Zokor ndi mankhwala omwe amachepetsa kuchuluka kwa cholesterol yamagazi yoyipa, amateteza thupi ku matenda oyipa a mtima ndi mitsempha yamagazi. Mankhwalawa ali ndi phindu pambuyo pa masabata 2-4 kuyambira pachiyambireni maphunziro.
Mapiritsi amalembedwa kwa odwala omwe ali ndi matenda a shuga; mu gulu ili la odwala, kuthekera kwa zovuta za m'magazi kumatsika ndi 55%, kufa ndi 30%, kuchuluka kwa opaleshoni yamtima ndi 37%.
Sali wodwala aliyense amene angathe kulipira mtengo wa statin; mtengo wapakati wa 10 mg ndi 500-700 rubles aku Russia. Kwa Zokor mu gawo la 20 mg muyenera kulipira pafupifupi 700-900 rubles.
Ngati, pazifukwa zilizonse, mapiritsi a Zokor sayenera odwala omwe ali ndi matenda ashuga, dokotala akuwonetsa kuti akuyenera kulandira chithandizo chofanana ndi mankhwalawa. Ma analogi otchuka komanso otchuka ayenera kutchedwa ndalama: Aterostat, Vasilip, Levomir, Zovatin. Zofananira zina zothandiza:
- Atromidine;
- Lovastatin;
- Liprimar;
- Rosuvastatin.
Mankhwalawa ali ndi kuchuluka kofanana pakati pa zinthu zomwe zimagwira, mulingo wawo wofanana. Mwakutero, kusiyana pakati pa mapiritsi kuli mwa wopanga, mtengo wazinthu zothandizira zomwe zimagwiritsidwa ntchito, njira yamalonda, kutchuka kwa mankhwala.
Malangizo ogwiritsira ntchito mankhwalawa
Kugwiritsa ntchito mankhwala Zokor kwenikweni kumayendetsedwa ndi chakudya chamagulu chamagululesterol. Mapiritsi amatchulidwa muyezo wa 5 mpaka 80 mg, kumwa pogona. Ndi zoletsedwa kupitirira mlingo woyenera, kuchuluka kwake kwa mankhwalawa kumasankhidwa payekha.
Kuwongolera sikuchitika mopitilira kamodzi pakapita masiku 30 alionse. Njira ya chithandizo ndi yayitali, ngati mankhwalawo adathetsedwa, mawonekedwe a wodwalayo amabwerera momwe adalili kale.
Mlingo wofanana ndi matenda ashuga, matenda a mtima, kugwidwa ndi 40 mg patsiku, kuphatikiza katundu ndi cardio. Ndi mtundu wofatsa wa hypercholesterolemia, kudya kumayamba ndi 10-20 mg wa chinthu chilichonse madzulo, ngati kuli kotheka, muchepetse cholesterol yotsika kwambiri kuposa 45%, kuchuluka kwa mankhwalawa kumawonjezeka mpaka 40 mg. Chithandizo chiyenera kuyang'aniridwa ndi dokotala.
Mlingo wambiri watsiku ndi tsiku sayenera kupitirira 10 mg ngati Zokor anakhazikitsidwa pamodzi ndi mankhwala:
- Cyclosporin;
- Danazole;
- Gemfibrozil.
Familial hypercholesterolemia (matenda oopsa a majini) imaphatikizapo kutenga 40 mg usiku uliwonse asanagone. Nthawi zina amasonyezedwa kugwiritsa ntchito 80 mg ya mankhwalawa, kugawa mlingo katatu, kusunga nthawi yomweyo.
Mukamagwiritsa ntchito limodzi ndi Verapamil ndi Amiodarone, mtengo wake ndi 20 mg. Mitundu ikuluikulu ya kulephera kwa impso imafuna kuchepetsa Mlingo watsiku ndi tsiku mpaka 10 mg.
Mankhwalawa amapangidwa mwa mawonekedwe a mapiritsi osalala, phukusi lililonse limakhala ndi zidutswa 14-28. Pamankhwala mutha kugula Zokor 10 kapena Zokor 20 mg. Kuphatikiza pa chophatikizira chachikulu cha simvastatin, mapiritsi ali ndi ascorbic acid (vitamini C), lactose monohydrate, wowuma, citric acid ndi talc.
Asanalandire chithandizo, ndikofunikira kuyesa kuyesa kwa chiwindi, ndiye kuti muyenera kubwereza kafukufukuyu nthawi ndi nthawi.
Ngati malire apamwamba a chizolowezi amapitilira katatu kapena kuposerapo, mankhwalawo akuwonetsedwa kuti asiya, m'malo mwake ndi analogue yofanana.
Zothandiza katundu
Mankhwalawa amalimbikitsidwa kwa odwala matenda ashuga omwe ali ndi chiyembekezo chokhala ndi matenda a mtima, omwe amapezeka ndi cholesterol yambiri yamagazi. Imayenderana ndi zizindikiro za matenda amtima, imachepetsa mwayi wa kufa m'matenda amtima, komanso imakhala njira yolepheretsa zovuta zam'magazi, monga matenda a mtima, kugunda kwa mtima.
Anthu odwala matenda ashuga amatha kudalira kuteteza kuwonongeka kowopsa kwa ziwiya zotumphukira. Ndi matenda a ischemic ophatikizidwa ndi hypercholesterolemia, kukula kwa coronary atherosulinosis kumachedwa.
Kuchuluka kwazinthu zomwe zimagwira ntchito kumachitika pambuyo pa maola 1.3-2.4 mutatha mapiritsi a Zokor. Pafupifupi 85% ya chinthu chamlomo chimamwidwa nthawi yomweyo. Poyerekeza ndi mankhwala ena, simvastatin yapamwamba kwambiri m'maselo a chiwindi imawonedwa.
Lemberani Zokor:
- ngati kuli kotheka, opaleshoni yowonjezereka yamitsempha yamagazi;
- kufooketsa kuukira kwa angina pectoris;
- kuchepetsa cholesterol yotsika kwathunthu komanso yotsika;
- kuwonjezera cholesterol yopindulitsa;
- ngati kuli kotheka, onetsetsani kuchuluka kwa triglycerides.
Zinthu zoyambirira zikalowa m'chiwindi, zimapukusidwa, kenako metabolites ndi mankhwalawa zimachotsedwa pamodzi ndi bile. Kugwiritsa ntchito mankhwalawa sikudalira chakudya, chakudya sichikhudzanso mankhwala a pharmacokinetics.
Ndi kugwiritsa ntchito nthawi yayitali, kudzikundikira kwamtundu wa thupi sikumachitika.
Zochita Zosiyana ndi Zopikisana
Monga lamulo, Zokor imalekeredwa bwino ndi thupi, yowumbidwa mwachilengedwe. Ngakhale izi, monga mankhwala ena, pamakhala zovuta zoyipa. Pafupifupi 0.1-10% ya odwala matenda ashuga amapezeka ndi vuto la kuchepa kwa magazi, kupweteka kwa asthenic, kusowa kwa tsitsi, chizungulire, jaundice, ndi matenda ashuga a shuga.
Kuphatikiza apo, dermatomyositis, myalgia, kutupa mu kapamba, kukokana kwa minofu, dyspepsia sikuchotsedwa. Zotupa pakhungu, kuyabwa, zotumphukira nephropathy, paresthesia, rhabdomyolysis.
Kugwiritsa ntchito mapiritsi kungayambitse matenda a chitetezo cha m'thupi, matupi awo sagwirizana: kutupa, lupus syndrome, urticaria, kusokonezeka kwa chidwi cha kuwala, arthralgia. Odwala omwe ali ndi vuto la metabolic amadziwika ndi kuwonjezeka kwa ESR, khungu la hyperemia ndi kupumira movutikira.
Pali mbiri yaudindo:
- kuchuluka kwa creatine phosphokinase;
- kuchuluka kwa transaminase;
- kuchuluka zamchere phosphatase ndende.
Ngati zizindikiro zomwe zimaganizirazo zikuchitika, pakufunika kuti muchepetse mlingo wake kapena musiyeni kumwa, m'malo mwake muthane ndimankhwala.
Ali ndi Zokor ndi contraindication, amaphatikizapo kutenga pakati, nthawi yoyamwitsa, kusalolera kwa munthu payekhapayekha pazigawo zamankhwala. Simungamwe mapiritsi a matenda othandizira a chiwindi, kuphatikizapo transaminase yokwezeka ya etiology iliyonse. Kwa odwala matenda ashuga okhala ndi cholozera cha transaminase chokwezeka, mankhwalawa amayikidwa mosamala.
Umboni womwewo wa uchidakwa wambiri, rhabdomyolysis. Mapiritsi sinafotokozedwe paubwana.
Kuchita ndi mankhwala ena
Ndikofunikira kugwirizanitsa kutenga Zokor ndi mankhwala ena, izi zimapewe kuchepa kwa achire.
Fibates, kuwonjezera pa fenofibrate, nicotinic acid, pamodzi ndi Zokor, imawonjezera kuchuluka kwa hypocholesterolemic, ndikuwonjezera mwayi wokhala ndi myopathy.
Mapiritsi amathanso kukhudzana ndi zotsatira za ma coumarin anticoagulants; akagwiritsidwa ntchito limodzi, kuyan'aniridwa ndi dokotala akuwonetsedwa. Ndi njira iyi, kutaya magazi kungatheke.
Kugwiritsa ntchito limodzi ndi mankhwala ena kumawonjezera chiopsezo cha myopathy, nthawi zambiri timalankhula za mankhwala a Erythromycin, Terithromycin, Ketoconazole. Ndi bwino kuti musamwe mapiritsi apamwamba:
- Verapamil;
- Amiodarone;
- Danazole;
- Cyclosporin.
Malingaliro enanso ndi kupewa kudya kwambiri zipatso za malalanje, makamaka mphesa. Mankhwala amalimbikitsa ntchito ya mankhwala mu madzi am`magazi.
Mapiritsi a Zokor amagulitsidwa kokha mwamankhwala kuchokera kwa dokotala.
Alumali moyo wa mankhwalawo, malinga ndi kutentha kwa nyengo, siziposa zaka ziwiri kuchokera tsiku lopangidwa.
Malangizo apadera
Kugwiritsa ntchito nthawi yayitali kwa Zokor kungayambitse myopathy yokhala ndi zizindikiro: kupweteka kwa minofu, kufooka kwapafupipafupi, limodzi ndi kuwonjezeka kwa makumi a nthawi ya creatine phosphokinase.
Myopathy imadzipangitsa kumva ngati yachiwiri kulephera, imabweretsa zotsatira zoyipa. Kuchepa kwa myopathy kumawonjezeka ndi kuwonjezeka kwazinthu za m'madzi a m'magazi pakumwa mankhwala osokoneza bongo.
Aliyense wodwala matenda ashuga omwe Zokor adamulamula ayenera kudziwa kufunikira kukaonana ndi dokotala posachedwa kwa minofu iliyonse komanso makamaka ululu wosadziwika.
Kumayambiriro kwenikweni kwamankhwala, ndikuwonjezereka kulikonse kwa mankhwalawa, amafunikira kuwunika ndende ya creatine phosphokinase. Ngati zikuwonetsa kuti mungachite opaleshoni yomwe mukufuna kukonzekera, pewani kumwa mapiritsi masiku angapo njira yotsatirayi isanachitike. Chifukwa chake amachita izi m'masiku oyamba atatha kulowererapo.
Asanalandire chithandizo cha mankhwalawa komanso panthawi ya mankhwala, ndikofunikira kuwunika ntchito ya chiwindi, zowonjezera zimawonetsedwa kwa odwala matenda ashuga omwe amalandira kuchuluka kwa mankhwalawa.
Analogue of Zokora Rosuvastatin
Kwa odwala matenda ashuga omwe ali ndi mavuto ambiri a cholesterol, Zokor imasinthidwa ndi mapiritsi a rosuvastatin. Mankhwalawa amagwira ntchito yabwino kwambiri yotithandizira kuphatikiza cholesterol yapamwamba kwambiri komanso kutsitsa chinthu chochepa kwambiri.
Mankhwalawa amadziwika kuti ndi am'badwo wacinayi, amagwiritsidwa ntchito moyenera kuthana ndi hypercholesterolemia, ndipo amagwiritsidwa ntchito ngati mankhwala a prophylactic motsutsana ndi mitsempha ya mitsempha ndi zotsatira zake.
Chifukwa cha kuyeretsa kwamitsempha yamagazi, kupanga mapangidwe a atherosselotic, kuletsa kwa chitukuko cha ischemic stroke, komanso kugunda kwa mtima komwe kumapangitsa chidwi ndi matenda amtima.
Mapiritsi a Rosuvastatin ndi omwe amaphunziridwa kwambiri pakati pa ma statins, kugwirako kwake kwatsimikiziridwa koyesera. Chowoneka mosiyana ndi fanizo ndi zomwe:
- kulimbana ndi cholesterol yoyipa;
- mpumulo wa njira zotupa;
- onjezerani cholesterol yabwino.
Chofunikira kwambiri ndikulepheretsa kutupa kosafunikira mthupi la odwala matenda ashuga, chifukwa ndendende izi zomwe zimayambitsa matenda a atherosulinosis.
Mankhwalawa amathandizira kupanga nayitrogeni, ndikuthandizira kutsitsimutsa kwamitsempha yamagazi, ndikupanga zina zowonjezera. Mukatha kugwiritsa ntchito mapiritsi, zinthu zomwe zimagwira nthawi yomweyo zimalowa m'magazi am'magazi, zimagawidwa mothandizirana mu minyewa yonse. Komanso, kuyerekezera pang'onopang'ono kuposa kwa fanizo, kutalika kwa kutulutsa kumakhala kwapamwamba.
Peak plasma woipa angathe kufikiridwa 5 mawola ingestion. Ngakhale kuti mankhwalawa amalembedwa muyezo wotsika, izi sizimasokoneza kuyanjana kwina ndi mankhwala ena.
Zolepheretsa ndi zotsutsana
Monga mapiritsi ena, rosuvastatin ali ndi zotsutsana zomveka. Choyamba, tikulankhula za kusalolera chilichonse chopangira mankhwala (kuphatikiza zakuperekera). Kumbukirani kuti mankhwalawa sanatchulidwe kwa anthu odwala matenda ashuga panthawi yomwe ali ndi pakati, kwa ana ochepera zaka 18, kupatula ngati ali ndi cholowa cholowa.
Mapiritsi ndi oletsedwa pachimake chiwindi cholephera chifukwa cha kuwonongeka kwa ziwalo panthawi ya kuwonongeka kwa maselo, milingo yambiri ya chiwindi.
Kugwiritsa ntchito pamodzi ndi cyclosporine sikuyenera kuloledwa. Chinanso chomwe chikuyipitsa ndi myopathy - njira ya minofu yolimba, chotsogolera kukula kwake.
Zambiri zokhudzana ndi ma statins zimaperekedwa kanema munkhaniyi.
