Kugwiritsa ntchito mankhwala monga Maninil ndi Diabeteson kumakupatsani mwayi wolimbana ndi matenda a hyperglycemia, omwe amakwiya mthupi la wodwalayo chifukwa cha kupitirira kwa matenda a shuga a mtundu wachiwiri.
Iliyonse ya mankhwalawa ilibe zabwino zake, komanso zovuta zake.
Ndi chifukwa cha ichi kuti funso loti Maninil kapena Diabeteson, lomwe lili bwinoko, limakhala lothandiza kwa wodwalayo.
Kusankha mankhwala kumadalira zinthu zambiri. Zomwe zimakhudza kusankha kwa mankhwala ndi:
- mphamvu ya mankhwalawa;
- kufunikira kwa mavuto;
- machitidwe a thupi;
- Zotsatira zoyesa shuga;
- zimayambitsa matenda a shuga mellitus amtundu wachiwiri;
- kuchuluka kwa matenda.
Yankho la funso loti Diabeteson kapena Maninil ndi bwino kugwiritsa ntchito mankhwalawa lingaperekedwe kokha ndi dokotala yemwe akuchita chithandizo atalandira zonse zofunikira zokhudzana ndi wodwalayo ndikuphunzira mawonekedwe a matendawa.
Zokhudza matenda a shuga mthupi la munthu
Diabetes imagwiritsidwa ntchito pochiza matenda amtundu wa 2 shuga. Mankhwala ndi othandizira a hypoglycemic. Wachiwiri-sulfonylurea zotumphukira. Kukhazikitsidwa kwa mankhwala m'thupi kumathandizira kugwira ntchito kwa ma cell a pancreatic beta, zomwe zimapangitsa kuti awonjezeke kupanga kwawo kwa insulin.
Chidachi chimakhudza kuzindikira kwa insulin receptors pamitsempha yama cell ya zotumphukira za insulin zotengera thupi. Tiziwalo timene timakhala minofu komanso mafuta.
Kumwa mankhwalawa kumachepetsa nthawi yayitali yodwala pakati pakudya ndi kuyamba kwa kutulutsa kwa insulin ndi maselo a pancreatic beta kulowa m'magazi.
Kugwiritsidwa ntchito kwa matenda a shuga kumawongolera kapena kupangitsa kuti matendawa azikhala mwamphamvu kwambiri.
Mukamagwiritsa ntchito mankhwala, kuchepa kwamlingo wa cholesterol ya wodwala kumawonedwa. Izi zimapewa kukula m'mitsempha yamagazi ya wodwala yemwe ali ndi matenda a shuga 2, matenda am'magazi (micherrombosis) ndi atherosulinosis.
Mothandizidwa ndi yogwira yogwira pophika mankhwala, njira yamagazi ya cellcircular imasintha.
Poyerekeza ndi chitukuko cha matenda a shuga a nephropathy odwala, kugwiritsa ntchito mankhwalawa kumatha kuchepetsa kuchuluka kwa proteinuria.
Pharmacokinetics, zikuwonetsa ndi zotsutsana pakugwiritsira ntchito Diabeteson
Pambuyo pakumwa pakamwa kupita ku thupi, mankhwalawo amawonongeka mofulumira kwambiri. Kuchuluka kwa thupi kumakwaniritsidwa patatha maola 4 pambuyo popereka mankhwalawa. Mankhwala amamangidwa ndi mapuloteni a plasma, kuchuluka kwa mapangidwe ovuta kumafika pa 100.
Kamodzi m'matumbo a chiwindi, gawo lomwe limagwira limasinthidwa kukhala metabolites 8.
Kuchoka kwa mankhwalawa kumachitika kwa maola 12. Kuchotsera mankhwala kuchokera ku thupi ndi impso kudzera mwa msambo.
Pafupifupi 1% ya mankhwalawa amamuchotsa mkodzo osasinthika.
Chizindikiro chachikulu chogwiritsa ntchito a Diabetes ndi kupezeka kwa thupi la wodwala matenda a shuga 2, omwe samadalira insulini. Mankhwala angagwiritsidwe ntchito ngati prophylactic poulula zakuphwanya mu mawonekedwe a magazi a magazi.
Mankhwalawa amatha kugwiritsidwa ntchito pa nthawi yonse ya monotherapy komanso ngati chinthu chimodzi mukamagwiritsa ntchito mankhwala osokoneza bongo a shuga mellitus.
Milandu ikuluikulu yomwe imagwiritsidwa ntchito popanga mankhwalawa ndi iyi:
- kukhalapo kwa thupi la insulin-wodwala matenda a shuga a mtundu woyamba;
- matenda ashuga, malo okondweretsa;
- wodwalayo ali ndi zizindikiro za matenda a shuga a ketoacidosis;
- zosokoneza mu magwiridwe antchito a impso ndi chiwindi.
Simalimbikitsidwa kugwiritsa ntchito mankhwalawa molumikizana ndi glycosides ndi imidazole. Ngati pakumva kukhudzika kwa thupi la wodwalayo kuti sulfonamides ndi sulfanilurea, sizikulimbikitsidwa kuti mugwiritse ntchito matenda a shuga.
Kuphwanya malingaliro pazogwiritsidwa ntchito kwa mankhwalawa kumayambitsa kukula kwa zoyipa zoyipa mthupi.
Mlingo wogwiritsidwa ntchito komanso mavuto
Kugwiritsa ntchito mankhwalawa kumalimbikitsidwa kuti muyambe ndi mlingo wa 80 mg. Mlingo wovomerezeka tsiku lililonse sayenera kupitirira 320 mg.
Ndi bwino kumwa mankhwalawa kawiri patsiku m'mawa ndi madzulo. Njira ya chithandizo ndi odwala matenda ashuga imatha nthawi yayitali. Lingaliro logwiritsa ntchito ndikusiya kugwiritsa ntchito mankhwalawa limapangidwa ndi adotolo poganizira zotsatira za mayeso ndi machitidwe a thupi la wodwalayo.
Mukamagwiritsidwa ntchito pochiza matenda a shuga a mellitus Diabeteson, zotsatirapo zoyipa zitha kuoneka:
- Zilango zakusanza.
- Kumachitika kwa malingaliro a nseru.
- Maonekedwe a ululu m'mimba.
- Nthawi zina, leukopenia kapena thrombocytopenia amakula.
- Thupi lawo siligwirizana limatheka, lomwe limawoneka ngati zotupa pakhungu komanso kuyabwa.
- Ngati mankhwala osokoneza bongo amapezeka m'thupi la wodwalayo, zizindikiro za hypoglycemia zimawonekera.
Ngati dokotala amupatsa matenda a shuga. Kenako muyenera kuyeserera magazi pafupipafupi.
Sitikulimbikitsidwa kugwiritsa ntchito mankhwalawa limodzi ndi mankhwala okhala ndi verapamil ndi cimetidine.
Kugwiritsa ntchito Diabeteson, potsatira malamulo onse, kumatha kusintha mkhalidwe wa wodwala wokhala ndi matenda ashuga a 2.
Zomwe zimagwiritsidwa ntchito ndi Maninil
Maninil ndi mankhwala osokoneza bongo omwe amagwiritsidwa ntchito pakamwa. Chofunikira chachikulu pakuphatikizika kwa mankhwala ndi glibenclamide. Makampani opanga mankhwala amapanga mankhwala okhala ndi mapiritsi okhala ndi mulingo wosiyana wa zomwe zimagwira.
Kukonzekera kumawerengedwa m'ma CD. Phukusili lili ndi miyala 120.
Maninil ndi m'badwo wachiwiri wa sulfonylurea. Kugwiritsa ntchito mankhwalawa kungathandize kuti maselo a beta adzetse insulin. Kupanga kwa timadzi timeneti kumayambira m'maselo a kapamba atangodya. Hypoglycemic zotsatira zakumwa mankhwalawa zikupitilira maola 24.
Kuphatikiza pazomwe zimapangidwira, kapangidwe kake ka zinthu zimaphatikizanso izi:
- lactose monohydrate;
- wowuma mbatata;
- magnesium wakuba;
- talc;
- gelatin;
- utoto.
Mapiritsiwo ndi opinki mu utoto, mawonekedwe-osalala ali ndi chamfer chokhala ndi notch yomwe ili mbali imodzi ya piritsi.
Mukamamwa pakamwa, mankhwalawa amayamwa mwachangu ndipo amatsala pang'ono kumamwa. Nthawi yofika ndende kwambiri mutatha kugwiritsa ntchito mankhwalawa ndi maola 2,5. Yogwira pophika mankhwala imagwira mapuloteni a plasma pafupifupi kwathunthu.
Metabolism ya Glibenclamide imachitika m'maselo a chiwindi. Metabolism imayendera limodzi ndi kupangika kwa metabolites awiri osagwira ntchito. Imodzi mwa metabolites imachotseredwa ndi bile, ndipo gawo lachiwiri lomwe limapezeka ndi metabolism ya glibenclamide limatulutsidwa mkodzo.
Hafu ya moyo wamankhwala kuchokera m'thupi la wodwalayo pafupifupi maola 7.
Zizindikiro ndi contraindication kugwiritsa ntchito mankhwala ndi mavuto
Chizindikiro chachikulu chogwiritsa ntchito mankhwalawa ndicho kupezeka kwa wodwala wa matenda a shuga m'magulu a insulin. Amagwiritsidwa ntchito pokhazikitsa onse ovuta komanso monotherapy.
Sitikulimbikitsidwa kugwiritsa ntchito mankhwalawa popanga zovuta za matenda a shuga komanso pamodzi ndi dongo.
Monga mankhwala aliwonse, Maninil ali ndi zotsutsana zingapo pogwiritsira ntchito mankhwalawa.
Milandu yayikulu yomwe imagwiritsidwa ntchito pa mankhwalawa ndi:
- kukhalapo kwa hypersensitivity ku zigawo za mankhwala.
- Kukhalapo kwa chiwopsezo chowonjezereka cha zotumphukira za sulfonylurea, sulfonamides ndi mankhwala ena okhala ndi gulu la sulfonamide, popeza kuyambika kwamtanda ndikotheka.
- Wodwalayo ali ndi matenda amtundu 1.
- Mkhalidwe wa precoma, chikomokere ndi matenda ashuga ketoacidosis.
- Kupezeka kwa aimpso kulephera.
- The boma kuwonongeka kwa chakudya kagayidwe kachakudya matenda a matenda opatsirana.
- Kukula kwa leukopenia.
- Kupezeka kwa matumbo kutsekeka ndi paresis m'mimba.
- Kupezeka kwa chibadwa cha lactose tsankho kapena kupezeka kwa shuga ndi lactose malabsorption.
- Kupezeka mu thupi la kuchepa kwa shuga-6-phosphate dehydrogenase.
- Nthawi ya pakati ndi kuyamwa.
- Wodwala ndi wochepera zaka 18.
Chenjezo liyenera kuchitika ngati pali matenda a chithokomiro omwe amachititsa kuti chiwonetsero cha matenda a chiwindi chisachitike.
Muyeneranso kusamala ngati pali nthenda yotupa ya chithokomiro cha thupi m'thupi, kuchepa kwa chithokomiro cha anterior pituitary ndi kuledzera.
Zotsatira zoyipa kuchokera pakugwiritsa ntchito Maninil, kusokonezeka kwa m'mimba, kupweteka kwa mutu, kusokonezeka kwa malankhulidwe ndi masomphenya, komanso kuwonjezeka pang'ono kwa thupi kungawoneke.
Kodi Maninil kapena Diabeteson ali bwino?
Dziwani kuti ndi ndani mwa odwala omwe atchule Maninil kapena Diabeteson yemwe ayenera kukhala dokotala. Kusankha kwa mankhwalawa chithandizo kumachitika ndi dokotala wokhazikika malinga ndi zotsatira za kuyesedwa kwa thupi ndikuzindikira mawonekedwe onse a thupi la wodwala yemwe ali ndi matenda a shuga a 2.
Iliyonse ya mankhwalawa imagwira ntchito kwambiri. Mankhwala onse awiriwa amakhala ndi mphamvu zambiri mthupi ndipo amachepetsa bwino kuchuluka kwa hyperglycemia.
Palibe yankho lomveka bwino ku funso lomwe ndi kumwa mankhwalawa.
Tiyenera kukumbukira kuti sikulimbikitsidwa kugwiritsa ntchito, mwachitsanzo, Diabetes ngati wodwala walephera kapena aimpso.
Ubwino wakugwiritsa ntchito Maninil ndikuti mukamagwiritsa ntchito, wodwalayo sangadandaule za kuchuluka kwadzidzidzi kwa shuga mthupi, popeza nthawi ya mankhwalawa ndi tsiku lathunthu.
Nthawi yomweyo, wodwalayo sayenera kuiwala za mfundo zamankhwala othandizira odwala matenda ashuga komanso njira zomwe amamwa mankhwala zimatsimikizira kuti shuga imasungidwa pamlingo wovomerezeka.
Kanemayo munkhaniyi amapereka chithunzithunzi cha mankhwala a shuga.
