m'magazi kumakhala kosiyanasiyana.
Zizindikiro zogwiritsira ntchito ndi malangizo
Matendawa amalimbikitsidwa kuti agwiritsidwe ntchito kwa odwala omwe apezeka ndi matenda a shuga a 2, kuwonjezera:
- Ichi ndi mankhwala okhawo othandizira odwala omwe ali ndi vuto loyenera la glycemic, omwe amachitika chifukwa chochita zolimbitsa thupi kapena kudya.
- Choyezera chimakhazikitsidwa ngati wodwala walephera aimpso, momwe metformin imaletsedwa kutengedwa kapena ngati pali chosagwirizana ndi metformin ndi thupi.
- Trazent ikhoza kugwiritsidwa ntchito kuphatikiza thiazolidinedione, zotumphukira za sulfonylurea, ndi metformin. Kapena apo, pamene chithandizo ndi mankhwalawa, masewera, kutsatira zakudya sizinadzetse zotsatira zoyenera.
Contraindication kugwiritsa ntchito mankhwalawa
Zomwe zidafotokozedwa pamankhwala zimanena mosapita m'mbali kuti Trazhenta silivomerezeka kuti igwiritsidwe ntchito:
- pa mimba;
- ndi matenda a shuga 1
- pa mkaka wa m`mawere;
- musamwe mankhwala kwa ana osakwana zaka 18;
- iwo omwe ali ndi hypersensitive kumagawo ena a Trazhenta;
- anthu omwe ali ndi ketoacidosis yoyambitsidwa ndi matenda ashuga.
Njira yogwiritsira ntchito
Mlingo woyenera kwa odwala akuluakulu ndi 5 mg, mankhwalawa ayenera kumwedwa katatu patsiku, malangizo amawonetsa izi. Ngati mankhwalawa atengedwa molumikizana ndi metformin, ndiye kuti mlingo wotsiriza umakhala wosasinthika.
Kuyang'ana kwa odwala omwe ali ndi vuto la Impso sikufuna kusintha kwamtundu uliwonse.
Kafukufuku wa Pharmacokinetic akuwonetsa kuti Trazent ingafune kusintha kwa mlingo wa kukanika kwa chiwindi. Komabe, zomwe akumana nazo ndi ntchito ndi odwala oterewa zikadali kuchepa.
Kusintha kumeneku sikofunikira kwa odwala okalamba. Koma kwa gulu la anthu patatha zaka 80, madokotala samalimbikitsa kuti amwe mankhwalawa, chifukwa palibe chidziwitso pakugwiritsidwa ntchito kwachipatala pakadali pano.
Kuteteza kotheka kwa ana ndi achinyamata sikunakhazikitsidwebe.
Ngati wodwala yemwe akumamwa mankhwalawa nthawi iliyonse pachilichonse asowa mankhwalawo, ndiye kuti piritsi liyenera kutengedwa nthawi yomweyo. Koma musamachulukitse mlingo. Mutha kumwa mankhwalawa nthawi iliyonse, mosasamala chakudya.
Kodi mankhwala osokoneza bongo omwe angayambitsidwe angayambitse chiyani?
Malinga ndi maphunziro angapo azachipatala (omwe odwala odzipereka adayitanidwa), zikuwonekeratu kuti mankhwala osokoneza bongo omwe ali ndi kuchuluka kwa mapiritsi a 120 (600 mg) sanawononge thanzi la anthu awa.
Masiku ano, palibe milandu yokhudza kumwa mankhwala osokoneza bongo yolembedwa konse. Zachidziwikire, ngati munthu atatenga mlingo waukulu wa Trazhenta, ayenera kuchotsa zomwe zili m'mimba mwake, ndikupangitsa kusanza komanso kusanza. Pambuyo pake, sizipweteka kukaonana ndi dokotala.
Ndizotheka kuti katswiri azindikire zolakwika zilizonse ndikupereka chithandizo choyenera.
Kugwiritsa ntchito mankhwalawa pa mimba komanso mkaka wa m`mawere
Kugwiritsa ntchito kwa Trazenti ndi amayi panthawi yomwe akubala mwana sikunaphunzire. Komabe, maphunziro a nyama a mankhwalawa sanawonetse vuto la kubereka. Ngakhale izi, panthawi yoyembekezera, madokotala amalimbikitsa kupewa kugwiritsa ntchito mankhwalawa.
Zomwe zimapezeka chifukwa cha kusanthula kwa pharmacodynamic pa nyama zimasonyeza kudya kwa linagliptin kapena ziwiya zake mkaka wa m'mawere wamkazi.
Chifukwa chake, mphamvu ya mankhwalawa kwa akhanda omwe akuyamwitsa sakhala pambali.
Nthawi zina, madokotala angalimbikitse kuyimitsa kuyamwa ngati mkhalidwe wa mayiyo umafuna kutenga Trazenti. Kafukufuku wokhudzana ndi mphamvu ya mankhwalawa pa kuthekera kwa munthu kutenga pakati sanachitike. Kuyesa kwa nyama m'derali sikunadzetse zotsatira zoyipa; kuwunika kwa asayansi sikunatsimikizenso kuopsa kwa mankhwalawa.
Zotsatira zoyipa
Kuchuluka kwa zotsatira zoyipa mutatha kutenga Trazhenta ndizofanana ndi kuchuluka kwa zotsatira zoyipa mutatha kutenga placebo.
Izi ndi zomwe zimachitika mutatenga Trazhenty:
- kapamba
- kutsokomola
- nasopharyngitis (matenda opatsirana);
- hypertriglyceridemia;
- kudziwa magawo ena a mankhwalawa.
Zofunika! Zophatikizira Trazenti zingayambitse chizungulire. Chifukwa chake, mutamwa mankhwalawo, kuyendetsa galimoto ndikofunikira osavomerezeka!
Zotsatira zoyambira pamwambapa zimachitika makamaka ndi kuphatikiza kwa Trazhenta ndi mawonekedwe ake okhala ndi metformin ndi sulfonylurea.
The munthawi yomweyo kugwiritsa pioglitazone ndi linagliptin zimathandizira kuwonjezeka thupi, zimachitika kapamba, hyperlipidemia, nasopharyngitis, chifuwa, ndipo ena odwala hypersensitivity kuchokera chitetezo cha m'thupi.
Ndi munthawi yomweyo kugwiritsa ntchito mankhwalawa ndi metformin ndi sulfonylurea, zotupa za hypoglycemia pa nthawi yapakati, chifuwa, kapamba, nasopharyngitis ndi hypersensitivity ku zigawo zina za mankhwala zimachitika.
Moyo wa alumali ndi malingaliro
Malangizo omwe akuphatikizana ndi mankhwalawa akuti muyenera kusunga mankhwalawa pamtunda wosaposa 25 digiri yokha komanso malo obisika osafikirika ndi ana. Tsiku lotha ntchito kwa Trazenti ndi zaka 2,5.
Madokotala samapereka mankhwala kwa anthu omwe ali ndi matenda ashuga a ketoacidosis. Mankhwalawa saloledwanso mtundu wa 1 shuga. Mwayi wopanga hypoglycemia mutatenga Trazhenta ndi wofanana ndi omwe amatha kuchitika pogwiritsa ntchito placebo.
Zotsatira za sulfonylureas zimatha kuyambitsa hypoglycemia, motero, zinthu zamankhwala izi zimayenera kuphatikizidwa ndi linagliptin mosamala kwambiri. Ngati ndi kotheka, endocrinologist amatha kuchepetsa mlingo wa mankhwala a sulfonylurea.
Mpaka pano, palibebe deta yodalirika pa kafukufuku wazachipatala yemwe anganene za mgwirizano wa Trazhenta ndi hormone-insulin. Kwa anthu omwe akuvutika kwambiri ndi impso kulephera, mankhwalawa amadziwitsidwa limodzi ndi mankhwala ena a hypoglycemic, ndipo ndemanga zimakhalabe zabwino.
Kuchuluka kwa shuga m'magazi kumachepetsedwa bwino pamene wodwala atenga Trazhenta kapena mankhwala omwewo asanadye.
