Rosuvastatin Canon ndi mankhwala okhala ndi milomo yotsitsa lipid. Mankhwala ndi a gulu la ma statins.
Mankhwalawa ndi mpikisano wosankha wa HMG-CoA reductase, womwe umapangitsa kusintha kwa 3-hydroxy-3-methylglutaryl coenzyme A to mevalonate, yomwe imayang'anitsitsa cholesterol.
Cholinga chachikulu cha ntchito ya mankhwalawo ndi chiwindi, chiwalo chomwe chimagwira ntchito ya cholesterol synthesis ndi mphamvu ya lipoproteins yotsika.
Mankhwala tikulepheretsa ntchito ya HMG-CoA reductase. Mukamagwiritsa ntchito mankhwalawa, pafupifupi 90% ya rosuvastatin amayendayenda m'madzi a m'magazi.
Kugwiritsa ntchito mankhwalawa kumathandizira kukulitsa kuchuluka kwa zolandilira za LDL padziko nembanemba ya hepatocytes, yomwe imakulitsa kugwidwa ndi chidziwitso cha lipoproteins yotsika. Zotsatira zoterezi mthupi zimatsogolera kutsika kwa LDL mu plasma.
Zotsatira zakugwiritsidwa ntchito kwa mankhwalawa zimawonedwa kale sabata pambuyo poyambira mankhwalawa. Pambuyo milungu iwiri, achire zotsatira ukufika pazokwanira. Pambuyo pa nthawi imeneyi, kuchepa kwambiri kwa cholesterol m'thupi kumawonedwa ndipo ndikupitiliza nthawi zonse kugwiritsa ntchito mankhwalawa umasungidwa kwakanthawi kokwanira.
Kugwiritsa ntchito mankhwalawa kumatha kuthandizira kuchepetsa thupi chifukwa kuchotsedwa kwa lipids zochuluka kuchokera pamenepo.
Kumasulidwa mawonekedwe ndi mankhwala
Wopanga amapanga mankhwalawo ngati mapiritsi. Pamwambapa mapiritsiwo amaphatikizidwa ndi zokutira filimu yofiyira.
Mawonekedwe ake ndi ozungulira, biconvex. Pamalo oyaka, chiwopsezo chimayikidwa. Pamtanda, mankhwalawa ali ndi mtundu pafupifupi woyera.
Chofunikira chachikulu pa mankhwala ndi rauvastatin calcium. Izi zili mgulu lofanana ndi 10.4 mg, lomwe malinga ndi rosuvastatin koyera ndi 10 mg.
Kuphatikiza pazomwe zimagwira, mafuta omwe amaphatikizidwa ndi piritsi:
- calcium hydrogen phosphate dihydrate;
- pregelatinized chimanga wowuma;
- magnesium wakuba;
- povidone;
- microcrystalline mapadi.
Kuphatikizika kwa kuphatikizika kwa mafilimu kumapiritsi kumaphatikizapo zinthu izi:
- Selecoat AQ-01032 ofiira.
- Hydroxypropyl methyl cellulose.
- Macrogol-400.
- Macrogol-6000.
- Titanium dioxide
- Varnish zotayidwa potengera utoto Ponso 4R.
Wopanga mapiritsi opangidwa amawayika m'malo ophatikizira a PVC. Pamwamba paketiyo yokutidwa ndi zojambulazo. Phukusi lotere limasindikizidwa m'mabokosi amakatoni, momwe malangizo a mankhwalawo amayikidwa.
Mankhwala amapezeka pamapiritsi okhala ndi mitundu yosiyanasiyana ya mankhwala othandizira. Muzipatala, kutengera zosowa, mutha kugula mankhwala okhala ndi mapiritsi a rauvastatin 10, 20 ndi 40 mg piritsi limodzi. Mtengo wa mankhwalawa umatengera dera lomwe likugulitsidwa ku Russian Federation, kuchuluka kwa mankhwala othandizira pakupanga mankhwala ndi kuchuluka kwa mapiritsi amodzi phukusi limodzi. Mtengo wa phukusi limodzi, kutengera magawo omwe afotokozedwawu, ungasiyane ndi ma ruble 350 mpaka 850.
Wodwala amatha kugula mankhwala ngati wapatsidwa mankhwala kuchokera kwa dokotala.
Mankhwalawa amayenera kusungidwa pamtunda osapitirira 25 digiri Celsius m'malo owuma osagwirizana ndi ana ndi ziweto. Malo osungirako ayenera kutetezedwa ku dzuwa. Alumali moyo wa mankhwala ndi zaka ziwiri.
Nthawi imeneyi, kugwiritsa ntchito mankhwalawo kuletsedwa, kuyenera kutayidwa.
Zizindikiro ndi contraindication kuti mugwiritse ntchito
Musanagwiritse ntchito mankhwala a Rosuvastatin Canon, muyenera kuphunzira mosamala malangizo, gwiritsani ntchito mankhwalawa ndi madokotala ndi odwala, ndipo dziwani bwino za mtengo wa mankhwalawo ndi mtundu wosiyanasiyana wa mankhwala othandizira.
Kuwongolera pakugwiritsa ntchito mankhwalawa kumalimbikitsa kumwa mankhwala pokhapokha mutakambirana ndi dokotala.
Dokotalayo ndi amene amawona mulingo woyenera, poganizira zonse zomwe zikupezeka mthupi la wodwalayo.
Zizindikiro zazikulu pakugwiritsira ntchito mankhwalawa mogwirizana ndi malangizo omwe mungagwiritse ntchito ndi awa:
- kukhalapo kwa Fredrickson hypercholesterolemia (mtundu IIa, kuphatikizapo heterozygous hypercholesterolemia) kapena wosakanikirana wa hypercholesterolemia (mtundu IIb) monga chowonjezera chakudya, munthawi zotere kugwiritsa ntchito njira zosagwiritsa ntchito ma cellacological (zolimbitsa thupi, kuchepa thupi) sizokwanira;
- kukhalapo kwa mabanja a homozygous hypercholesterolemia, kuwonjezera pa zakudya ndi zina zokhala ndi lipid-kuchepetsa (mwachitsanzo, LDL-apheresis), kapena ngati kugwiritsidwa ntchito kwa mankhwalawa sikugwira ntchito mokwanira;
- kukhalapo kwa hypertriglyceridemia (mtundu IV malinga ndi Fredrickson) monga kuwonjezera pa zakudya zomwe mumagwiritsa ntchito.
Contraindication pakugwiritsira ntchito mankhwalawa ali ndi kusiyana kutengera ndende ya mapiritsi a othandizira.
Chifukwa chake mapiritsi okhala ndi 10 ndi 20 mg wa rosuvastatin, wodwalayo ali ndi zotsutsana zotsatirazi:
- Matenda a chiwindi mu gawo logwira, komanso kuchuluka kwa transaminase.
- Zowonongeka zazambiri za impso.
- Kukhalapo kwa myopathy wodwala.
- Kugwiritsa ntchito mankhwalawa ndi cyclosporine.
- Nthawi ya bere komanso nthawi ya mkaka wa m'mawere.
- Kukonzeratu zakutsogolo kwa zovuta za myotoxic.
- Zaka zosakwana 18.
- Hypersensitivity pamagawo a mankhwala.
Pogwiritsa ntchito mapiritsi omwe amakhala ndi rosuvastatin 40 mg, contraindication ogwiritsira ntchito ndi awa:
- aimpso ndi chiwindi kulephera;
- kunyamula mwana ndi kuyamwitsa;
- ntchito mogwirizana ndi cyclosporine;
- kukhalapo kwa matenda a chiwindi mu pachimake gawo chitukuko;
- kupezeka kwa thupi la kutchulidwa tsankho kwa zigawo za mankhwala.
Mankhwala osokoneza bongo omwe wodwala amakhala nawo akamatenga mitundu yambiri ya tsiku ndi tsiku.
Pakakhala mankhwala osokoneza bongo, chithandizo cha mankhwala chimayikidwa ndipo chiwindi chimagwira, komanso ntchito za CPK, zimayang'aniridwa.
Palibe mankhwala achindunji omwe amagwiritsidwa ntchito pakachitika bongo. Njira ya hemodialysis siyothandiza.
Malangizo ogwiritsira ntchito mankhwalawa
Mankhwala amaperekedwa pakamwa, nthawi iliyonse masana, mosasamala zakudya.
Piritsi liyenera kumezedwa lonse popanda kuphwanya, pomwe mukumwa uyenera kupita ndi kumwa madzi ambiri.
Pankhani yoika mankhwalawa muyezo wa 5 mg, piritsi lokhala ndi gawo la 10 mg la magawo lingagawidwe pakati.
Asanayambe kuchita mankhwala ndi Rosuvastatin, Canon amafunikira kuti wodwalayo azikhala ndi kudya kwa hypocholesterol kwakanthawi. Kugwirizana ndi zakudya zoterezi kumafunikanso mankhwala atangoyamba kumene.
Mlingo wa mapiritsi a cholesterol umasankhidwa ndi dokotala woganizira zotsatira za kusanthula ndi maphunziro a thupi la wodwalayo atatha kudya chakudya chamagulu ndi machitidwe ake.
Kuphatikiza apo, Mlingo wa mankhwala ogwiritsidwa ntchito ungakhudzidwe ndi cholinga cha njira yothandizira achire komanso chikhalidwe cha momwe thupi limayankhira pakugwiritsa ntchito Canon pochiza Rosuvastatin.
Malinga ndi malangizo ogwiritsira ntchito, mulingo woyenera wa mankhwalawa ndi 5 kapena 10 mg kamodzi patsiku.
Pogwiritsa ntchito munthawi yomweyo rosuvastatin wokhala ndi michere kapena nicotinic acid wokwanira osaposa gramu imodzi patsiku, mlingo woyambirira ndi 5 mg kamodzi patsiku.
Posankha mlingo, dokotala amayenera kutsogoleredwa ndi zotsatira za kuchuluka kwa cholesterol m'thupi la wodwalayo ndikuwonetsetsa kuti ali ndi vuto la mtima. Kuphatikiza apo, katswiriyo ayenera kuganiziranso za ngozi zomwe zingachitike chifukwa chogwiritsa ntchito mankhwalawa munthawi ya mankhwala.
Ngati ndi kotheka, Mlingo wa mankhwala omwe amagwiritsidwa ntchito amasinthidwa masabata anayi alionse.
Kugwiritsa ntchito Mlingo wa 40 mg kumachitika kokha mwa odwala omwe ali ndi vuto lalikulu la chitukuko cha hypercholesterolemia komanso pamaso pa chiwopsezo chachikulu cha zovuta mu ntchito ya mtima wamthupi, komanso pakupezeka kwa kuthamanga kwa magazi kwa wodwala. Pankhani yogwiritsa ntchito mlingo woyenera wovomerezeka munthawi ya chithandizo, wodwalayo ayenera kuyang'aniridwa ndi adokotala.
Kugwiritsa ntchito mankhwala mu mulingo wapamwamba kumatsutsana mwa odwala omwe amadziwika kuti aimpso amalephera komanso kuwonongeka kwampweya.
Mwa gulu ili la odwala, mlingo womwe umalimbikitsa ndi 5 mg tsiku lililonse patsiku limodzi.
Zotsatira zoyipa ndi mawonekedwe a Rosuvastatin Canon
Pogwiritsa ntchito mankhwalawa, mavuto amabwera m'thupi la wodwalayo.
Kuchulukana kwa mavuto kumadalira mlingo womwe amagwiritsidwa ntchito komanso mawonekedwe a munthu wodwala.
Kuchokera kumbali ya dongosolo lamkati lamanjenje, kupweteka mutu, chizungulire, ndipo nthawi zina, kulephera kukumbukira kungachitike.
Pa gawo logaya chakudya, zotsatira zoyipa zimawonekera ndikuwonekera kwa kudzimbidwa, nseru, kupweteka kwam'mimba, kawirikawiri, kukula kwa kapamba ndi jaundice.
Njira yothandizira kupuma imatha kuyankha mankhwalawa ndi mawonekedwe monga kutsokomola komanso kufupika kwa mpweya.
Kuchokera ku minculoskeletal system, kuoneka kwa myalgia ndikotheka. Myopathies ndipo, nthawi zina, arthralgia.
Mbali ya kwamikodzo, mbali imodzi imatha kudziwonetsa ngati proteinuria, zotupa zotumphukira ndipo, kawirikawiri, hematuria.
Chifukwa chotenga mankhwalawa, wodwalayo amatha kuwona zizindikiro za matenda amtundu wa 2.
Ngati vuto lakutenga thupi pakumwa mankhwalawo lapezeka, lingathe kuthandizidwa ndi adokotala omwe ali ndi matendawa.
Mpaka pano, opanga mankhwala amapereka zoposa 10 mankhwala osiyanasiyana omwe ali fanizo la Rosuvastatin Canon.
Zida izi ndi:
- Akorta,
- Mertenil.
- Rosart.
- Rosistark.
- Rosuvastatin Sotex.
- Rosuvastatin SZ.
- Rosulip.
- Rosucard.
- Roxer.
- Rustor.
- Tevastor
Mankhwalawa amathandizanso thupi, koma amakhala ndi kusiyana kwakukulu pamlingo, zomwe zimathandiza wodwala kusankha njira yoyenera kwambiri, yotsika mtengo komanso yothandizirana ndi achire.
Mankhwala Rosuvastatin akufotokozedwa mu kanema munkhaniyi.
