Cholesterol okwera m'magazi amatsogolera kukukula kwa zoopsa. Ndi hyperglycemia, dongosolo lamtima limasokonekera, ma atherosclerosis amawoneka, ndipo mafupa amafuta amapangika pamitsempha ndi mitsempha.
Mitsempha yamagazi ikasunthidwa, kufalikira kwa magazi kumangokulira ndipo hypoxia imachitika. Izi zimatha kudwala matenda a mtima, sitiroko, komanso thrombosis. Zonsezi nthawi zambiri zimabweretsa imfa.
Makamaka omwe ali pachiwopsezo cha kukhala ndi atherosulinosis ndi odwala matenda ashuga, omwe, motsutsana ndi maziko a hyperglycemia, thupi lonse limasokonezeka. Chifukwa chake, ayenera kuyang'anitsitsa thanzi lawo komanso osalola kuti cholesterol yoyipa ikumane m'magazi.
Masiku ano, makampani opanga zamankhwala amapereka matani amafuta ochepetsa mphamvu ya cholesterol. Chimodzi mwazabwino kwambiri zamankhwala ndi simvastol. Koma musanamwe mankhwalawa, muyenera kudziwa malangizo a mankhwalawo ndikuyang'ana kwa dokotala.
Pharmacological kanthu, zikuchokera ndi mawonekedwe akumasulidwa
Simvastol imalepheretsa kupanga cholesterol ndikuletsa ntchito ya enzyme yomwe imakhudzana ndi kapangidwe ka mevalonate. Izi zimachepetsa ndende ya triglycerides, otsika komanso otsika Mlingo wa lipoprotein m'mwazi.
Mankhwalawa ali ndi zotsatira zowonjezereka, chifukwa chake zimawonekera pokhapokha masiku 14 atatha kugwiritsa ntchito. Simvastol imalowetsedwa mwachangu mumtsinje wamagazi, kuphatikiza kwakukulu kumakwaniritsidwa mphindi 120 pambuyo pa kuperekedwa.
Mu chiwindi, mankhwalawa amasinthidwa, zomwe zimapangitsa kuti pakhale ma beta-hydroxyl acid, omwe ali ndi mphamvu yamankhwala. Kuchotsa hafu ya moyo wa metabolites ndi maola 2. Amatuluka m'thupi makamaka m'matumbo.
Gawo lalikulu la simvastol ndi simvastatin. Pulogalamuyi imapezeka ndi kupesa kwa aspergillus terreus.
Zina za mankhwalawa:
- macrogol;
- citric acid ndi lactose monohydrate;
- utoto wachitsulo;
- butylydroxyanisole,
- magnesium wakuba;
- utoto wachitsulo;
- titaniyidi dayidi ndi zina zotero.
Mankhwala amapezeka piritsi. Phukusi limodzi lili ndi mapiritsi 14 kapena 28. Mu kapisolo wapinki muli 10 mg, chikasu - 20 mg, mu bulauni - 40 mg ya chinthu chomwe chikugwira ntchito.
Zizindikiro ndi contraindication
Kugwiritsa ntchito simvastatin kumawonetsedwa kwa mtundu woyamba wa hypercholesterolemia IIa kapena IIb ndikuwonjezereka kwa kukulitsa kwa atherosulinosis ndi kusachita bwino kwa mankhwala othandizira ndikuchita masewera olimbitsa thupi. Komanso, mankhwalawa amatha kuthandizira ndi mtima ischemia monga kupewa kupewa kwa stroko, mtima.
Simvastol imapangidwira cholesterol yapamwamba, yophatikizidwa ndi hypertriglyceridemia. Mankhwalawa amadziwitsidwa pakukonzekera kusinthanso mtima kuti muchepetse zovuta.
Contraindication kugwiritsa ntchito simvastatin - matenda a chiwindi, myopathy, tsankho kwa zigawo zikuluzikulu za mankhwala. Mankhwalawa sanatchulidwe muubwana ndi unyamata.
Mosamala, simvastol imagwiritsidwa ntchito pazotsatirazi:
- matenda a chiwindi;
- uchidakwa;
- chisokonezo chamagetsi chamagetsi;
- kuthamanga kwa magazi;
- kuvulala
- kulephera kwaimpso;
- kuchepa kwa minofu ya mafupa;
- zovuta za endocrine;
- matenda opatsirana opatsirana;
- kulephera kwa kagayidwe kachakudya njira;
- pakati ndi hepatitis B
Komanso mapiritsi sayenera kumwedwa pambuyo pochita opareshoni. Makamaka, mankhwalawa amaphatikizidwa ndikuwonjezera ziwalo zamkati pamene ma immunosuppressants amagwiritsidwa ntchito.
Malangizo ogwiritsira ntchito mapiritsi
Buku logwiritsira ntchito mankhwalawa likuti amamwa kamodzi patsiku, amasambitsidwa ndi madzi. Komanso, nthawi yakumwa Simvastol siyenera kuyanjana ndi kugwiritsa ntchito chakudya.
Asanayambe komanso mankhwala, zakudya za anticholesterol ziyenera kutsatira. Pa gawo loyambirira la mankhwalawa, tikulimbikitsidwa kumwa mapiritsi mu 10 mg ndi 20 mg.
Kutengera ndi kuopsa kwa hypercholesterolemia, adokotala amatha kusintha kuchuluka kwa yogwira kuyambira 10 mpaka 80 mg patsiku. Ngati ndi kotheka, masiku 28 aliwonse dokotala amasintha. Odwala ambiri, achire kwambiri pazomwe zimachitika pomatenga 20 mg ya Simvastol patsiku.
Ndi cholowa cholowa hypercholesterolemia (homozygous), kuchuluka kwa mankhwalawa tsiku lililonse ndi 40 mg / tsiku kapena 80 mg patsiku, logawidwa pazigawo zitatu (20/20/40 mg).
Ndi matenda a mtima ofunikira, mlingo woyenera ndi 20-40 mg patsiku. Ngati kuchuluka kwa LDL ndi kochepera 1.94 mmol / L, ndipo mulingo wa ma chocoler ndi 3.6 mmol / L, ndiye kuti mlingo umachepetsedwa.
M'matenda a impso, amatenga ma fibrate, nicotinic acid ndi Simvastol, kuchuluka kwa otsiriza patsiku sikoposa mamiligalamu 10.
Odwala omwe amamwa Amiodarone kapena Verapamil ayenera kumwa Simvastol muyezo mpaka 20 mg patsiku.
Zotsatira zoyipa ndi kuyanjana kwa mankhwala
Munthawi ya chithandizo ndi Simvastol, zimachitika zingapo zoyipa. Chifukwa chake, mutatha kumwa mankhwalawa, ziwalo zam'mimba zimasokonezeka, zomwe zimawonetsedwa ndi matenda am'mimba, kudzimbidwa, kuphulika, kapamba, nseru, hepatitis.
Nthawi zina mavuto amakhudza minculoskeletal system. Zotsatira zake ndi minofu kukokana, myalgia, malaise, myopathy, rhabdomyolysis.
Pogwiritsa ntchito simvastatin, matupi awo sagwirizana angayambike, monga urticaria, polymyalgia, lupus, malungo, vasculitis, angioedema, nyamakazi yokhala ndi nyamakazi, kufupika. Dermatological zimachitika akhoza kukhala - hyperemia ndi kuyabwa kwa khungu, dermatomyositis, photosensitivity, alopecia.
Kugwiritsa ntchito simvastol kumatha kusokoneza magwiridwe antchito amanjenje:
- kulakwira;
- mutu
- zotumphukira neuropathy;
- asthenic syndrome;
- kuwonongeka kwamawonekedwe mu shuga;
- kusowa tulo
- minofu kukokana;
- paresthesia.
Zotsatira zoyipa zomwe zimachitika mutatha kutenga Simvastol zimaphatikizanso kuchepa kwa potency, kulephera kwa impso, kuchepa magazi, kutentha kwambiri, komanso kugunda mtima kwachangu. Simvastatin imathanso kukhudza magawo a labotale, omwe amawonetsedwa ndi thrombocytopenia, kuchuluka kwa ESR, eosinophilia.
Pankhani yokhudzana ndi mankhwalawa, ndikofunikira kudziwa kuti mankhwalawa amawonjezera mphamvu ya anticoagulants, yomwe imawonjezera mwayi wokhetsa magazi. The achire zotsatira za Simvastol kumawonjezera limodzi ake limodzi ndi mphesa zipatso.
Ngati mumwa mapiritsi okhala ndi Verapamil, cytostatics, Erythromycin, nicotinic acid, Amiodarone, othandizira antifungal, Diltiazem, HIV protease inhibitors, Telithromycin, Clarithromycin, ndiye kuti mwayi wa myopathy ukuwonjezeka.
Analogs, ndemanga ndi mitengo
Pali mankhwala ambiri omwe amapangidwa pamaziko a simvastatin. Chifukwa chake, mutha kusintha Simvastol ndi njira zotsatirazi - Simgal, Ariescor, Zovatin, Levomir, Zokor, Simvor, Actalipid.
Analogue odziwika bwino a Simvastol ndi Avestatin. Wothandizanso wina wamankhwala ndi Vasilip. Palinso mankhwala angapo omwe amatchedwa yogwira pophika.
Mankhwalawa akuphatikizapo Simvastatin Alkaloid / Vero / SZ / Teva / Pfizer / Chaikafarm / Ferein. Zofananira zina ndi zina m'malo mwa mankhwalawa Simvastol - Simvakol, Zorstat, Simlo, Sinkard, Aterostat.
Simvastatin ali ndi malingaliro abwino. Izi zimachitika chifukwa cha kuchuluka kwa mankhwalawa othandizira mankhwalawa komanso chiopsezo chochepa chokhala ndi zovuta zoyipa.
Komabe, anthu omwe amamwa mapiritsi a simvostatin amazindikira kuti mankhwalawa amatha kutsitsa cholesterol yoyipa ndi 20%. LDL yotsala ndiyofunika kuchotsedwa mthupi kudzera mu mankhwala othandizira.
Odwala ena akuti Simvastol adawathandiza kupewa opareshoni. Ndipo atatha maphunziro a miyezi isanu ndi umodzi, mkhalidwe wamtima ndi mitsempha yamagazi idayenda bwino kwambiri, zomwe zidatsimikiziridwa ndi mayeso a labotale.
Mtengo wa mankhwalawa umatengera mlingo wake. Chifukwa chake, Simvastol No. 28 10 mg imadya pafupifupi 187-210 rubles, ndi Simvastol 20 mg - mpaka 330 rubles.
Momwe mungachepetse cholesterol m'mwazi tiziuza katswiri wa kanemayu munkhaniyi.
