Metformin zentiva imagwiritsidwa ntchito mosamala m'zochitika zachipatala, monga imodzi mwazamankhwala a matenda a shuga a 2.
Masiku ano, makampani opanga zamankhwala amatulutsa mitundu yambiri yamankhwala ochepetsa shuga, ndipo metformin zentiva ndi amodzi mwa iwo.
Zizindikiro pakugwiritsa ntchito mankhwala
Mankhwala Metformin zentiva akhala akugwiritsidwa ntchito ngati mankhwala ochiritsa matenda a shuga a 2 osakanikirana ndi zakudya zomwe dokotala wamupatsa.
Mankhwalawa amalola kuti asangobweretsa kuchuluka kwa glucose pamtengo pafupi ndi chizindikiro cha thupi, komanso amathandizira kuti athetse kulemera kwakukulu ndikuwongolera pamitundu yokhazikika, chomwe ndichofunikira kwa anthu omwe ali ndi vutoli.
Masiku ano, chifukwa cha kafukufuku wopitilira, zinthu zatsopano za chinthuchi zikupezeka, ndipo kugwiritsa ntchito kwake kukukulira, kulola kugwiritsa ntchito mankhwalawa osati pakulimbana ndi matenda.
Metformin zentiva angagwiritsidwe ntchito pochotsa ndi kuchiza matenda otsatirawa:
- Imathandizira kuteteza ubongo ku ukalamba, womwe umalola kuti uzigwiritsira ntchito prophylactic zolinga motsutsana ndi matenda a Alzheimer's.
- Mosangalatsa zimakhudza mitsempha yamagazi ndi mitsempha. Chifukwa chake, mothandizidwa ndi metformin, kukula kwa mitsempha ya mitsempha, kulephera kwa mtima, matenda oopsa, komanso kupimitsa mtima kwamitsempha.
- Amachepetsa mwayi wokhala ndi khansa.
- Amathandizira kusintha kwa potency mwa abambo, omwe anali opuwala chifukwa cha matenda osiyanasiyana a senile.
- Zimalepheretsa kukula kwa mafupa a anthu odwala matenda ashuga. Makamaka nthawi zambiri, azimayi amakhala ndi vuto la mafupa osaneneka atasiya kusamba, popeza pali kuchepa kwakukulu kwa mahomoni - estrogen.
- Zokhudza bwino chithokomiro cha chithokomiro.
- Ili ndi ntchito yoteteza mokhudzana ndi njira yopumira.
Ngakhale kuti mankhwala ali ndi zabwino zambiri, sizingatheke kunena kuti ndi athanzi ndipo amatha kuchiritsa matenda ambiri.
Monga mankhwala ena, metformin imatha kugwiritsidwa ntchito monga momwe dokotala amafotokozera, momwe mungathere chifukwa cha zovuta zake zonse.
Pharmacological zimatha piritsi
Mankhwalawa ndi a gulu la Biguanides, lomwe limagwiritsidwa ntchito pakamwa.
Mankhwalawa a hypoglycemic amathandizira kutsika kwam'magazi a shuga.
Chimodzi mwamaubwino amakulu a mankhwalawa ndikuti, mosiyana ndi mankhwala omwe amachokera ku sulfonylureas, sayambitsa hypoglycemia. Katunduyu akufotokozedwa ndikuti Metformin simalimbikitsa kuteteza insulin chifukwa cha maselo a beta a kapamba.
Mukamamwa molondola, mankhwalawa amathandizira kuzindikira kwa zotumphukira za minyewa yolumikizira insulin, zomwe zimapangitsa kuti shuga agwiritsidwe ntchito kwambiri ndi maselo odalira insulin. Zimathandizira kuchepetsa kupanga kwa glucose ndi ma cell a chiwindi chifukwa choletsa njira za gluconeogenesis ndi glycogenolysis. Mwa zina zabwino zimatha kuphatikizidwanso chifukwa chakuchepetsa mayamwidwe a shuga m'matumbo.
Zotsatira zabwino za metformin pa lipid metabolism zawonedwanso:
- kutsika kwa cholesterol yonse;
- amathandizira kukonza magazi;
- kuchepa kwa LDL ndi triglycerides.
Chofunikanso ndichakuti kusamalidwa kwa chakudya choyenera, limodzi ndi kugwiritsa ntchito metformin, kumathandizira kuchepa pang'onopang'ono m'thupi la wodwalayo.
Malangizo ogwiritsira ntchito mankhwalawa
Mankhwala Metformin Zentiva amapangidwa mu mawonekedwe a piritsi osiyanasiyana.
Wopanga mankhwalawa amapezeka ku Republic of Slovakia, pomwe Czech Republic imakhala ngati mwiniwake walembetsa.
Mankhwala atha kugulidwa pafupifupi ku malo aliwonse a mankhwalawa muyezo zotsatirazi:
- 500 mg ya mankhwala othandizira piritsi limodzi;
- 850 mg yogwira ntchito;
- 1000 mg ya metformin.
Kutengera mlingo wake, malamulo omwe amamwe mankhwalawa amatha kusiyanasiyana. Dziwani kuti ndi madokotala okhawo omwe angalimbikitse kugwiritsa ntchito mankhwalawa, kuphatikizapo m'malo mwa mankhwala omwe adamwa kale.
Njira yochizira imayikidwa mu Mlingo, womwe umatsimikiziridwa ndi zotsatira za kusanthula ndi maphunziro a thupi ndi machitidwe a wodwala. Chizindikiro chachikulu chomwe muyenera kulabadira mukazindikira mlingo ndi kuchuluka kwa shuga m'magazi am'magazi komanso kuchuluka kwa odwala.
Mlingo wocheperapo womwe mankhwalawa amayamba ndi 500 mg ya mankhwalawa ndikuwonjezereka kwina. Komanso, muyezo umodzi womwewo sungathe kupitirira chiwerengero chomwe chatchulidwa pamwambapa. Kuti mulekererane bwino mankhwalawo, komanso ngati pali Mlingo wokhazikika, kuchuluka kwake kungagawike pawiri kapena katatu masana. Chifukwa chake, zitha kuteteza kukula kwa zoyipa.
Mulingo woyenera wa mankhwalawa sayenera kupitirira 3000 mg yogwira ntchito.
Mankhwalawa amatengedwa pakamwa, pambuyo pake, patatha maola awiri kapena atatu, ntchito yake yayikulu imayamba kuonekera. Pafupifupi maola asanu ndi limodzi atatha kumwa mankhwalawa, plasma ndende ya metformin imachepa, popeza kuyamwa kwa chinthucho kumatha.
Nthawi zina, ndizovomerezeka kumwa mankhwalawa chifukwa cha prophylactic, ndipo mlingo uyenera kuchepetsedwa kawiri kapena katatu.
Kutheka kwakukulu kwa kumwa mankhwalawa kumatheka pambuyo pa milungu iwiri yamankhwala.
Ngati, pazochitika zina, mankhwala adasowa, palibe chifukwa chowalipirira pochulukitsa mlingo wotsatira.
Mukamamwa mankhwalawa, ndikofunikira kuganizira njira yachilengedwe ya kagayidwe kachakudya ndi thanzi labwino, popeza pamakhala chiopsezo cha lactic acidosis.
Njira zopewera kugwiritsa ntchito mankhwalawa
Kugwiritsa ntchito molakwika kwa Metformin kumatha kuyambitsa zovuta zambiri, zovuta zamavuto a thupi la munthu atseguka. Ichi ndichifukwa chake mankhwalawa amayenera kuperekedwa ndi adokotala, poganizira zonse zomwe wodwalayo ali, kukula kwa chitukuko cha matenda ndi matenda ena okhudzana ndi matendawa.
Zowonetsa zazikulu za mankhwalawa zimaphatikizapo izi:
- Kukula kwa mavuto ndi ziwalo zam'mimba, matenda am'mimba, omwe amatha kukhala limodzi ndi kupangidwa kwa mpweya, kupweteka m'mimba kapena m'mimba.
- Zotsatira zosasangalatsa zachitsulo mkamwa zitha kuwoneka pambuyo povulala.
- Kusanza ndi kusanza.
- Kuperewera kwamagulu ena a mavitamini, makamaka B12. Ichi ndichifukwa chake akulimbikitsidwa kuti mitundu yambiri ya mankhwala osinthika, omwe amatha kusintha mulingo wa zinthu zonse zofunika mthupi.
- Kukula kwa thupi lawo siligwirizana ndi zigawo za chinthu cholemba.
- Kutsika kwa shuga m'magazi m'munsi mwofunikira.
- Mawonekedwe a lactic acidosis.
- Megaloblastic anemia.
Ndipo ngakhale Metformin ikuphatikizidwa ndi gulu la mankhwala otetezeka, muyenera kuwerenga mosamala mawonetsedwe onse oyipa. Mankhwala oterowo amatha kukhala owopsa ngati simutsatira malamulo oyenera kutsata.
Chimodzi mwazinthu zoyipa zomwe zimadza chifukwa chogwiritsa ntchito mankhwalawa ndi lactic acidosis mu matenda a shuga. Vutoli limayendera limodzi ndi zizindikiro monga kugona kwambiri, kuwonda minofu, kuchepa thupi komanso kuthamanga magazi, komanso kupuma movutikira.
Ndi kukula kwa matenda oterewa, wodwala amafunikira kuchipatala mwachangu. Lactic acidosis ndi imodzi mwazotsatira zoyipa zomwe zimachitika chifukwa cha mankhwala osokoneza bongo ambiri.
Metformin Zentiva ndi oletsedwa kugwiritsa ntchito pamaso pa chinthu chimodzi kapena zingapo:
- metabolic acidosis mu pachimake kapena matenda mitundu;
- vuto la kudwala matenda ashuga kapena kholo;
- ndi mavuto akulu pantchito ya impso;
- chifukwa cha kusowa kwamadzi;
- matenda akuluakulu opatsirana akaonekera kapena pambuyo pawo;
- kulephera kwa mtima kapena kulowerera kwamtima;
- mavuto ndi yachibadwa ntchito kwa kupuma thirakiti;
- uchidakwa wosatha.
Amaletsanso kumwa mankhwalawa pambuyo poti achitidwe opaleshoni (osachepera masiku awiri asanafike pa opareshoni ndi masiku awiri atadutsa).
Ma Analogs a Metformin Zentiva
Maumboni a odwala amawonetsa zabwino zomwe chithandizo cha metformin chimabweretsa. Mtengo wake wapadera m'gawo la Russian Federation ukhoza kuchoka pa 100 mpaka 150 ma ruble, kutengera malo omwe amapezeka.
Ngati ndi kotheka, dokotala yemwe amapezekapo akhoza kusintha mankhwala ena ndi omwewo kapena mawonekedwe omwewo. Mpaka pano, msika wama pharmacological umapereka fanizo zotsatirazi za mankhwala a Metformin, omwe, malinga ndi ndemanga, amakhalanso ndi zotsatirapo zabwino:
- Glucophage - mapiritsi ochepetsera shuga omwe amapezeka mosiyanasiyana. Chofunikira chachikulu ndi metformin hydrochloride. Imathandizira kusintha magazi m'magazi popanda kuyambitsa hypoglycemia. Gawo lamitengo yamapiritsi oterowo, monga lamulo, sapitilira ma ruble 200.
- Glycon ndi mankhwala, omwe amapangika pomwe pali zinthu ziwiri zogwira ntchito nthawi imodzi - metformin ndi glibenclamide. Ichi ndi chophatikizira chomwe chimaphatikiza zomwe zimapangidwa ndi Biguanides ndi zotumphukira za sulfonylurea. Amagwiritsidwanso ntchito pothana ndi matenda am'mimba otchedwa II mellitus. Mtengo wapakati wa mankhwalawo ndi ma ruble 210-240.
- Diasphor ndi mankhwala ochokera pagulu la Biguanide, omwe ndi chithunzi chonse cha mapiritsi a Metformin. Mtengo wake wapakati pamasitolo azitawuni amatha kukhala 250 mpaka 350 rubles.
- Metadiene - mapiritsi ochokera ku kalasi ya dimethylbiguanides, omwe amapezeka osiyanasiyana. Kutengera kuchuluka kwa zinthu zomwe zimagwira, mtengo wa mankhwalawo umakhazikitsidwa. Monga lamulo, mtengo wa Sofamed m'magawo osiyanasiyana amzindawu sapitilira ma ruble 130.
- Nova Met.
- Glibenclamide.
Mpaka pano, kuchuluka kwa ma analogi kapena kutengera mawu ndi zambiri. Onsewa, monga lamulo, ali ndi zofanana kapena zofanana, koma amasiyana makampani opanga, mtengo, dzina.
Kuphatikiza apo, akatswiri azachipatala amalimbikitsa kugwiritsa ntchito zida zamankhwala zomwe zili, kuphatikiza pazogwira ntchito, kuchuluka kochepa kwa zida zothandizira.
Zambiri pazamankhwala Metformin zikuwonetsedwa mu kanema munkhaniyi.
