Tricorrhine ndi mankhwala ochepetsa mphamvu ya lipid omwe amagwiritsidwa ntchito ngati dyslipidemia, komanso amagwiritsidwa ntchito ngati matenda a shuga, ngati chithandizo cha zakudya komanso zochita zolimbitsa thupi sizinathandize.
Mankhwala amachepetsa mulingo wa fibrinogen komanso zomwe zili mu atherogenic pamagawo a cholesterol m'magazi (VLDL, LDL), ndikuwonjezera kuchuluka kwa uric acid.
Kutulutsa mawonekedwe ndi kapangidwe kake
Tricor amagulitsidwa monga mapiritsi okhala ndi filimu mu phukusi la mapiritsi 30. Piritsi lililonse limakhala ndi fenofibrate ya micronized 145 mg, ndi zinthu zotsatirazi:
- lactose monohydrate,
- sodium lauryl sulfate,
- sucrose
- hypopellose,
- silicon dioxide
- crospovidone
- script sodium.
Zochizira
Fenofibrate ndichokera ku fibric acid. Imatha kusintha magawo azigawo zingapo za lipids m'magazi. Mankhwala ali ndi mawonekedwe awa:
- Kuchulukitsa chilolezo
- Kuchepetsa kuchuluka kwa atherogenic lipoproteins (LDL ndi VLDL) mwa odwala omwe ali pachiwopsezo cha matenda a mtima,
- Kweza mulingo wa cholesterol "wabwino" (HDL),
- Amachepetsa kwambiri zomwe zimapangitsa kuti ma cholesterol agwiritsidwe ntchito,
- Lowers fibrinogen ndende,
- Amachepetsa mulingo wa uric acid m'magazi komanso mapuloteni C osagwira.
Kuchuluka kwa fenofibrate m'magazi a anthu kumawonekera patangopita maola ochepa mutangogwiritsa ntchito kamodzi. Pazinthu zomwe zimagwiritsidwa ntchito kwa nthawi yayitali, palibe zotsatira zowonjezereka.
Kugwiritsa ntchito mankhwala Tricor pa mimba
Zidziwitso zazing'ono zanenedwapo zakugwiritsa ntchito fenofibrate panthawi yapakati. Poyeserera nyama, mphamvu ya teratogenic ya fenofibrate siinawululidwe.
Embryotoxicity zinachitika ngati mbali ya mayeso preclinical pa nkhani ya Mlingo poizoni thupi la mayi wapakati. Pakadali pano, palibe chiwopsezo kwa anthu chomwe chadziwika. Komabe, mankhwalawa pa nthawi ya pakati amatha kugwiritsidwa ntchito pokhapokha pakuwunika mosamala kuchuluka kwa mapindu ndi zoopsa.
Popeza palibe zambiri zolondola zokhudzana ndi chitetezo cha mankhwalawa Tricor pa nthawi yoyamwitsa, ndiye kuti panthawiyi sichinalembedwe.
Otsutsa otsatirawa kumwa mankhwala Tricor ndi:
- Kutengeka kwakukulu mu fenofibrate kapena zigawo zina za mankhwala;
- Kulephera mwamphamvu kwaimpso, mwachitsanzo, matenda amchiwindi;
- Zaka mpaka 18;
- Mbiri ya photosensitization kapena Phototoxicity mankhwalawa ketoprofen kapena ketoprofen;
- Matenda osiyanasiyana a ndulu;
- Kuyamwitsa;
- Endo native galactosemia, osakwanira misempha ya lactase, malabsorption a galactose ndi glucose (mankhwalawa ali ndi lactose);
- Endo native fructosemia, sucrose-isomaltase akusowa (mankhwalawa ali ndi sucrose) - Tricor 145;
- Momwe thupi limasokonekera ndi batala la nandolo, mtedza, soya lecithin, kapena mbiri yofananira yazakudya (popeza pali chiwopsezo cha hypersensitivity).
Ndikofunikira kugwiritsa ntchito malonda mosamala, ngati alipo:
- Kulephera kwamkati ndi / kapena chiwindi;
- Kuledzera;
- Hypothyroidism;
- Wodwala ali wokalamba;
- Wodwalayo ali ndi mbiri yokhudza matenda obadwa nawo a minofu.
Mlingo wa mankhwala ndi njira yogwiritsira ntchito
Mankhwalawa amayenera kutengedwa pakamwa, kumeza lonse ndikumwa madzi ambiri. Piritsi imagwiritsidwa ntchito nthawi iliyonse masana, sizitengera chakudya (cha Tricor 145), komanso nthawi yomweyo ndi chakudya (cha Tricor 160).
Akuluakulu amatenga piritsi limodzi kamodzi patsiku. Odwala omwe amatenga kapisozi imodzi ya Lipantil 200 M kapena piritsi 1 la Tricor 160 patsiku amatha kuyamba kutenga piritsi limodzi la Tricor 145 popanda kusintha kwa mlingo wina.
Odwala omwe amatenga kapisozi imodzi ya Lipantil 200 M patsiku ali ndi mwayi wosinthira piritsi limodzi la Tricor 160 popanda kusintha kwa mlingo wina.
Odwala okalamba ayenera kugwiritsa ntchito mlingo woyenera wa akulu: piritsi limodzi la Tricor kamodzi patsiku.
Odwala omwe ali ndi vuto la impso ayenera kuchepetsa kuchuluka kwa kufunsa dokotala.
Chonde dziwani: kugwiritsa ntchito mankhwala Tricor mwa odwala omwe ali ndi matenda a chiwindi sanaphunzire. Ndemanga sizimapereka chithunzi chomveka.
Mankhwalawa amayenera kumwedwa kwa nthawi yayitali, ndikuyang'ana zomwe mankhwala omwe munthu amadya asanayambe kugwiritsa ntchito mankhwalawa. Kugwiritsa ntchito bwino kwa mankhwalawa kuyenera kuwunikiridwa ndi dokotala.
Chithandizo chimayesedwa ndi milingo ya seramu lipid. Tikulankhula za LDL cholesterol, cholesterol yathunthu ndi triglycerides. Ngati chithandizo chamankhwala sichinachitike pakatha miyezi yochepa, ndiye kuti njira yina yochiritsira ndiyofunika kukambirana.
Mankhwala osokoneza bongo
Palibe mafotokozedwe a milandu yambiri. Koma ngati mukukayikira kuti atero, mutha kuchita chithandizo chamankhwala komanso chothandizira. Hemodialysis siyothandiza pano.
Momwe mankhwalawa amakhudzira ndi mankhwala ena
- Ndi anticoagulants mkamwa: fenofibrate imathandizira kugwira ntchito kwa anticoagulants pamlomo ndikuwonjezera ngozi ya kutuluka magazi. Izi ndichifukwa chakuchotsa kwa anticoagulant kuchokera kumalo omanga mapuloteni a plasma.
Mu magawo oyamba a mankhwala a fenofibrate, ndikofunikira kuti muchepetse mlingo wa anticoagulants ndi wachitatu, pang'onopang'ono kusankha mlingo. Mlingo uyenera kusankhidwa motsogozedwa ndi mulingo wa INR.
- Ndi cyclosporine: mafotokozedwe angapo woopsa milandu yafupika chiwindi ntchito mankhwala ndi cyclosporine ndi fenofibrate. Ndikofunikira kuyang'anira ntchito ya chiwindi nthawi zonse mu odwala ndikuchotsa fenofibrate ngati pali kusintha kwakukulu pamagawo a labotale.
- Ndi HMG-CoA reductase inhibitors ndi ma fiber ena: mukamatenga fenofibrate ndi HMG-CoA reductase inhibitors kapena ma fiber ena, chiwopsezo cha kuledzera pa minofu ya minofu chimakulanso.
- Ndi ma enzymes a cytochrome P450: kafukufuku wama microsomes a chiwindi cha anthu amawonetsa kuti fenofibroic acid ndi fenofibrate sakhala ngati zoletsa za cytochrome P450 isoenzymes:
- CYP2D6,
- CYP3A4,
- CYP2E1 kapena CYP1A2.
Pa mankhwalawa othandizira, mankhwalawa ndi olepheretsa CYP2C19 ndi CYP2A6 isoenzymes, komanso ma CYP2C9 inhibitors ocheperako.
Malangizo apadera ochepa mukamamwa mankhwalawa
Musanayambe kugwiritsa ntchito mankhwalawa, muyenera kuchitira mankhwala omwe cholinga chake ndi kuthetsa zomwe zimayambitsa matenda ena owopsa a hypercholesterolemia, omwe tikukambirana:
- shuga wachiwiri wosalamulirika,
- hypothyroidism
- nephrotic syndrome
- dysproteinemia,
- matenda a chiwindi
- Zotsatira zamankhwala
- uchidakwa.
Mphamvu ya chithandizo imawunikidwa potengera zomwe zili lipids:
- cholesterol yathunthu
- LDL
- seramu triglycerides.
Ngati mankhwalawa sanawonekere kwa miyezi yopitilira atatu, ndikofunikira kuyamba kugwiritsa ntchito njira zina.
Odwala omwe ali ndi hyperlipidemia omwe amatenga njira zakulera za mahomoni kapena estrogens ayenera kudziwa mtundu wa hyperlipidemia, ikhoza kukhala yoyamba kapena yachiwiri. Muzochitika izi, kuwonjezereka kwa lipids kumatha kuyambitsidwa ndi kudya kwa estrogen, komwe kumatsimikiziridwa ndi kuwunika kwa odwala.
Pogwiritsa ntchito Tricor kapena mankhwala ena omwe amachepetsa kuchuluka kwa lipids, odwala ena amatha kuwona kuwonjezeka kwa hepatic transaminases.
Mwambiri, kuchuluka kumakhala kocheperako komanso kwakanthawi, kumadutsa popanda chizindikiro chowoneka. Kwa miyezi 12 yoyambirira ya mankhwalawa, ndikofunikira kuyang'anitsitsa kuchuluka kwa transaminases (AST, ALT), miyezi itatu iliyonse.
Odwala omwe, panthawi ya chithandizo, amakhala ndi kuchuluka kwa transaminases, amafunikira chisamaliro chapadera ngati kuchuluka kwa ALT ndi AST ndi 3 kapena kuposa nthawi yayitali kuposa poyambira. Zikatero, mankhwalawa amayenera kuimitsidwa msanga.
Pancreatitis
Pali mafotokozedwe amilandu ya chitukuko cha kapamba pamagwiritsidwe a Traicor. Zoyambitsa za kapamba:
- Kuperewera kwa mankhwalawa kwa anthu omwe ali ndi hypertriglyceridemia,
- Kuwonetsedwa mwachindunji ndi mankhwalawo,
- Kuwonetsera kwachiwiri komwe kumalumikizidwa ndi miyala kapena mapangidwe a matope mu ndulu, yomwe imayendetsedwa ndi kutsekeka kwa wamba bile duct.
Minofu
Pogwiritsa ntchito Tricor ndi mankhwala ena omwe amachepetsa kuchuluka kwa lipids, milandu yokhudza kupweteka kwa minofu ya minofu yanenedwapo. Kuphatikiza apo, milandu yachilendo ya rhabdomyolysis amalembedwa.
Mavuto oterewa amakula pafupipafupi ngati pali matenda a impso kapena mbiri ya hypoalbuminemia.
Mavuto azovuta zama minofu amatha kukayikiridwa ngati wodandaula adandaula:
- Minofu kukokana ndi kukokana
- Zofooka zambiri
- Diffuse myalgia,
- Myositis
- Kukula kodziwika kwa ntchito ya creatine phosphokinase (5 kapena kuposeranso nthawi kuyerekeza ndi malire apamwamba).
Ndikofunikira kudziwa kuti pazochitika zonsezi, chithandizo ndi Tricor ziyenera kusiyidwa.
Odwala omwe amatchulidwa kuti myopathy, mwa anthu achikulire zaka 70, komanso odwala omwe ali ndi mbiri yolemetsa, rhabdomyolysis imatha kuoneka. Kuphatikiza apo, zinthu zimasokonekera:
- Matenda a minofu
- Matenda a impso,
- Hypothyroidism,
- Mowa.
Mankhwalawa amalangizidwa kwa odwala okhawo pokhapokha ngati chithandizo chomwe akuyembekezeredwa chithandizo chikuchuluka kwambiri kuopsa kwa rhabdomyolysis.
Mukamagwiritsa ntchito Traicor limodzi ndi HMG-CoA reductase inhibitors kapena ma fiber ena, chiopsezo cha zovuta zowopsa pakhungu la minofu chimakulanso. Izi zimachitika makamaka pamene wodwalayo anali ndi matenda a minofu asanayambe chithandizo.
Kuphatikiza pamodzi ndi Triicor ndi statin kungakhale kokha ngati wodwalayo ali ndi dyslipidemia wosakanikirana komanso chiopsezo cha mtima. Sipangakhale mbiri yokhudza matenda a minofu. Kuzindikirika kwambiri kwa zizindikiro za poizoni m'thupi.
Ntchito yamalonda
Ngati kuwonjezeka kwa kuchuluka kwa creatinine kwa 50% kapena kupitilira kwalembedwa, ndiye kuti mankhwalawa ayenera kuyimitsidwa. M'miyezi itatu yoyambirira ya chithandizo cha Treicor, ndende ya creatinine iyenera kutsimikizika.
Ndemanga za mankhwalawa zilibe chidziwitso pakusintha kwathanzi poyendetsa galimoto ndikuwongolera makina.
