Vasilip ndi mankhwala osokoneza bongo omwe amatsitsa lipid. Chofunikira kwambiri pakuchitapo kwake ndikuti cholinga chake ndi kutsitsa mulids (mafuta) m'magazi. Vasilip amapezeka mwa mawonekedwe a mapiritsi oyera mu chipolopolo cha filimu, chozungulira, chopendekera pang'ono mbali zonse ziwiri.
Chofunikira chachikulu pa mankhwalawa ndi simvastatin. Mulinso zinthu zina monga lactose monohydrate, pregelatinized starch, anhydrous citric acid, vitamini C, starch chimanga, magnesium stearate ndi microcrystalline cellulose. Chipolopolo cha piritsi palokha chimakhala ndi talc, propylene glycol, hypromellose ndi titanium dioxide.
Mlingo wa mankhwalawa ndi wa mitundu iwiri - 20 ndi 40 mg uliwonse.
Limagwirira ntchito vas vas
Popeza Vasilip ndi wa mankhwala ochepetsa lipid, momwe amagwirira ntchito ndioyenera. Choyamba, vasilip imachepetsa kuchuluka kwa mafuta m'thupi m'magazi. Pali mitundu iwiri ya cholesterol - "yoyipa" komanso "yabwino." Yemwe “woipa” ndiwotsika pamakina am'mapapo, ndipo "wabwino" ndiwopanda kuchuluka.
Vasilip imakhudzanso gawo loyambirira la mapangidwe a cholesterol. Zimaphatikizapo kutembenuka kwa HMG-CoA (hydroxymethylglutaryl-coenzyme A) kukhala mevalonic acid. Kusintha uku kumachitika mothandizidwa ndi enzyme HMG-CoAreductase. Vasilip imakhumudwitsa enzyme iyi, chifukwa chomwe cholesterol imangokhala. Mankhwalawa amakhudzanso cholesterol, yomwe ili kale m'thupi. Amachepetsa kuchuluka kwa cholesterol yomwe imakhudzana ndi lipoproteins yotsika, komanso amachepetsa kuchuluka kwa triglycerides.
Ndizinthu zamtundu wa lipid zomwe ndizomwe zimayambitsa mapangidwe a atherosulinotic ku lumen ya mitsempha. Koma mankhwalawa amachulukitsa cholesterol "yabwino" - yolumikizana ndi lipoproteins yapamwamba. Mlingo wa apolipoprotein B nawonso umachepetsedwa - mapuloteni onyamula omwe ali ndi udindo woyendetsa cholesterol mthupi lonse.
Kuphatikiza pa kuchepetsa milingo yamtundu wina wa lipids, chopangira chachikulu cha Vasilip chimakhudza khoma lamitsempha yamagazi ndi magazi eni ake. Zinthu zamagazi monga macrophages, zomwe zimatsogolera pakupanga kwa cholesterol amana, zimalepheretseka ndi mankhwalawo, ndipo zolembera zimawonongeka. Komanso kapangidwe kazinthu zomwe zimatchedwa isoprenoids, zomwe zimapangitsa kukula kwa maselo mumitsempha yamagazi, zimachepetsedwa kwambiri, chifukwa pomwe khoma la chotengera silinakome, ndipo mandimu awo samakhala ochepa. Kuphatikiza apo, Vasilip amapaka bwino mitsempha yamagazi ndikuyenda bwino kwa magazi.
Zotsatira zazikulu zimawonedwa pakatha mwezi umodzi ndi theka.
Pharmacokinetics wa Vasilip
Vasilip wameza. Imayamwa bwino kudzera pa khoma la matumbo aang'ono. Kuchuluka kwa mankhwalawa kumawonedwa ola limodzi kapena awiri atatha kumwa, koma pambuyo pa maola 12 amatsikira mpaka 10%. Mankhwalawa amatha kumwa ndi chakudya, izi sizingakhudze zotsatira zake. Komanso siziunjikira m'thupi pogwiritsa ntchito nthawi yayitali. Mankhwala amamangidwa kwambiri pamapuloteni amwazi, pafupifupi 100%.
Vasilip amasinthidwa kukhala othandizira m'chiwindi. Pulogalamuyi imatchedwa beta hydroxy acid. Kutulutsa kwake (kuchotsedwa) kumachitika kudzera m'matumbo akulu. Mankhwalawa amachotseredwa mu mawonekedwe a metabolites (mankhwala otembenuka).
Gawo lake laling'ono limachotsedwa impso, koma mawonekedwe ake osafunikira amapezeka kudzera mu impso.
Kuchotsa hafu ya moyo - nthawi yomwe kuchuluka kwa mankhwalawa m'magazi kumachepera ndendende 2 - ndi ofanana ndi ola limodzi ndi mphindi makumi asanu ndi anayi.
Zizindikiro ndi contraindication kuti mugwiritse ntchito
Madokotala nthawi zambiri amapereka mankhwala a vasilip ku matenda monga atherosulinosis. Cholinga chake mu hypercholesterolemia kapena dyspidemia wosakanikirana (kuphwanya chiŵerengero cha lipids zingapo zamagazi), limodzi ndi zochitika zolimbitsa thupi, kuchepa thupi, kutsatira zakudya zomwe zakhazikitsidwa, kapena pokhapokha ngati pali mankhwala ena.
Chizindikiro china ndi homozygous cholowa cholowa hypercholesterolemia. Mwachilengedwe, mofanananira, zakudya ndi kudya kwa mankhwala ena a antiatherosocolotic ziyenera kutsatiridwa. Vasilip adapangidwanso kuti apewe matenda a mtima ndi matenda amtundu wa chifuwa kapena matenda ashuga, popeza pamakhala chiopsezo cha matenda amtima, minyewa komanso matenda osiyanasiyana a mtima. Ndipo yomaliza imangokwezedwa cholesterol posakhalapo mawonetseredwe azachipatala.
Vasilip amatsatiridwa pazinthu monga:
- matenda a chiwindi mu pachimake siteji kapena mawonekedwe;
- kuchuluka kwakuchuluka kwa ma enzymes a chiwindi popanda chifukwa chokhazikika;
- mimba ndi mkaka wa m`mawere;
- zaka zazing'ono;
- thupi lawo siligwirizana ndi simvastatin kapena zina zilizonse za mankhwala.
Iyenera kuthandizidwa makamaka kwa odwala omwe ali ndi matenda otsatirawa:
- Ndi kumwa kwambiri mowa.
- Pamaso pa matenda okhudza chiwindi.
- Kupezeka kwa kusalinganika kwa electrolyte mthupi.
- Zophwanya zazikulu za endocrine system ndi metabolism.
- Kutsitsa kwakanthawi kochepa (hypotension).
- Zilonda zam'mimba za thupi.
- Matenda a minofu.
- Khunyu yopanda vuto.
- Opaleshoni yayikulu kapena kuvulala koopsa.
- Kupanda lactase, enzyme yomwe imaphwanya lactose (shuga ya mkaka).
- Kuphwanya njira za mayamwidwe lactose.
Kugwiritsa ntchito munthawi yomweyo mankhwala monga cyclosporine, fenofibrate, amiodarone, verapamil, diltiazem, nicotinic acid, gemfibrozin, komanso msuzi wa mphesa, amafunikanso kusamala mukamagwiritsa ntchito vasilip.
Malangizo ogwiritsira ntchito mankhwalawa
Musanagwiritse ntchito mankhwalawa, muyenera kufunsa dokotala kuti amwe momwe mungamwere bwino komanso kuti mudziwe zakumwa zake. Njira yodziwika bwino yoyenera kumwa mankhwalawa ndi kumwa kamodzi kapena kangapo patsiku nthawi yogona.
Ndikulimbikitsidwa kumwa mankhwalawo ndendende usiku, chifukwa usiku kuphatikizika kwa cholesterol yambiri kumachitika, ndipo zotsatira za mankhwalawo zimayamba kutchulidwa. Nthawi zambiri yambani ndi 10 mg. Mlingo wovomerezeka waukulu ndi 80 mg patsiku. Amalembera odwala omwe ali ndi mitundu yapamwamba yamatenda, komanso pachiwopsezo cha zovuta zochokera mumtima ndi m'mitsempha yamagazi. Mlingo wofunikira nthawi zambiri umasankhidwa patatha mwezi umodzi. Kutalika kwa nthawi ya maphunzirowa amasankhidwa mosiyanasiyana kwa wodwala aliyense ndi madokotala.
Tiyenera kukumbukira kuti mukatenga Wazilip, wodwalayo payekhapayekha amapanga zakudya, zomwe ayenera kutsatira. Nthawi zina, mankhwala ena ochepetsa lipid amalembedwanso. Kwa odwala omwe ali ndi matenda monga hypercholesterolemia, chithandizo chimayamba ndi 10 mg, koma amatha kuchulukitsidwa mpaka 40 mg kuti akwaniritse tanthauzo lake. Kwa mtundu wobadwa nawo matendawa, makonzedwe a Vazilip amawagawa katatu m'malo mwake amapereka mankhwala ovomerezeka (80 mg), kapena 40 mg ya mankhwala omwe amaperekedwa kamodzi patsiku asanagone.
Vasilip ali ndi kufunika komwe kumagwiritsidwa ntchito kamodzi komanso molumikizana ndi ma anticholesterolemic othandizira, makamaka, omwe amapezeka ndi bile acid. Awa ndi mankhwala monga colestyramine, colestipol.
Pogwiritsa ntchito cyclosporine, gemfibrozil, nicotinic acid kapena mankhwala osakanikirana ndi gulu la maforikali, amayamba ndi 5 mg, ndipo mlingo wovomerezeka ndi 10 mg. Pankhaniyi, simuyenera kupitilira muyeso uwu. Ngati wodwala amwa mankhwala osokoneza bongo motsutsana ndi arrhythmia ndi kuthamanga kwa magazi, monga Amiodarone ndi Verapamil, ndiye kuti mlingo wa Vasilip suyenera kupitanso 20 mg patsiku, popeza kusakhazikika kwawo sikumakhazikika.
Ngati munthu akudwala kwambiri gawo la kulephera kwa impso, momwe kuchuluka kwa kusefedwa kwa glomerular sikupitirira 30 ml / min., Ndipo Vasilip amapatsidwa mlingo wosaposa 10 mg patsiku. Mlingo uyenera kuchuluka kwambiri, ndipo pankhaniyi wodwala ayenera kuyang'aniridwa pafupipafupi.
Ngati kulephera kwapakati kwakhungu kumakhazikika, mulingo wake sasintha. Izi ndizomwe zimachitikiranso okalamba.
Zotsatira zoyipa za vasilip ndi bongo
Monga mankhwala ambiri, Vasilip amatha kupangitsa kuti mawonekedwe ena ayambe kudwala.
Zotsatira zoyipa zogwiritsa ntchito vasilip ndizosowa.
Pali zotsatira zoyipa kuchokera kumagulu osiyanasiyana.
Matumbo dongosolo: kuvuta defecating, kupweteka pamimba, kupanga mpweya wambiri, kudzimbidwa, nseru, nthawi zina kusanza, kutsegula m'mimba, kusintha kwa chiwindi ndi kapamba, kuwonjezeka kwa magawo a labacteria a chiwindi, alkaline phosphatase ndi creatine phosphokinase.
Mitsempha yam'mimba ndi zotengera zam'mimba: kupweteka m'mutu, chizungulire, kusokonezeka kwa mtima, mitsempha, mavuto atagona, mawonetsero olimbitsa thupi, kuperewera kwamaso komanso kulawa.
Musculoskeletal system: myopathies (pathologies a minofu system), kuphatikizika kwa minofu, kupweteka kwa minofu ndi kupindika kokhazikika.
Mawonekedwe a mziwopsezo: chithunzi chokwanira cha kumva kwambiri kwa mankhwalawa, komwe kumatupa, mawonekedwe a lupus, kupweteka kwambiri kwa minofu, dermatomyositis, kuchepa kwa kuchuluka kwa maselo, kuwonjezeka kwa kuchuluka kwa eosinophils, vasculitis, kuthamanga kwa kuchuluka kwa erythrocyte sedimentation, ululu ndi kutupa kwa mafupa, uritisaria kudziwa kuwala, kutentha thupi, kufupika kwa nkhope, kufooka kwambiri, kupuma movutikira.
Mawonekedwe amtundu wa khungu: totupa, kuyimitsidwa, khosi lozungulira la mutu (alopecia).
Kuphatikiza apo, pakhoza kuchepa kuchuluka kwa maselo ofiira am'magazi ndi hemoglobin (magazi m'thupi), kulephera kwa impso, kutsika kwa libido, ndi palpitations.
Mankhwala osokoneza bongo a Vasilip amawonedwa pakadutsa mlingo wa 3.6 g. Pankhaniyi, ndikofunikira kuti muzitsuka m'mimba, kumwa makala opaka kapena mankhwala otsekemera kuti mankhwala otsalawo asakhale ndi nthawi yoti amwe, ndipo omwe akubwera msanga achoke mthupi. Wodwala ayenera kuyang'aniridwa pafupipafupi.
Pali ma fanizo a Vasilip monga Atorvastatin, Krestor, Lovastatin, Rosuvastatin, Akorta. Onsewa ali m'gulu la ma statins. Mankhwala angagulidwe ku mankhwala aliwonse omwe mungalembe. Vasilip ndi wotsika mtengo kwambiri - mkati mwa ma ruble 250. Musanagwiritse ntchito, onetsetsani kuti mwawerenga bukuli.
Katswiri mu kanema mu nkhaniyi atchulapo za simvastatin ndi mankhwala ozitengera.
