Mankhwala a Baeta, omwe amagwira ntchito omwe ndi exenatide, amaonedwa ngati mankhwala apadera a hypoglycemic. Chida chimagwiritsidwa ntchito pochiza matenda a shuga a 2, makamaka olemedwa ndi kunenepa kwambiri.
Kugwiritsa ntchito bwino kwa mankhwalawa kumagwirizanitsidwa ndi kapangidwe ka zinthu zofunika kwambiri, zomwe zimachepetsa kuchuluka kwa shuga m'magazi.
Imawonjezera kubisika kwa insulin, komanso, polimbikitsa ma insretin, imakhalanso ndi zotsatira zina zotsitsa shuga:
- imawonjezera kugwira ntchito kwa maselo a pancreatic beta, omwe amatsogolera pakuwonjezeka kwa insulin;
- amachepetsa katulutsidwe wa glucagon, amene amachititsa kuchuluka kwa shuga mu chiwindi;
- Imachepetsa kumasula.
Ubwino wambiri wa chinthu monga exenatide ndikuti umachulukitsa kupanga insulini kuchokera parenchyma, kenako ndikuyimitsa katulutsidwe wake pamene magazi a shuga abwerera mwachizolowezi.
Chifukwa chake, kuthekera kwa dziko la hypoglycemic mwa munthu kuli pafupifupi zero.
Thupi likalowa m'thupi la munthu, nthawi yomweyo limayamba kugwira ntchito ndikufika pachimake mu maola awiri. Kutalika kwa exenatide ndi maola 24, kotero kuyambitsa kwake kamodzi patsiku kumapereka kuchepa kwa kuchuluka kwa shuga nthawi yomweyo.
Kuphatikiza apo, exenatide amachepetsa chilimbikitso cha odwala matenda ashuga, chifukwa, amadya chakudya chochepa, mphamvu yam'mimba imachepa, ndipo samatuluka mwachangu.
Chifukwa chake, chinthu choterocho sichimangolimbitsa shuga m'magazi, komanso zimathandizira kuchotsa ma kilogalamu 4-5 owonjezera.
Malangizo ogwiritsira ntchito mankhwalawa
Mankhwala okhawo okhala ndi exenatide ndi Baeta. Kuphatikiza pa gawo lalikulu, pali zochepa zazinthu zina zowonjezera: sodium acetate trihydrate, mannitol, metacresol, acetic acid ndi madzi osungunuka.
Zimapangidwa ndi makampani awiri aku Sweden - AstraZeneca ndi Bristol-Myers squibb Co (BMS). Baeta ili ndi mawonekedwe amodzi okha - 250 mg ampoules omwe ali ndi yankho lomveka, chifukwa chilichonse chimakhala cholembera chapadera chokhala ndi kuchuluka kwa 1.2 kapena 2.4 ml.
Mankhwalawa amagulitsidwa ndi mankhwala, ndiye adokotala okhawo omwe angapereke kwa wodwala. Wodwala akapeza ma ampoules, ayenera kuwerenga mosamala malangizo kuti agwiritse ntchito.
Mankhwalawa amagwiritsidwa ntchito limodzi ndi monotherapy komanso ndi chithandizo chowonjezera cha mtundu wachiwiri wa matenda a shuga, pakakhala kotheka kuwongolera glycemia. Malangizowa ali ndi mndandanda wamankhwala omwe mungagwiritse ntchito mankhwala a Bayet:
- biguanides;
- zotumphukira sulfonylurea;
- Thiazolidinedione;
- kuphatikiza kwa thiazolidinedione ndi metformin;
- kuphatikiza kwa sulfonylurea ndi metformin.
Mlingo wa mankhwalawa ndi 5 mcg patsiku 1 ola limodzi asanadye. Amabayidwa pansi pakhungu pakhungu, pamphumi kapena pa ntchafu. Ngati mankhwalawa adachita bwino, patatha masiku 30, muyezo umakulitsidwa mpaka 10 mgg kawiri pa tsiku. Pankhani yophatikiza mankhwalawa ndi mankhwala a sulfonylurea, mankhwalawa amafunika kuchepetsedwa kuti muchepetse kuchepa msanga kwa shuga. Pakukhazikitsa yankho, malamulo otsatirawa ayenera kutsatiridwa:
- mankhwalawa samaperekedwa pakudya;
- Osaba jakisoni kapena kudzera m'mitsempha;
- ngati yankho lasintha mtundu kapena kukhala ndi tinthu tambiri, siligwiritsidwa ntchito;
- Pa chithandizo, kupanga anti-antibody ndikotheka.
Mankhwalawa amayenera kusungidwa m'malo opanda ana kutali ndi kutentha kwa 2-8C.
Moyo wa alumali ndi zaka ziwiri, ndipo yankho mu cholembera ndi masiku 30 mosinthika ndi 25 digiri.
Contraindication ndi zoyipa zimachitika
Monga mankhwala ena, Mankhwala a Bayeta ali ndi zotsutsana:
- mtundu 1 matenda a shuga;
- ketoacidosis (mavuto mu chakudya kagayidwe kachakudya);
- kulephera kwa impso (CC mtengo wochepera 30 ml / min);
- kukhudzidwa ndi magawo a mankhwala;
- matenda a m'mimba dongosolo popanda kudzimbidwa;
- kunyamula mwana ndi kuyamwitsa;
- ana ndi achinyamata ochepera zaka 18.
Pazifukwa zilizonse, mwachitsanzo, kugwiritsa ntchito mosayenera mankhwalawa, zotsatira zoyipa zingachitike:
- thupi lawo siligwirizana - urticaria, totupa pakhungu, kuyabwa;
- kusokoneza kwam'mimba dongosolo - nseru ndi kusanza, kugona mwachangu, kudzimbidwa kapena kutsekula m'mimba, kunachepetsa chilimbikitso ndi kulemera;
- kusokonezeka kwa chapakati mantha dongosolo - mkwiyo, kutopa, chizungulire ndi matenda ashuga ndi mutu;
- hepatic kapena aimpso kulephera;
- kuchuluka kwa seramu creatinine;
- hypoglycemic state, hyperhidrosis, kapamba.
Zikatero, wodwalayo ayenera kufunsa dokotala yemwe amasintha mankhwalawo.
Mungafunike kuchepetsa mlingo kapena kusiya kumwa mankhwalawa.
Mtengo, ndemanga ndi fanizo la mankhwala
Mankhwala a Baeta atha kugulidwa ku malo ogulitsa mankhwala kapena kuyika oda pa intaneti. Popeza mankhwalawo amalowetsedwa kunja, mtengo wake umakhala, motero, wokwera kwambiri. Chifukwa chake, sikuti aliyense angathe kugula.
Mtengo umasiyanasiyana malinga ndi kuchuluka kwa yankho, mtengo wa mayendedwe komanso malire a wogulitsa:
- 1.2 ml syringe cholembera - kuchokera 4246 mpaka 6398 ma ruble aku Russia;
- 2.4 ml syringe cholembera - kuchokera ku 5301 mpaka 8430 rubles aku Russia.
Odwala ambiri omwe adalandira yankho la Bayet adakhutira ndi mankhwalawa. Choyamba, chimagwiritsidwa ntchito kamodzi patsiku, ndipo chachiwiri, chimachepetsa shuga ndi thupi mwa munthu wonenepa.
Komabe, atatulutsira mankhwalawo, opangawo adachita kafukufuku wotsatsa malonda pomwe odwala omwe adasankhidwa mwanjira yomwe adatenga nawo gawo. Zotsatira za kafukufukuyu zikuwonetsa kuti anthu ambiri omwe amamwa mankhwalawo anali ndi zotsatirazi:
- Flatulence, kudzimbidwa, nthawi zina - pachimake kapamba.
- Urticaria, pruritus, alopecia (kutaya tsitsi), angioedema, zotupa za maculopapular.
- Kutopa chifukwa cha kusanza, kuwonda osafunikira.
- Kutopa, kusowa kapena kusokoneza kukoma.
- Kuwonongeka kwa impso, kukwezeka kwa creatinine, kulephera kwa aimpso kapena kukula kwake.
- Nthawi zina anaphylactic zimachitika.
Ponena za fanizo lomwe lili ndi zinthu zomwezi, sizipezeka. Mumsika wamankhwala ku Russia, mutha kupeza mankhwala okhawo omwe ali ndi vutoli. Izi zikuphatikizapo ma incretin mimetics - Viktoza ndi Januvius. Zambiri zokhudzana ndi izi zimapezeka pa intaneti kapena funsani dokotala.
Ndipo, choncho, exenatide, yomwe imapangidwa pokonzekera Bayeta, imachepetsa shuga m'magazi ndipo siziwatsogolera ku hypoglycemia. Dokotala amamulembera mankhwalawa, kuthetsa zomwe zingachitike mwanjira zotsutsana, zovuta zomwe zimachitika komanso kuganizira zomwe wodwalayo ali nazo. Kugwiritsa ntchito mankhwalawa molondola, mutha kuchotsa zizindikiritso za shuga kwa nthawi yayitali. Khalani athanzi!
Kuti mukwaniritse chipukuta mokhazikika, chithandizo cha matenda a shuga a 2 chiyenera kukhala chokwanira. Momwe mungachiritsire matenda auzeni katswiri muvidiyoyi.
