Mankhwala Vazonit ndi a gulu la angioprotective othandizira. Amasintha magazi ku ziwalo, amateteza mapangidwe a mitsempha ya magazi. Zotsatira zabwino zimadziwika chifukwa chobwezeretsa mawonekedwe a magazi. Mankhwalawa amaperekedwa mu mtundu umodzi. Amasiyanitsidwa ndi gawo lokwanira pochiza matenda omwe amayamba chifukwa cha magazi opatsika ziwalo ndi ziwalo zosiyanasiyana za magawo a magazi.
ATX
C04AD03 Pentoxifylline.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwalawa ali ngati mapiritsi. Pentoxifylline imagwiritsidwa ntchito ngati chogwira ntchito. Mlingo wake mu piritsi limodzi ndi 600 mg. Chidacho chili ndi zinthu zina, kuphatikizapo:
- hypromellose;
- ma cellcose a microcrystalline;
- crospovidone;
- silicon dioxide colloidal;
- magnesium wakuba.
Mankhwala Vazonit ndi a gulu la angioprotective othandizira.
Zotsatira za pharmacological
Katundu wa mankhwala omwe amafunsidwa: angioprotective, antiplatelet. Kuphatikiza apo, mankhwalawa amathandizira kukulitsa mitsempha yamagazi. Pa mankhwala, kusintha kwa magazi kumadziwikiridwa, zomwe zimapangitsa kuti madzi ake azitha. Mwanjira ina, izi zimaperekedwa chifukwa cha kuchepa kwa maselo ofiira am'magazi, kusinthidwa chifukwa chakukula kwa matenda.
Kuchulukana kwa erythrocyte nembanemba kumakulanso. Mankhwala amalepheretsa kuyanjana kwawo ndi mapulateleti. Zotsatira zake, kuchuluka kwa mamasukidwe amwazi ndikudziwikiratu. Izi zimathandizidwa ndi kuchepa kwa milingo ya fibrinogen, kugwira ntchito kwa chiwonongeko cha magazi owundana. M'madera omwe magazi amaperekedwa kwa ziwalo ndi ziwalo zomwe zinali ndi vuto lalikulu, zomwe zimapangitsa kuti pakhale mpweya wabwino komanso kuperekera kwa michere zimadziwika. Izi ndichifukwa chobwezeretsa ma microcirculation. Mankhwalawa amachepetsa ziwiya zamagetsi.
Kuphatikiza apo, mankhwalawa amathandizira kukulitsa mitsempha yamagazi.
Zotsatira zabwino mthupi zimachitika chifukwa chakuti wothandizirayo amafunsidwa ndi xanthines. Izi ndi zinthu zosungunuka kwambiri za crystalline purine zomwe zimapezeka mu minofu kulikonse.
Pharmacokinetics
Kugawa kwofananira kwa metabolites pazinthu zomwe zimagwira thupi lonse kumadziwika. Madzi kulowa m'magazi amachokera m'mimba. Ntchito yapamwamba kwambiri ya mankhwalawa imatheka palibe kale kuposa maola 3-4 mutatha kutenga kapisozi. Kusintha kwa yogwira pophika kumachitika m'chiwindi. Chifukwa achire zotsatira kumatha salinso kuposa 12 maola.
Mankhwalawa amachotseredwa pakukodza. Potere, ma metabolites ambiri amatuluka m'thupi.
Kodi amatchulidwa?
Mankhwala omwe amafunsidwa nthawi zambiri amagwiritsidwa ntchito ngati matenda a mtima, kuphatikizapo:
- matenda osiyanasiyana ozungulira mu zotumphukira mitsempha, izi zimaphatikizapo matenda: atherosulinosis obliterans (chizungulire, kupweteka kwa mutu, kusokonezeka kwa chidwi), kulumikizana pakubwera ndi ma microcirculation kumapeto, matenda a Raynaud;
- angioneuropathy, encephalopathy yamitundu yosiyanasiyana;
- ischemic sitiroko, kuchira pambuyo apoplexy sitiroko;
- viruro neuroinawon;
- kusintha kwa kapangidwe ka minofu ya trophic chikhalidwe, chomwe chingachitike chifukwa chophwanya ochepa kapena venous microcirculation, izi zimachitika ndi matenda monga venous insuffence, kuphwanya kapangidwe ka khungu pakapsa, frostbite, zilonda zam'mimba za trophic chikhalidwe, kuchulukitsa kwa thrombophlebitis;
- kusokonezeka kwa khutu chifukwa cha kusokonezeka kwa magazi m'zigawo za khutu lapakati;
- Kuwonongeka kwamaso popanga matenda a ophthalmic, kuphatikiza matenda omwe amayamba chifukwa cha kuwonongeka kwa maso, kumakhalanso ndi matenda ochitika m'matumbo;
- kukanika kwamtundu wa amuna, kupsinjika ndi kuwonongeka kwa mtima;
- mbiri ya mphumu ya bronchial;
- chidwi kuperewera kusokonezeka ischemic.
Contraindication
Mayendedwe akuluakulu a malire ndi mitundu yovuta yamatenda a mtima. Izi zikuphatikiza:
- Zotsatira zoyipa zosagwirizana ndi munthu zomwe zimagwiritsidwa ntchito popanga mankhwala, komanso za xanthine zotumphukira;
- magazi, makamaka olemetsa;
- myocardial infarction mu pachimake gawo;
- hemorrhagic sitiroko;
- porphyria;
- hemorrhege mu ziwalo masomphenya;
- zaka za odwala ochepera zaka 18, chifukwa chosowa chidziwitso cha mankhwalawa pa thupi la ana.
Ndi chisamaliro
Kuphatikiza pa kutsutsana kotheratu komwe takambirana pamwambapa, pali zoletsa zina zingapo zomwe zingathe kuphwanya vuto mwadzidzidzi. Zina mwa izo ndi:
- kufanana kwa thupi la wodwalayo kukokomeza;
- kuwonongeka kwa ziwiya za ubongo zamtundu wa atherosulinotic;
- kukulitsa mtima;
- zilonda zam'mimba zotupa zam'mimba zodutsa m'mimba (makamaka m'mimba ndi duodenum);
- aakulu aimpso kulephera, chiwindi kukanika;
- ntchito zaposachedwa.
Momwe mungatenge vasonite?
Kuti muchepetse mkwiyo, mankhwalawo amayenera kuledzera osafuna kutafuna. Mapiritsiwo amatsukidwa ndi madzi. Kutalika kwa maphunzirowa kumatsimikiziridwa payekhapayekha. Nthawi zambiri, mapiritsi amalimbikitsidwa kuti azimwedwa nthawi yayitali kuyambira milungu iwiri mpaka miyezi ingapo.
Asanadye kapena pambuyo chakudya?
Ndi bwino kumwa mankhwala mukamadya.
Akuluakulu
Malangizo ogwiritsira ntchito:
- Mlingo wa tsiku ndi tsiku wogwira ndi 1200 mg.
- Mlingo wa mankhwalawa uyenera kugawidwa mu Mlingo wa 2-3.
- Zizindikiro zoonekera bwino za matendawa zitachepa, mulingo umachepetsedwa mpaka 300 mg (kuchuluka kwa tsiku lililonse). Malangizowa amagwira ntchito makamaka kwa odwala omwe ali ndi matenda a chiwindi.
Mlingo wa tsiku ndi tsiku wogwira ndi 1200 mg.
Odwala omwe ali ndi vuto la impso amalephera mankhwala ochepa - 600 mg patsiku. Ngati ndi kotheka, Mlingowu umagawidwanso mu Mlingo wa 2-3. Ndi pentoxifylline wocheperako, njira yothandizira imayenera kuyambikanso panthawi yomwe wodwala amakonda kutsika magazi.
Kwa ana
Mankhwala sanatchulidwe.
Ndi matenda ashuga
Kugwiritsa ntchito mlingo waukulu kwambiri kumayambitsa hypoglycemia. Kupewa izi, kuwerengetsa kuchuluka kwa pentoxifylline ndikofunikira. Mlingo weniweni wa odwala omwe ali ndi matenda ashuga amatsimikiziridwa payekhapayekha.
Zotsatira zoyipa
Popeza kuti mankhwalawo amagwira ntchito zamankhwala amtunduwu, nthawi zambiri zimachitika zovuta kuzichita. Kukula kwa mawonekedwe awo kumadalira mtundu wamatenda ndi momwe thupi liliri panthawi yomwe zizindikirozi zimachitika. Gulu la matenda ambiri limaphatikizira kuwonongeka kwa mawonekedwe aziphuphu, kutupa kwa mucous nembanemba amkati, kunenepa kwa misomali, kufooka mthupi, komanso kupweteka m'khutu.
Gulu la matenda ambiri limaphatikizira kuwonongeka kwa mawonekedwe owonekera.
Matumbo
Pali mwayi wocheperako kudya, womwe nthawi zambiri umachitika chifukwa cha mseru. Kusintha kumachitika pafupipafupi, ndipo chopondapo chimasokonekera. Pali kuuma pamlomo wamkamwa, kupweteka m'dera la epigastric. Zizindikiro za chiwindi michere chimasintha, jaundice kapena cholecystitis, hepatitis imayamba.
Kuchokera pamtima
Ngati kuchuluka kwa mankhwalawa kumachitika pafupipafupi, ndiye kuti phokoso lakumtima limasweka, kuthamanga kumadzuka.
Pakati mantha dongosolo
Mikhalidwe yopweteka, mavuto ogona, mavuto ofatsa amisala (chisangalalo, nkhawa, nkhawa). Mutu ndi chizungulire zitha kuwoneka.
Kuchokera pakatikati wamanjenje, mutu ndi chizungulire zitha kuwoneka.
Pa khungu ndi mafuta onunkhira
Hyperemia yamtundu wakunja waumboni imadziwika. Wodwalayo amadandaula za "kutentha kwa thupi" kumtunda. Pali zotupa.
Kuchokera pa hemopoietic dongosolo ndi heestasis
Nthawi zina leukopenia ndi thrombocytopenia amapezeka ndi vasonitis. Kapangidwe ka magazi kakusintha. Pazifukwa izi, tikulimbikitsidwa kuwunika magawo a biochemical. Pali magazi, nthawi zambiri m'malo ogaya chakudya.
Matupi omaliza
Zizindikiro zakale zimawonekera: kuyabwa, totupa pakhungu, urticaria imatha kupuma, kupuma kumakhala kovuta chifukwa cha kutupira kwa m'mimba. Kugwedezeka kwa anaphylactic sikupezeka pafupipafupi.
Urticaria ikhoza kukhala.
Malangizo apadera
Ngati maanticoagulants amagwiritsidwa ntchito limodzi ndi vasonitis, kayendedwe ka magazi ndikofunikira. Kuphatikiza apo, kuthamanga kwa magazi kuyenera kuyang'anidwa mwa odwala omwe amakonda hypo- komanso matenda oopsa. Odwala atachitidwa opaleshoni amalimbikitsidwa kuti azitha kuwonetsa monga hemoglobin, hematocrit. Tiyenera kukumbukira kuti kusuta kumatha kupangitsa kuchepa kwa mankhwalawa.
Kuyenderana ndi mowa
Sitikulimbikitsidwa kugwiritsa ntchito zinthu zokhala ndi zakumwa zoledzeretsa ndipo nthawi yomweyo imwani mapiritsi a vasonit.
Zokhudza mphamvu pakuwongolera njira
Palibe malamulo okhwima. Komabe, Popeza mankhwalawa amayambitsa matenda amitsempha yamagetsi, tikulimbikitsidwa kuti mupewe ntchito zomwe zimafuna kuwonjezeka, kapena kusamala.
Mankhwala ndi oletsedwa panthawi yoyembekezera.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Mankhwala ndi oletsedwa kugwiritsidwa ntchito.
Gwiritsani ntchito mu ukalamba
Mlingo wocheperako umaperekedwa, chifukwa mwa odwala a gululi pali kuchuluka kwa mankhwalawa. Pamodzi ndi izi, pang'onopang'ono pakuchepa kwa ntchito ya pentoxifylline metabolites. Kuphatikiza apo, zinthu izi zimatha kubweretsa kuwonjezeka kwa kukula kwa mawonetsedwe amachitidwe osagwirizana.
Bongo
Ndi kuchuluka kosalamulira kwa pentoxifylline, zizindikiro zimachitika:
- kugona
- kuchuluka kwa kutentha kwa thupi;
- kutsika kwa kupanikizika, komwe kumawonetsedwa ndi nseru;
- zinthu zopweteketsa mtima;
- kukomoka
- magazi m'matumbo am'mimba, nthawi zambiri kusanza ndi chinthu chakuda.
Choyamba, kupukusa kwa m'mimba kumachitika. Ndiye chithandizo chamankhwala ndi mankhwala.
Kuchita ndi mankhwala ena
Wothandizirayo pamafunso amakhudza anticoagulants, antimicrobial zinthu za gulu la cephalosporin, valproic acid. Pali kuchuluka kwamphamvu kwa mankhwala monga Insulin, mankhwala omwe amachotsa zizindikiro za hypotension, mankhwala a hypoglycemic pakugwiritsa ntchito pakamwa. Cimetidine amathandizira kuwonjezeka kwa kuchuluka kwa yogwira magazi m'magazi a magazi. Sizoletsedwa kugwiritsa ntchito nthawi yomweyo zinthu zomwe zimachokera ku xanthine.
Analogi
Mukamasankha mankhwala omwe angafotokozedwe m'malo mwa Wasonite, dziwani za mtundu wa yogwira pophatikizika, ndende yake. Njira yotulutsira sichinthu chofunikira kwambiri, chifukwa nthawi zonse pamakhala mwayi womwe ungayambirenso mankhwalawa.
Mukamasankha mankhwala omwe angafotokozedwe m'malo mwa Wasonite, dziwani za mtundu wa yogwira pophatikizika, ndende yake.
Kupatula komwe kuli pokhapokha ngati wodwala akulimbikitsidwa mtundu wina wa mankhwala pazifukwa zamankhwala (mwachitsanzo, pakusanza kapena pakumeza mapiritsi omeza). Malo oyamba kwambiri pakati pa analogu ndi Vasonit Retard. Zina m'malo: Pentoxifylline, Pentoxifylline Zentiva, Trental.
Kupita kwina mankhwala
Mankhwala omwe mumalandira amaperekedwa.
Kodi ndingagule popanda kulandira mankhwala?
Palibe mwayi wogula popanda mankhwala. Chokhacho chokha ndi kugula pazinthu zapaintaneti, koma pakali pano palibe chitsimikiziro chotsimikizika ndi mtundu wa mankhwalawo.
Mtengo wa maluwa
Mtengo wa ndalamazi zomwe zikufunsidwa (zopangidwa ku Ukraine, Russia kapena mayiko ena) ndizofanana ndipo zimakhala ma ruble 430.
Zosungidwa zamankhwala
Kutentha kotsimikizika kwa chipinda kumakhala mkati mwa + 25 ° ะก.
Palibe mwayi wogula popanda mankhwala.
Tsiku lotha ntchito
Gwiritsani ntchito mankhwalawa mkati mwa zaka 5 kuyambira tsiku lopanga. Mapeto a nthawi imeneyi, mankhwalawo amataya zinthu zake, ndipo mwayi wokhala ndi zovuta zosayembekezereka umawonjezeka.
Ndemanga za Wasonite
Kuunika kwa ogula kumathandizira ntchito yosankha mankhwala oyenera kwambiri.
Madokotala
Ruban D.V.
Chipangizochi chimagwira bwino ntchito zake zazikulu (kubwezeretsa miyendo yamiyendo ndi kulumikizana kwina, kuchotsa kwa zizindikiro zamitsempha yamagazi, etc.). Koma ndikufuna kudziwa kuti mukamalandira chithandizo, mavuto amayambitsidwa nthawi zambiri, yomwe imabweza Wasonite chifukwa chakufuna kufotokozeranso kuchuluka kwa mankhwalawo kapena kusaka analogue yovuta.
Odwala
Nikita Ivanov, Alupka
Nthawi ina zapitazo adapezeka kuti ali ndi vuto la kubisala. Zotsatira za mankhwalawa zidakhutira kwathunthu: chizungulire chinazimiririka nthawi yomweyo, komanso mutu. Memory idasinthidwa, ndipo nayo, kulingalira kunabwezeretseka. Zinali zabwino kuti panalibe zotsatila panthawi ya chithandizo.
