Mukaphunzira nkhaniyi, muphunzira momwe mungachitire matenda ashuga amtundu wa 2 ndipo, nthawi zina, lembani matenda ashuga 1 mothandizidwa ndi mapiritsi. Ngati muli ndi matenda ashuga, ndiye kuti mwawonapo kale pakhungu lanu lomwe madokotala sangathe kudzitamandira bwino pamankhwala othandizira matenda a shuga ... kupatula okhawo omwe azunza kuti aphunzire tsamba lathu. Mukatha kuwerenga tsambali, mudzadziwa zambiri za mankhwala a shuga kuposa omwe mumakapezeka nawo ku chipatala cha endocrinologist. Ndipo koposa zonse, mutha kuzigwiritsa ntchito moyenera, ndiye kuti, bweretsani shuga m'magazi ndikubwezeretsa thanzi lanu lonse.
Mankhwala ndi gawo lachitatu la mankhwala a matenda a shuga a 2. Izi zikutanthauza kuti ngati magawo awiri oyamba - chakudya chochepa chamafuta ndi maphunziro olimbitsa thupi mosangalala - sizithandiza kusunga shuga wabwinobwino m'magazi, ndiye pokhapokha timalumikiza mapiritsi. Ndipo ngati mankhwalawa sathandizira mokwanira, mulingo wachinayi womaliza ndi jakisoni wa insulin. Werengani zambiri zamankhwala 2 a shuga. Pansipa mupeza kuti zina mwa mankhwala a shuga omwe madokotala amakonda kupereka ndizopweteketsa, ndipo ndibwino kuzichita popanda iwo.
Kuthetsa shuga m'magazi a mtundu 1 ndi matenda ashuga 2, chinthu chachikulu ndikudya zakudya zochepa. Werengani mndandanda wazakudya zoletsedwa komanso mndandanda wazakudya chololedwa chokhala ndi chakudya chamagulu ochepa. Munthu wamba amamwa magalamu a 250-400 a chakudya tsiku lililonse. Munalandira chamoyo chomwe chibadwa sichitha kupirira ndi izi. Ndipo zotsatirazi - mwapeza matenda a shuga. Ngati simukudya zoposa 20-30 magalamu a chakudya patsiku, shuga m'magazi anu amatha kusintha ndipo mudzamva bwino. Ndikotheka kuti kangapo muchepetse mlingo wa mankhwalawa a shuga ndi insulin. Ndi matenda ashuga, ndikofunika kuti mudye mapuloteni ambiri ndi mafuta, m'malo mwa chakudya, kuphatikiza mafuta azinyama, omwe madokotala ndi atolankhani amakonda kutiwopseza.
Ngati mwayamba kudwala matenda ashuga, ndiye werengani nkhani ya Alpha Lipoic Acid ya Diabetesic Neuropathy.
Wodwala yemwe ali ndi matenda ashuga asintha zakudya zamagulu ochepa, mapiritsi ndi insulin nthawi zambiri amayenera kuyikidwa kwa okhawo omwe ndi aulesi kwambiri kuti azilimbitsa thupi. Ndikupangira chidwi chanu nkhani yokhudza kusangalala ndi maphunziro akuthupi. Ndi mwayi wa 90%, maphunziro olimbitsa thupi adzakuthandizani ndi matenda a shuga a 2 kuti mukhale ndi shuga wabwinobwino popanda mapiritsi komanso makamaka popanda jakisoni wa insulin.
Kodi ochiritsa matenda ashuga ndi ati?
Pofika chapakati pa 2012, pali magulu otsatirawa a mankhwala a shuga (kupatula insulin):
- Mapiritsi omwe amachititsa chidwi cha maselo ku insulin.
- Mankhwala omwe amalimbikitsa kapamba kuti apange insulin yambiri.
- Mankhwala atsopano a shuga kuyambira m'ma 2000s. Izi zimaphatikizapo mankhwala omwe amachita mosiyanasiyana, chifukwa chake nkovuta kuti kuphatikiza bwino. Awa ndi magulu awiri a mankhwalawa omwe ali ndi ntchito ya insretin, ndipo mwina ena ambiri adzawonekera pakapita nthawi.
Palinso mapiritsi a glucobai (acarbose) omwe amalepheretsa kuyamwa kwa shuga m'matumbo am'mimba. Nthawi zambiri zimayambitsa kukhumudwa, ndipo koposa zonse, ngati mumatsatira zakudya zamafuta ochepa, ndiye kuti kuzimva sizimveka konse. Ngati simungathe kutsatira zakudya zamafuta ochepa, chifukwa mumayamba kususuka, ndiye gwiritsani ntchito mankhwala omwe ali ndi shuga omwe amakuthandizani kuti musakhale ndi chidwi. Ndipo glucobaia sikhala othandiza kwambiri. Chifukwa chake, zokambirana zake pamapeto apa.
Tikukumbutsaninso: mankhwala a mapiritsi atha kukhala othandiza kwa matenda ashuga a 2 okha. Mtundu 1 wa shuga, palibe mankhwala, majakisoni a insulin okha. Kufotokozera. Mapiritsi a Siofor kapena Glucophage a mtundu woyamba wa shuga angayesedwe ngati wodwalayo watupa kwambiri, kuti khungu lake la insulini limachepa, motero amakakamizidwa kubaya ma insulin ofunika kwambiri. Kukhazikitsidwa kwa Siofor kapena Glucofage pamenepa muyenera kukambirana ndi adokotala.
Magulu a mankhwala omwe amatulutsa shuga m'magazi
Mndandanda watsatanetsatane wa mankhwalawa amtundu wa shuga wachiwiri kupatula insulin amauzidwa pansipa. Zikuwoneka kuti palibe ambiri aiwo. Posachedwa, tsatanetsatane watsatanetsatane wa mankhwalawa udzawonekera patsamba lathu.
Gulu la mankhwala osokoneza bongo | Mayina apadziko lonse lapansi | Mayina amalonda (Mlingo wopangidwa, mg) | Kangati patsiku kuti mutenge | Kutalika kwa kuchitapo kanthu, maola |
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Sulfonylureas | Glibenclamide |
| 1-2 | 16-24 |
Glibenclamide yopanda ma micron |
| 1-2 | 16-24 | |
Gliclazide |
| 1-2 | 16-24 | |
Gliclazide Yosinthidwa (yowonjezeredwa) |
| 1 | 24 | |
Glimepiride |
| 1 | 24 | |
Glycidone | Glenrenorm (30) | 1-3 | 8-12 | |
Glipizide | Movoglechen (5) | 1-2 | 16-24 | |
Kutulutsidwa Kwakutulutsidwa Glipizide (Wowonjezera) | Glibens retard (5; 10) | 1 | 24 | |
Ma glinids (meglitinides) | Repaglinide |
| 3-4 | 3-4 |
Nateglinide | Starlix (60; 120; 180) | 3-4 | 3-4 | |
Biguanides | Metformin |
| 1-3 | 8-12 |
Metformin wokhala ndi nthawi yayitali |
| 1-2 | 12-24 | |
Pangamira (glitazones) | Pagogazone |
| 1 | 16-24 |
Glucagon-ngati Peptide-1 Receptor Agonists | Exenatide | Baeta (5, 10 mcg) jakisoni wofinya | 2 | 12 |
Liraglutide | Victoza (0,6; 1,2; 1.8) wa jakisoni wansanja | 1 | 24 | |
Dipeptyl Peptidase-4 Inhibitors (Gliptins) | Sitagliptin | Januvius (25; 50; 100) | 1 | 24 |
Vildagliptin | Galvus (50) | 1-2 | 16-24 | |
Saxagliptin | Onglisa (2,5; 5) | 1 | 24 | |
Linagliptin | Trazhenta (5) | 1 | 24 | |
Alpha Glucosidase Inhibitors | Acarbose | Glucobai (50; 100) | 3 | 6-8 |
Mankhwala osakanikirana | Glibenclamide + Metformin |
| 1-2 | 16-24 |
Glyclazide + Metformin | Glimecomb (40/500) | 1-2 | 16-24 | |
Glimepiride + metformin | Amaryl M (1/250; 2/500) | 1 | 24 | |
Glipizide + Metformin | Metglib (2.5 / 400) | 1-2 | 16-24 | |
Vildagliptin + Metformin | Galvus Met (50/500; 50/850; 50/1000) | 1-2 | 16-24 | |
Sitagliptin + metformin | Yanumet (50/500; 50/850; 50/1000) | 1-2 | 24 | |
Saxagliptin + Metformin | Kutalika kwa Combogliz (2.5 / 1000; 5/1000) | 1 | 24 |
Ngati mukufuna insulini, yambani ndi nkhani "Chithandizo cha matenda a shuga ndi insulin. Ndi insulin iti yoti musankhe. " Mtundu wachiwiri wa matenda ashuga, odwala amawopa pachithandizo cha insulin. Chifukwa majakisoni a insulini amathandizira kuti zikondamoyo zanu “zitheke” ndikuziteteza kuti zisawonongeke komaliza. Mutha kuwerenga zambiri pansipa.
Gome lotsatirali likuthandizani kudziwa zomwe magulu osiyanasiyana a mankhwalawo ali nawo.
Kuyerekeza mphamvu, zabwino ndi zovuta zamankhwala amakono a shuga
Gulu la mankhwala osokoneza bongo | Mapindu ake | Zoyipa | Contraindication |
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Matani othandizira kuchepetsa insulin | |||
Biguanides: metformin (siofor, glucophage) |
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Pangamira (pioglitazone) |
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Mankhwala omwe amalimbikitsa katemera wa insulin (secretaryariats) | |||
Kukonzekera kwa Sulfonylurea:
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Meglitinides:
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Mankhwala okhala ndi ntchito ya insretin | |||
Zoletsa za DPP-4:
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Glucagon-ngati peptide-1 receptor agonists:
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Glucose mayamwidwe oletsa othandizira | |||
Alpha Glucosidase Inhibitor - Acarbose |
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Insulin | |||
Insulin |
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| Palibe contraindication ndi choletsa mlingo mpaka zotsatira zimatheka. |
Kugwiritsa ntchito bwino mitundu ya mankhwala a shuga a 2, choyamba, ndi kutsatira mfundo ziwiri izi:
- kukana kumwa mapiritsi aliwonse omwe amachititsa kuti insulini isungidwe ndi kapamba (sulfonylureas, meglitinides);
- ngati pali zisonyezo zochizira matenda a shuga ndi insulin, ndiye kuti muyenera kuyambitsa jakisoni mwachangu, osayesa kuisintha ndi mankhwala, zina, zitsamba kapena mankhwala ena.
Tiona izi mwatsatanetsatane, chifukwa ndizofunikira kwambiri.
Ndi mitundu yanji ya mankhwala a shuga omwe samathandiza, koma kuvulaza
Pali mankhwala osokoneza bongo omwe samabweretsa zabwino kwa odwala, koma kuvulaza kosalekeza. Ndipo tsopano mudzazindikira kuti mankhwalawa ndi chiyani. Mankhwala ovuta a shuga ndi mapiritsi omwe amathandizira kapamba kuti apange insulin yambiri. Aperekeni! Amayambitsa kuwonongeka kwakukulu kwa thanzi la odwala matenda ashuga. Mapiritsi omwe amathandizira kupanga insulin ndi kapamba amaphatikiza mankhwala ochokera ku sulfonylurea zotumphukira ndi magulu a meglitinides. Madokotala amakondabe kuwalembera mtundu wachiwiri wa matenda ashuga, koma izi ndi zolakwika komanso zovulaza kwa odwala. Tiyeni tiwone chifukwa.
Mtundu wachiwiri wa matenda ashuga, odwala, monga lamulo, samatulutsanso insulini yocheperako, komanso katatu, kuposa anthu athanzi opanda mapiritsi awa. Mutha kutsimikizira kuyesedwa kwa magazi uku ndi C-peptide. Vuto lomwe limakhala ndi odwala omwe ali ndi matenda ashuga ndikuwonetsetsa kuti maselo amatha kuchepa mphamvu. Vutoli limatchedwa insulin kukana. Zikatero, kumwa mapiritsi omwe amathandizira kubisalira kwa insulin ndi kapamba kumakhala kofanana kukwapula kavalo wovutitsidwa, yemwe, ndi mphamvu zake zonse, amakoka ngolo yayikulu. Hatchi yabwinobwino imatha kufa m'misala.
Udindo wa kavalo woyendetsedwa ndi kapamba wako. Ili ndi maselo a beta omwe amapanga insulin. Amagwira ntchito kale ndi katundu wambiri. Mothandizidwa ndi mapiritsi a sulfonylurea zotumphukira kapena meglitinides ", ndiye kuti amafa kwambiri. Zitatha izi, kupanga kwa insulin kumachepa, ndipo mtundu wachiwiri wa matenda ashuga wachiwiri umasanduka mtundu wovuta kwambiri komanso wosachiritsika wodwala wa insulin 1.
Chododometsa china chachikulu cha mapiritsi opanga insulin ndi chakuti amachititsa hypoglycemia. Izi zimachitika ngati wodwala wamwa mapiritsi olakwika kapena waiwala kudya nthawi. Njira zochizira matenda amtundu wa 2 omwe timalimbikitsa kuti tichepetse magazi, pomwe chiopsezo cha hypoglycemia ndi zero.
Kafukufuku wamkulu adawonetsa kuti zochokera ku sulfonylurea zimachulukitsa kufa kwa zifukwa zonse pakati pa odwala omwe amawatenga, kuphatikizapo kufa kwa matenda a mtima ndi khansa. Zimasokoneza kayendedwe ka magazi m'mitsempha ndi m'mitsempha ina, ndikutseka njira za calcium za ATP zomwe zimatsitsimutsa mitsempha yamagazi. Izi sizikutsimikiziridwa kokha chifukwa cha mankhwala aposachedwa a gululi. Koma siziyenera kutengedwanso, pazifukwa zomwe tafotokozazi.
Ngati matenda a shuga a mtundu wa 2 amayang'aniridwa mosamala ndi zakudya zamagulu ochepa a carbohydrate, masewera olimbitsa thupi, komanso jakisoni wa insulin ngati pakufunika, maselo owonongeka a beta atha kubwezeretsanso ntchito yawo. Phunzirani ndikutsatira pulogalamu yochizira matenda ashuga amtundu wa 2. Izi ndizabwino koposa kumwa mapiritsi - sulfonylurea derivatives kapena meglitinides, omwe amapha ma cell a beta ndikukulitsa zovuta za odwala matenda ashuga. Sitingathe kulembapo mayina onse a mapiritsiwa pano, chifukwa alipo ambiri.
Izi zikuyenera kuchitika. Werengani malangizo am'mapiritsi a shuga omwe mudawalembera. Ngati zidzachitike kuti ali m'gulu la sulfonylurea zotumphukira kapena meglitinides, musatenge. M'malo mwake, phunzirani ndikutsatira pulogalamu yachiwiri ya matenda ashuga. Palinso mapiritsi ena ophatikiza omwe ali ndi zosakaniza ziwiri zogwira ntchito: a sulfonylurea derivative plus metformin. Ngati mwapatsidwa mwayi wosankha, ndiye kuti sinthani kuchokera ku metformin ya "pure" (Siofor kapena Glyukofazh).
Njira yoyenera yothanirana ndi matenda amtundu wa 2 ndikuyesera kusintha kukhudzidwa kwa maselo kuti apange insulin. Werengani nkhani yathu yokhudza insulin. Imakuuzani momwe mungachitire. Pambuyo pake, simuyenera kulimbikitsa kupanga insulin. Ngati vuto la matenda ashuga silotsogola, ndiye kuti insulin yakeyo ndi yokwanira kukhalabe ndi shuga.
Osayesa kulowetsa jakisoni wa insulin ndi mapiritsi.
Chitani magazi okwanira masiku atatu, makamaka sabata lathunthu. Ngati pafupifupi shuga itatha chakudya itakhala 9 mmol / L kapena kuposa, nthawi yomweyo yambani kuthandizidwa ndi insulin, kuphatikiza zakudya zamagulu ochepa. Chifukwa palibe mankhwala omwe angathandize pano. Choyamba, mothandizidwa ndi jakisoni wa insulini komanso chakudya choyenera, onetsetsani kuti shuga yanu yamagazi ikutsikira pazomwe mukufuna. Ndipo mukaganiziratu momwe mungagwiritsire ntchito mapiritsiwo kuti muchepetse insulin kapena ngakhale kusiya.
Anthu odwala matenda amtundu wa 2 amakonda kuchedwetsa kuyamba kwawo kwa mankhwala a insulin. Zachidziwikire chifukwa cha ichi mudapita patsamba la mankhwala osokoneza bongo, sichoncho? Pazifukwa zina, aliyense amakhulupirira kuti chithandizo cha insulin chitha kunyalanyazidwa mosavomerezeka, ndipo zovuta za shuga zimawopseza wina, koma osati iwo. Ndipo awa ndiopusa kwambiri kwa odwala matenda ashuga. Ngati "woyembekezerayo" wamwalira ndi vuto la mtima, ndiye ndinene kuti anali ndi mwayi. Chifukwa pali zosankha zoyipa:
- Mimbulu ndikudula mwendo;
- Akhungu;
- Imfa yopweteka chifukwa cha kulephera kwa impso.
Izi ndi zovuta za matenda ashuga zomwe mdani woipa kwambiri sangafune. Poyerekeza ndi iwo, kufa mwachangu komanso kosavuta kuchokera ku vuto la mtima ndizopambana kwenikweni. Komanso, mdziko lathu, lomwe silimalimbikitsa nzika zake olumala kwambiri.
Chifukwa chake, insulin ndi njira yabwino yothandizira matenda a shuga a 2. Ngati mumamukonda kwambiri, ndiye kuti amakupulumutsirani kwa mnzake wapamtima wazovuta izi. Ngati zikuwoneka kuti insulini singagawidwe, ndiye kuti yambani jekeseni mwachangu, osataya nthawi. Ngati khungu lachitika kapena atadulidwa miyendo, wodwala matenda ashuga nthawi zambiri amakhala ndi zaka zingapo zolemala. Munthawi imeneyi, amakwanitsa kuganizira mofatsa za momwe anali munthu wopanda tanthauzo pomwe sanayambe jekeseni wa insulin panthawi yake ...
Nthawi zina, kupanga ubwenzi ndi insulin ndikofunikira, komanso mwachangu:
- Pazakudya zamafuta ochepa, shuga m'magazi anu akamaliza kudya amapitilira 9mmol / L ndi pamwambapa.
- Kuphatikiza kwa zakudya zamagulu ochepa a carbohydrate, masewera olimbitsa thupi ndi mapiritsi a "kumanja" sikuthandizirani kuchepetsa shuga mukatha kudya m'munsimu 6.0 mmol / L.
Kondani insulini ndi mtima wanu wonse chifukwa ndi bwenzi lanu lalikulu, mpulumutsi ndi chitetezo chanu ku zovuta za matenda ashuga. Ndikofunikira kudziwa luso la jakisoni wopanda ululu, phatikizani insulin mokonzekera nthawi imodzi ndikuchita zina kuti mlingo wake uthepe. Ngati mungagwiritse ntchito pulogalamu ya chithandizo cha matenda ashuga (ndikofunikira kwambiri kuchita masewera olimbitsa thupi), ndiye kuti mutha kulimbana ndi insulin yaying'ono. Mwakuthekera kwakukulu, mutha kukana jekeseni kwathunthu. Koma izi sizingachitike pokhapokha ngati pali zovuta za matenda ashuga.
Mapiritsi omwe amachititsa chidwi cha maselo ku insulin
Monga mukudziwira, mwa odwala ambiri omwe ali ndi matenda a shuga a 2, kapamba amapanga insulin yokwanira, kapenanso katatu kuposa momwe amafunira. Vuto ndilakuti anthuwa amakhala ndi chidwi chochepa cha maselo kuti agwire insulin. Kumbukirani kuti vutoli limatchedwa insulin kukana, i.e., insulin kukana. Pali mitundu ingapo ya mankhwala omwe amathetsa pang'ono. M'mayiko olankhula Chirasha, mankhwalawa awiriwa akupezeka - metformin (mapiritsi a Siofor kapena Glyukofazh) ndi pioglitazone (wogulitsidwa pansi pa mayina a Actos, Pioglar, Diaglitazone).
Pulogalamu yothandiza ya matenda a shuga a 2 imayamba ndi kadyedwe kochepa kamthupi, komanso masewera olimbitsa thupi mosangalatsa. Izi ndi njira zamphamvu komanso zothandiza kutengera shuga m'magazi. Koma muzovuta, sizothandiza mokwanira, ngati kuti wodwalayo sanasamalire bwino mankhwalawo. Ndipo, kuphatikiza pa iwo, mapiritsi amathandizidwanso omwe amawonjezera chidwi cha maselo kuti agwire insulin. Ngati mugwiritsa ntchito kuphatikiza zakudya zamagulu ochepa a carbohydrate, masewera olimbitsa thupi komanso othandizira insulin, mwayi ndikuti mutha kuthana ndi matenda osokoneza bongo popanda kupangira jakisoni. Ndipo ngati mukufunikabe kubaya insulin, ndiye kuti mankhwalawa amakhala ochepa.
Kumbukirani kuti palibe piritsi la shuga lomwe lingalowe m'malo mwa zakudya ndi masewera olimbitsa thupi. Maphunziro akuthupi ndi chisangalalo ndi chida chothandiza kwambiri kukulitsa chidwi cha maselo kuti aphe insulin ndikuwongolera matenda ashuga. Mankhwala othandiza sangafanane nawo. Ndipo ngakhale zili choncho, sizingatheke kupewa zovuta za matenda ashuga ngati simutsatira zakudya zamagulu ochepa.
Siofor (Glucophage) - mankhwala odziwika bwino a matenda a shuga a 2
Mankhwala otchuka a matenda a shuga a mtundu wa 2 ndi metformin, omwe amagulitsidwa monga mapiritsi a Siofor ndi Glucofage m'maiko olankhula Russia. Werengani nkhani yathu yatsatanetsatane yokhudza mapiritsi awa. Metformin imakulitsa chidwi cha maselo kuti agwiritse ntchito insulin, potero amachepetsa shuga la magazi ndikuthandizira kuchepetsa thupi ndi ma kilogalamu angapo. Imalepheretsanso zomwe zimachitika mu ghostin ya mahomoni motero imathandizira kupewa kudya kwambiri.
Mothandizidwa ndi mankhwalawa, zotsatira za kuyesedwa kwa magazi pazinthu zowopsa zamtima zimasintha. Zimatsimikizidwanso kuti kutenga metformin kumachepetsa chiopsezo cha kufa ndi khansa ndi mtima. Mavuto obwera chifukwa cha matenda ashuga amatuluka chifukwa shuga ochulukirapo yemwe amapezeka m'magazi amamangiriza mapuloteni osiyanasiyana ndikuwadalitsa ntchito yawo. Chifukwa chake, metformin imalepheretsa izi, ndipo zimachitika mosasamala kanthu kuti zimapangitsa bwanji kuchepetsa magazi. Zimathandizanso kuthamanga kwa magazi m'matumbo, kumachepetsa kuvundikira komanso kusayenda bwino kwa ma capillaries, komanso kumachepetsa chiopsezo cha kukha mwazi m'maso ndi matenda ashuga a retinopathy.
Thiazolidinedione Matenda A shuga
Mankhwala a shuga a m'gulu la thiazolidinedione amalepheretsa kulephera kwa impso, kuwonjezera pazomwe zimapangitsa kuchepetsa magazi. Amaganiza kuti amatseka machitidwe a majini omwe amachititsa kuti thupi lizikundana. Chifukwa cha izi, thiazolinediones amathandizira kuchedwetsa kapenanso kulepheretsa kukula kwa matenda ashuga amtundu wa 2 omwe ali pachiwopsezo chachikulu cha anthu. Kumbali inayi, zatsimikiziridwa kuti mankhwalawa amawonjezera chiopsezo cha mafupa azimayi pambuyo pochita kusamba.
Thiazolinediones amachititsanso kuti madzi azisungika m'thupi. Izi ndizosavomerezeka kwa odwala matenda a shuga omwe ali ndi mtima wofundira, chifukwa matupi awo amakhala atadzaza kale ndimadzi. M'mbuyomu, panali mankhwala awiri ochokera ku gulu la thiazolidinedione: rosiglitazone ndi pioglitazone. Komabe, kugulitsa rosiglitazone kunali koletsedwa pomwe kunatenga kuti kumawonjezera chiopsezo cha matenda a mtima, ndipo tsopano pioglitazone yokha ndiyoyikidwa kwa odwala.
Kodi mankhwala omwe amachepetsa kukana insulin
Mankhwala a Metformin ndi pioglitazone amathandizira kuti maselo azikhala ndi insulin. Ndipo zilibe kanthu kuti ndi mtundu wanji wa insulini - yomwe kapambayu wapanga, kapena amene wodwalayo adalandira ndi jakisoni. Zotsatira za zomwe mapiritsi amatsutsana ndi insulin kukana, shuga m'magazi omwe ali ndi matenda a shuga a 2 amatsika, ndipo gawo labwino ndilakuti palibe zotsatira zoyipa.
Komabe, zopindulitsa za metformin ndi pioglitazone sizimathera pamenepo. Kumbukirani kuti insulini ndiye mahomoni akuluakulu omwe amachititsa kuti mafuta azikhala ochepa komanso kuti muchepetse kunenepa. Wodwala yemwe ali ndi matenda a shuga a mtundu wachiwiri kapena / kapena kunenepa kwambiri akamamwa mapiritsiwo, ndiye kuti insulin yake ya m'magazi imachepa ndikufikira yachilendo. Chifukwa cha izi, kulemera kowonjezeranso kumayima, ndipo nthawi zambiri kumatha kutaya ma kilogalamu angapo. Ngati matenda a shuga a mtundu 2 sanakulirebe, ndipo muyenera kungoyang'anira kunenepa kwambiri, ndiye kuti metformin nthawi zambiri imayikidwa. Chifukwa ali ndi chiopsezo choyipa, ndipo pioglitazone ali nacho, ngakhale yaying'ono.
Monga mukudziwa, mafuta ochulukirapo omwe munthu amakhala nawo, amakhala olimba kwambiri chifukwa cha insulini komanso Mlingo wambiri wa insulin. Kumwa mapiritsi omwe amachititsa chidwi cha maselo kuti agwire insulin, amathandizira kuchepetsa kuchuluka kwa insulin. Komanso, izi zimawonekera mwa odwala osati mtundu wachiwiri wa shuga, komanso matenda a shuga 1. Kunenepa kwambiri ndi kukana insulini ndizizindikiro zomwe metformin (Siofor kapena Glucofage) imalangizidwanso kwa odwala omwe ali ndi matenda a shuga 1 kuti achepetse insulin. Onaninso: "Momwe mungachepetse thupi ndikudya zakudya zamafuta ochepa."
Tipereka zitsanzo kuchokera ku zomwe Dr Bernstein adachita. Adali ndi wodwala matenda ashuga amtundu wa 2 komanso onenepa kwambiri. Wodwalayo adafunikira jakisoni 27 wa insulin yayitali usiku wonse, ngakhale adatsatira zakudya zamafuta ochepa. Adatsatira malangizo omwe adafotokozedwa mu gawo la "Momwe Mungatengere Mlingo Waukulu wa Insulin". Atayamba kumwa glucophage, mlingo wa insulin unachepetsedwa kukhala magawo 20. Izi akadali mlingo waukulu, komabe kuposa 27 mayunitsi.
Momwe mungagwiritsire ntchito mapiritsi awa
Mapiritsi omwe amathandizira chidwi cha maselo kuti apange insulin amayenera kulembedwa kwa odwala omwe ali ndi matenda a shuga 2 ngati sangathe kuchepetsa thupi pazakudya zochepa, komanso makamaka ngati sangathe kuchepetsa shuga m'magazi awo. Werengani malingaliro omwe ali ndi zolinga zoyenera zosamalidwa ndi matenda a shuga. Musanapange regimen ya kumwa mankhwala a matenda ashuga, muyenera kutsata shuga yonse yamagazi kwa masiku 3-7 ndikulemba zotsatira zake. Tikukukumbutsani kuti ngati shuga m'magazi kamodzi chakudya itatha 9,0 mmol / L kapena kuposa, ndiye kuti muyenera kuyambitsa jakisoni mwachangu. Ndipo pokhapokha ganizirani za momwe mungachepetsere mlingo wake ndi mapiritsi.
Mudzaona kuti shuga amawonjezeka kuposa nthawi ina iliyonse, kapena amakwezeka nthawi yonseyo. Kutengera izi, onani nthawi yomwe mukufuna kumwa mapiritsi a shuga. Mwachitsanzo, shuga wanu wamagazi nthawi zonse amakwezedwa m'mawa. Izi zimatchedwa "chodabwitsa cha m'bandakucha." Poterepa, yesani kutenga glucophage yayitali-usiku. Yambani ndi mlingo wocheperako ndikuwonjezera pang'onopang'ono. Werengani mwatsatanetsatane "Momwe mungayendetsere zovuta zam'mawa".
Kapena mita ya glucose imawonetsa kuti shuga ya magazi ikwera pambuyo chakudya, mwachitsanzo, mutatha kudya chakudya chamadzulo. Poterepa, tengani Siofor mwachangu 2 maola musanadye. Ngati pali matenda am'mimba kuchokera ku regimen iyi, tengani Siofor ndi chakudya. Komanso gwiritsani ntchito mapiritsi a shuga kuti muthandizire kuthandizira. Ngati shuga wamagazi amasungidwa pang'ono kuzungulira nthawi, ndiye kuti mutha kuyesa Mlingo wa 500 kapena 850 mg wa Siofor nthawi iliyonse musanadye, komanso usiku.
Motani ndipo bwanji mutenge metformin ndi pioglitazone palimodzi
Metformin (mapiritsi a Siofor ndi Glucofage) amagwira ntchito, akumachepetsa kukana kwa insulin m'maselo a chiwindi. Zimapangitsanso pang'ono kuyamwa kwa mafuta m'matumbo. Pioglitazone amachita mosiyanasiyana. Zimakhudza minofu ndi adipose minofu, zimakhudza chiwindi mochepera. Izi zikutanthauza kuti ngati metformin sikumachepetsa shuga m'magazi, ndiye zomveka kuwonjezera pioglitazone kwa iye, mosemphanitsa.
Chonde dziwani kuti pioglitazone sikuwonetsa zotsatira zake pakuchepetsa shuga lamwazi nthawi yomweyo, koma masabata angapo atayamba kuyambitsa makonzedwe. Mumamwa metformin, tsiku lililonse pioglitazone sayenera kupitirira 30 mg.
Zoyipa zamankhwala zomwe zimachepetsa kukana insulin
Mapiritsi omwe amachititsa chidwi cha maselo kupita ku insulin ndi chimodzi mwazida zabwino kwambiri zomwe tili nazo pakuwongolera shuga. Komabe, amakhalanso ndi zovuta zawo.
Zotsatira zoyipa za Metformin
Mapiritsi a Siofor ndi Glucofage (zomwe zimagwira ntchito metformin) sizimayambitsa zotsatira zoyipa. Komabe, mwa anthu omwe amawatenga, nthawi zambiri amayambitsa kukhumudwa - kutulutsa, mseru, matenda am'mimba. Izi zimachitika ndi odwala osachepera ⅓ omwe amamwa mankhwala a Siofor othamanga.
Anthu amazindikira msanga kuti Siofor amathandizira kuchepetsa thupi pogwiritsa ntchito ma kilogalamu angapo, ndipo ndi matenda amtundu wa 2 amabweretsa shuga m'magazi pafupi ndi zabwinobwino. Chifukwa cha izi zopindulitsa, ali okonzeka kupirira mavuto ndi m'mimba. Mavutowa amakhala ocheperako ngati mungasinthe kuchokera ku Siofor kupita ku Glucophage kuchitapo kanthu. Komanso, odwala ambiri amawona kuti zovuta zakudya zam'mimba zomwe zimatenga Siofor zimafooka ndi nthawi, thupi likazolowera mankhwalawa. Ndi ochepa okha omwe sangathe kulekerera mankhwalawa konse.
Masiku ano, Metformin ndi mankhwala omwe amakonda kwambiri a anthu ambiri odwala matenda ashuga padziko lonse lapansi. Adakhala ndi wotsogolera - phenformin. Mu 1950s, adazindikira kuti zitha kuyambitsa lactic acidosis, yoopsa, yomwe ikhoza kufa. Mukumwa phenformin, lactic acidosis idapezeka mwa odwala ofooka omwe kale anali ndi vuto la mtima kapena kuwonongeka kwambiri kwa impso. Unduna wa Zaumoyo umachenjeza kuti metformin ikhoza kuyambitsanso lactic acidosis ngati muli ndi vuto la mtima, chiwindi kapena impso. Ngati mavutowa palibe, ndiye kuti chiwopsezo cha lactic acidosis ndi zero.
Zotsatira zoyipa za pioglitazone
Mwa anthu ena, pioglitazone (Actos, Pioglar, Diaglitazone) amachititsa kuti madzi asungidwe. Izi zimawonetsedwa ndi kutupa kwamiyendo ndi kuchepa kwa kuchuluka kwa maselo ofiira am'magazi m'magazi a m'magazi. Komanso, akumwa pioglitazone, wodwalayo amatha kulemera pang'ono. Izi zimachitika chifukwa cha kudzikundikira kwa madzimadzi, koma osati mafuta. Odwala odwala matenda ashuga omwe amatenga pioglitazone komanso nthawi yomweyo amalandira jakisoni wa insulin, chiopsezo cha matenda a mtima chikuwonjezeka. Kwa odwala matenda ashuga, tsiku lililonse pioglitazone sayenera kupitirira 30 mg.Ngati, motsutsana ndi maziko a chithandizo cha insulini ndikumwa mapiritsi awa, muwona kuti miyendo yanu iyamba kutupa, ndiye kusiya kumwa pioglitazone nthawi yomweyo.
Zadziwika m'magazini kuti kutenga pioglitazone kangapo kudapangitsa kuti chiwindi chisasinthidwe. Kumbali ina, mankhwalawa amakulitsa mbiri ya cholesterol, ndiko kuti, amachepetsa cholesterol yoyipa m'magazi ndikuwonjezera kuchuluka kwa cholesterol yabwino. Popeza pioglitazone ikhoza kuyambitsa kusungunuka kwa madzimadzi, sangathe kulembedwa kwa odwala omwe ali ndi vuto lililonse la mtima, matenda a impso kapena m'mapapo.
Mu thupi, pioglitazone imasinthidwa ndi chiwindi. Pachifukwa ichi, enzyme yomweyo imagwiritsidwa ntchito, yomwe imasokoneza mankhwala ena ambiri otchuka. Ngati mumamwa mankhwala angapo nthawi yomweyo kupikisana pa enzyme yomweyo, ndiye kuti kuchuluka kwa mankhwala m'magazi kumatha kuchuluka. Sikoyenera kumwa pioglitazone ngati mukuthandizidwa kale ndi antidepressants, antifungal mankhwala, kapena maantibayotiki ena. Mu malangizo a pioglitazone phunzirani mosamala gawo "Kuyanjana ndi mankhwala ena". Ngati muli ndi mafunso, kambiranani ndi dokotala kapena wafiziki wa mankhwala ku pharmacy.
Zoyenera kuchita ngati shuga m'magazi akadali pamwamba kwambiri
Ngati mapiritsi a shuga amachepetsa shuga m'magazi, koma osakwanira, ndiye kuti izi zitha kukhala chifukwa cha zovuta ndi chakudya chanu. Mwambiri, mumadya michere yambiri kuposa momwe mumayembekezera. Choyamba, muyenera kupenda zakudya zanu mosamala kuti mudziwe komwe zakudya zowonjezera zimalowa. Werengani momwe mungathanirane ndi vuto la kudya zakudya zamafuta komanso momwe mankhwalawo amathandizira kuti muzilakalaka kudya komanso kusachita bwino.
Shuga wamagazi mwa odwala matenda a shuga amawonjezeranso matenda kapena kutupa kwaposachedwa. Zomwe zimayambitsa zovuta ndizopangira mano, chimfine, kapena matenda a impso. Kuti mumve zambiri, werengani nkhani yofotokoza kuti, “Chifukwa chiyani shuga umatha kupitiliza kudya zakudya zamafuta ochepa, komanso momwe ungazikonzere.”
Timalimbikitsa kuchita masewera olimbitsa thupi mosangalala ndi mtundu wachiwiri wa matenda ashuga. Ngati zakudya zamagulu ochepa komanso mapiritsi sizithandiza kwenikweni, ndiye kuti pali chisankho - maphunziro akuthupi kapena jakisoni wa insulin. Komabe, simungathe kuchita chimodzi kapena chimodzi, koma musadabwe kuti mudzafuna kudziwa bwino zovuta za matenda ashuga ... Ngati wodwala wodwala matenda ashuga pafupipafupi komanso mwamphamvu amapanga maphunziro olimbitsa thupi molingana ndi njira zomwe timalimbikitsa, ndiye kuti mwina atakwanitsa 90%. shuga popanda jakisoni wa insulin. Ngati mukufunikabe kubaya insulini, zikutanthauza kuti muli kale ndi matenda amtundu 1, osayesa matenda ashuga 2. Mulimonsemo, kudya zakudya zamafuta ochepa komanso kuchita masewera olimbitsa thupi kumathandizira pakulimbana ndi insulin yambiri.
Mankhwala owonjezera omwe amalimbikitsa chidwi cha maselo kuti apange insulin
Kafukufuku wasonyeza kuti vitamini A mu milingo yoposa 25,000 IU patsiku amatsitsa insulin kukana. Akuti ngati vitamini A amatengedwa mopitilira 5,000 IU patsiku, izi zitha kuchititsa kuchepa kwa calcium calcium m'mafupa. Ndipo mulingo wambiri wa Vitamini A amaonedwa kuti ndi woopsa kwambiri. Chifukwa chake, mutha kumwa beta-carotene muyezo wabwino - uwu ndiye "patsogolo", womwe m'thupi la munthu umasandulika kukhala vitamini A pakufunika. Iye si wowopsa.
Kuperewera kwa magnesium m'thupi ndi pafupipafupi komanso chifukwa chachikulu cha insulin. Ku United States, mwa anthu, malo ogulitsira a magnesium m'thupi amatsimikiziridwa mwa kusanthula milingo yama magnesium m'maselo ofiira amwazi. Timachita mayeso a seramu magnesium, koma sizolondola ndipo motero osathandiza. Kuperewera kwa magnesium kumakhudza osachepera 80% aanthu. Kwa aliyense yemwe ali ndi matenda ashuga, tikulimbikitsani kuti muyesere kumwa mapiritsi a magnesium okhala ndi vitamini B6. Pambuyo pa masabata atatu, werengani momwe akukhudzira thanzi lanu komanso kuchuluka kwa insulini. Ngati zotsatira zake zili zabwino, pitilizani. Zindikirani Pakulephera kwa impso, magnesium siyingatengedwe.
Kuperewera kwa thupi kwa thupi kumapangitsa khungu kupanga. Ichi ndi mahomoni omwe amalepheretsa munthu kudya kwambiri komanso kusokoneza kulemera. Kuperewera kwa Zinc kumakhalanso ndi vuto lililonse ku chithokomiro cha chithokomiro. Buku la America lonena za chithandizo cha matenda ashuga limalimbikitsa kuyesedwa kwa magazi kwa seramu zinc, ndikumatenga zowonjezera ngati zapezeka. M'mayiko olankhula Chirasha, kudziwa ngati muli ndi zinc zokwanira mthupi lanu ndizovuta. Chifukwa chake, timalimbikitsa kuyesera kutenga zowonjezera za zinc, monga ndi magnesium.
Mapiritsi a Zinc kapena makapisozi amayenera kumwedwa kwa mwezi umodzi kuti mumvetsetse zomwe zimachitika. Ndi magnesium, munjira iyi ndikosavuta, chifukwa kayendetsedwe ka kayendetsedwe kake kamawonekera patatha masabata atatu. Kuchokera pakutenga zowonjezera zazitsulo, anthu ambiri amawona kuti misomali ndi tsitsi lawo linayamba kukula bwino. Ngati muli ndi mwayi, ndiye kuti mutha kuchepetsa kuchuluka kwa insulin popanda kuthana ndi vuto la matenda ashuga. Kodi kugwiritsidwa ntchito kwa zinc kwa thupi, kukufotokozedwa mwatsatanetsatane mu buku la Atkins "Supplements: njira yachilengedwe mosiyanasiyana ndi mankhwala."
Vanadium Sulfate
Palinso chinthu choterocho - vanadium. Ichi ndi chitsulo cholemera. Mchere wake, makamaka vanadium sulfate, umakhala ndi zotsatirazi: zimatsitsa insulin kukana, zimafooketsa chilimbikitso ndipo, mwina, zimagwira m'malo mwa insulin. Ali ndi kuthekera kwakukulu kotsitsa shuga m'magazi m'magazi a shuga. Vanadium ikhonza kukhala njira yothandiza yodwala matenda ashuga, koma madokotala amachitapo kanthu mwachidwi, poopa mavuto.
Mchere wa Vanadium umathandizira kutsitsa shuga wamagazi poletsa michere ya tyrosine phosphatase. Ma enzyme amenewa amatenga mbali yofunika kwambiri machitidwe osiyanasiyana mthupi la munthu. Sizinatsimikiziridwe kuti zoletsa za ntchito yake ndizotetezeka ndipo sizikhala ndi zotsatirapo zoyipa zazitali. Mayesero osakanizika a vanadium othandizira mwa anthu sanakhalepo mpaka milungu 3. Ndipo odzipereka omwe ali ofunitsitsa kuchita nawo ziyeso zazitali sangapezeke.
Komabe, vanadium sulfate ndichakudya chowonjezera chomwe chimagulitsidwa kwambiri ku United States. Kwa zaka zambiri, pakhala palibe zodandaula za zovuta kuchokera kwa iwo omwe amamwa. Dr. Bernstein lero adalimbikitsa kuti asamachiritse matenda ashuga ndi mankhwalawa kufikira chitetezo chake chitatsimikiziridwa. Izi zikugwiranso ntchito m'magulu onse a odwala, kupatula oyendetsa ndege omwe amayendetsa ndege. Alibe kusankha kwina, chifukwa mwanjira inayake amafunika kuwongolera matenda ashuga, ndipo amaletsedwa kugwiritsa ntchito insulin, chifukwa chowopseza kuti ataya chilolezo chouluka ndege.
Mawu ena owerengeka kwa oyendetsa ndege omwe ali ndi matenda ashuga, koma sayenera kumwa insulini. Choyamba, pitani pachakudya chochepa chamafuta, komanso khalani ndi maphunziro achisangalalo mosangalatsa. Gwiritsani ntchito mankhwala onse omwe ali ndi "shuga" omwe adatchulidwa pamwambapa, komanso zowonjezera - vitamini A, magnesium, zinki komanso vanadium sulfate. Ndipo pali chida china chodziwika bwino chomwe chingakhale chothandiza kwa inu.
Malo ogulitsira azitsulo ofunika kwambiri mthupi awonetsedwa kuti amachepetsa minyewa. Izi ndizofunikira kwambiri kwa amuna, chifukwa azimayi amapereka chuma chambiri nthawi ya kusamba. Chitani kafukufuku wamagazi a seramu ferritin kuti muwone mulingo wazitsulo. M'mayiko olankhula ku Russia, kusanthula kumeneku kungathe kudutsidwa, mosiyana ndi kuwunika kwa magnesium ndi zinc. Ngati kuchuluka kwanu kwazitsulo m'thupi kuli kwapakati, ndiye ndikofunika kuti mukhale wopereka magazi. Muyenera kupereka magazi ochulukidwa kwambiri kotero kuti malo anu azitsulo ali pafupi ndi malire ovomerezeka. Mwina chifukwa cha izi, chidwi cha maselo anu kupita ku insulin chidzakulirakulira. Osatenga oposa 250 mg a vitamini C patsiku, chifukwa Vitamini iyi imakulitsa kuyamwa kwachitsulo ku zakudya.
Mankhwala Atsopano Atsopano
Mankhwala atsopano a shuga ndi ma dipeptyl peptidase-4 zoletsa ndi glucagon-ngati peptide-1 receptor agonists. Mwachidziwitso, amapangidwira kuti muchepetse shuga wamagazi mukatha kudya ndi shuga yachiwiri. Pochita izi, amakhala ndi mphamvu yofooka kwambiri m'magazi a magazi, ofooka kwambiri kuposa metformin (Siofor kapena Glucofage).
Komabe, zotsatira za dipeptyl peptidase-4 zoletsa (Galvus, Januvia ndi Onglisa) pakuchepetsa shuga pambuyo pakudya ndi matenda amtundu wa 2 amatha kuthana ndi zovuta za metformin ndi pioglitazone. Mutha kugwiritsa ntchito imodzi mwazamankhwala ngati chithandizo chachitatu cha matenda ashuga ngati dokotala akufotokozerani, ngati metformin kuphatikiza pioglitazone sizithandiza kwenikweni.
Glucagon-ngati peptide-1 receptor agonists ndi Victoza ndi Baeta. Amakhala osangalatsa kwa ife osati chifukwa amachepetsa shuga pang'ono, koma chifukwa amathandizira kuti azilakalaka kudya, makamaka Viktoza. Awa ndi othandiza kuchiza matenda osokoneza bongo. Onse a Baeta ndi Viktoza sapezekanso m'mapiritsi, koma m'matumba a syringe. Ayenera kukwapulidwa ngati insulin. Potengera momwe majakisoniwa amathandizira, odwala amakhala bwino pakudya chamafuta ochepa, samakhala ndi vuto la kususuka kwambiri. Kuti mumve zambiri, onani nkhani yakuti "Mankhwala A shuga Kuthanso Kulakalaka."
Victoza ndi Baeta ndi mankhwala atsopano, okwera mtengo komanso othandizira. Ndipo muyenera kuchita jakisoni, ndipo izi sizosangalatsa aliyense. Koma mankhwalawa amathandizira kwambiri kuyambika kwa kumverera kwodzaza. Mutha kudya mosapumira, ndipo simudzafuna kudya kwambiri. Chifukwa cha izi, kuwongolera matenda a shuga kumasintha kwambiri. Ndipo koposa zonse, zonsezi ndizotetezeka, popanda zovuta zapadera. Ubwino wogwiritsa ntchito Victoza kapena Baeta kuti muchepetse kudya kwambiri ndizambiri. Amalipira zovuta zonse zomwe zimakhudzana ndi kugwiritsa ntchito ndalamazi.
Zomwe mapiritsi a shuga amachititsa hypoglycemia
Mapiritsi a shuga omwe amathandizira kapamba kuti apange insulin yambiri nthawi zambiri amayambitsa hypoglycemia. Wodwalayo nthawi zambiri amakumana ndi zovuta zake, ndipo ngati pali vuto lalikulu la hypoglycemia izi zimatha kulemala kapena kufa. Tikukulimbikitsani kuti musiye kumwa mapiritsi omwe amalimbikitsa maselo a beta a kapamba kuti apange insulin. Kuopsa kwa hypoglycemia ndi chimodzi mwazifukwa izi, ngakhale sizofunikira kwambiri; mwatsatanetsatane, onani nkhani pamwambapa.
Mankhwala omwe amachititsa chidwi cha minyewa kuti agwire insulin, chiopsezo cha hypoglycemia chimakhala chovuta, mosiyana ndi mapiritsi omwe amalimbikitsa kapamba. Mankhwala oletsa kukana insulini samakhudza dongosolo la pancreatic lodziyimira lokha. Ngati magazi a shuga agwa, kapambayu amasiya kudzaza magazi ndi insulin, ndipo sipadzakhala hypoglycemia. Njira yokhayo yoopsa ngati mutamwa mapiritsi omwe amatsitsa insulin, kuphatikiza jakisoni wa insulin. Pankhaniyi, hypoglycemia ndiyotheka.
Kuphatikiza mankhwala a shuga: musagwiritse ntchito!
Makampani opanga zamankhwala akutulutsa mankhwala ophatikiza matenda ashuga pofuna kuyesa kuyipitsa ufulu womwe opikisana nawo amawateteza, kapena kuti angokulitse mzere wawo wamalonda ndikupeza malo ambiri pamafufuzidwe ogulitsa mankhwala. Izi sizimachitika kawirikawiri mcholinga cha odwala, koma ndi cholinga chowonjezera malonda ndi phindu. Kugwiritsa ntchito mapiritsi osakaniza a shuga nthawi zambiri sichikhala chanzeru. Mwanjira yabwino, imakhala yodula kwambiri, ndipo zopweteka kwambiri - ndizovulaza.
Kuphatikiza koopsa ndi komwe kumakhala ndi sulfonylureas. Kumayambiriro kwa nkhaniyi, tafotokoza mwatsatanetsatane chifukwa chake ndikofunikira kumwa mapiritsi a m'gululi. Onetsetsani kuti simumamwa zinthu zovulaza kapamba wanu ngati gawo la mankhwala ophatikizira a shuga. Kuphatikiza kwa metformin ndi DPP-4 inhibitors ndizofala. Zilibe zovulaza, koma zitha kukhala zokwera mtengo. Fananizani mitengo. Zitha kutheka kuti mapiritsi awiri osiyana ndi otsika mtengo kuposa amodzi ophatikizidwa.
Mutha kufunsa mafunso okhudzana ndi mankhwala a shuga mu ndemanga. Oyang'anira tsambalo amawayankha mwachangu.