Cholestyramine ndi mankhwala a hypocholesterolemic, omwe amayimilidwa ndi resin ya ion-exchange yomwe imamanga asidi a m'matumbo a m'mimba. Mankhwalawa amagwira ntchito ngati Copolymer (mtundu wa ma polima wokhala ndi zigawo zosiyanasiyana) zamafakitale ndi divinylbenzene.
Mankhwalawa amagwiritsidwa ntchito pofuna kukonza mkhalidwe wa odwala omwe ali ndi cholesterol yayikulu mthupi komanso kuwonongeka kwa bile acid. Mankhwalawa amalekeredwa bwino ndi odwala, kawirikawiri samatsogolera pakukula kwa zoyipa.
Cholestyramine sichifotokozedwa kawirikawiri ngati mankhwala amakono. Nthawi zambiri, odwala amaphunzira za mankhwalawa pophunzira ndemanga za anthu ena. Mwina izi zikuchitika chifukwa cha kukwera mtengo kwa mankhwalawo. Mtengo ndi ma ruble a 1800-2000, phukusi lili ndi mapiritsi 12 a 4000 mg aliyense.
Mutha kugula mankhwala pa intaneti kokha, koma osagulitsika, chifukwa zinthu zomwe sizikulembetsedwa ku Russian Federation. Ganizirani malangizo omwe mungagwiritse ntchito, contraindication ndi fanizo la cholestyramine.
Pharmacological zochita ndi zikuonetsa ntchito
Mankhwalawa amalimbikitsa kumangiriza kwa ma asidi a bile m'mimba, chifukwa chotsatira kuti mapangidwe osakira a chelate amapangidwa, omwe amachotsedwa m'thupi laumunthu mwachilengedwe - limodzi ndi ndowe.
Mankhwalawa amathandizira kuchepetsa kuyamwa kwa cholesterol ndi ma lipid acid ena, amathandizira kupanga mapangidwe a bile acid mu minyewa ya chiwindi (munkhwala, mankhwala othandizira amatchedwa "ndemanga").
Mankhwala onse omwe ali ndi chophatikizira ichi amayang'ana kwambiri kuchepetsa kutsika kwa cholesterol. Poyerekeza ndi kuzungulira kwa enterohepatic, zoposa 97% za ma asidi a bile zimabwezeretsedwanso m'matumbo, kenaka lekani chiwindi ndikuchotsedwanso ndi bile kachiwiri. Chifukwa chake, chiwindi chimangokakamizidwa kuti "achotse" cholesterol kuti apange ma acid owonjezera a bile.
Malangizo ogwiritsira ntchito amalimbikitsa kugwiritsa ntchito mankhwalawa pazinthu zotsatirazi:
- Hyperlipoproteinemia yamtundu wachiwiri, makamaka wachiwiri "a";
- Kupewa kwa kusintha kwa atherosclerotic ndi matenda monga angina pectoris, infarction ya myocardial, matenda a mtima. Dokotala amatha kukupatsani mankhwala ngati njira zina sizinaperekenso chithandizo chamankhwala;
- Kupuma kwa kuyimitsidwa kwina kosayang'ana kumbuyo kwa kutsekeka kwamtundu wa biliary.
Mankhwala opangidwa ndi Cholestyramine samalimbikitsidwanso kuti azikhala ndi vuto lililonse.
Malangizo ogwiritsira ntchito mankhwalawa
Odwala ambiri, ataphunzira za mankhwalawa, akufunafuna zambiri pamutuwu: "Malangizo a Cholestyramine ogwiritsira ntchito ndi mtengo." Mtengo wa mankhwalawa ndiwokwera, ngakhale kuti ndi woyenera kutero, zili kwa akatswiri azachipatala kusankha. Ngati mumagula mankhwalawa pa intaneti, ndiye kuti azitenga pafupifupi ma ruble 2000.
Simungatenge ngati mbiri ya phenylketonuria. Zotsutsana zina zimaphatikizapo kutenga pakati, kuyamwitsa, kuyanjana ndi zinthu zazikulu zomwe zimagwira.
Nthawi zambiri, mankhwalawa amapezeka mu mawonekedwe a mapiritsi kapena ufa pakukonzekera kuyimitsidwa kuti mugwiritse ntchito mkati. Mapiritsi ayenera kumwedwa pakamwa musanadye. Ufa nthawi zambiri umasakanizidwa ndi madzi. Koma amaloledwa kuphatikiza ndi mkaka wa skim kapena msuzi wachilengedwe.
Mlingo umatsimikiziridwa payekhapayekha. Ganizirani chizindikiro choyambirira cha cholesterol m'magazi, mtundu wa matenda, matenda opatsirana, mwachitsanzo, matenda a shuga. Ponena za matenda ashuga, maphunziro pazokhudza shuga ya magazi sanachitidwe.
Cholestyramine imatha kubweretsa mavuto:
- Ululu mu epigastric dera, kudzimbidwa kwa nthawi yayitali.
- Kuchulukitsa kwa mpweya.
- Kusanza, kusanza.
- Kusokoneza kwam'mimba komanso m'mimba.
- Pachimake kapamba, anorexia.
- Kuchulukitsa kuyendetsa.
Kugwiritsa ntchito nthawi yayitali kumatha kuyambitsa matumbo, kutsekeka kwa magazi, komanso kusokonezeka kwa magazi. Kafukufuku wachitika pokhudzana ndi momwe mankhwalawo amathandizira. Asayansi ena amati kuphatikiza ndi kaboni yoyambitsa kumabweretsa zabwino kwambiri.
Mukamamwa mankhwalawa, muyenera kutsatira njira yumwa, nthawi ndi nthawi muziyang'anira zomwe zimachitika mu triglycerides ndi cholesterol m'thupi.
Mitu ya mankhwalawa
Mankhwala ofanana ndi awa ndi monga Studran, Colestir, Ipokol, Cholestan, Colestyramine, ndi mankhwala ena. Cholestan si mankhwala, koma zakudya zowonjezera, zomwe zimapangitsa rutin ndi allicin. Muli akupanga kuchokera ku masamba a artichoke, mababu a adyo, glycine, turmeric muzu wochotsa ndi zinthu zina.
Cholestan ali ndi contraindication: hypersensitivity kwa mankhwala, nthawi ya pakati ndi yoyamwitsa, kapamba kapena biliary pancreatitis. Musanagwiritse ntchito, ndikulimbikitsidwa kukaonana ndi dokotala kuti mugwirizane ndi mankhwala ena.
Akuluakulu amatenga mapiritsi 5 kapena makapisozi awiri patsiku ndi zakudya. Njira ya mankhwalawa imachokera ku milungu itatu mpaka isanu ndi umodzi. Ndemanga za odwala ndizabwino, malingaliro a madokotala sawonetsedwa.
The fanizo la achire zotsatira zimaphatikizapo mankhwala kuchokera gulu la statins:
- Atorvastatin;
- Lovastatin;
- Simvastatin;
- Pravastatin et al.
Kapangidwe kamankhwala kamayimiriridwa ndi magawo omwe amagwira ntchito omwe amatha kuchepetsa kuchuluka kwa cholesterol "yoyipa". Mlingo umakhazikitsidwa kutengera ndi zaka, poganizira zotsatira za mayeso.
Cholestyramine ndi mankhwala a hypocholesterolemic, koma madokotala ake sakupereka mankhwala chifukwa mankhwalawa sanalembetsedwe mwalamulo. Chifukwa chake, kuti muchepetse magazi m'magazi, amalimbikitsa kufananiza kwa mankhwala, operekedwa m'njira zosiyanasiyana.
Zambiri pa cholesterol zimaperekedwa mu kanema munkhaniyi.
