Rosuvastatin North Star: Zizindikiro zakugwiritsira ntchito, zoyipa ndi mlingo

Rosuvastatin SZ (North Star) ndi m'gulu la ma statins omwe ali ndi lipid-kuchepetsa.

Mankhwala amagwiritsidwa ntchito moyenera matenda omwe amaphatikizika ndi vuto la lipid metabolism, komanso kupewa matenda ena a mtima. Zambiri pazamankhwala zimatha kupezeka muzinthu izi.

Pa msika wama pharmacological, mutha kupeza mankhwala ambiri okhala ndi mankhwala a rosuvastatin, pansi pazina zosiyanasiyana. Rosuvastatin SZ imapangidwa ndi kampani yopanga zoweta North Star.

Piritsi limodzi lili ndi calcium, 5, 10, 20, kapena 40 mg ya calcium ya rosuvastatin. Pakatikati pake mumaphatikizapo shuga mkaka, povidone, sodium stearyl fumarate, primellose, MCC, aerosil ndi calcium hydrophosphate dihydrate. Mapiritsi a Rosuvastatin SZ ndi biconvex, ali ndi mawonekedwe ozungulira ndipo amaphimbidwa ndi chipolopolo cha pinki.

Gawo lolimbikira ndi choletsa HMG-CoA reductase. Kuchita kwake ndikufuna kuwonjezera kuchuluka kwa ma enzymes a hepatic LDL, kupititsa patsogolo kuphatikizika kwa LDL ndikuchepetsa chiwerengero chawo.

Chifukwa chogwiritsa ntchito mankhwalawa, wodwalayo amatha kutsitsa cholesterol "yoyipa" ndikuwonjezera kuchuluka kwa "zabwino". Zotsatira zabwino zitha kuonedwa kale patadutsa masiku 7 chiyambireni chithandizo, ndipo pakatha masiku 14 ndizotheka kukwaniritsa 90% ya zotsatira zabwino. Pambuyo masiku 28, zamadzimadzi metabolism amabwerera mwakale, pambuyo pake mankhwala othandizira amafunikira.

Zapamwamba kwambiri za rosuvastatin zimawonedwa patatha maola 5 mutatsitsidwa pakamwa.

Pafupifupi 90% yazinthu zomwe zimagwira ntchito zimamangidwa ndi albin. Kuchotsa kwake m'thupi kumachitika ndi matumbo ndi impso.

Zizindikiro ndi contraindication kuti mugwiritse ntchito

Rosuvastatin-SZ amalembera matenda a lipid metabolism komanso kupewa matenda a mtima.

Monga lamulo, kugwiritsa ntchito mapiritsiwa kumafunikira kuti azitsatira zakudya zama hypocholesterol ndi masewera.

Tsamba lophunzitsira lili ndi zisonyezo zotsatirazi:

• chachikulu, m'mabanja homozygous kapena hypercholesterolemia yosakanikirana (monga njira zina zosagwiritsa ntchito mankhwala);
• hypertriglyceridemia (IV) monga chowonjezera cha zakudya zapadera;
• atherosulinosis (kuletsa kufotokozeredwa kwa cholesterol malo ndi kusintha mulingo wa cholesterol wathunthu ndi LDL);
• kupewa matenda opha ziwopsezo, kuchepa kwa masinthidwe am'mimba komanso kugunda kwamtima (ngati pali zinthu zina monga ukalamba, kuchuluka kwa mapuloteni a C-reaction, kusuta, ma genetics komanso kuthamanga kwa magazi).

Dokotala amaletsa kumwa mankhwalawa Rosuvastatin SZ 10mg, 20mg ndi 40mg ngati apeza wodwala:

1. Hypersensitivity payekha pazinthu zosiyanasiyana.
2. Kulephera kwakukulu kwa aimpso (ndi CC <30 ml / min).
3. Glucose-galactose malabsorption, kusowa kwa lactase kapena lactose tsankho.
4. Zaka mpaka 18;
5. Matenda a chiwindi opita patsogolo.
6. Kudya kwathunthu kwa HIV proteinase ndi ma cyclosporin blockers.
7. Kuchulukitsa mulingo wa CPK nthawi 5 kapena kupitirira malire apamwamba.
8. Mgwirizano wazovuta za myotoxic.
9. Mimba komanso nthawi yobereka.
10. Kuperewera kwa kulera (mwa akazi).

Kuti contraindication ntchito Rosuvastatin SZ ndi kukula kwa 40 mg kuwonjezera pazomwezi ndiwonjezerapo:

• zolimba mpaka zolimba aimpso;
• hypothyroidism;
• a fuko la Mongoloid;
• mowa;
• zinthu zomwe zimapangitsa kuwonjezeka kwa milingo ya rosuvastatin.

Komanso chosokoneza ndi kupezeka kwa mbiri yakale ya banja / minofu ya minofu.

Malangizo ogwiritsira ntchito mankhwalawa

Mapiritsi ayenera kumeza lonse ndi madzi akumwa. Amatengedwa mosasamala chakudyacho nthawi ina iliyonse masana.

Asanayambe komanso kugwiritsa ntchito mankhwala, wodwala amakana zinthu monga mafinya (impso, ubongo), mazira, nkhumba, mafuta anyama, zakudya zina zamafuta, zinthu zophika buledi kuchokera ku ufa wa premium, chokoleti ndi maswiti.

Dotolo amawona mlingo wa mankhwalawa malinga ndi kuchuluka kwa cholesterol, zolinga zamankhwala komanso machitidwe a wodwala.

Mlingo woyambirira wa rosuvastatin ndi 5-10 mg patsiku. Ngati sizotheka kukwaniritsa zomwe mukufuna, mulingo umachulukitsidwa mpaka 20 mg moyang'aniridwa ndi katswiri. Kuwunikira mosamala ndikofunikanso popereka mankhwala a 40 mg, wodwalayo akapezeka ndi vuto lalikulu la hypercholesterolemia komanso mwayi wokhudzana ndi mtima.

Masiku 14-28 atayamba kugwiritsa ntchito mankhwalawa, ndikofunikira kuyang'anira kagayidwe ka lipid.

Palibe chifukwa chosinthira kuchuluka kwa mankhwalawa kwa odwala okalamba komanso odwala matendawa. Ndi genetic polyformism, chizolowezi cha myopathy kapena cha mtundu wa a Mongoloid, mlingo wa wothandizira wokhala ndi lipid sayenera kupitirira 20 mg.

Mphamvu yotentha yosungiramo mankhwala si yoposa 25 digiri Celsius. Moyo wa alumali ndi zaka zitatu. Sungani malondawo pamalo otetezedwa ku chinyezi ndi dzuwa.

Zotsatira zoyipa ndi Kugwirizana

Mndandanda wonse wazotsatira zoyipa zomwe zimachitika mukamagwiritsa ntchito mankhwalawa zimafotokozedwa mu malangizo ogwiritsira ntchito.

Monga lamulo, zotsatira zoyipa mukamamwa mankhwalawa ndizosowa kwambiri.

Ngakhale akuwoneka ngati alibe zoyipa, amakhala ofatsa ndipo amapita okha.

Mu malangizo ogwiritsira ntchito, mndandanda wazotsatira zoyipa zimaperekedwa:

1. Endocrine dongosolo: chitukuko cha osakhudzana ndi insulin-wodwala matenda a shuga (mtundu 2).
2. Dongosolo lachitetezo: Quincke edema ndi zina zomwe hypersensitivity zimachitika.
3. CNS: chizungulire komanso migraine.
4. Dongosolo la urinary: proteinuria.
5. M`mimba thirakiti: dyspeptic matenda, kupweteka kwa epigastric.
6. Matenda a minofu ndi mafupa: myalgia, myositis, myopathy, rhabdomyolysis.
7. Khungu: kuyabwa, ming'oma, ndi zotupa.
8. Biliary dongosolo: kapamba, ntchito yayitali ya hepatic transaminases.
9. Zizindikiro zasayansi: hyperglycemia, milirubin yayikulu, phosphatase ya alkal, ntchito ya GGT, kusowa kwa chithokomiro.

Chifukwa cha kafukufuku wam'mbuyo wakugulitsa, zotsatirapo zoyipa zidadziwika:

• thrombocytopenia;
• jaundice ndi hepatitis;
• Stevens-Johnson syndrome;
• kusokonezeka kwa kukumbukira;
• zotumphukira kufalikira;
• matenda ashuga polyneuropathy;
• gynecomastia;
• hematuria;
• kupuma movutikira ndi chifuwa chowuma;
• arthralgia.

Nthawi zina, kugwiritsa ntchito Rosuvastatin SZ ndi mankhwala ena kumatha kubweretsa zotsatirapo zosayembekezereka. Pansipa pali mawonekedwe a mankhwalawa munthawi yomweyo mukamakambirana ndi ena:

1. Ma protein protein blockers - kukulitsa mwayi wa myopathy ndikuwonjezera kuchuluka kwa rosuvastatin.
2. HIV proteinase blockers - kuwonetsedwa kowonjezereka kwa ntchito yogwira ntchito.
3. Cyclosporine - kuchuluka kwa rosuvastatin mopitilira kasanu ndi kawiri.
4. Gemfibrozil, fenofibrate ndi mafupa ena, nicotinic acid - gawo lochulukirapo la zinthu komanso chiopsezo cha myopathy.
5. Erythromycin ndi maacacid okhala ndi aluminium ndi magnesium hydroxide - kuchepa kwa zomwe zili rosuvastatin.
6. Ezetimibe - kuwonjezeka kwazinthu zomwe zikugwira ntchito.

Popewa kukula kwa zovuta zomwe zimachitika chifukwa chogwiritsa ntchito munthawi yomweyo mankhwala osagwirizana, ndikofunikira kudziwitsa dokotala zamatenda onse omwe amafanana.

Mtengo, ndemanga ndi fanizo

Popeza mankhwalawa Rosuvastatin amapangidwa ndi chomera cha mankhwala "North Star", mtengo wake siwokwera kwambiri. Mutha kugula mankhwala pa mankhwala aliwonse am'mudzimo.

Mtengo wa phukusi limodzi lokhala ndi mapiritsi 30 a 5 mg aliyense ndi ma ruble 190; 10 mg iliyonse - ma ruble 320; 20 mg iliyonse - ma ruble 400; 40 mg aliyense - 740 ma ruble.

Pakati pa odwala ndi madokotala, mutha kupeza ndemanga zambiri zabwino za mankhwalawa. Kuphatikiza kwakukulu ndi mtengo wotsika mtengo komanso wamphamvu othandizira. Komabe, nthawi zina pamakhala ndemanga zoyipa zomwe zimagwirizanitsidwa ndi kupezeka kwa zoyipa.

Eugene: "Ndidapeza kagayidwe ka lipid kalekale. Ndidayesa mankhwala ambiri kwanthawi yonse. Choyamba ndidatenga Liprimar, koma ndasiya, chifukwa mtengo wake udali wowoneka bwino. Krestor adandiuza, koma sizinali za mankhwala otsika mtengo. Ndidapeza malembedwe ake, omwe anali Rosuvastatin SZ. Ndakhala ndikumwa mapiritsiwa pakadali pano, ndikumva bwino, cholesterol yanga yabwerera mwakale. "

Tatyana: "M'nyengo yotentha, mafuta a cholesterol adakwera mpaka 10, pomwe nthawiyo ndi 5.8. Ndidapita kwa akatswiri odziwa zamankhwala ndipo adandiuza kuti ndi Rosuvastatin. Dotolo adati mankhwalawa sakukhudzanso chiwindi. Pakadali pano ndikutenga Rosuvastatin SZ, zonse zimakwanira koma pali "koma" - nthawi zina mutu umakusokoneza. "

Gawo logwira ntchito la rosuvastatin limapezeka m'mankhwala ambiri opangidwa ndi opanga osiyanasiyana. Mgwirizano ukuphatikiza:

• Akorta;
• Crestor
• Mertenyl;
• Rosart
• Ro-Statin;
• Rosistark;
• Rosuvastatin Canon;
• Roxer;
• Rustor.

Ndi hypersensitivity payekha ku rosuvastatin, dokotala amasankha analogue yothandiza, i.e. wothandizira wokhala ndi chinthu china chogwira ntchito, koma kupanga zomwezi zimachepetsa lipid yomweyo. Mu pharmac mungagule mankhwala ngati awa:

1. Atorvastatin.
2. Atoris.
3. Vasilip.
4. Vero-simvastatin.
5. Zokor.
6. Simgal.

Chinthu chachikulu pa chithandizo cha cholesterol yayikulu ndikutsatira malingaliro onse a katswiri, kutsatira zakudya ndi kukhala ndi moyo wokangalika. Chifukwa chake, ndizotheka kuthana ndi matenda ndikuletsa mavuto osiyanasiyana.

Mankhwala Rosuvastatin SZ akufotokozedwa mwatsatanetsatane mu kanema munkhaniyi.