Galvus Met: kufotokozera, malangizo, malingaliro, kugwiritsa ntchito mapiritsi

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Galvus ndi mankhwala azachipatala omwe machitidwe ake amayang'aniridwa ndikuchiza matenda a shuga a 2. Chofunikira chachikulu pa mankhwalawa ndi Vildagliptin. Mankhwalawa amapezeka ngati mapiritsi. Mankhwalawa ali ndi malingaliro abwino kuchokera kwa madokotala komanso odwala onse.

Zochita za vildagliptin zimakhazikitsidwa ndi kukondoweza kwa kapamba, ndiko kuti zida zake zapamwamba. Izi zimabweretsa kutsika kosavuta pakupanga enzyme dipeptidyl peptidase-4.

Kuchepetsa msanga kwa enzyme iyi kumalimbikitsa kukulira kwa katulutsidwe kazinthu ngati glucagon 1 peptide ndi insulinotropic polypeptide.

Zizindikiro zogwiritsidwa ntchito

Mankhwala amagwiritsidwa ntchito pochiza matenda a shuga a mtundu wachiwiri:

  • monga mankhwala okhawo omwe amaphatikizidwa ndi zakudya komanso zolimbitsa thupi Zoyang'anira zikuwonetsa kuti chithandizo chotere chimapereka mphamvu yayitali;
  • kuphatikiza ndi metformin kumayambiriro kwa mankhwala, osakwanira chifukwa chamadya komanso kuchuluka kwa zochitika zolimbitsa thupi;
  • kwa anthu omwe amagwiritsa ntchito analogues yomwe ili ndi vildagliptin ndi metformin, mwachitsanzo Galvus Met.
  • Mankhwala osokoneza bongo omwe ali ndi vildagliptin ndi metformin, komanso kuwonjezera kwa mankhwala okhala ndi sulfonylureas, thiazolidinedione, kapena insulin. Amagwiritsidwa ntchito pazochitika za kulephera kwa chithandizo cha mankhwala a monotherapy, komanso zakudya komanso zolimbitsa thupi;
  • monga katatu mankhwala osagwiritsa ntchito mankhwalawa omwe ali ndi mankhwala a sulfonylurea ndi metformin, omwe kale amagwiritsidwa ntchito pokhapokha ngati zakudya zimawonjezera;
  • monga katatu mankhwala osagwiritsa ntchito mankhwalawa omwe ali ndi insulin ndi metformin, omwe adagwiritsidwa ntchito kale, omwe amapezeka pakudya komanso kuchuluka kwa zolimbitsa thupi.

Mlingo ndi njira zogwiritsira ntchito mankhwalawa

Mlingo wa mankhwalawa amasankhidwa aliyense payekha kwa wodwala aliyense potengera zovuta za matendawa komanso kulolerana kwake ndi mankhwalawa. Kulandila kwa Galvus masana sikudalira chakudya. Malinga ndi ndemanga, popanga matenda, mankhwalawa amaperekedwa nthawi yomweyo.

Mankhwalawa ndi monotherapy kapena osakanikirana ndi metformin, thiazolidinedione kapena insulin amatengedwa kuchokera 50 mpaka 100 mg patsiku. Ngati wodwalayo ali ndi vuto lalikulu komanso insulini imagwiritsidwa ntchito kukhazikika pamlingo wa shuga mthupi, ndiye kuti mlingo wa tsiku ndi tsiku ndi 100 mg.

Mukamagwiritsa ntchito mankhwala atatu, mwachitsanzo, vildagliptin, zotumphukira za sulfonylurea ndi metformin, chizolowezi cha tsiku ndi tsiku ndi 100 mg.

Mlingo wa 50 mg tikulimbikitsidwa kuti atenge kumwa kamodzi m'mawa, mlingo wa 100 mg uyenera kugawidwa pawiri: 50 mg m'mawa ndi chimodzimodzi gawo lamadzulo. Ngati pazifukwa zina mankhwalawo adaphonya, ayenera kumwa mwachangu, osapitirira muyeso wa tsiku ndi tsiku wa mankhwalawo.

Mlingo wa tsiku ndi tsiku wa Galvus pochiza mankhwala awiri kapena kuposa ndi 50 mg patsiku. Popeza mankhwalawa omwe amagwiritsidwa ntchito popanga zovuta pamodzi ndi Galvus amalimbikitsa zotsatira zake, tsiku lililonse 50 mg imafanana ndi 100 mg patsiku ndi monotherapy ndi mankhwalawa.

Ngati mankhwalawa sakupezeka, tikulimbikitsidwa kuti muwonjezere mlingo wa mankhwalawo mpaka 100 mg patsiku, komanso mankhwala a metformin, sulfonylureas, thiazolidinedione, kapena insulin.

Odwala omwe ali ndi vuto lakumagwira ntchito kwamkati, monga impso ndi chiwindi, mlingo waukulu wa Galvus suyenera kupitilira 100 mg patsiku. Pankhani ya kufooka kwakukulu mu ntchito ya impso, tsiku ndi tsiku mlingo sayenera kupitirira 50 mg.

Analogs a mankhwalawa, omwe ali ndi mawonekedwe a code ya ATX-4: Onglisa, Januvia. Omwe amafananirana ndi zinthu zomwezo ndi Galvus Met ndi Vildaglipmin.

Ndemanga za odwala za mankhwalawa, komanso kafukufuku akuwonetsa kusinthasintha kwawo pochiza matenda ashuga.

Kufotokozera za mankhwala Galvus Met

Galvus Met imatengedwa pakamwa, kutsukidwa ndi madzi ambiri. Mlingo wa tsiku ndi tsiku wa mankhwalawa amasankhidwa aliyense payekhapayekha, komabe, popeza kuchuluka kwa mankhwalawa sikuyenera kupitirira 100 mg.

Mu gawo loyambirira, kuchuluka kwa mankhwalawa omwe amamwa amathandizidwa kudziwa kuchuluka kwa vildagliptin ndi / kapena metformin. Pofuna kuthana ndi mavuto obwera chifukwa chogaya chakudya, mankhwalawa amatengedwa ndi chakudya.

Ngati chithandizo cha vildagliptin sichikupereka zotsatira zoyenera, ndiye kuti Galvus Metom chithandizo chitha kutumikiridwa. Pongoyambira, mlingo wa 50 mg kawiri patsiku umalimbikitsidwa, pambuyo pake mutha kuwonjezera mlingo mpaka mphamvu itakwaniritsidwa.

Ngati chithandizo ndi metformin sichitha, kutengera mlingo womwe waperekedwa kale, Galvus Met akulimbikitsidwa kuti atenge gawo limodzi ndi metformin mogwirizana ndi 50 mg / 500 mg, 50 mg / 850 mg, 50 mg / 1000 mg. Mlingo wa mankhwalawa agawidwe pawiri.

Ngati vildagliptin ndi metformin adalembedwa, aliyense mwanjira ya mapiritsi osiyana, ndiye kuti Galvus Met ikhoza kutumikiridwa kuwonjezera pa iwo, monga chithandizo chowonjezera mu 50 mg patsiku.

Kuphatikiza mankhwala omwe ali ndi mankhwala osokoneza bongo a sulfonylurea kapena insulin, kuchuluka kwa mankhwalawa kumawerengedwa motere: 50 mg 2 pa tsiku monga analog ya vildagliptin kapena metformin, kuchuluka kwa mankhwalawa.

Galvus Met imakhudzana ndi odwala omwe akuvutika ndi vuto la impso kapena akuwoneka impso. Izi ndichifukwa choti Galvus Met ndi zinthu zake zomwe zimagwira zimachotsedwa m'thupi pogwiritsa ntchito impso. Mwa anthu omwe ali ndi zaka, ntchito ya ziwalo izi imayamba kuchepa.

Izi nthawi zambiri zimadziwika ndi odwala opitilira zaka 65. Odwala amsinkhu uwu amatumizidwa Galvus Met muyezo wochepa kuti azikhala ndi shuga wamagazi pamlingo woyenera.

Mankhwalawa akhoza kuthandizidwa atatsimikizira mawonekedwe a impso. Kuwunika ntchito ya impso mwa okalamba kuyenera kuchitidwa pafupipafupi.

Zotsatira zoyipa

Kugwiritsa ntchito mankhwala ndi Galvus Met kumatha kukhudza ntchito ya ziwalo zamkati ndi mkhalidwe wathupi lathunthu. Zotsatira zoyipa zomwe zimadziwika kwambiri ndi izi:

  • chizungulire ndi mutu;
  • miyendo yanjenjemera;
  • kumverera kozizira;
  • kusanza pamodzi ndi kusanza;
  • gastroesophageal Reflux;
  • kupweteka ndi kupweteka kwambiri pamimba;
  • khungu lawo siligwirizana;
  • kusokonezeka, kudzimbidwa ndi matenda otsekula m'mimba;
  • kutupa
  • otsika thupi kukana matenda ndi ma virus;
  • mphamvu zochepa zogwira ntchito komanso kutopa mwachangu;
  • matenda a chiwindi ndi kapamba, mwachitsanzo, hepatitis ndi kapamba;
  • kusenda kwambiri pakhungu;
  • mawonekedwe a matuza.

Contraindication kugwiritsa ntchito mankhwalawa

Zotsatira ndi ndemanga zotsatirazi zingakhale zotsutsana pamankhwala awa:

  1. thupi lawo siligwirizana kapena kusalolera kwa yogwira mankhwala;
  2. matenda a impso, kulephera kwa impso ndi vuto la chiwopsezo;
  3. zinthu zomwe zingayambitse vuto laimpso, monga kusanza, kutsegula m'mimba, kutentha thupi komanso matenda opatsirana;
  4. matenda a mtima dongosolo, mtima kulephera, myocardial infarction;
  5. matenda kupuma;
  6. matenda ashuga ketoacidosis oyambitsidwa ndi nthenda, chikomokere, kapena mkhalidwe wofala, ngati zovuta za matenda ashuga. Kuphatikiza pa mankhwalawa, kugwiritsa ntchito insulin ndikofunikira;
  7. kudzikundikira kwa lactic acid mthupi, lactic acidosis;
  8. mimba ndi kuyamwitsa;
  9. mtundu woyamba wa matenda ashuga;
  10. zakumwa zoledzeretsa kapena zakumwa zoledzeretsa;
  11. kutsatira chakudya chokhwima, komwe kudya calorie sikoposa 1000 patsiku;
  12. zaka odwala. Kukhazikitsidwa kwa mankhwalawa sikulimbikitsidwa kwa odwala ochepera zaka 18. Anthu opitilira zaka zopitilira 60 amalimbikitsidwa kumwa mankhwalawa moyang'aniridwa ndi madokotala;
  13. Mankhwala ayimitsidwa kutenga masiku awiri opaleshoni isanachitike, maphunziro a radiographic kapena kuyambitsa kusiyana. Ndikulimbikitsidwanso kukana kugwiritsa ntchito mankhwalawa kwa masiku awiri pambuyo pa njirazi.

Popeza mukamamwa Galvus kapena Galvus Meta, imodzi mwazowopsa ndi lactic acidosis, ndiye kuti odwala omwe ali ndi matenda a chiwindi ndi impso sayenera kugwiritsa ntchito mankhwalawa kuchiza matenda amtundu wa 2.

Odwala a zaka zopitilira 60, chiopsezo cha zovuta za matenda a shuga zimachulukana kangapo, kupezeka kwa lactic acidosis yomwe imayamba chifukwa cha mankhwala osokoneza bongo - metformin. Chifukwa chake, iyenera kugwiritsidwa ntchito mosamala kwambiri.

Kugwiritsa ntchito mankhwalawa panthawi yapakati komanso poyamwitsa

Zotsatira za mankhwalawa kwa amayi apakati sizinaphunzirebe, chifukwa chake makonzedwe ake saloledwa kwa amayi apakati.

Pankhani ya kuchuluka kwa shuga m'magazi a amayi apakati, pamakhala chiwopsezo cha kubereka kwa mwana mwa mwana, komanso kupezeka kwa matenda osiyanasiyana ngakhale kufa kwa mwana wosabadwayo. Pankhani ya shuga ochulukirapo, tikulimbikitsidwa kugwiritsa ntchito insulin kuti isinthe.

Pophunzira momwe mankhwalawa amathandizira thupi la mayi wapakati, mlingo womwe umadutsa kambiri nthawi 200 unayambitsidwa. Pankhaniyi, kuphwanya chitukuko cha mwana wosabadwayo kapena zovuta zilizonse zachitukuko sizinapezeke. Ndi kukhazikitsidwa kwa vildagliptin osakanikirana ndi metformin paziwerengero cha 1:10, kuphwanya kwa fetal sikunalembedwe.

Komanso, palibe deta yodalirika pazinthu zomwe ndi gawo la mankhwalawa nthawi yoyamwitsa limodzi ndi mkaka. Pankhaniyi, amayi oyamwitsa salimbikitsidwa kumwa mankhwalawa.

Zokhudza kugwiritsa ntchito mankhwalawa ndi anthu ochepera zaka 18 sizinafotokozedwe pakadali pano. Zotsatira zoyipa zogwiritsa ntchito mankhwalawa ndi odwala a m'badwo uno sizikudziwika.

Kugwiritsa ntchito mankhwalawa ndi odwala azaka zopitilira 60

Odwala a zaka zopitilira 60 chifukwa choopsa cha zovuta kapena mavuto omwe amadza chifukwa ch kumwa mankhwalawa amayenera kuwonetsetsa kuti ali ndi mankhwalawa ndikuyang'aniridwa ndi dokotala.

Malangizo apadera

Ngakhale kuti mankhwalawa amagwiritsidwa ntchito kuti matenda abwinobwino asakhale mtundu wa shuga wachiwiri, awa si ma insulin analogues. Mukamagwiritsa ntchito, madokotala ankalimbikitsa nthawi zonse kudziwa ntchito za chiwindi.

Izi ndichifukwa choti vildagliptin, yomwe ndi gawo la mankhwalawa, imapangitsa kuti ntchito ya aminotransferases iwonjezeke. Izi sizipeza chiwonetsero chilichonse, koma zimayambitsa kusokonezeka kwa chiwindi. Izi zimawonedwa mwa odwala ambiri ochokera ku gulu lowongolera.

Odwala omwe amamwa mankhwalawa kwa nthawi yayitali koma osagwiritsa ntchito mawonekedwe awo amalimbikitsidwa kuti azichita kuyezetsa magazi kamodzi pachaka. Cholinga cha phunziroli ndikuwonetsa zopatuka kapena zoyipa zilizonse poyambira komanso kukhazikitsidwa kwakanthawi kwa njira zowathetsera.

Ndi mavuto amanjenje, kupsinjika, minyewa, mphamvu ya mankhwala kwa wodwalayo itha kuchepetsedwa kwambiri. Makamaka wodwala akuwonetsa zovuta za mankhwalawa monga mseru komanso chizungulire. Ndi zizindikiro zoterezi, ndikulimbikitsidwa kuti musayendetse kapena kugwira ntchito yowopsa.

Zofunika! Maola 48 asanakudziwe mtundu uliwonse wa mankhwalawa ndikugwiritsa ntchito wothandizira wosiyana, ndikulimbikitsidwa kuti musiyire kumwa mankhwalawa. Izi ndichifukwa choti kusiyana komwe kuli iodini, pophatikizana ndi zigawo zina za mankhwala, kumatha kuwononga kwambiri ntchito za impso ndi chiwindi. Potengera izi, wodwalayo atha kukhala ndi lactic acidosis.

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